Nomenclature for Factors of the HLA System
December 2007
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2008 71:262-3
- Human Immunology. 2007 69:139-40
- International Journal of Immunogenetics. 2007 35:175-6
The following sequences have been submitted to the Nomenclature Committee since the November 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author |
|---|---|---|---|
| A*0339 | CTM-1698446 | EU305401 | Antonio Balas, Madrid, Spain |
| A*2319Q | ALX0010 | DQ145282, DQ145283 |
Edward Ball, Cleveland, USA |
| A*2319Q | 95230 | EF656476 | Mary Sue Leffell, Baltimore, USA |
| A*240215 | 2007-4627 | AM922284 | Florian Emmerich, Berlin, Germany |
| B*150107 | 90484 | DQ869010 | Mary Sue Leffell, Baltimore, USA |
| B*4459 | Cairjo | AM922196 | Paul Dunn, Auckland, New Zealand |
| B*5314 | D28023 | AM911066 | Odile Avinens, Montpellier, France |
| B*5529 | 2007-4621 | AM922105 | Florian Emmerich, Berlin, Germany |
| Cw*050104 | LUMC-C40 | AM922328 | Jacqy DH Anholts, Leiden, The Netherlands |
| G*0110 | ML1699 | EU290672 | Ma Luo, Winnipeg, Manitoba, Canada |
| G*0111 | ML1837 | EU290673 | Ma Luo, Winnipeg, Manitoba, Canada |
| DRB1*1167 | IME1278-06ROMA | EF640930 | Carlo Carcassi, Cagliari, Italy |
| DRB1*1475 | 2647934 | AM922324 | Sabine Schuett, Berlin, Germany |
| DPA1*0204 | DP56 | EU304462 | Lixing Yan, Hangzhou, China |
| MICA*055 | P218 | EU254723 | Juergen Glas, Munich, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| DRB5*010101 | MHHZ-00020722 | AM159646 | Rainer Blasczyk, Hannover, Germany |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*030105 | (1) |
| A*110202 | (2) |
| A*2474 | (3) |
| A*6836 | (4) |
| B*0748 | (2) |
| B*3579 | (4) |
| B*3580 | (5) |
| B*3712 | (2) |
| B*3922 | (4) |
| B*4453 | (6) |
| B*9515 | (2) |
| Cw*0217 | (7) |
| Cw*0220 | (8) |
| Cw*0333 | (7) |
| DRB1*115402 | (2) |
| DRB1*1373 | (2) |
| DRB1*150106 | (2) |
| DQB1*0632 | (9) |
References
- Albis-Camps M, Blasczyk R, Horn PA. Haplotype-specific sequence-based typing shows the novel allele HLA-A*030105. Tissue Antigens. 2008 71:85-6.
- Zhang B, Lazaro AM, Xing P, Cheng S, Hurley CK. Characterization of seven new HLA alleles from the Henan and Gansu Provinces of China. Tissue Antigens. 2008 71:95-6.
- Kwon OJ, Kim J, Park K, Oh JW, Park C. Identification of a new HLA-A*24 variant, A*2474, by sequence-based typing in the Korean population. Tissue Antigens. 2008 71:86-7.
- Sanchez-Gordo F, Balas A, Garcia-Sanchez F, Prat I, Vicario JL. Report of a novel B*3579 allele in an Ecuadorian family: confirmation and extension of A*6836 and B*3922 sequences. Tissue Antigens. 2008 71:88-9.
- Aureli A, Liberatore G, Papola F, Adorno D, Piancatelli D. Identification of a novel HLA-B allele, HLA-B*3580, with possible implication in transplantation and CTL response. Tissue Antigens. 2008 71:90-1.
- Ulrich S, Posch U, Helmberg W, Lanzer G. A new HLA-B*44 variant, B*4453, identified by haplotype-specific extraction and sequencing-based typing. Tissue Antigens. 2008 71:91-2.
- Minevich G, Kuhn L, Polistena C, Nuara J, Winchester R. Description of two new HLA-C alleles in a Black South African population. Tissue Antigens. 2008 71:72-6.
- Balas A, Bustamante L, Garcia-Sanchez F, Vicario JL. The new HLA-C allele, Cw*0220, shows a new polymorphism at amino acid position 169. Tissue Antigens. 2008 71:93.
- Emmerich F, Schonemann C, Diederich G, Horn PA, Salama A. Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632. Tissue Antigens. 2008 71:94-5.
