Nomenclature for Factors of the HLA System

October 2007

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the September 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author
A*6607 BJ061913 EU140343 Xiaoyan Shan, Beijing, China
A*680202 BRABRI EU189866 Youri Serov, Indianapolis, USA
A*9235 FBCCB5942 AB355648 Yukari Kuroda, Fukuoka, Japan
B*3584 BY00263 EU185515 Carolyn K Hurley, Washington DC, USA
B*5715 NT00744 EU185513 Carolyn K Hurley, Washington DC, USA
B*5716 BS723143 AM889027 Jean-Marie Tiercy, Geneva, Switzerland
B*5816 BY00260 EU185518 Carolyn K Hurley, Washington DC, USA
Cw*150204 BJ049 EU169936 Na Liu, Beijing, China

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*020605 BY00264 EU185509 Carolyn K Hurley, Washington DC, USA
A*0254 NT00746 EU185511 Carolyn K Hurley, Washington DC, USA
A*0284 NT00747 EU185510 Carolyn K Hurley, Washington DC, USA
A*1119 NT00745 EU185512 Carolyn K Hurley, Washington DC, USA
A*6836 scu00946 EU189033 Francisco de Paula Sanchez Gordo, Malaga, Spain
B*0753 NT00743 EU185514 Carolyn K Hurley, Washington DC, USA
B*130204 MST987659354 EU086373 Reinhard Kelsch, Muenster, Germany
B*3706 BY00259 EU185519 Carolyn K Hurley, Washington DC, USA
B*3811 BY00261 EU185517 Carolyn K Hurley, Washington DC, USA
B*3920 BY00258 EU185520 Carolyn K Hurley, Washington DC, USA
B*3939 BY00262 EU185516 Carolyn K Hurley, Washington DC, USA
DPB1*110101 H348 AM887530 Carlos Vilches, Madrid, Spain

Table 3: Recently Published Sequences


Sequence References
A*260104 (1)
A*7411 (1)
B*3576 (2)
Cw*010205 (3)
Cw*0116 (3)
Cw*0117 (3)
Cw*0118 (3)
Cw*0218 (3)
Cw*030406 (3)
Cw*030407 (3)
Cw*0336 (3)
Cw*0337 (3)
Cw*033801 (3)
Cw*0426 (3)
Cw*0427 (3)
Cw*0615 (3)
Cw*0616N (3)
Cw*0743 (3)
Cw*0747 (3)
Cw*0748 (3)
Cw*0813 (1)
Cw*1518 (3)
Cw*1520 (3)
Cw*1608 (1)
Cw*1704 (1)
Cw*1803 (3)
DRB1*130502 (1)
DQB1*0622 (4)

References

  1. Tu B, Mack SJ, Lazaro A, et al. HLA-A, -B, -C, -DRB1 allele and haplotype frequencies in an African American population. Tissue Antigens. 2007 69:73-85.
  2. Aubert V, Mayerat C, Lopez N, Pantaleo G. Sequence analysis of the novel HLA-B35 (B*3576) allele in an African individual. Tissue Antigens. 2007 70:439-41.
  3. Lebedeva TV, Ohashi M, Mastromarino SA, Alosco SM, Yu N. New HLA-C alleles identified in minority populations. Tissue Antigens. 2007 70:441-2.
  4. Chang Y, Fan TX, Santana Z, Day NK. Identification of a novel allele HLA-DQB1*0622. Tissue Antigens. 2007 70:442-4.