Nomenclature for Factors of the HLA System
December 2006
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2006 69:290-2
- Human Immunology. 2007 68:216-8
- International Journal of Immunogenetics. 2006 34:69-70
The following sequences have been submitted to the Nomenclature Committee since the November 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author | References |
|---|---|---|---|---|
| A*0326 | CTM-0695183 | EF158451 | Antonio Balas, Madrid, Spain | |
| A*3019 | 265969 | EF050037 | Kaimo Hirv, Ulm, Germany | |
| A*9209 | 152173 | DQ885885 | Kaimo Hirv, Ulm, Germany | |
| B*0831 | BY00141 | EF173482 | Carolyn K Hurley, Washington, USA | |
| B*3571 | 0058277 | EF126033 | Bahra Salam, London, United Kingdom | |
| B*3572 | BY00142 | EF173483 | Carolyn K Hurley, Washington, USA | |
| B*5146 | 142253 | DQ885884 | Kaimo Hirv, Ulm, Germany | |
| B*5411 | CTJ-10063 | EF136579 | Lina Yan, Tianjin, China | |
| B*5619N | TBC62727 | AB282749 | Masahiro Satake, Tokyo, Japan | |
| B*9522 | 261464 | DQ885886 | Kaimo Hirv, Ulm, Germany | |
| Cw*0217 | C-HLA-370, C-HLA-493 | AM419012 | Gregory Minevich, NewYork, USA | |
| Cw*0335 | 261327 | DQ924972 | Kaimo Hirv, Ulm, Germany | |
| Cw*0515 | 255961 | DQ885883 | Kaimo Hirv, Ulm, Germany | |
| Cw*12030102 | BGC | AM412763 | Jiang Wei, Nanjing, China | |
| P*01010101 | APD | CR925767 | Stephan Beck, Cambridge, United Kingdom | |
| P*01010101 | BOLETH | AB023058 | Hidetoshi Inoko, Isehara, Japan | (1) |
| P*01010101 | COX | AL671561 | Stephan Beck, Cambridge, United Kingdom | (2) |
| P*01010102 | QBL | AL844851 | Stephan Beck, Cambridge, United Kingdom | (3) |
| P*02010101 | MANN | BX927141 | Stephan Beck, Cambridge, United Kingdom | |
| P*02010101 | DBB | CR759769 | Stephan Beck, Cambridge, United Kingdom | |
| P*02010101 | MLF | CR788234 | Stephan Beck, Cambridge, United Kingdom | |
| P*02010101 | CGM1 | AC004172 | Daniel E Geraghty, Seattle, USA | |
| P*02010101 | CGM1 | AC004192 | Daniel E Geraghty, Seattle, USA | |
| P*02010102 | PGF | AL645939 | Stephan Beck, Cambridge, United Kingdom | (2) |
| P*02010102 | SSTO | BX005428 | Stephan Beck, Cambridge, United Kingdom | |
| P*02010102 | RPCI-3 | AL022723 | Stephan Beck, Cambridge, United Kingdom | |
| DRB1*0463 | ADN6428, ADN6429 | AM412363 | Fran�oise Hau, Rouen, France | |
| DRB3*0222 | KHYRHib | AM413002 | Anne Dormoy, Strasbourg, France | |
| DQB1*0630 | GN00420 | AY094140 | Carolyn K Hurley, Washington, USA | |
| MICB*0020102 | MCF | CR753864 | Stephan Beck, Cambridge, United Kingdom | |
| MICB*0040102 | APD | CR788288 | Stephan Beck, Cambridge, United Kingdom | |
| MICB*0050202 | PITOUT | EF051580 | Jesus Martinez-Borra, Oviedo, Spain | |
| MICB*0050202 | MANN | BX927320 | Stephan Beck, Cambridge, United Kingdom | |
| MICB*0050203 | SSTO | BX005469 | Stephan Beck, Cambridge, United Kingdom | |
| MICB*0050204 | WT51 | EF051579 | Jesus Martinez-Borra, Oviedo, Spain |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| A*2606 | TBC47774 | AB282890 | Masahiro Satake, Tokyo, Japan |
| A*3004 | TBC62791 | AB282891 | Masahiro Satake, Tokyo, Japan |
| B*1538 | TBC38656 | AB285119 | Masahiro Satake, Tokyo, Japan |
| B*3923 | TBC62790 | AB285120 | Masahiro Satake, Tokyo, Japan |
| B*5410 | CTJ-11362 | EF136580 | Lina Yan, Tianjin, China |
| Cw*1602 | 37771 | AM419439 | Thibaut Gervais, Brussels, Belgium |
| MICB*003 | DBB | CR753820 | Stephan Beck, Cambridge, United Kingdom |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*1118 | (4) |
| A*240208 | (5) |
| A*2630 | (6) |
| A*2915 | (6) |
| A*3114N | (7) |
| A*3211Q | (5) |
| A*680105 | (6) |
| A*9202 | (6) |
| B*1822 | (5) |
| B*2734 | (8) |
| B*3938Q | (5) |
| B*4068 | (9) |
| B*4606 | (5) |
| B*4607N | (5) |
| B*5139 | (5) |
| Cw*0321 | (5) |
| Cw*0734 | (5) |
| Cw*0742 | (10) |
| DRB1*1155 | (11) |
| DRB3*020205 | (12) |
References
- Shiina T, Tamiya G, Oka A, et al.: Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region. Proc Natl Acad Sci U S A 1999: 96:13282-7.
- Stewart CA, Horton R, Allcock RJ, et al.: Complete MHC haplotype sequencing for common disease gene mapping. Genome Res 2004: 14:1176-87.
- Traherne JA, Horton R, Roberts AN, et al.: Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History. PLoS Genet 2006 2:e9.
- Voorter CE, Gervais T, Palusci F, Latinne D, van den Berg-Loonen EM: A novel HLA-A*11 allele, A*1118, identified by sequence-based typing. Tissue Antigens 2006 68:524-6.
- Tang TF, Hou L, Tu B, et al.: Identification of nine new HLA class I alleles in volunteers from the Singapore stem cell donor registries. Tissue Antigens 2006 68:518-20.
- Gill KK, Leligdowicz A, Luo M, Bielawny T, Brunham R, Plummer FA: Identification of four novel HLA-A alleles from an East African population by high-resolution sequence-based typing. Hum Immunol 2006 67: 833-8.
- Smith DM, Gardner WB, Baker JE, Cox ST, Kresie LA: A new HLA-A*31 null allele, A*3114N. Tissue Antigens 2006 68:526-7.
- Witter K, Albert T, Volgger A, Zahn R, Scholz S: Routine HLA sequence-specific-oligonucleotide typing and confirming sequence-based typing of a prospective bone marrow donor identified a novel B*27 allele, HLA-B*2734. Tissue Antigens 2006 68:527-8.
- Bernardo I, Castillo-Rama M, Paz-Artal E, Grande C, Castro-Panete MJ: A new HLA-B allele, HLA-B*4068, identified in an Equatorian individual. Tissue Antigens 2006 68:528-30.
- Balas A, Garcia-Sanchez F, Vicario JL: Sequencing of a new HLA-C allele, HLA-Cw*0742, with a novel HLA polymorphism at exon 3. Tissue Antigens 2006 68:530-1.
- Witter K, Wittmann G, Lehmeier AM, Albert T, Kauke T: A novel HLA-DRB1*11 allele, DRB1*1155, was found in a patient through routine DRB1 typing using sequence-specific primers (SSP) and confirmed by allele-specific sequence-based typing. Tissue Antigens 2006 68:531-3.
- Curcio M, Fornaciari S, Mariotti ML, Presciuttini S, Scatena F: Identification of a novel HLA-DRB3 allele, DRB3*020205, by sequence-based typing. Tissue Antigens 2006 68:533-4.
