Nomenclature for Factors of the HLA System
June 2007
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2007 70:352-3
- Human Immunology. 2007 68:802-3
- International Journal of Immunogenetics. 2007 70:397-8
The following sequences have been submitted to the Nomenclature Committee since the May 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author |
|---|---|---|---|
| A*0128 | BJ038 | EF672087 | Xiaomei He, Beijing, China |
| A*2479 | 87044 | EF656474 | Mary Sue Leffell, Baltimore, USA |
| A*3022 | BY00182 | EF656467 | Carolyn K Hurley, Washington, USA |
| A*3313 | BY00185 | EF656470 | Carolyn K Hurley, Washington, USA |
| A*680107 | 94333 | EF656475 | Mary Sue Leffell, Baltimore, USA |
| A*6840 | BY00188 | EF656473 | Carolyn K Hurley, Washington, USA |
| B*0758 | 99415CB | AB306895 | Hidetoshi Inoko, Isehara, Kanagawa, Japan |
| Cw*0517 | C138944 | EF650025 | Robert Endres, Tempe, USA |
| DRB1*1164 | BJ036 | EF660334 | Na Liu, Beijing, China |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| A*0125 | BY00186 | EF656471 | Carolyn K Hurley, Washington, USA |
| A*2912 | BY00187 | EF656472 | Carolyn K Hurley, Washington, USA |
| A*3311 | BY00181 | EF656466 | Carolyn K Hurley, Washington, USA |
| A*9213N | BY00184 | EF656469 | Carolyn K Hurley, Washington, USA |
| A*9222 | BY00183 | EF656468 | Carolyn K Hurley, Washington, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*110106 | (1) |
| A*3309 | (2) |
| B*080104 | (3) |
| B*3570 | (4) |
| DRB1*0464 | (5) |
| DRB1*140503 | (6) |
| DQB1*0319 | (7) |
References
- Zhu FM, Chen NY, Zhang W, He J, Yan LX: Sequence analysis of the novel allele HLA-A*110106 in the Chinese population. Tissue Antigens 2007 70:70-1.
- Altermann WW, Erhuma M, Seliger B, Schlaf G: A novel HLA-A*33 (A*3309) allele in a Caucasian family that differs at protein position 66 from HLA-A*3308. Tissue Antigens 2007 70:69-70.
- Eiz-Vesper B, Blasczyk R, Horn PA: Haplotype-specific amplification and nucleotide sequencing reveal the novel allele HLA-B*080104. Tissue Antigens 2007 70:71-2.
- Schlaf G, Erhuma ME, Seliger B, Foell J, Altermann WW: A novel HLA-B*35 (B*3570) allele of a Caucasian family differing with one amino acid mismatch from HLA-B*3503 allele in exon 4. Tissue Antigens 2007 70:72-3.
- Endres RO, Wetzsteon PJ, Stein J, Norman DJ: A novel DRB1*04 allele. Tissue Antigens 2007 70:76-8.
- Kwon OJ, Park SY, Oh JW, Nah SY, Jeong SM: Characterization of a new HLA-DRB1*1405 variant, HLA-DRB1*140503, identified by sequence-based typing. Tissue Antigens 2007 70:75-6.
- Witter K, Mautner J, Albert T, Zahn R, Kauke T: HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102. Tissue Antigens 2007 70:73-5.
