Nomenclature for Factors of the HLA System

June 2007

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

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The following sequences have been submitted to the Nomenclature Committee since the May 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at :

Table 1: New Sequences

Sequence Cell identification Accession number Submitting Author
A*0128 BJ038 EF672087 Xiaomei He, Beijing, China
A*2479 87044 EF656474 Mary Sue Leffell, Baltimore, USA
A*3022 BY00182 EF656467 Carolyn K Hurley, Washington, USA
A*3313 BY00185 EF656470 Carolyn K Hurley, Washington, USA
A*680107 94333 EF656475 Mary Sue Leffell, Baltimore, USA
A*6840 BY00188 EF656473 Carolyn K Hurley, Washington, USA
B*0758 99415CB AB306895 Hidetoshi Inoko, Isehara, Kanagawa, Japan
Cw*0517 C138944 EF650025 Robert Endres, Tempe, USA
DRB1*1164 BJ036 EF660334 Na Liu, Beijing, China

Table 2: Confirmatory Sequences

Sequence Cell Identification Accession Number Submitting Author
A*0125 BY00186 EF656471 Carolyn K Hurley, Washington, USA
A*2912 BY00187 EF656472 Carolyn K Hurley, Washington, USA
A*3311 BY00181 EF656466 Carolyn K Hurley, Washington, USA
A*9213N BY00184 EF656469 Carolyn K Hurley, Washington, USA
A*9222 BY00183 EF656468 Carolyn K Hurley, Washington, USA

Table 3: Recently Published Sequences

Sequence References
A*110106 (1)
A*3309 (2)
B*080104 (3)
B*3570 (4)
DRB1*0464 (5)
DRB1*140503 (6)
DQB1*0319 (7)


  1. Zhu FM, Chen NY, Zhang W, He J, Yan LX: Sequence analysis of the novel allele HLA-A*110106 in the Chinese population. Tissue Antigens 2007 70:70-1.
  2. Altermann WW, Erhuma M, Seliger B, Schlaf G: A novel HLA-A*33 (A*3309) allele in a Caucasian family that differs at protein position 66 from HLA-A*3308. Tissue Antigens 2007 70:69-70.
  3. Eiz-Vesper B, Blasczyk R, Horn PA: Haplotype-specific amplification and nucleotide sequencing reveal the novel allele HLA-B*080104. Tissue Antigens 2007 70:71-2.
  4. Schlaf G, Erhuma ME, Seliger B, Foell J, Altermann WW: A novel HLA-B*35 (B*3570) allele of a Caucasian family differing with one amino acid mismatch from HLA-B*3503 allele in exon 4. Tissue Antigens 2007 70:72-3.
  5. Endres RO, Wetzsteon PJ, Stein J, Norman DJ: A novel DRB1*04 allele. Tissue Antigens 2007 70:76-8.
  6. Kwon OJ, Park SY, Oh JW, Nah SY, Jeong SM: Characterization of a new HLA-DRB1*1405 variant, HLA-DRB1*140503, identified by sequence-based typing. Tissue Antigens 2007 70:75-6.
  7. Witter K, Mautner J, Albert T, Zahn R, Kauke T: HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102. Tissue Antigens 2007 70:73-5.