Nomenclature for Factors of the HLA System

August 2007

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the July 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

A number of sequences have been found to have been named in error. In each case the allele name that was assigned suggested that the allele had a novel amino acid sequence, whereas it differed only by a single silent substitution from a previously described allele. New names have been assigned to these alleles and the original names abandoned, these alleles are listed in Table 4.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author
A*020117 KILIMir AM712907 Anne Dormoy, Strasbourg, France
A*0333 MHHN-574610 AM778452 Rainer Blasczyk, Hannover, Germany
A*0334 MHHN-563903 AM778555 Rainer Blasczyk, Hannover, Germany
A*0335 107028 AM779474 Juergen Enczmann, Duesseldorf, Germany
A*111502 BY00103 DQ473291 Carolyn K Hurley, Washington DC, USA
A*241302 FRFCB AM268430 Anne Dormoy, Strasbourg, France
A*301102 BY00146 EF422076 Carolyn K Hurley, Washington DC, USA
A*3024 78175 AM778131 Juergen Enczmann, Duesseldorf, Germany
A*9229 BJ040 EF685282 Lei Ni, Beijing, China
A*9230 K18125 AB354233 Etsuko Maruya, Kyoto, Japan
A*9231 76460 AM778130 Juergen Enczmann, Duesseldorf, Germany
B*070207 MHHAKB-490085 AM778679 Rainer Blasczyk, Hannover, Germany
B*071802 DNA78151 AM778128 Juergen Enczmann, Duesseldorf, Germany
B*0834 99239 AM778129 Juergen Enczmann, Duesseldorf, Germany
B*152702 RA1242 EF622511 Min Yu, Chicago, USA
B*350803 NT00699 EF195110 Carolyn K Hurley, Washington DC, USA
B*3580 F866 EU056568 Anna Aureli, L'Aquila, Italy
B*3581 FFM86952 AM778468 Veronika Brixner, Frankfurt, Germany
B*4612 B13403 EU081878 Lixing Yan, Hangzhou, China
B*510902 NT00701 EF195108 Carolyn K Hurley, Washington DC, USA
B*5150 49916 AM779473 Juergen Enczmann, Duesseldorf, Germany
B*5528 105488 AM779472 Juergen Enczmann, Duesseldorf, Germany
B*5621 45112351 EU079373 Chi Zhang, Harbin, China
B*9535 MHHAKB-438106 AM778232 Rainer Blasczyk, Hannover, Germany
B*9536 B13403 EU081879 Lixing Yan, Hangzhou, China
B*9537 BJ047 EU099586 Zhixin Zhang, Beijing, China
B*9538 BJ048 EU091341 Shuang Cui, Beijing, China
B*9539 BJ046 EU079372 Lijun Wang, Beijing, China
Cw*020206 MHHUDS-587930 AM778451 Rainer Blasczyk, Hannover, Germany
Cw*0220 CTM-4697391 EU080975 Antonio Balas, Madrid, Spain
Cw*041502 NT00664 DQ525630 Carolyn K Hurley, Washington DC, USA
Cw*0429 070214 AM747469 Martin Danzer, Linz, Austria
Cw*072702 BY00073 DQ270210,
DQ270211		 Carolyn K Hurley, Washington DC, USA
Cw*151002 TBC17874 AB196346 Masahiro Satake, Tokyo, Japan
DRB1*030106 MHHN-593833 AM777659 Rainer Blasczyk, Hannover, Germany
DRB1*0337 BY00232 EU071682 Carolyn K Hurley, Washington DC, USA
DRB1*0338 BY00237 EU084397 Carolyn K Hurley, Washington DC, USA
DRB1*0339 BY00253 EU095397 Carolyn K Hurley, Washington DC, USA
DRB1*040103 BY00238 EU084396 Carolyn K Hurley, Washington DC, USA
DRB1*040505 BY00236 EU084398 Carolyn K Hurley, Washington DC, USA
DRB1*040505 R030242430 DQ836315 Linda Smith, Perth, Australia
DRB1*0466 JAMC7746AN AM773422 Ann-Margaret Little, London, United Kingdom
DRB1*0467 BJ042 EF687782 Lin Wang, Beijing, China
DRB1*0468 BY00241 EU095409 Carolyn K Hurley, Washington DC, USA
DRB1*0469 BY00245 EU095405 Carolyn K Hurley, Washington DC, USA
DRB1*0470 BY00248 EU095401 Carolyn K Hurley, Washington DC, USA
DRB1*0471 BY00250 EU095400 Carolyn K Hurley, Washington DC, USA
DRB1*0833 BJ045 EU079376 Wei Li, Beijing, China
DRB1*0834 BY00240 EU084394 Carolyn K Hurley, Washington DC, USA
DRB1*116501 BY00235 EU084399 Carolyn K Hurley, Washington DC, USA
DRB1*116502 MMarsh1 EU090251 Youri Serov, Indianapolis, USA
DRB1*1166 BY00246 EU095403 Carolyn K Hurley, Washington DC, USA
DRB1*1381 BY00230 EU071684 Carolyn K Hurley, Washington DC, USA
DRB1*143202 MHHN-159365 AM493247 Rainer Blasczyk, Hannover, Germany
DRB1*1526 BY00229 EU071685 Carolyn K Hurley, Washington DC, USA
DRB1*1613N MDA-DR16N EU078908 Marcelo Fernandez Vina, Houston, USA
DRB3*0223 NSB971105 AM747470 Martin Danzer, Linz, Austria
MICA*01203 AA-MUC,
AM(child1)-MUC,
AS(child2)-MUC		 Y18110 Ekkehard D Albert, Muenchen, Germany
MICB*00505 PUM324-95 AJ606909,
AJ606910,
AJ606911		 Rainer Blasczyk, Hannover, Germany

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*9202 ML1359 EU095649 Ma Luo, Winnipeg, Manitoba, Canada
A*9223 DCI29186 EU031440 Sallyanne Fossey, Nashville, USA
B*520602 scu01715 EU080976 Francisco de Paula Sanchez Gordo, Malaga, Spain
B*5713 MHHN-593828 AM778678 Peter Horn, Hannover, Germany
Cw*0344 71156 AM779475 Juergen Enczmann, Duesseldorf, Germany
Cw*140203 ML1806 EU095650 Ma Luo, Winnipeg, Manitoba, Canada
DRB1*0329 BY00247 EU095402 Carolyn K Hurley, Washington DC, USA
DRB1*0417 BY00255 EU095395 Carolyn K Hurley, Washington DC, USA
DRB1*0454 BY00239 EU084395 Carolyn K Hurley, Washington DC, USA
DRB1*090102 A6 DQ140279 Chin-Hee Song, Gyeonggi-do, South Korea
DRB1*1158 BY00252 EU095398 Carolyn K Hurley, Washington DC, USA
DRB1*1520 BY00231 EU071683 Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences


Sequence References
A*2468 (1)
A*68020103 (2)
A*9206 (3)
B*3563 (4)
B*5149 (5)

Table 4 : Renamed Alleles


Old name New name
A*1128 A*111502
A*2465 A*241302
A*3021 A*301102
B*9530 B*152702
B*3573 B*350803
B*5147 B*510902
Cw*0421 Cw*041502
Cw*0734 Cw*072702
Cw*1514 Cw*151002
DRB1*1466 DRB1*143202
MICA*021 MICA*01203
MICB*017 MICB*00505

References

  1. Yan LX, Zhu FM, He JJ, Chen NY: HLA-A*2468, a new allele identified by sequence-based typing in the Chinese population. Tissue Antigens 2007 70:256-7.
  2. Balas A, Sanchez-Garcia F, Bustamante L, Garcia-Sanchez F, Vicario JL: HLA-A*68020103 shows an eight nucleotides deletion within intron 2 but has normal mRNA splicing and serological recognition. Tissue Antigens 2007 70:258-9.
  3. Zhu FM, He JJ, Yan LX: Identification of a novel allele HLA-A*9206 by sequence-based typing in the Chinese population. Tissue Antigens 2007 70:257.
  4. Lee KW: A novel hybrid allele (B*3563) originated from B*350101 and B*4001-like alleles. Tissue Antigens 2007 70:260-2.
  5. Endres RO, Redman H, Scavello GS: A novel HLA-B*51 allele, HLA-B*5149. Tissue Antigens 2007 70:259-60.