Nomenclature for Factors of the HLA System
July 2007
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2007 70:445-7
- Human Immunology. 2007 68:938-40
- International Journal of Immunogenetics. 2007 34:479-81
The following sequences have been submitted to the Nomenclature Committee since the June 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
The cell surface expression of the B*1308 allele has been brought into question, as such a 'Q' suffix has been added to this allele name, making it B*1308Q. The sequence Cw*0502 was recently shown to be in error and has been shown to be identical to Cw*0509, the name Cw*0502 has now been abandoned.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author |
|---|---|---|---|
| A*0129 | BY00201 | EU029775 | Carolyn K Hurley, Washington DC, USA |
| A*0130 | BY00200 | EU029776 | Carolyn K Hurley, Washington DC, USA |
| A*020116 | LUMC-A21 | AM746482 | Jacqy Anholts, Leiden, The Netherlands |
| A*020605 | BY00193 | EU029783 | Carolyn K Hurley, Washington DC, USA |
| A*030106 | LUMC-A5 | AM746339 | Jacqy Anholts, Leiden, The Netherlands |
| A*0331 | MHHZ-00023725 | AM748070 | Rainer Blasczyk, Hannover, Germany |
| A*0332 | BY00196 | EU029780 | Carolyn K Hurley, Washington DC, USA |
| A*2480 | LUMC-A23 | AM746483 | Jacqy Anholts, Leiden, The Netherlands |
| A*2481 | BY00189, BY00198 |
EU029786 | Carolyn K Hurley, Washington DC, USA |
| A*2482 | BY00197 | EU029779 | Carolyn K Hurley, Washington DC, USA |
| A*2917 | BY00204 | EU029772 | Carolyn K Hurley, Washington DC, USA |
| A*3023 | LUMC-A16 | AM746480 | Jacqy Anholts, Leiden, The Netherlands |
| A*3119 | MHHN-574599 | AM749668 | Rainer Blasczyk, Hannover, Germany |
| A*320103 | BY00190 | EU029785 | Carolyn K Hurley, Washington DC, USA |
| A*340102 | QC358 | AM748386 | Paul Dunn, Auckland, New Zealand |
| A*6841 | G0424060013350 | EU048251 | Catherine Cormack, London, United Kingdom |
| A*9227 | BJ041 | EF687770 | Zhongmei Wang, Beijing, China |
| A*9228 | BY00199 | EU029777 | Carolyn K Hurley, Washington DC, USA |
| B*070206 | LUMC-B1 | AM746337 | Jacqy Anholts, Leiden, The Netherlands |
| B*0759 | LUMC-B2 | AM746338 | Jacqy Anholts, Leiden, The Netherlands |
| B*150106 | LUMC-B9, V50340 |
AM748045 | Jacqy Anholts, Leiden, The Netherlands |
| B*1827 | LUMC-B14 | AM746478 | Jacqy Anholts, Leiden, The Netherlands |
| B*352002 | LUMC-B7 | AM749669 | Jacqy Anholts, Leiden, The Netherlands |
| B*3578 | K112206 | AM747815 | Ciaran Dunne, Dublin, Eire |
| B*3579 | scu00946 | EF679203 | Francisco de Paula Sanchez Gordo, Malaga, Spain |
| B*3817 | G042406000536Z | EU030284 | Susan Wallace, London, United Kingdom |
| B*3943 | LUMC-B10 | AM748046 | Jacqy Anholts, Leiden, The Netherlands |
| B*4078 | BJ037 | EF679333 | Wei Li, Beijing, China |
| B*4455 | R37148 | AM746211 | Hien Tran, Heidelberg, Germany |
| B*4819 | BJ043 | EU022558 | Wei Li, Beijing, China |
| B*520602 | TBC64726 | AB327275 | Masahiro Satake, Tokyo, Japan |
| B*8103 | ShanXi005 | EU048339 | Demei Zhang, Taiyuan, China |
| B*9533 | BJ044 | EU022523 | Lijun Wang, Beijing, China |
| B*9534 | P2476 | EU046491 | Lixing Yan, Hangzhou, China |
| Cw*0219 | DN1277.4 | EU003584 | Min Yu, Chicago, USA |
| Cw*033802 | 2007373 | EU005272 | Heung-Bum Oh, Seoul, Korea |
| Cw*0342 | LUMC-C8 | AM746340 | Jacqy Anholts, Leiden, The Netherlands |
| Cw*0343 | LUMC-C11 | AM746341 | Jacqy Anholts, Leiden, The Netherlands |
| Cw*0344 | LUMC-C20 | AM746481 | Jacqy Anholts, Leiden, The Netherlands |
| Cw*0345 | RA1243 | EU003583 | Min Yu, Chicago, USA |
| Cw*0346 | UCLADNAExt#466 | EF650024 | Robert Endres, Tempe, USA |
| Cw*0428 | LUMC-C26 | AM748048 | Jacqy Anholts, Leiden, The Netherlands |
| Cw*060203 | LUMC-C28 | AM749672 | Jacqy Anholts, Leiden, The Netherlands |
| Cw*070108 | R37397 | AM749066 | Hien Tran, Heidelberg, Germany |
| Cw*070109 | LUMC-C22 | AM749670 | Jacqy Anholts, Leiden, The Netherlands |
| Cw*0750 | LUMC-C4 | AM748044 | Jacqy Anholts, Leiden, The Netherlands |
| Cw*0751 | 0089 | EU017384 | Zahra Mehdizadeh Kashi, Beaverton, USA |
| Cw*0815 | LUMC-C27 | AM749671 | Jacqy Anholts, Leiden, The Netherlands |
| DRB1*0117 | BY00214 | EU029796 | Carolyn K Hurley, Washington DC, USA |
| DRB1*0118 | BY00212 | EU029794 | Carolyn K Hurley, Washington DC, USA |
| DRB1*0119 | BY00209, BY00208 |
EU029791, EU029790 |
Carolyn K Hurley, Washington DC, USA |
| DRB1*0336 | LUMC-DRB15 | AM746479 | Jacqy Anholts, Leiden, The Netherlands |
| DRB1*0465 | KHM2/171877 | AM765992 | Klaus Witter, M�nchen, Germany |
| DRB1*1002 | BY00228 | EU071686 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1216 | 45112875 | EF688603 | Chi Zhang, Harbin, China |
| DRB1*1380 | BY00221 | EU029803 | Carolyn K Hurley, Washington DC, USA |
| DRB1*144402 | BY00215 | EU029797 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1469 | BY00210 | EU029792 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1470 | BY00207 | EU029788 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1471 | BY00206 | EU029787 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1472 | BY00211 | EU029793 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1473 | BY00216 | EU029798 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1474 | BS640629 | AM774161 | Jean-Marie Tiercy, Geneva, Switzerland |
| DRB1*1523 | BY00222, BY00233 |
EU029804, EU071681 |
Carolyn K Hurley, Washington DC, USA |
| DRB1*1524 | BY00218, BY00224 |
EU029800, EU071690 |
Carolyn K Hurley, Washington DC, USA |
| DRB1*1525 | BY00225 | EU071689 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1612 | BY00219, BY00226 |
EU029801, EU071688 |
Carolyn K Hurley, Washington DC, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| A*0115N | BY00202 | EU029771 | Carolyn K Hurley, Washington DC, USA |
| A*2443 | BY00205 | EU029774 | Carolyn K Hurley, Washington DC, USA |
| A*3115 | BY00203 | EU029773 | Carolyn K Hurley, Washington DC, USA |
| A*3309 | BY00194 | EU029782 | Carolyn K Hurley, Washington DC, USA |
| A*340101 | QC358 | AM748385 | Paul Dunn, Auckland, New Zealand |
| A*6836 | BY00191 | EU029784 | Carolyn K Hurley, Washington DC, USA |
| A*7411 | BY00195 | EU029781 | Carolyn K Hurley, Washington DC, USA |
| B*3922 | scu00946m | EF679202 | Francisco de Paula Sanchez Gordo, Malaga, Spain |
| Cw*0716 | E770 | EF640739 | Angelica Canossi, L'Aquila, Italy |
| DRB1*0711 | BY00192 | EU029789 | Carolyn K Hurley, Washington DC, USA |
| DRB1*110107 | 06460211 | AM712089 | Alois W�lpl, Martinsried, Germany |
| DRB1*1331 | BY00223 | EU071691 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1461 | BY00213 | EU029795 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1468 | BY00217 | EU029799 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1515 | BY00220 | EU029802 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1610 | BY00227 | EU071687 | Carolyn K Hurley, Washington DC, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*2467 | (1) |
| A*2916 | (2) |
| A*9208 | (3) |
| B*4071 | (4) |
| B*4207 | (5) |
| G*0108 | (6) |
| DRB1*0710N | (7) |
| DRB1*110404 | (8) |
| DRB1*1161 | (8) |
| MICB*0050204 | (9) |
References
- Witter K, Zahn R, Albert T, Volgger A, Kauke T: Identification of a novel HLA-A*24 allele, HLA-A*2467. Tissue Antigens 2007 70:169.
- Erhuma M, Radam C, Schlaf G, Seliger B, Behre G, Altermann WW: A novel HLA-A*29 allele (A*2916) of a Caucasian relative to an ALL patient containing a point mutation in a putatively conserved region which was identified through the loss of a specific amplificate in a low-resolution SSP-PCR kit. Int J Immunogenet 2007 34:235-6.
- Yan LX, Zhu FM, Zhang W, Xu XG: Identification of a novel allele HLA-A*9208 by sequence-based typing. Tissue Antigens 2007 70:170.
- Park J, Kwon OJ, Hong SA, Kwon SY, Cho NS: Identification of a novel HLA-B*40 allele, HLA-B*4071, by sequence-based typing. Tissue Antigens 2007 70:170-1.
- Eiz-Vesper B, Deluca DS, Blasczyk R, Horn PA: The nature of recombination in HLA-B*4207. Tissue Antigens 2007 70:164-8.
- Moscoso J, Serrano-Vela JI, Perez-Saborido B, Moreno E, Arnaiz-Villena A: A novel HLA-G allele (HLA-G*0108) with an alpha-3 domain amino acid change. Tissue Antigens 2007 70:171-3.
- Eiz-Vesper B, Blasczyk R, Horn PA: Description of the first HLA-DRB1 null allele. Immunogenetics 2007 59:507-10.
- Longhi E, Frison S, Serafini M, Karpasitou K, Poli F: Identification of two novel HLA-DRB1*11 alleles (DRB1*110404 and DRB1*1161) in two Italian cord blood units. Int J Immunogenet 2007 34:237-9.
- Martinez-Borra J, Rodrigo L, Rodriguez-Rodero S, et al.: The allele MICB*0050204, over-represented in the Caucasian population, has an additional exon resulting from a new splice junction sequence. Hum Immunol 2007 68:705-7.
