Nomenclature for Factors of the HLA System
April 2007
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2007 70:174-6
- Human Immunology. 2007 68:797-9
- International Journal of Immunogenetics. 2007 34:393-4
The following sequences have been submitted to the Nomenclature Committee since the March 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author |
|---|---|---|---|
| A*0126 | BY00162 | EF536018 | Carolyn K Hurley, Washington, USA |
| A*0127N | 156519SR | AM503963 | Francesca Poli, Milano, Italy |
| A*020114 | D54464, D54467 |
EF495117 | Lee Ann Baxter-Lowe, San Francisco, USA |
| A*020115 | CTM-6696126 | EF526079 | Antonio Balas, Madrid, Spain |
| A*020604 | BY00164 | EF536017 | Carolyn K Hurley, Washington, USA |
| A*023503 | BY00168 | EF563137 | Carolyn K Hurley, Washington, USA |
| A*1131 | 227719 | EF465413 | Edward KL Yang, Hualien, Taiwan |
| A*2635 | BY00166 | EF563135 | Carolyn K Hurley, Washington, USA |
| A*310103 | CB0120020005 | AM503964 | Francesca Poli, Milano, Italy |
| A*3118 | BY00172 | EF563141 | Carolyn K Hurley, Washington, USA |
| A*3311 | BY00163 | EF536019 | Carolyn K Hurley, Washington, USA |
| A*68020103 | CTM-3695374 | EF502101 | Antonio Balas, Madrid, Spain |
| A*6839 | BY00165 | EF563134 | Carolyn K Hurley, Washington, USA |
| A*9217 | Henan10 | EF526712 | Bowei Zhang, Zhengzhou, China |
| A*9218 | BY00171 | EF563140 | Carolyn K Hurley, Washington, USA |
| A*9219 | BY00170 | EF563139 | Carolyn K Hurley, Washington, USA |
| A*9220 | BY00169 | EF563138 | Carolyn K Hurley, Washington, USA |
| B*0756 | 94858 | EF517947 | Mary Sue Leffell, Baltimore, USA |
| B*1319 | BJ034 | EF555208 | Zhixin Zhang, Beijing, China |
| B*1320 | BJ037013 | EF195123 | Xiaoyan Shan, Beijing, China |
| B*2738 | SAUVSer | AM689935 | Anne Dormoy, Strasbourg, France |
| B*3576 | 07032086 | AM495256 | Vincent Aubert, Lausanne, Switzerland |
| B*3942 | BJ038186 | EF195124 | Xiaoyan Shan, Beijing, China |
| B*4076 | CTJ-14665 | EF495153 | Lina Yan, Tianjin, China |
| B*4077 | SCU00449 | EF521874 | Francisco de Paula Sanchez Gordo, Malaga, Spain |
| B*410302 | 18428 | EF467860 | Anajane Smith, Seattle, USA |
| B*4454 | Y40482 | EF545134 | Mette Christiansen, Aarhus N, Denmark |
| B*4611 | 051348043 | EF419280 | Wei Dong, Philadelphia, USA |
| B*510108 | Shani004 | EF542833 | Demei Zhang, Taiyuan, China |
| B*5149 | C138639 | EF540341 | Robert Endres, Tempe, USA |
| B*5313 | NT00734 | EF563146 | Carolyn K Hurley, Washington, USA |
| B*5413 | 20051539M, 20051539seq |
AB301477 | Hidetoshi Inoko, Isehara, Kanagawa, Japan |
| B*5527 | Shanxi003 | EF542832 | Demei Zhang, Taiyuan, China |
| Cw*0341 | K16155 | AB300723 | Etsuko Maruya, Kyoto, Japan |
| Cw*0749 | TEER | AM696284 | Bouke Hepkema, Groningen, The Netherlands |
| Cw*1521 | BJxeuwenlong | EF379939 | Zhixin Zhang, Beijing, China |
| DQB1*0631 | 06430111 | AM490069 | Alois W�lpl, Martinsried, Germany |
| DRB1*0713 | G046706009456V | EF362805 | Catherine Cormack, London, United Kingdom |
| DRB1*0714 | 25313-06 | EF550999 | Fred Schmitt, Seattle, USA |
| DRB1*110107 | CGE691 | AM689932 | Jean-Marie Tiercy, Geneva, Switzerland |
| DRB1*1467 | CTJ-15231 | EF495154 | Lina Yan, Tianjin, China |
| DRB1*1468 | NT00729 | EF536016 | Carolyn K Hurley, Washington, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| A*0106 | NT00730 | EF563145 | Carolyn K Hurley, Washington, USA |
| A*2414 | NT00733 | EF563142 | Carolyn K Hurley, Washington, USA |
| A*2465 | BY00167 | EF563136 | Carolyn K Hurley, Washington, USA |
| A*6816 | NT00731 | EF563144 | Carolyn K Hurley, Washington, USA |
| B*15010101 | CUI23 | EF203076 | Jorge Martinez-Laso, Madrid, Spain |
| B*15170101 | CU40A | EF203077 | Jorge Martinez-Laso, Madrid, Spain |
| B*1562 | NT00726 | EF536013 | Carolyn K Hurley, Washington, USA |
| B*270502 | CU40B | EF203078 | Jorge Martinez-Laso, Madrid, Spain |
| B*3520 | NT00732 | EF563143 | Carolyn K Hurley, Washington, USA |
| B*3530 | NT00727 | EF536014 | Carolyn K Hurley, Washington, USA |
| B*4075 | BJ039117 | EF195125 | Xiaoyan Shan, Beijing, China |
| B*4501 | CU45A | EF203079 | Jorge Martinez-Laso, Madrid, Spain |
| B*5601 | CU45C | EF203080 | Jorge Martinez-Laso, Madrid, Spain |
| Cw*0743 | BJchenhua | EF195154 | Chunji Gao, Beijing, China |
| DRB1*0906 | NT00728 | EF536015 | Carolyn K Hurley, Washington, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*020112 | (1) |
| A*0297 | (2) |
| A*0326 | (3) |
| B*1576 | (4) |
| B*2736 | (5) |
| B*350802 | (6) |
| B*5618 | (5) |
| B*5813 | (7) |
| B*9518 | (8) |
| Cw*1609 | (9) |
| DQB1*0317 | (10) |
References
- Horn PA, Hallensleben M, Eiz-Vesper B, Blasczyk R: Sequence analysis of the new allele HLA-A*020112. Tissue Antigens 2007 69:361-2.
- Garino E, Miertus J, Berrino M, et al.: Molecular aspects of a novel HLA-A*02 allele (A*0297): the first HLA class I allele mutated at codon 232. Tissue Antigens 2007 69:342-7.
- Balas A, Garcia-Sanchez F, Vicario JL: Complete coding sequence of a new HLA-A allele, HLA-A*0326. Tissue Antigens 2007 69:362-3.
- Dapprich J, Witter K, Gabel HW, Murphy NB, Albert ED: Identification of a new HLA-B allele (B*1576) by haplotype specific extraction. Hum Immunol 2007 68:418-21.
- Li Z, Zou HY, Shao CP, Tang S, Wang DM: Identification of a novel HLA-B*56 allele, B*5618 and an extension of B*2736 by sequence-based typing. Tissue Antigens 2007 69:365-6.
- Vidan-Jeras B, Ambroz N, Fae I, Kemperle I, Fischer G: HLA-B*350802, a novel allele, which has arisen by silent mutation at codon 67. Tissue Antigens 2007 69:363.
- Yoon S, Baek JY, Hur SS, Kwon OJ, Kwack K: Identification of a novel HLA-B*58 allele, B*5813, by sequence-based typing of DNA from Korean baby cord blood. Tissue Antigens 2007 69:366-7.
- An SP, Yan LN, Li SY, et al.: HLA-B*9518 allele identified in the Chinese population. Tissue Antigens 2007 69:363-5.
- Canossi A, Liberatore G, Del Beato T, Oumhani K, Adorno D: Sequence-based typing characterization of the novel HLA-Cw*1609 allele in the Moroccan Chaouya group. Tissue Antigens 2007 69:367-70.
- Chu CC, Lin CY, Trejaut JA, Wu MM, Lin M: HLA-DQB1*0317 is a novel allele with an unusual DR-DQ haplotype. Tissue Antigens 2007 69:370-2.
