Nomenclature for Factors of the HLA System

June 2006

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

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The following sequences have been submitted to the Nomenclature Committee since the May 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at :

Table 1: New Sequences

Sequence Cell identification Accession number Submitting Author
A*1129 051407cb AM261865 Martin Danzer, Linz, Austria
A*2465 FRFCB AM268430 Anne Dormoy, Strasbourg, France
A*2466 BY00120 DQ782329 Carolyn K. Hurley, Washington, USA
A*2505 DN435.5 DQ645957 Yu Min, Chicago, USA
A*6834 NT00669 DQ648004 Carolyn K. Hurley, Washington, USA
B*0830N 264040 DQ641496 Kaimo Hirv, Ulm, Germany
B*4068 TMO-399 DQ647703 Ivan Bernardo, Madrid, Spain
B*5813 2006042530 DQ648737 Oh-Joong Kwon, Seoul, South Korea
Cw*0216 NT00671 DQ648007 Carolyn K. Hurley, Washington, USA
Cw*0327 NT00672 DQ648006 Carolyn K. Hurley, Washington, USA
Cw*0328 TBC60311 AB257505 Masahiro Satake, Tokyo, Japan
Cw*0329 TBC34836 AB257506 Masahiro Satake, Tokyo, Japan
Cw*0422 NT00673 DQ648008 Carolyn K. Hurley, Washington, USA
Cw*070107 BY00121 DQ782328 Carolyn K. Hurley, Washington, USA
Cw*0740 2681943 AM261864 Martin Danzer, Linz, Austria
Cw*1219 GAGI8381AN AM261030 Ann-Margaret Little, London, UK
DRB1*0330 MHHZ-00020533 AM269468 Rainer Blasczyk, Hannover, Germany
DRB1*0331 TZDR03 DQ666333 Edward K. L. Lang, Hualien, Taiwan
DRB1*0460 157748 AM261439 Francesca Poli, Milano, Italy
DRB1*1374 K107946 AM279417 Ann-Margaret Little, London, UK
DRB1*1462 BY00118 DQ782331 Carolyn K. Hurley, Washington, USA
DQB1*060403 WF215-200 DQ503425 Kerry Nolan, Milwaukee, USA
DQB1*060802 STFO3416AN AM279416 Ann-Margaret Little, London, UK

Table 2: Confirmatory Sequences

Sequence Cell Identification Accession Number Submitting Author References
A*1123 NT00670 DQ648005 Carolyn K. Hurley, Washington, USA  
A*2459 BY00117 DQ782332 Carolyn K. Hurley, Washington, USA  
A*3308 BY00116 DQ782333 Carolyn K. Hurley, Washington, USA  
B*180101 QBL AL845443 Stephan Beck, Cambridge, UK (1)
DRB1*0327 BY00119 DQ782330 Carolyn K. Hurley, Washington, USA  

Table 3: Recently Published Sequences

Sequence References
Cw*070105 (2)
Cw*1408 (2)
DRB5*0113 (3)


  1. Traherne JA, Horton R, Roberts AN, et al.: Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History. PLoS Genet 2006 2:e9.
  2. Keynan Y, Luo M, Lacap P, Brunham R, Plummer FA: Identification of two novel HLA-C alleles, Cw*070105 and Cw*1408, from East African women. Hum Immunol 2006 67:359-62.
  3. Garino E, Berrino M, Bertinetto F, et al.: Identification of a new allele, HLA-DRB5*0113, through three different molecular biology techniques. Tissue Antigens 2006 67:427-9.