Nomenclature for Factors of the HLA System
May 2008
Compiled by Steven GE Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2008 72:224-6
- Human Immunology. 2008 69:526-31
- International Journal of Immunogenetics. 2008 35:353-5
The following sequences have been submitted to the Nomenclature Committee since the April 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author |
|---|---|---|---|
| A*1133 | JMDP36K002 | AB434757 | Kenji Tadokoro, Tokyo, Japan |
| A*1134 | BY00325 | EU716062 | Carolyn K Hurley, Washington DC, USA |
| A*1135 | HistoCB40216 | EU680956 | Hoon Han, Seoul, South Korea |
| A*2487 | JMDP01K009 | AB434097 | Kenji Tadokoro, Tokyo, Japan |
| A*2488 | JMDP36K003 | AB434758 | Kenji Tadokoro, Tokyo, Japan |
| A*2489 | 071SX132 | EU643640 | Jianping Cai, Beijing, China |
| A*2490N | BY00331 | EU716068 | Carolyn K Hurley, Washington DC, USA |
| A*3318 | SZ-14 | EU665684 | Zhen Li, Shenzhen, China |
| A*6843 | DOPIRos | AM950323 | Anne Dormoy, Strasbourg, France |
| A*9246 | JMDP36K001 | AB434692 | Kenji Tadokoro, Tokyo, Japan |
| A*9247 | NT00793 | EU682451 | Carolyn K Hurley, Washington DC, USA |
| B*0766 | JMDP01K013 | AB435170 | Kenji Tadokoro, Tokyo, Japan |
| B*350403 | JMDP36K007 | AB435078 | Kenji Tadokoro, Tokyo, Japan |
| B*3592 | JMDP36K005 | AB434760 | Kenji Tadokoro, Tokyo, Japan |
| B*3593 | JMDP36K007x | AB434761 | Kenji Tadokoro, Tokyo, Japan |
| B*3594 | JMDP01K014 | AB435234 | Kenji Tadokoro, Tokyo, Japan |
| B*3714 | 2007-1414 | AM993049 | Florian Emmerich, Berlin, Germany |
| B*3944 | JMDP36K0079 | AB435079 | Kenji Tadokoro, Tokyo, Japan |
| B*3945 | JMDP36K008 | AB435164 | Kenji Tadokoro, Tokyo, Japan |
| B*407202 | JMDP01K015 | AB435235 | Kenji Tadokoro, Tokyo, Japan |
| B*4091 | JMDP36K010 | AB435080 | Kenji Tadokoro, Tokyo, Japan |
| B*4461N | JMDP01K018 | AB435544 | Kenji Tadokoro, Tokyo, Japan |
| B*4462 | BY00323 | EU682449 | Carolyn K Hurley, Washington DC, USA |
| B*4463 | BY00324 | EU682448 | Carolyn K Hurley, Washington DC, USA |
| B*4464 | BY00322 | EU682450 | Carolyn K Hurley, Washington DC, USA |
| B*4615N | JMDP01K019 | AB435545 | Kenji Tadokoro, Tokyo, Japan |
| B*4616 | JMDP-1K040 | AB436533 | Kenji Tadokoro, Tokyo, Japan |
| B*5157 | JMDP36K011 | AB435165 | Kenji Tadokoro, Tokyo, Japan |
| B*5214 | 306458 | EU672816 | Edward KL Yang, Hualien, Taiwan |
| B*5414 | JMDP36K013 | AB435167 | Kenji Tadokoro, Tokyo, Japan |
| B*5415 | JMDP01K024 | AB435519 | Kenji Tadokoro, Tokyo, Japan |
| B*5532 | JMDP36K014 | AB435168 | Kenji Tadokoro, Tokyo, Japan |
| B*5819 | JMDP36K016 | AB435237 | Kenji Tadokoro, Tokyo, Japan |
| B*5903 | JMDP01K025 | AB435520 | Kenji Tadokoro, Tokyo, Japan |
| B*7806 | JMDP01K026 | AB435521 | Kenji Tadokoro, Tokyo, Japan |
| B*9548 | JMDP36K004 | AB434759 | Kenji Tadokoro, Tokyo, Japan |
| B*9549N | SZ-15 | EU693920 | Hong-Yan Zou, Shenzhen, China |
| Cw*0122 | 37-12333 | AB378484 | Nobuo Araki, Kobe, Japan |
| Cw*0349 | UD130000 | EU669571 | Kyung Wha Lee, Anyang City, South Korea |
| Cw*0433 | LUMC-C51 | AM991287 | Jacqy DH Anholts, Leiden, The Netherlands |
| Cw*0757 | CTM-9699551 | EU683684 | Antonio Balas, Madrid, Spain |
| DRB1*010105 | CTM-5099261 | EU683685 | Antonio Balas, Madrid, Spain |
| DRB1*0120 | JMDP36K017 | AB436794 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*0340 | 60648330 | EU660882 | Reinhard Kelsch, Muenster, Germany |
| DRB1*040506 | JMDP01K028 | AB436777 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*0475 | HAN-1022 | AY766103 | Georgena Wohlwend, Seattle, USA |
| DRB1*0476 | HAN-1026 | EU678649 | Georgena Wohlwend, Seattle, USA |
| DRB1*0477 | JMDP01K027 | AB436776 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*0835 | JMDP01K041 | AB436800 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*090104 | JMDP36K018 | AB436795 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*1169 | BY00327 | EU716064 | Carolyn K Hurley, Washington DC, USA |
| DRB1*120203 | JMDP36K021 | AB436796 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*1480 | JMDP01K030 | AB436778 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*150206 | JMDP36K022 | AB436797 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*1528 | JMDP01K031 | AB436801 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*1529 | JMDP01K032 | AB436798 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*1530 | JMDP01K033 | AB436799 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*1531 | BY00328 | EU716065 | Carolyn K Hurley, Washington DC, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| A*2410 | JMDP36K023 | AB436621 | Kenji Tadokoro, Tokyo, Japan |
| A*2425 | JMDP01K038 | AB436158 | Kenji Tadokoro, Tokyo, Japan |
| A*2430 | JMDP01K010 | AB434098 | Kenji Tadokoro, Tokyo, Japan |
| A*2462 | JMDP01K011 | AB434492 | Kenji Tadokoro, Tokyo, Japan |
| A*2617 | JMDP01K012 | AB434691 | Kenji Tadokoro, Tokyo, Japan |
| B*0753 | NT00977 | EU716061 | Carolyn K Hurley, Washington DC, USA |
| B*1532 | JMDP36K024 | AB436622 | Kenji Tadokoro, Tokyo, Japan |
| B*1563 | JMDP36K025 | AB436623 | Kenji Tadokoro, Tokyo, Japan |
| B*3534 | JMDP36K029 | AB436627 | Kenji Tadokoro, Tokyo, Japan |
| B*3535 | JMDP36K027 | AB436625 | Kenji Tadokoro, Tokyo, Japan |
| B*4019 | JMDP01K017 | AB435236 | Kenji Tadokoro, Tokyo, Japan |
| B*480301 | JMDP36K028 | AB436626 | Kenji Tadokoro, Tokyo, Japan |
| B*520103 | JMDP01K022 | AB435517 | Kenji Tadokoro, Tokyo, Japan |
| B*5211 | JMDP36K012 | AB435166 | Kenji Tadokoro, Tokyo, Japan |
| B*5212 | LINAPau | AM950324 | Anne Dormoy, Strasbourg, France |
| B*5212 | JMDP01K020 | AB435516 | Kenji Tadokoro, Tokyo, Japan |
| B*5305 | JMDP01K023 | AB435518 | Kenji Tadokoro, Tokyo, Japan |
| B*5504 | JMDP01K039 | AB436532 | Kenji Tadokoro, Tokyo, Japan |
| B*5510 | JMDP36K026 | AB436624 | Kenji Tadokoro, Tokyo, Japan |
| Cw*0606 | LUMC-C50 | AM991286 | Jacqy DH Anholts, Leiden, The Netherlands |
| Cw*0705 | NT00976 | EU716071 | Carolyn K Hurley, Washington DC, USA |
| Cw*1405 | NT00975 | EU716070 | Carolyn K Hurley, Washington DC, USA |
| Cw*1511 | NT00974 | EU716069 | Carolyn K Hurley, Washington DC, USA |
| DRB1*040504 | HAN-1025 | EU678648 | Georgena Wohlwend, Seattle, USA |
| DRB1*0426 | HAN-1024 | EU678647 | Georgena Wohlwend, Seattle, USA |
| DRB1*0440 | HAN-1023 | EU678646 | Georgena Wohlwend, Seattle, USA |
| DRB1*1382 | BY00329 | EU716066 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1472 | BY00330 | EU716067 | Carolyn K Hurley, Washington DC, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*0299 | (1) |
| A*0323 | (1) |
| A*1127 | (1) |
| A*2318 | (2) |
| A*3314 | (3) |
| B*1316 | (1) |
| B*2736 | (1) |
| B*4083 | (4) |
| B*4816 | (1) |
| B*510203 | (5) |
| B*5521 | (1) |
| B*5812 | (1) |
| Cw*0113 | (6) |
| Cw*0207 | (6) |
| Cw*0212 | (6) |
| Cw*0216 | (6) |
| Cw*030305 | (6) |
| Cw*0318 | (6) |
| Cw*0327 | (6) |
| Cw*0411 | (6) |
| Cw*0417 | (6) |
| Cw*0508 | (6) |
| Cw*0512 | (6) |
| Cw*0514 | (6) |
| Cw*0613 | (6) |
| Cw*070107 | (6) |
| Cw*0722 | (6) |
| Cw*0733N | (6) |
| Cw*0735 | (6) |
| Cw*0739 | (6) |
| Cw*1216 | (6) |
| Cw*1218 | (6) |
| Cw*1515 | (6) |
| Cw*1517 | (6) |
| Cw*1607 | (6) |
| DRB1*0458 | (1) |
| DRB1*1372 | (1) |
| DRB1*1462 | (1) |
| DPA1*010304 | (7) |
| DPA1*0110 | (7) |
| DPA1*0204 | (8) |
References
- Shan X, Xiao Y, Wang L, Lazaro AM, Hurley CK. Identification of 11 novel HLA alleles found during typing of unrelated registry donors in China. Tissue Antigens. 2008 71:578-9
- Aureli A, Del Beato T, Papola F, Adorno D, Piancatelli D. A new HLA-A allele identified in a leukemic patient attending hematopoietic cell transplantation: A*2318. Tissue Antigens. 2008 71:568-9
- Lee KW, Huh JW, Seong CM. A new HLA-A*33 variant, HLA-A*3314, identified in a Korean individual. Tissue Antigens. 2008 71:570
- Lee KW. A novel HLA-B*40 allele, HLA-B*4083, identified in a Korean individual. Tissue Antigens. 2008 71:571-2
- Zhu FM, He J, Zhang W, Yan LX. Identification of a novel HLA-B*510203 allele in a Chinese individual. Tissue Antigens. 2008 71:572-3
- Lazaro AM, Xiao Y, Cao K, et al. Twenty-three novel alleles increase diversity at the HLA-C locus. Tissue Antigens. 2008 71:560-3
- Lee KW. Description of two novel HLA-DPA1 alleles: DPA1*0110 and DPA1*010304. Tissue Antigens. 2008 71:575-7
- Zhao H, Dai WJ, He YM, Zhu FM, Yan LX. A novel HLA-DPA1*0204 allele was identified in a Chinese individual. Tissue Antigens. 2008 71:577-8
