Nomenclature for Factors of the HLA System
February 2007
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2007 70:80-2
- Human Immunology. 2007 68:623-5
- International Journal of Immunogenetics. 2007 34:221-2
The following sequences have been submitted to the Nomenclature Committee since the January 2007 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author |
|---|---|---|---|
| A*110107 | TBC63500 | AB292218 | Masahiro Satake, Tokyo, Japan |
| A*260105 | TBC63337 | AB292217 | Masahiro Satake, Tokyo, Japan |
| A*3021 | BY00146 | EF422076 | Carolyn K Hurley, Washington, USA |
| A*3310 | NT00715 | EF375695 | Carolyn K Hurley, Washington, USA |
| A*9212 | TBC63782 | AB292417 | Masahiro Satake, Tokyo, Japan |
| B*0753 | NT00714 | EF375692 | Carolyn K Hurley, Washington, USA |
| B*0754 | NT00718 | EF422078 | Carolyn K Hurley, Washington, USA |
| B*0833 | ADBA10260AN | AM492196 | Ann-Margaret Little, London, UK |
| B*130204 | NT00706 | EF375690 | Carolyn K Hurley, Washington, USA |
| B*1826 | K110228 | AM492197 | Ann-Margaret Little, London, UK |
| B*270510 | 93520 | EF215529 | Mary Sue Leffell, Baltimore, USA |
| B*3574 | NT00704 | EF375689 | Carolyn K Hurley, Washington, USA |
| B*3575 | DGLM1 | EF426474 | Lia Mele, Alessandria, Italy |
| B*3816 | BT00710 | EF375691 | Carolyn K Hurley, Washington, USA |
| B*4072 | TAKA87874AN | AM491776 | Ann-Margaret Little, London, UK |
| B*440303 | 93455 | EF215530 | Mary Sue Leffell, Baltimore, USA |
| B*4610 | NT00708 | EF375698 | Carolyn K Hurley, Washington, USA |
| B*5526 | NT00719 | EF422080 | Carolyn K Hurley, Washington, USA |
| B*5620 | R06-978 | AM422124 | Jean-Marie Tiercy, Geneva, Switzerland |
| B*9527 | 93977 | EF215531 | Mary Sue Leffell, Baltimore, USA |
| Cw*010205 | 277745 | AM422978 | Tatiana Lebedeva, Dedham, USA |
| Cw*0115 | 241551 | AM422968 | Tatiana Lebedeva, Dedham, USA |
| Cw*0116 | 250226 | AM422972 | Tatiana Lebedeva, Dedham, USA |
| Cw*0117 | 255993 | AM489405 | Tatiana Lebedeva, Dedham, USA |
| Cw*0118 | 277100 | AM422975 | Tatiana Lebedeva, Dedham, USA |
| Cw*0218 | 250052 | AM422969 | Tatiana Lebedeva, Dedham, USA |
| Cw*030406 | 275410 | AM489409 | Tatiana Lebedeva, Dedham, USA |
| Cw*030407 | 277614 | AM422977 | Tatiana Lebedeva, Dedham, USA |
| Cw*0336 | 277287 | AM422976 | Tatiana Lebedeva, Dedham, USA |
| Cw*0337 | 250072 | AM422970 | Tatiana Lebedeva, Dedham, USA |
| Cw*0338 | 280091 | AM422980 | Tatiana Lebedeva, Dedham, USA |
| Cw*0339 | P973 | EF422359 | Chengya Wang, Province, China |
| Cw*0425 | 238305 | AM422966 | Tatiana Lebedeva, Dedham, USA |
| Cw*0426 | 266302 | AM489408 | Tatiana Lebedeva, Dedham, USA |
| Cw*0427 | 277012 | AM422974 | Tatiana Lebedeva, Dedham, USA |
| Cw*0615 | 250288 | AM422973 | Tatiana Lebedeva, Dedham, USA |
| Cw*0616N | 279827 | AM422979 | Tatiana Lebedeva, Dedham, USA |
| Cw*0747 | 257299 | AM489406 | Tatiana Lebedeva, Dedham, USA |
| Cw*0748 | 281146 | AM422964 | Tatiana Lebedeva, Dedham, USA |
| Cw*1221 | BY00148 | EF422081 | Carolyn K Hurley, Washington, USA |
| Cw*1518 | 258119 | AM489407 | Tatiana Lebedeva, Dedham, USA |
| Cw*1519 | 280144 | AM422981 | Tatiana Lebedeva, Dedham, USA |
| Cw*1520 | 280716 | AM422983 | Tatiana Lebedeva, Dedham, USA |
| Cw*1803 | 280415 | AM422982 | Tatiana Lebedeva, Dedham, USA |
| DRB1*030104 | VTIS65942 | DQ133168 | Brian D Tait, Melbourne, Australia |
| DRB1*0332 | VTIS103774 | DQ133169 | Brian D Tait, Melbourne, Australia |
| DRB1*0464 | C136004 | EF158822 | Robert Endres, Tempe, USA |
| DRB1*110404 | 028807 | AM491357 | Francesca Poli, Milano, Italy |
| DRB1*1161 | 157429 | AM490640 | Francesca Poli, Milano, Italy |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| A*01010101 | APD | CR759913 | Stephan Beck, Cambridge, UK |
| A*0260 | NT00703 | EF370118 | Carolyn K Hurley, Washington, USA |
| A*0322 | NT00717 | EF422079 | Carolyn K Hurley, Washington, USA |
| A*3402 | NT00702 | EF370117 | Carolyn K Hurley, Washington, USA |
| B*0737 | NT00737 | EF375693 | Carolyn K Hurley, Washington, USA |
| B*1568 | H050-2 | EF101896 | Chengya Wang, Nanjing, China |
| B*350402 | NT00716 | EF375696 | Carolyn K Hurley, Washington, USA |
| B*3526 | NT00705 | EF375688 | Carolyn K Hurley, Washington, USA |
| B*3548 | NT00707 | EF375687 | Carolyn K Hurley, Washington, USA |
| B*3937 | NT00712 | EF375694 | Carolyn K Hurley, Washington, USA |
| B*5120 | NT00709 | EF375697 | Carolyn K Hurley, Washington, USA |
| B*5122 | NT00711a | EF375685 | Carolyn K Hurley, Washington, USA |
| B*550104 | BY00145 | EF370119 | Carolyn K Hurley, Washington, USA |
| B*560501 | TBC63580 | AB292219 | Masahiro Satake, Tokyo, Japan |
| B*5711 | NT00721 | EF422077 | Carolyn K Hurley, Washington, USA |
| B*670102 | TBC63059 | AB292220 | Masahiro Satake, Tokyo, Japan |
| Cw*0335 | 237313 | AM422965 | Tatiana Lebedeva, Dedham, USA |
| Cw*0507N | BY00147 | EF422082 | Carolyn K Hurley, Washington, USA |
| Cw*0743 | 250097 | AM422971 | Tatiana Lebedeva, Dedham, USA |
| Cw*0746 | 238921 | AM422967 | Tatiana Lebedeva, Dedham, USA |
| G*0106 | APD | CR925767 | Stephan Beck, Cambridge, UK |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*0114 | (1) |
| A*68020102 | (2) |
| B*1314 | (3) |
| B*5522 | (4) |
| Cw*0331 | (5) |
| DRB1*0331 | (6) |
| DRB1*1375 | (7) |
References
- Crowley J, Dunne C, Cox ST, Little AM: An unlikely rare result of HLA-A*0236, *3601 masking the presence of a novel allele A*0114. Tissue Antigens 2007 69:200-1.
- Longhi E, Frison S, Andreini E, et al.: Complete Sequencing of the HLA-A*68020102 Novel Allele Identified in Two Caucasoid Families. Hum Immunol 2007 68:206-10.
- Witter K, Zahn R, Lubke S, Albert T, Kauke T: A novel HLA-B*13 allele, B*1314, was found through routine HLA class I sequence-specific oligonucleotide typing and confirmed by sequence-based HLA typing. Tissue Antigens 2007 69:201-2.
- Yan LX, Zhu FM, Zhang W: Sequence analysis of the novel allele HLA-B*5522 in the Chinese population. Tissue Antigens 2007 69:202-3.
- Nesci S, Malagoli A, Iliescu A, Buffi O, Carella G: Characterization of the novel allele HLA-Cw*0331 by sequence-based typing. Tissue Antigens 2007 69:203-4.
- Yang KL, Chu CC, Huang CH, et al.: Discovery of HLA-DRB1*0331 in a Taiwanese marrow donor and the importance of sequence-based typing in a rare or previously unrecognized allele. Int J Immunogenet 2007 34:91-5.
- Sanchez-Gordo F, Balas A, Ortiz M, Prat I, Vicario JL: A new human leukocyte antigen DRB1 allele, HLA-DRB1*1375. Tissue Antigens 2007 69:204-5.
