Nomenclature for Factors of the HLA System
January 2008
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2008 71:580-1
- Human Immunology. 2008 69:314-6
- International Journal of Immunogenetics. 2008 35:343-4
The following sequences have been submitted to the Nomenclature Committee since the December 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author |
|---|---|---|---|
| A*020118 | MHHI-603528 | AM906168 | Rainer Blasczyk, Hannover, Germany |
| A*020119 | LUMC-A41 | AM932284 | Jacqy DH Anholts, Leiden, The Netherlands |
| A*110109 | 73043 | AM931011 | Juergen Enczmann, Duesseldorf, Germany |
| A*2485 | LZ-3 | EU352655 | Hong-Yan Zou, Shenzhen, China |
| A*3007 | NT00764 | EU330463 | Carolyn K Hurley, Washington DC, USA |
| A*3314 | LWS-061204 | EU399237 | Kyung Wha Lee, Anyang City, South Korea |
| B*150108 | MHHZ-00033538 | AM931064 | Rainer Blasczyk, Hannover, Germany |
| B*2740 | 269088 | EU341811 | Edward KL Yang, Hualien, Taiwan |
| B*3586 | NT00711 | EF375686 | Carolyn K Hurley, Washington DC, USA |
| B*3587 | MHHZ-00023391 | AM493308 | Rainer Blasczyk, Hannover, Germany |
| B*3588 | BY00269 | EU330466 | Carolyn K Hurley, Washington DC, USA |
| B*4081 | ZHY-2 | EU366958 | Hong-Yan Zou, Shenzhen, China |
| B*4082 | LUMC-B43 | AM932286 | Jacqy DH Anholts, Leiden, The Netherlands |
| B*4083 | B07-2657 | EU399238 | Kyung Wha Lee, Anyang City, South Korea |
| B*442802 | MHHAKB-518404 | AM920502 | Peter Horn, Hannover, Germany |
| B*442802 | MHHAKB-518813 | AM920465 | Rainer Blasczyk, Hannover, Germany |
| B*5315 | NT00770 | EU330470 | Carolyn K Hurley, Washington DC, USA |
| B*5530 | HZZJCB5723 | EU422994 | Lixing Yan, Hangzhou, China |
| B*9540 | D28140 | AM905050 | Odile Avinens, Montpellier, France |
| B*9541 | FR | EU378915 | Frederick Bradley Johnson, Philadelphia, USA |
| Cw*040105 | x47 | EU369696 | Zhihui Deng, ShenZhen, China |
| Cw*0432 | MHHC-602813 | AM931046 | Rainer Blasczyk, Hannover, Germany |
| Cw*0518 | 109342 | AM931012 | Juergen Enczmann, Duesseldorf, Germany |
| Cw*0519 | LUMC-C42 | AM932285 | Jacqy DH Anholts, Leiden, The Netherlands |
| DRB1*010104 | OT11400 | AM931296 | Sofia Tavoularis, Ottawa, Ontario, Canada |
| DRB1*1168 | HO013276 | AM931006 | Sofia Tavoularis, Ottawa, Ontario, Canada |
| DRB1*131403 | HO007970 | AM931007 | Sofia Tavoularis, Ottawa, Ontario, Canada |
| DRB1*1383 | MHHN-611087 | AM931066 | Rainer Blasczyk, Hannover, Germany |
| DRB1*1476 | HO013533 | AM933133 | Sofia Tavoularis, Ottawa, Ontario, Canada |
| DPA1*010304 | BM4129BM4066 | DQ274061 | Kyung Wha Lee, Anyang City, South Korea |
| DPA1*0110 | BM3950 | DQ274060 | Kyung Wha Lee, Anyang City, South Korea |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| A*290202 | NT00767 | EU330467 | Carolyn K Hurley, Washington DC, USA |
| A*2909 | NT00765 | EU330464 | Carolyn K Hurley, Washington DC, USA |
| A*3207 | NT00761 | EU330460 | Carolyn K Hurley, Washington DC, USA |
| B*130202 | NT00773 | EU375812 | Carolyn K Hurley, Washington DC, USA |
| B*1503 | NT006891 | EF156370 | Carolyn K Hurley, Washington DC, USA |
| B*1540 | NT00762 | EU330461 | Carolyn K Hurley, Washington DC, USA |
| B*1811 | NT00776 | EU375809 | Carolyn K Hurley, Washington DC, USA |
| B*1828 | MHHAKB-477183, MHHAKB-468157 |
AM931047, AM931065 |
Peter Horn, Hannover, Germany |
| B*2709 | NT00775 | EU375810 | Carolyn K Hurley, Washington DC, USA |
| B*350402 | NT00774 | EU375811 | Carolyn K Hurley, Washington DC, USA |
| B*3516 | NT00771 | EU330471 | Carolyn K Hurley, Washington DC, USA |
| B*3911 | NT00768 | EU330468 | Carolyn K Hurley, Washington DC, USA |
| B*5143 | NT00766 | EU330465 | Carolyn K Hurley, Washington DC, USA |
| B*5523 | NT00769 | EU330469 | Carolyn K Hurley, Washington DC, USA |
| DRB1*0468 | BY00242 | EU095408 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1166 | BY00249 | EU095404 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1319 | NT00772 | EU375813 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1341 | NT00763 | EU330462 | Carolyn K Hurley, Washington DC, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*0127N | (1) |
| A*030105 | (2) |
| A*110202 | (3) |
| A*2474 | (4) |
| A*6836 | (5) |
| B*0748 | (3) |
| B*3579 | (5) |
| B*3580 | (6) |
| B*3712 | (3) |
| B*3922 | (5) |
| B*4453 | (7) |
| B*9515 | (3) |
| Cw*0217 | (8) |
| Cw*0220 | (9) |
| Cw*0333 | (8) |
| DRB1*115402 | (3) |
| DRB1*1373 | (3) |
| DRB1*150106 | (3) |
| DQB1*0632 | (10) |
References
- Longhi E, Frison S, Andreini E, Karpasitou K, Serafini M, Poli F. Description of HLA-A*0127N, a novel nonexpressed allele identified by SBT. Hum Immunol. 2007 68:913-4
- Albis-Camps M, Blasczyk R, Horn PA. Haplotype-specific sequence-based typing shows the novel allele HLA-A*030105. Tissue Antigens. 2008 71:85-6
- Zhang B, Lazaro AM, Xing P, Cheng S, Hurley CK. Characterization of seven new HLA alleles from the Henan and Gansu Provinces of China. Tissue Antigens. 2008 71:95-6
- Kwon OJ, Kim J, Park K, Oh JW, Park C. Identification of a new HLA-A*24 variant, A*2474, by sequence-based typing in the Korean population. Tissue Antigens. 2008 71:86-7
- Sanchez-Gordo F, Balas A, Garcia-Sanchez F, Prat I, Vicario JL. Report of a novel B*3579 allele in an Ecuadorian family: confirmation and extension of A*6836 and B*3922 sequences. Tissue Antigens. 2008 71:88-9
- Aureli A, Liberatore G, Papola F, Adorno D, Piancatelli D. Identification of a novel HLA-B allele, HLA-B*3580, with possible implication in transplantation and CTL response. Tissue Antigens. 2008 71:90-1
- Ulrich S, Posch U, Helmberg W, Lanzer G. A new HLA-B*44 variant, B*4453, identified by haplotype-specific extraction and sequencing-based typing. Tissue Antigens. 2008 71:91-2
- Minevich G, Kuhn L, Polistena C, Nuara J, Winchester R. Description of two new HLA-C alleles in a Black South African population. Tissue Antigens. 2008 71:72-6
- Balas A, Bustamante L, Garcia-Sanchez F, Vicario JL. The new HLA-C allele, Cw*0220, shows a new polymorphism at amino acid position 169. Tissue Antigens. 2008 71:93
- Emmerich F, Schonemann C, Diederich G, Horn PA, Salama A. Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632. Tissue Antigens. 2008 71:94-5
