Nomenclature for Factors of the HLA System
November 2007
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2007 71:260-1
- Human Immunology. 2007 69:68-70
- International Journal of Immunogenetics. 2007 35:173-4
The following sequences have been submitted to the Nomenclature Committee since the October 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author |
|---|---|---|---|
| A*230302 | NT00754 | EU275160 | Carolyn K Hurley, Washington DC, USA |
| A*2317 | LUMC-A33 | AM904553 | Jacqy DH Anholts, Leiden, The Netherlands |
| A*2318 | F438 | EU253478 | Anna Aureli, L'Aquila, Italy |
| A*2484N | 06500234 | AM849046 | Steffen Schwab, Martinsried, Germany |
| A*6842 | NT00752 | EU275152 | Carolyn K Hurley, Washington DC, USA |
| A*9236 | BY00174 | EU256485 | Carolyn K Hurley, Washington DC, USA |
| A*9237 | 4034892 | EU167538 | Reinhard Kelsch, Muenster, Germany |
| B*0761 | LUMC-B34 | AM904554 | Jacqy DH Anholts, Leiden, The Netherlands |
| B*0762 | MHHAKB-519696 | AM906167 | Rainer Blasczyk, Hannover, Germany |
| B*0835 | NT00750 | EU256488 | Carolyn K Hurley, Washington DC, USA |
| B*1828 | MHHAKB-438906 | AM906169 | Peter Horn, Hannover, Germany |
| B*2739 | NT00755 | EU275159 | Carolyn K Hurley, Washington DC, USA |
| B*3585 | LUMC-B37 | AM904557 | Jacqy DH Anholts, Leiden, The Netherlands |
| B*400106 | BJ035 | EF612726 | Zhixin Zhang, Beijing, China |
| B*4079 | RVEN | EU233478 | Bouke Hepkema, Groningen, The Netherlands |
| B*4080 | NT00759 | EU275155 | Carolyn K Hurley, Washington DC, USA |
| B*4458N | BY00266 | EU256486 | Carolyn K Hurley, Washington DC, USA |
| B*5152 | MHHI-603335 | AM906166 | Rainer Blasczyk, Hannover, Germany |
| Cw*0347 | NT00748 | EU256491 | Carolyn K Hurley, Washington DC, USA |
| G*010114 | TXH12-2R3 | EU220991 | Antonio Arnaiz-Villena, Madrid, Spain |
| DRB1*040304 | NT00760 | EU275154 | Carolyn K Hurley, Washington DC, USA |
| DRB1*0472 | ESGR11535AN | AM899948 | Ann-Margaret Little, London, United Kingdom |
| DRB1*0473 | LUMC-DR35 | AM904555 | Jacqy DH Anholts, Leiden, The Netherlands |
| DRB1*135002 | CB5046 | EU290674 | Lixing Yan, Hangzhou, China |
| DRB1*1382 | LUMC-DR36 | AM904556 | Jacqy DH Anholts, Leiden, The Netherlands |
| DQB1*030104 | NT00757 | EU275157 | Carolyn K Hurley, Washington DC, USA |
| DQB1*0321 | NT00756 | EU275158 | Carolyn K Hurley, Washington DC, USA |
| DQB1*060202 | 72330002 | AM900764 | Steffen Schwab, Martinsried, Germany |
| DPB1*410102 | TZ-V603 | EU153252 | Marie Lin, Taipei, Taiwan |
| MICA*054 | IDAM73501AN | AM899996 | Ann-Margaret Little, London, United Kingdom |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| A*680202 | NT00753 | EU275161 | Carolyn K Hurley, Washington DC, USA |
| A*6810 | NT00749 | EU256490 | Carolyn K Hurley, Washington DC, USA |
| B*400102 | MT214 | EU233477 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| B*400201 | MT456 | EU233475 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| B*400201 | ND1665 | EU233474 | Bouke Hepkema, Groningen, The Netherlands |
| B*40060102 | MT193 | EU233476 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| B*4422 | NT00751 | EU256487 | Carolyn K Hurley, Washington DC, USA |
| Cw*072702 | BY00265 | EU256489 | Carolyn K Hurley, Washington DC, USA |
| DRB1*0337 | BY00254 | EU095396 | Carolyn K Hurley, Washington DC, USA |
| DRB1*040505 | BY00251 | EU095399 | Carolyn K Hurley, Washington DC, USA |
| DRB1*110202 | BY00267 | EU256484 | Carolyn K Hurley, Washington DC, USA |
| DRB1*116501 | BY00234, BY00244, BY00243 |
EU084400, EU095406, EU095407 |
Carolyn K Hurley, Washington DC, USA |
| DQB1*0205 | NT00758 | EU275156 | Carolyn K Hurley, Washington DC, USA |
| MICA*019 | HANGZHOUA31 | EU267602 | Lixing Yan, Hangzhou, China |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*0281 | (1) |
| A*0289 | (1) |
| A*240212 | (2) |
| A*240214 | (3) |
| A*3117 | (4) |
| A*3215 | (3) |
| A*340102 | (5) |
| A*9224 | (1) |
| B*9507 | (6) |
| B*9524 | (7) |
| Cw*033802 | (8) |
| Cw*0346 | (9) |
| Cw*0517 | (10) |
| G*0109 | (11) |
| DRB1*0832 | (12) |
| DQB1*060302 | (3) |
References
- Balas A, Alonso-Nieto M, Sanchez-Gordo F, Garcia-Sanchez F, Vicario JL. Description of three new HLA-A*02 subtypes in Caucasians: A*0281, A*0289 and A*9224. Tissue Antigens. 2007 70:515-6.
- Liu N, Zhang Z. Identified a novel allele HLA-A*240212 by sequence-based typing. Tissue Antigens. 2007 70:516-7.
- Heinold A, Bauer M, Opelz G, Scherer S, Schmidt AH, Tran TH. Identification and characterization of three novel HLA alleles, HLA-A*240214, HLA-A*3215 and HLA-DQB1*060302. Tissue Antigens. 2007 70:511-4.
- Yan LX, Zhu FM, Zhang W. Identification of a novel allele HLA-A*3117 in the Chinese cord blood donor. Tissue Antigens. 2007 70:517-8.
- Dunn PP, Rantes C, Hall C, et al. Identification of a variant HLA-A*3401 allele, A*340102, in an educational DNA typing sample. Tissue Antigens. 2007 70:518-9.
- Hammond L, Street J, Johnson J, Pepperall J, Darke C. A new HLA-B*15 variant - B*9507. Tissue Antigens. 2007 70:519-21.
- Zhu FM, He JJ, He J, Yan LX. A novel HLA-B*15 allele, B*9524, identified by sequence-based tying in the Chinese population. Tissue Antigens. 2007 70:521-2.
- Kim MH, Oh HB, Kwon OJ. A novel HLA-Cw*03 allele, Cw*033802, identified by sequence-based typing. Tissue Antigens. 2007 70:522-4.
- Endres RO, Redman H, Baumbach A, Capper J. A novel HLA-C locus allele with codon 54 deletion, Cw*0346. Tissue Antigens. 2007 70:524-5.
- Endres RO, Redman H, Baumbach A, Capper J. A novel HLA-Cw*05 allele, Cw*0517. Tissue Antigens. 2007 70:525-7.
- Kang H, Yun HS, Song MY, Lee JK, Kwack K. Identification of novel HLA-G subtype, HLA-G*0109, by sequencing in the Korean population. Tissue Antigens. 2007 70:529-30.
- Dang CW, Chu CC, Liu TY, Lin M, Lee YJ. A novel HLA-DRB1 allele, DRB1*0832, identified by sequence-based typing method. Tissue Antigens. 2007 70:527-9.
