Nomenclature for Factors of the HLA System

February 2008

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the January 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell Identification Accession Number Submitting Author
A*020118 A15111 EU376018 Antonio Amoroso, Torino, Italy
A*110203 SZ-11 EU492459 Hong-Yan Zou, Shenzhen, China
A*260106 CambsA26 AM922174 Reyna Goodman, Cambridge, United Kingdom
A*3216 268059 EU410616 Joannis Mytilineos, Ulm, Germany
A*3315 07112601 EU478436 Jihyang Lim, Seoul, South Korea
A*9238 CambsA2 AM922173 Reyna Goodman, Cambridge, United Kingdom
A*9239 07221358 EU431985 Joannis Mytilineos, Ulm, Germany
A*9240 A11962 EU376019 Antonio Amoroso, Torino, Italy
B*0763 263776 EU410615 Joannis Mytilineos, Ulm, Germany
B*4084 320500011612 EU481038 Jun He, Suzhou, China
B*4085 410028 EU434882 Sung-Hee Han, Seoul, South Korea
B*4086 SDBC-1 EU434746 Chuanfu Zhu, Jinan, China
B*4613 B19205 EU515127 Lixing Yan, Hangzhou, China
B*580102 B28287 EU499350 Lixing Yan, Hangzhou, China
B*9542 NT00781 EU484049 Carolyn K Hurley, Washington DC, USA
Cw*0120 07213718 EU428006 Joannis Mytilineos, Ulm, Germany
Cw*0348 SZ-10 EU442891 Hong-Yan Zou, Shenzhen, China
Cw*070202 LUMC-C44 AM934701 Jacqy DH Anholts, Leiden, The Netherlands
Cw*0754 266653 EU410614 Joannis Mytilineos, Ulm, Germany
Cw*1611 07221287 EU431984 Joannis Mytilineos, Ulm, Germany
DQB1*0403 06222422 EU410617 Joannis Mytilineos, Ulm, Germany

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*0255 NT00783 EU484046 Carolyn K Hurley, Washington DC, USA
A*0308 NT00777 EU484053 Carolyn K Hurley, Washington DC, USA
A*1129 06d05591,
07d00393		 AM746507 Jacqy DH Anholts, Leiden, The Netherlands
A*6831 NT00778 EU484052 Carolyn K Hurley, Washington DC, USA
B*1308Q LUMC-B45 AM934702 Jacqy DH Anholts, Leiden, The Netherlands
B*1514 NT00785 EU484044 Carolyn K Hurley, Washington DC, USA
B*1825 NT00782 EU484048 Carolyn K Hurley, Washington DC, USA
B*3515 NT00784 EU484045 Carolyn K Hurley, Washington DC, USA
B*3908 NT00780 EU484050 Carolyn K Hurley, Washington DC, USA
B*4008 NT00779 EU484051 Carolyn K Hurley, Washington DC, USA
B*401403 D24298 AM493904 Odile Avinens, Montpellier, France
B*9506 79475 AM904558 Jacqy DH Anholts, Leiden, The Netherlands
Cw*0718 LUMC-C38 AM904560 Jacqy DH Anholts, Leiden, The Netherlands
Cw*0726 79475 AM904559 Jacqy DH Anholts, Leiden, The Netherlands
Cw*0746 LUMC-C24 AM748047 Jacqy DH Anholts, Leiden, The Netherlands
Cw*1513 LUMC-C39 AM904561 Jacqy DH Anholts, Leiden, The Netherlands
DRB1*1518 I053612 EU375479 Georgena Wohlwend, Seattle, USA
DRB1*1522 I077864 EU375478 Georgena Wohlwend, Seattle, USA
DRB1*1527 I982583 EU375477 Georgena Wohlwend, Seattle, USA

Table 3: Recently Published Sequences


Sequence References
A*0110 (1)
A*0112 (1)
A*0112 (1)
A*0113 (1)
A*0117 (1)
A*0117 (1)
A*0263 (1)
A*0280 (1)
A*0292 (1)
A*0316 (1)
A*0325 (1)
A*111502 (1)
A*1117 (1)
A*1122 (1)
A*1123 (1)
A*1123 (1)
A*2441 (1)
A*2450 (1)
A*2455 (1)
A*2456 (1)
A*2456 (1)
A*2457 (1)
A*2457 (1)
A*2475 (2)
A*2627 (1)
A*2909 (1)
A*2914 (1)
A*3013 (1)
A*3016 (1)
A*3213 (1)
A*3407 (1)
A*3408 (1)
A*3408 (1)
A*6828 (1)
A*6829 (1)
A*6830 (1)
A*6831 (1)
A*6834 (1)
A*9201 (1)
B*15010101 (3)
B*15170101 (3)
B*270502 (3)
B*4501 (3)
B*480102 (4)
B*5601 (3)
Cw*0716 (5)
Cw*0751 (6)
DRB1*0715 (7)
DRB1*1613N (8)

References

  1. Lazaro AM, Xiao Y, Cao K, et al. Thirty-two novel HLA-A alleles identified during intermediate resolution testing. Tissue Antigens. 2008 71:165-8.
  2. Kwon OJ, Oh Y, Oh JW, Seo KH, Park C. A new HLA-A*24 variant, A*2475, identified by sequence-based typing in the Korean population. Tissue Antigens. 2008 71:175-6.
  3. Roman A, Cervera I, Head J, Rodriguez M, Martinez-Laso J. Generation of HLA-B*1516/B*1567/B*1595 and B*1517 alleles (B15 specific group) by transpecies evolution. Hum Immunol. 2007 68:1001-8.
  4. Chen MJ, Chu CC, Shyr MH, Lin PY, Yang KL. Discovery of HLA-B*480102 in Taiwanese. Int J Immunogenet. 2008 35:15-8.
  5. Canossi A, Liberatore G, Del Beato T, Piazza A, Adorno D. Identification of the very uncommon allele HLA-Cw*0716 in a Caucasian renal transplant recipient: extension of the exon 4 sequence. Tissue Antigens. 2008 71:176-8.
  6. Thompson EM, Kashi ZM, Martin RK, Alcorn JL, Tidey L. Identification of the novel HLA-C allele Cw*0751. Tissue Antigens. 2008 71:178-9.
  7. Balas A, Bustamante L, Garcia-Sanchez F, Vicario JL. Sequencing of a novel HLA-DRB1*07 allele with a new polymorphism at amino acid position 21 (DRB1*0715). Tissue Antigens. 2008 71:179-80.
  8. Zhao W, Guerrero E, Kerman RH, Cano P, Fernandez-Vina MA. DRB1*1613N: a novel DRB1 allele with a premature termination codon. Tissue Antigens. 2008 71:180-2.