Nomenclature for Factors of the HLA System

December 2007

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the November 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at :

Table 1: New Sequences

Sequence Cell identification Accession number Submitting Author
A*0339 CTM-1698446 EU305401 Antonio Balas, Madrid, Spain
A*2319Q ALX0010 DQ145282,
Edward Ball, Cleveland, USA
A*2319Q 95230 EF656476 Mary Sue Leffell, Baltimore, USA
A*240215 2007-4627 AM922284 Florian Emmerich, Berlin, Germany
B*150107 90484 DQ869010 Mary Sue Leffell, Baltimore, USA
B*4459 Cairjo AM922196 Paul Dunn, Auckland, New Zealand
B*5314 D28023 AM911066 Odile Avinens, Montpellier, France
B*5529 2007-4621 AM922105 Florian Emmerich, Berlin, Germany
Cw*050104 LUMC-C40 AM922328 Jacqy DH Anholts, Leiden, The Netherlands
G*0110 ML1699 EU290672 Ma Luo, Winnipeg, Manitoba, Canada
G*0111 ML1837 EU290673 Ma Luo, Winnipeg, Manitoba, Canada
DRB1*1167 IME1278-06ROMA EF640930 Carlo Carcassi, Cagliari, Italy
DRB1*1475 2647934 AM922324 Sabine Schuett, Berlin, Germany
DPA1*0204 DP56 EU304462 Lixing Yan, Hangzhou, China
MICA*055 P218 EU254723 Juergen Glas, Munich, Germany

Table 2: Confirmatory Sequences

Sequence Cell Identification Accession Number Submitting Author
DRB5*010101 MHHZ-00020722 AM159646 Rainer Blasczyk, Hannover, Germany

Table 3: Recently Published Sequences

Sequence References
A*030105 (1)
A*110202 (2)
A*2474 (3)
A*6836 (4)
B*0748 (2)
B*3579 (4)
B*3580 (5)
B*3712 (2)
B*3922 (4)
B*4453 (6)
B*9515 (2)
Cw*0217 (7)
Cw*0220 (8)
Cw*0333 (7)
DRB1*115402 (2)
DRB1*1373 (2)
DRB1*150106 (2)
DQB1*0632 (9)


  1. Albis-Camps M, Blasczyk R, Horn PA. Haplotype-specific sequence-based typing shows the novel allele HLA-A*030105. Tissue Antigens. 2008 71:85-6.
  2. Zhang B, Lazaro AM, Xing P, Cheng S, Hurley CK. Characterization of seven new HLA alleles from the Henan and Gansu Provinces of China. Tissue Antigens. 2008 71:95-6.
  3. Kwon OJ, Kim J, Park K, Oh JW, Park C. Identification of a new HLA-A*24 variant, A*2474, by sequence-based typing in the Korean population. Tissue Antigens. 2008 71:86-7.
  4. Sanchez-Gordo F, Balas A, Garcia-Sanchez F, Prat I, Vicario JL. Report of a novel B*3579 allele in an Ecuadorian family: confirmation and extension of A*6836 and B*3922 sequences. Tissue Antigens. 2008 71:88-9.
  5. Aureli A, Liberatore G, Papola F, Adorno D, Piancatelli D. Identification of a novel HLA-B allele, HLA-B*3580, with possible implication in transplantation and CTL response. Tissue Antigens. 2008 71:90-1.
  6. Ulrich S, Posch U, Helmberg W, Lanzer G. A new HLA-B*44 variant, B*4453, identified by haplotype-specific extraction and sequencing-based typing. Tissue Antigens. 2008 71:91-2.
  7. Minevich G, Kuhn L, Polistena C, Nuara J, Winchester R. Description of two new HLA-C alleles in a Black South African population. Tissue Antigens. 2008 71:72-6.
  8. Balas A, Bustamante L, Garcia-Sanchez F, Vicario JL. The new HLA-C allele, Cw*0220, shows a new polymorphism at amino acid position 169. Tissue Antigens. 2008 71:93.
  9. Emmerich F, Schonemann C, Diederich G, Horn PA, Salama A. Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632. Tissue Antigens. 2008 71:94-5.