Nomenclature for Factors of the HLA System
July 2006
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2006 68:535-6
- Human Immunology. 2006 67:1017-8
- International Journal of Immunogenetics. 2006 33:447-8
The following sequences have been submitted to the Nomenclature Committee since the June 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author |
|---|---|---|---|
| A*2632 | 2006051203 | DQ780570 | Oh-Joong Kwon, Seoul, South Korea |
| A*3212 | MHHN-154465 | AM282701 | Rainer Blasczyk, Hannover, Germany |
| A*6835 | A016699 | DQ788799 | Wei Dong, Philadelphia, USA |
| B*1317 | BY00124 | DQ832588 | Carolyn Hurley, Washington, USA |
| B*5143 | 73626 | DQ834251 | Mary Sue Leffell, Baltimore, USA |
| B*9517 | BY000123 | DQ832587 | Carolyn Hurley, Washington, USA |
| Cw*0330 | MT-10-06 | DQ780571 | Oh-Joong Kwon, Seoul, South Korea |
| Cw*0330 | MT-10-06 | DQ784564 | Min Yu, Chicago, USA |
| Cw*0423 | CB4737 | DQ788797 | Wei Dong, Philadelphia, USA |
| Cw*0424 | A016658 | DQ788798 | Wei Dong, Philadelphia, USA |
| Cw*0741 | VEGJC1 | AM237285 | Anne Dormoy, Strasbourg, France |
| DRB1*1611 | K9505074 | DQ837166 | Marie Lin, Taipei, Taiwan |
| DQB1*030203 | OLI | AM286421 | Xavier Lafarge, Bordeaux, France |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| B*2736 | SAMPLE-7319 | DQ840458 | Lina Yan, Tianjin, China |
| B*5136 | BY00122 | DQ832586 | Carolyn Hurley, Washington, USA |
| B*5614 | BY00125 | DQ832583 | Carolyn Hurley, Washington, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*0119 | (1) |
| A*0319 | (2) |
| B*3564 | (3) |
| B*3812 | (4) |
| B*4904 | (5) |
| Cw*140204 | (6) |
| DRB1*1213 | (7) |
| DRB1*1456 | (8) |
References
- Schlaf G, Wahle A, Seliger B, Altermann WW: A novel HLA-A*0119 allele of a Caucasian family containing a mutation in a highly conserved region. Int J Immunogenet 2006 33:247-8.
- Jeong SM, Park SY, Kim JH, Kwon OJ, Nah SY: Identification of a novel HLA-A*03 allele, HLA-A*0319, by sequence-based typing. Tissue Antigens 2006 68:87-8.
- Hwang SH, Lim YS, Kwon OJ, Heo YS, Oh HB: Structural aspects of the B*3564 molecule, a novel HLA-B*35 allele identified by sequence-based typing. Tissue Antigens 2006 68:90-1.
- Aureli A, Piancatelli D, Ozzella G, Liberatore G, Piazza A, Adorno D: B*3812: a new HLA-B38 variant identified by sequence-based typing. Tissue Antigens 2006 68:91-3.
- Nesci S, Buffi O, Iliescu A, Scalari P, Luchetti MM: HLA-B*4904, a new allele identified in two unrelated individuals from the same Italian region. Tissue Antigens 2006 68:89-90.
- Piancatelli D, Del Beato T, Aureli A, Papola F, Adorno D: A new HLA-CW*14 allele, Cw*140204, identified by allele-specific DNA amplification and sequencing. Tissue Antigens 2006 68:93-5.
- Jeong SM, Lee MN, Kim JH, Kwon OJ, Nah SY: A novel HLA-DRB1*12 allele, HLA-DRB1*1213, identified by sequence-based typing. Tissue Antigens 2006 68:95-7.
- Baek JY, Yun HS, Hur SS, Kwon OJ, Kwack K: Identification of a novel HLA-DRB1*14 allele, DRB1*1456, in the cord blood of a Korean baby. Tissue Antigens 2006 68:97-8.
