Nomenclature for Factors of the HLA System

August 2008

Compiled by Steven GE Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

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The following sequences have been submitted to the Nomenclature Committee since the May 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author References
A*025602 HB08053124 EU998646 Tsung-Dao Lee, Taipei, Taiwan  
A*0342 DIOUF AM712914 Valerie Dubois, Lyon, France  
A*2492 BJ55 EU862819 Zhixin Zhang, Beijing, China  
A*2493 SENE AM493679 Valerie Dubois, Lyon, France  
A*2918 GACH AM493680 Valerie Dubois, Lyon, France  
A*3320 YC040208 EU98095 Yenhui Chang, St. Petersburg, USA  
A*9251 7080859 FM204792 Jean-Marie Tiercy, Geneva, Switzerland  
B*0838 49595 FM177891 Jayne Johnson, Pontyclun, United Kingdom  
B*1323 BJ067050 EU884291 Xiaoyan Shan, Beijing, China  
B*1830 BY00343 EU924809 Carolyn K Hurley, Washington DC, USA  
B*1831 BY00345 EU924807 Carolyn K Hurley, Washington DC, USA  
B*350203 HSP-B350203 FM205711 Oscar de la Calle-Martin, Barcelona, Spain  
B*390106 1346 EU981815 Jie Liu, Harbin, HeiLongjiang, China  
B*490102 NT01007 EU924804 Carolyn K Hurley, Washington DC, USA  
B*5158 Allcord2423 EU839991 Byeong Min Ahn, Seoul, South Korea  
B*5159 LuluX01 EU871625 Lulu Xiao, GuangZhou, GuangDong Province, China  
B*5160 NT01010 EU924800 Carolyn K Hurley, Washington DC, USA  
B*5161 DEDKM2710684 AM493681 Valerie Dubois, Lyon, France  
B*5416 BJ074508 EU939322 Xiaoyan Shan, Beijing, China  
B*5820 CHET AM497780 Valerie Dubois, Lyon, France  
B*9551 RMAT AM747238 Valerie Dubois, Lyon, France  
Cw*070203 LUMC-C54 FM201491 Jacqy DH Anholts, Leiden, The Netherlands  
Cw*0763 UCLA0565 FJ009630 Kai Cao, Los Angeles, USA  
Cw*0819 42270 FM177892 Jayne Johnson, Pontyclun, United Kingdom  
Cw*1411 319348-C14new AM980455 Tatiana Lebedeva, Dedham, USA  
DRB1*03010102 QBL AL929581 Stephan Beck, London, United Kingdom (1)
DRB1*1170 31485 FM205011 Juergen Enczmann, Duesseldorf, Germany  
DRB1*1483 BY00347 EU924810 Carolyn K Hurley, Washington DC, USA  
DRB1*15010102 NA10923 AY663406 Maynard Olson, Seattle, USA (2)
DRB1*15030102 NA14663 AY663411 Maynard Olson, Seattle, USA (2)

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting Author References
A*0307 NT01005 EU924806 Carolyn K Hurley, Washington DC, USA  
A*3008 NT01009 EU924801 Carolyn K Hurley, Washington DC, USA  
A*6805 NT01006 EU924805 Carolyn K Hurley, Washington DC, USA  
A*6812 NT01008 EU924803 Carolyn K Hurley, Washington DC, USA  
A*9222 BY00344 EU924808 Carolyn K Hurley, Washington DC, USA  
B*0835 461129019 AM747237 Valerie Dubois, Lyon, France  
B*5309 BY00346 EU924802 Carolyn K Hurley, Washington DC, USA  
Cw*0760 HSP-Cw7 FM201315 Oscar de la Calle-Martin, Barcelona, Spain  
DRB1*010101 HOM-2 AM493435 Steven GE Marsh, London, United Kingdom  
DRB1*010201 NA01018 AY663400 Maynard Olson, Seattle, USA (2)
DRB1*03010101 COX AL662842 Stephan Beck, London, United Kingdom (3)
DRB1*03010101 NA01018 AY663399 Maynard Olson, Seattle, USA (2)
DRB1*03010101 NA10923 AY663407 Maynard Olson, Seattle, USA (2)
DRB1*110101 NA00576 AY663412 Maynard Olson, Seattle, USA (2)
DRB1*110102 NA01960 AY663397 Maynard Olson, Seattle, USA (2)
DRB1*110401 NA14661 AY663394 Maynard Olson, Seattle, USA (2)
DRB1*120101 NA14660 AY663396 Maynard Olson, Seattle, USA (2)
DRB1*130101 NA03715 AY663415 Maynard Olson, Seattle, USA (2)
DRB1*130201 NA14663 AY663413 Maynard Olson, Seattle, USA (2)
DRB1*140501 NA04535 AY663408 Maynard Olson, Seattle, USA (2)
DRB1*1454 NA10540 AY663405 Maynard Olson, Seattle, USA (2)
DRB1*15010101 PGF AL713966 Stephan Beck, London, United Kingdom (3)
DRB1*150201 NA03715 AY663414 Maynard Olson, Seattle, USA (2)
DRB1*15030101 NA14660 AY663395 Maynard Olson, Seattle, USA (2)

References

  1. Traherne JA, Horton R, Roberts AN, et al. Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet. 2006 2:e9
  2. Raymond CK, Kas A, Paddock M, et al. Ancient haplotypes of the HLA Class II region. Genome Res. 2005 15:1250-7
  3. Stewart CA, Horton R, Allcock RJ, et al. Complete MHC haplotype sequencing for common disease gene mapping. Genome Res. 2004 14:1176-87