Nomenclature for Factors of the HLA System
April 2006
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2006 68:270-2
- Human Immunology. 2006 67:839-41
- International Journal of Immunogenetics. 2006 33:385-7
The following sequences have been submitted to the Nomenclature Committee since the March 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting Author | References |
|---|---|---|---|---|
| A*010104 | DA894.3 | DQ485722 | Yu Min, Chicago, USA | |
| A*0120 | MOHA43089AN | AM183561 | Ann-Margaret Little, London, UK | |
| A*0297 | A6793 | DQ409217 | Antonio Amoroso, Torino, Italy | |
| A*0298 | X0003339 | AY897620 | Lia Mele, Alessandria, Italy | |
| A*0299 | BY00094 | DQ465611 | Carolyn K. Hurley, Washington, USA | |
| A*0323 | BY00096 | DQ465612 | Carolyn K. Hurley, Washington, USA | |
| A*1127 | BY00099 | DQ465608 | Carolyn K. Hurley, Washington, USA | |
| A*1128 | BY00103 | DQ473291 | Carolyn K. Hurley, Washington, USA | |
| A*2463 | TBC5990 | AB253623 | Masahiro Satake, Tokyo, Japan | |
| A*2629 | UKE-A2629 | AM183783 | Thomas Binder, Hamburg, Germany | |
| A*2630 | m11449 | DQ494176 | Ma Luo, Winnipeg, Canada | |
| A*2915 | m11842 | DQ494177 | Ma Luo, Winnipeg, Canada | |
| A*3017 | 118641, 118642 |
DQ409216 | Antonio Amoroso, Torino, Italy | |
| A*680105 | m1216 | DQ494175 | Ma Luo, Winnipeg, Canada | |
| A*68020102 | 125400 | AM235886 | Francesca Poli, Milano, Italy | |
| A*6833 | 20725, 20726 |
DQ438173, DQ438174, DQ438175 |
Michael Aubrey, Aurora, USA | |
| A*9201 | NT00659 | DQ473292 | Carolyn K. Hurley, Washington, USA | |
| A*9202 | m1210, m1270 |
DQ494174 | Ma Luo, Winnipeg, Canada | |
| B*0748 | BY00085 | DQ455017 | Carolyn K. Hurley, Washington, USA | |
| B*0749N | WLODslaw | AM236599 | Anne Dormoy, Strasbourg, France | |
| B*1316 | BY00087 | DQ455015 | Carolyn K. Hurley, Washington, USA | |
| B*2736 | BY00091 | DQ455018, DQ455019 |
Carolyn K. Hurley, Washington, USA | |
| B*3712 | BY00100 | DQ473294 | Carolyn K. Hurley, Washington, USA | |
| B*4066 | CB4254 | DQ181794 | Yan Li, Guangzhou, China | |
| B*4816 | BY00083 | DQ455014 | Carolyn K. Hurley, Washington, USA | |
| B*5521 | BY00088 | DQ455012 | Carolyn K. Hurley, Washington, USA | |
| B*5522 | HZB9385 | DQ458812, DQ458813, DQ458814 |
Lixing Yan, Hangzhou, China | |
| B*5812 | BY00092, BY00086 |
DQ455013, DQ455020 |
Carolyn K. Hurley, Washington, USA | |
| B*9515 | BY00084 | DQ455016 | Carolyn K. Hurley, Washington, USA | |
| B*9516 | 06090213 | AM259370 | Alois W�lpl, Martinsried, Germany | |
| Cw*030405 | VTIS142034 | DQ417102, DQ417103 |
Brian D. Tait, Melbourne, Australia | |
| Cw*0326 | TBC59902 | AB253624 | Masahiro Satake, Tokyo, Japan | |
| Cw*0419 | 06-00632 | DQ453525 | Cynthia Moehlenkamp, Albuquerque, USA | |
| Cw*0420 | VTIS143819 | DQ417108, DQ417109 |
Brian D. Tait, Melbourne, Australia | |
| Cw*070106 | VTIS141767 | DQ417104, DQ417105 |
Brian D. Tait, Melbourne, Australia | |
| Cw*1218 | BY00098 | DQ465613 | Carolyn K. Hurley, Washington, USA | |
| DRB1*0458 | BY00101 | DQ473290 | Carolyn K. Hurley, Washington, USA | |
| DRB1*1372 | BY00102 | DQ473293 | Carolyn K. Hurley, Washington, USA | |
| DRB1*1459 | WEIFr | AM233907 | Anne Dormoy, Strasbourg, France | |
| H*01010101 | LCL721 | M32106 | Peter Parham, Stanford, USA | (1) |
| H*01010101 | BOLETH | AF055066 | Annie Hampe, Rennes, France | (2) |
| H*01010101 | DBB | CR388220 | Stephan Beck, Cambridge, UK | |
| H*01010102 | JY | X12432 | Barry Duceman, New York, USA | (3) |
| H*01010103 | 3.1.0 | M31944 | Sherman Weissman, New Haven, USA | (4) |
| H*0102 | QBL | AL845454 | Stephan Beck, Cambridge, UK | (5) |
| H*02010101 | COX | AL671561 | Stephan Beck, Cambridge, UK | (6) |
| H*02010101 | APD | CT009496 | Stephan Beck, Cambridge, UK | |
| H*02010101 | RPCI5 | AB023057 | Hidetoshi Inoko, Isehara, Japan | (7) |
| H*02010102 | LCL721 | M96336 | Daniel E. Geraghty, Seattle, USA | (8) |
| H*0202 | MANN | BX927141 | Stephan Beck, Cambridge, UK | |
| H*0202 | CGM1 | AC004194 | Daniel E. Geraghty, Seattle, USA | |
| H*0203 | SSTO | BX284699 | Stephan Beck, Cambridge, UK | |
| H*0204 | PGF | AL645929 | Stephan Beck, Cambridge, UK | (6) |
| H*0205 | LBF | M32105 | Peter Parham, Stanford, USA | (1) |
| H*0206 | JG | J00191 | Bertrand Jordan, Marseille, France | (9) |
| H*0301 | BB | M32104 | Peter Parham, Stanford, USA | (1) |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| A*0282N | BY00095 | DQ465610 | Carolyn K. Hurley, Washington, USA |
| A*0290 | BY00093 | DQ455021 | Carolyn K. Hurley, Washington, USA |
| A*1109 | VTIS143208 | DQ417106, DQ417107 |
Brian D. Tait, Melbourne, Australia |
| A*2456 | NT00657 | DQ455022 | Carolyn K. Hurley, Washington, USA |
| A*2458 | BY00097 | DQ465609 | Carolyn K. Hurley, Washington, USA |
| A*2910 | VTIS115031 | DQ417098, DQ417099 |
Brian D. Tait, Melbourne, Australia |
| A*68020101 | 86988 | AM235885 | Francesca Poli, Milano, Italy |
| B*0710 | 0200201604Haplo | AM236752 | Silvia Ulrich, Graz, Austria |
| B*0717 | TBC59473 | AB256953 | Masahiro Satake, Tokyo, Japan |
| B*3517 | TBC31121 | AB256954 | Masahiro Satake, Tokyo, Japan |
| B*5610 | TBC26606 | AB254370 | Masahiro Satake, Tokyo, Japan |
| B*7805 | TBC24079 | AB254369 | Masahiro Satake, Tokyo, Japan |
| Cw*0214 | NT00658 | DQ465614 | Carolyn K. Hurley, Washington, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*3113 | (10) |
| B*070502 | (11) |
| B*4441 | (12) |
| B*4608 | (13) |
| B*5137 | (14) |
| DRB1*1211 | (15) |
| DRB1*0451 | (16) |
| DQA1*0107 | (17) |
| DQA1*0602 | (17) |
| DPB1*010103 | (18) |
References
- Zemmour J, Koller BH, Ennis PD, et al.: HLA-AR, an inactivated antigen-presenting locus related to HLA-A. Implications for the evolution of the MHC. J Immunol 1990 144:3619-29.
- Hampe A, Coriton O, Andrieux N, et al.: A 356-Kb sequence of the subtelomeric part of the MHC Class I region. DNA Seq 1999 10:263-99.
- Duceman B, Wang AM: A novel human major histocompatibility complex class I-type DNA sequence. Nucleic Acids Res 1988 16:10391.
- Chorney MJ, Sawada I, Gillespie GA, Srivastava R, Pan J, Weissman SM: Transcription analysis, physical mapping, and molecular characterization of a nonclassical human leukocyte antigen class I gene. Mol Cell Biol 1990 10:243-53.
- Traherne JA, Horton R, Roberts AN, et al.: Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History. PLoS Genet 2006 2:e9.
- Stewart CA, Horton R, Allcock RJ, et al.: Complete MHC haplotype sequencing for common disease gene mapping. Genome Res 2004 14:1176-87.
- Shiina T, Tamiya G, Oka A, et al.: Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region. Proc Natl Acad Sci USA 1999 96:13282-7.
- Geraghty DE, Koller BH, Pei J, Hansen JA: Examination of four HLA class I pseudogenes. Common events in the evolution of HLA genes and pseudogenes. J Immunol 1992 149:1947-56.
- Malissen M, Malissen B, Jordan BR: Exon/intron organization and complete nucleotide sequence of an HLA gene. Proc Natl Acad Sci USA 1982 79:893-7.
- Zhu FM, Lv QF, He JJ, et al.: A new HLA-A allele, A*3113, identified by sequence-based typing in the Chinese population. Tissue Antigens 2006 67:250-1.
- Horn PA, Verboom M, Blasczyk R: Sequence analysis of the novel allele HLA-B*070502. Tissue Antigens 2006 67:251-3.
- Hoelsch K, Lenggeler I, Knabe H, Hartel K, Klein HG, Woelpl A: Identification of a novel HLA-B*44 variant (B*4441) in three unrelated Caucasian individuals. Tissue Antigens 2006 67:247-9.
- Yan LX, Zhu FM, Lv QF, Zhang W: Identification of a novel HLA-B*4608 allele in the Chinese population. Tissue Antigens 2006 67:253-4.
- Baek JY, Cha YY, Heo YS, Kwack K, Kwon OJ: Identification of a novel HLA-B*51 allele, HLA-B*5137, in the Korean population. Tissue Antigens 2006 67:254-5.
- Horn PA, DeLuca DS, Jindra P, Blasczyk R: The replacement mutation in HLA-DRB1*1211 affects a likely keystone position. Hum Immunol 2005: 66:1254-7.
- Baek JY, Song CH, Heo YS, Kwon OJ, Kwack K: Identification of a new HLA-DRB1 variant, DRB1*0451, in the Korean population. Tissue Antigens 2006 67:256-7.
- Hancock LN, Cordovado SK, Hendrix M, Simone AE, Mueller PW: Identification of two novel DQA1 alleles, DQA1*0107 and DQA1*0602, by sequence-based typing in the GoKinD population. Hum Immunol 2005: 66:1248-53.
- Ludajic K, Fae I, Fischer GF: Characterization of a new HLA-DPB1 allele, DPB1*010103. Tissue Antigens 2006 67:255-6.
