Nomenclature for Factors of the HLA System
May 2006
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2006 68:273-5
- Human Immunology. 2006 67:842-4
- International Journal of Immunogenetics. 2006 33:389-90
The following sequences have been submitted to the Nomenclature Committee since the April 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author | References |
|---|---|---|---|---|
| A*030105 | Z-00023171 | AM261460 | Rainer Blasczyk, Hannover, Germany | |
| A*0324 | T05-915 | DQ403156, DQ403157 |
Rajeshree Patel, London, UK | |
| A*2464 | BM05-322, BM05-316 |
DQ523225 | Ee-Chee Ren, Singapore, Singapore | |
| A*2631 | 4497370 | DQ530236 | Antonio Balas, Madrid, Spain | |
| A*9203 | K9503143 | DQ485737 | Marie Lin, Taipei, Taiwan | |
| B*0750 | FFM1840AN | AM236590 | Ann-Margaret Little, London, UK | |
| B*350106 | BY00106 | DQ514598 | Carolyn K. Hurley, Washington, USA | |
| B*3814 | UA-2005-TP-3911 | AM261745 | Mats Bengtsson, Uppsala, Sweden | |
| B*4067 | TBC35457 | AB257503 | Masahiro Satake, Tokyo, Japan | |
| B*5142 | 604706 | AM260212 | Mats Bengtsson, Uppsala, Sweden | |
| B*5210 | 0601407 | DQ537945 | Cynthia Moehlenkamp, Albuquerque, USA | |
| B*5617 | BY00105 | DQ514600 | Carolyn K. Hurley, Washington, USA | |
| B*5902 | TBC60261 | AB257504 | Masahiro Satake, Tokyo, Japan | |
| Cw*0215 | US-1-0446-2875-8 | AM260635 | Alois W�lpl, Martinsried, Germany | |
| Cw*030305 | BY00111 | DQ514597 | Carolyn K. Hurley, Washington, USA | |
| Cw*0421 | NT00664 | DQ525630 | Carolyn K. Hurley, Washington, USA | |
| Cw*0514 | NT00667 | DQ535033, DQ535035 |
Carolyn K. Hurley, Washington, USA | |
| Cw*06020102 | PAT541 | DQ249182 | Philip Stuart, Ann Arbor, USA | (1) |
| Cw*0739 | BY00112 | DQ514599 | Carolyn K. Hurley, Washington, USA | |
| DPB1*1902 | BS169 | DQ485789 | Dimitri Monos, Philadelphia, USA | |
| DRB1*0459 | NT00660 | DQ525631 | Carolyn K. Hurley, Washington, USA | |
| DRB1*115402 | BY00110 | DQ514604 | Carolyn K. Hurley, Washington, USA | |
| DRB1*1156 | NT00666 | DQ525634 | Carolyn K. Hurley, Washington, USA | |
| DRB1*1157 | NT00668 | DQ535034 | Carolyn K. Hurley, Washington, USA | |
| DRB1*1215 | KS9504263 | DQ533486 | Marie Lin, Taipei, Taiwan | |
| DRB1*1373 | BY00108 | DQ514602 | Carolyn K. Hurley, Washington, USA | |
| DRB1*1460 | DR14VEDA | AM259285 | Irma Joosten, Nijmegen, The Netherlands | |
| DRB1*1461 | BJ003 | DQ494324 | Zhixin Zhang, Beijing, China | |
| DRB1*150106 | BY00109, BY00107 | DQ514603, DQ514601 |
Carolyn K. Hurley, Washington, USA | |
| DRB1*1520 | DR15donnew | AM258966 | Irma Joosten, Nijmegen, The Netherlands | |
| DRB1*1521 | BY00113 | DQ525633 | Carolyn K. Hurley, Washington, USA | |
| DRB1*1522 | NT00665 | DQ525632 | Carolyn K. Hurley, Washington, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author | References |
|---|---|---|---|---|
| A*2452 | BY00115 | DQ535036 | Carolyn K. Hurley, Washington, USA | |
| A*260101 | QBL | AL845454 | Stephan Beck, Cambridge, UK | (2) |
| B*070201 | PAT541 | DQ249181 | Philip Stuart, Ann Arbor, USA | (1) |
| B*080101 | PAT135 PAT144 | DQ249172, DQ249174 |
Philip Stuart, Ann Arbor, USA | (1) |
| B*140201 | PAT135 PAT218 | DQ249173, DQ249176 |
Philip Stuart, Ann Arbor, USA | (1) |
| B*15010101 | PAT218 | DQ249177 | Philip Stuart, Ann Arbor, USA | (1) |
| B*380101 | PAT144 PAT495 | DQ249175, DQ249179 |
Philip Stuart, Ann Arbor, USA | (1) |
| B*4446 | JUCH70904AN | AM236591 | Ann-Margaret Little, London, UK | |
| B*5001 | PAT541 | DQ249182 | Philip Stuart, Ann Arbor, USA | (1) |
| B*570101 | PAT495 | DQ249180 | Philip Stuart, Ann Arbor, USA | (1) |
| Cw*0210 | MAN527 | Z96924 | Steven G.E. Marsh, London, UK | |
| Cw*030401 | PAT218 | DQ249177 | Philip Stuart, Ann Arbor, USA | (1) |
| Cw*06020101 | PAT495 | DQ249180 | Philip Stuart, Ann Arbor, USA | (1) |
| Cw*070101 | PAT135 PAT144 | DQ249172, DQ249174 |
Philip Stuart, Ann Arbor, USA | (1) |
| Cw*07020103 | PAT541 | DQ249181 | Philip Stuart, Ann Arbor, USA | (1) |
| Cw*0802 | PAT135 PAT218 | DQ249173, DQ249176 |
Philip Stuart, Ann Arbor, USA | (1) |
| Cw*120301 | PAT144, PAT495 | DQ249175, DQ249179 |
Philip Stuart, Ann Arbor, USA | (1) |
| DQA1*050101 | QBL | AL935026 | Stephan Beck, Cambridge, UK | (2) |
| DRA*0101 | QBL | AL935032 | Stephan Beck, Cambridge, UK | (2) |
| DRB1*030101 | QBL | AL929581 | Stephan Beck, Cambridge, UK | (2) |
| DRB1*1331 | NT00661 | DQ525629 | Carolyn K. Hurley, Washington, USA | |
| E*01010101 | QBL | AL844213 | Stephan Beck, Cambridge, UK | (2) |
| G*01010201 | QBL | BX001005 | Stephan Beck, Cambridge, UK | (2) |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*0290 | (3) |
| B*270402 | (4) |
| B*3936 | (5) |
| B*4059 | (6) |
| B*4814 | (7) |
| Cw*0322Q | (8) |
| DRB1*1370 | (9) |
| MICA*00703 | (10) |
| MICA*01802 | (10) |
| MICA*053 | (10) |
References
- Nair RP, Stuart PE, Nistor I, et al.: Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet 2006 78:827-51.
- Traherne JA, Horton R, Roberts AN, et al.: Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History. PLoS Genet 2006 2:e9.
- Liu ML, Ye SH, Qi J, Liu S, Zhang Y: Identification of an HLA-A*02 allele variant (A*0290) in a Chinese donor. Tissue Antigens 2006 67:338-9.
- Jeong SM, Hur SS, Kwon OJ, Nah SY: A new HLA-B*27 allele, HLA-B*270402, identified by sequence-based typing. Tissue Antigens 2006 67:340-1.
- Yan LX, Zhu FM, Lv QF, Zhang W, He J: Identification of a novel HLA-B*39 allele, B*3936, by sequencing-based typing. Tissue Antigens 2006 67:341-2.
- Shan X, Gao G, He X, Wu G, Zhang Z: Identification of a novel HLA-B allele HLA-B*4059 in Chinese bone marrow donors. Tissue Antigens 2006 67:339-40.
- Liu ML, Qi J, Liu S, Zhang Y, Wei XQ: Identification of a novel HLA-B*48 allele, B*4814, in a Chinese marrow donor of Han descent. Tissue Antigens 2006 67:342-3.
- Middleton D, Meenagh A, Marsh SG, Martin J: A HLA-Cw*03 allele, Cw*0322Q with limited or no expression. Tissue Antigens 2006 67:343-5.
- Horn PA, Zingsem J, Eckstein R, Blasczyk R: Novel HLA-DRB1*1370 allele identified in a cord blood donor and her mother. Tissue Antigens 2006 67:345-7.
- Quiroga I, Sweeney D, Sutton PM, et al.: The identification of three novel MICA alleles by sequence-based typing. Tissue Antigens 2006 67:321-5.
