Nomenclature for Factors of the HLA System
January 2006
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2006 67:438-9
- Human Immunology. 2006 67:551-3
- International Journal of Immunogenetics. 2006 33:225-6
The following sequences have been submitted to the Nomenclature Committee since the December 2005 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author |
|---|---|---|---|
| A*0291 | 2005102723 | DQ348073, DQ348074 |
Oh-Joong Kwon, Seoul, South Korea |
| A*0292 | NT00641 | DQ354438, DQ354439 |
Carolyn K. Hurley, Washington, USA |
| A*110202 | NT00640 | DQ354440, DQ354441 |
Carolyn K. Hurley, Washington, USA |
| A*240211 | 2005101727 | DQ333354, DQ333355 |
Oh-Joong Kwon, Seoul, South Korea |
| A*2459 | B8299 | DQ313255, DQ313256, DQ313257 |
Lixing Yan, Hangzhou, China |
| A*2460N | TBC56401 | AB247152 | Masahiro Satake, Tokyo, Japan |
| A*3016 | NT00643 | DQ354436, DQ354437 |
Carolyn K. Hurley, Washington, USA |
| A*6831 | NT00644 | DQ354432, DQ354433 |
Carolyn K. Hurley, Washington, USA |
| B*0746 | UA-225-TP3611 | AM182459 | Mats Bengtsson, Uppsala, Sweden |
| B*2733 | NG1807444 | DQ367066, DQ367067 |
David Smillie, Sheffield, United Kingdom |
| B*370102 | NT00628 | DQ334729, DQ334730 |
Carolyn K. Hurley, Washington, USA |
| B*3939 | NT00632 | DQ334737, DQ334738 |
Carolyn K. Hurley, Washington, USA |
| B*3940N | 89951 | DQ351214 | Mary Sue Leffell, Baltimore, USA |
| B*5140 | NT00630 | DQ334733, DQ334734 |
Carolyn K. Hurley, Washington, USA |
| B*9510 | NT00631 | DQ334735, DQ334736 |
Carolyn K. Hurley, Washington, USA |
| Cw*0213 | JUNYa | AM180649 | Anne Dormoy, Strasbourg, France |
| Cw*0214 | MHHNEE144 | AM180651 | Rainer Blasczyk, Hannover, Germany |
| Cw*0323 | TBC56206 | AB247153 | Masahiro Satake, Tokyo, Japan |
| Cw*040104 | NEE138 | AM180722 | Rainer Blasczyk, Hannover, Germany |
| Cw*0418 | MHHNEE110 | AM180629 | Rainer Blasczyk, Hannover, Germany |
| Cw*070105 | ML1954 | DQ314860 | Ma Luo, Winnipeg, Canada |
| Cw*070105 | MHHNEE329 | AM180941 | Rainer Blasczyk, Hannover, Germany |
| Cw*0735 | NT00636 | DQ334743, DQ334744 |
Carolyn K. Hurley, Washington, USA |
| Cw*0736 | CTM-3691986 | DQ359691 | Antonio Balas, Madrid, Spain |
| Cw*0814 | TBC56207 | AB247154 | Masahiro Satake, Tokyo, Japan |
| Cw*120304 | LEUVio | AM180647 | Anne Dormoy, Strasbourg, France |
| Cw*1408 | ML270 | DQ314861 | Ma Luo, Winnipeg, Canada |
| Cw*150203 | DED | AM180648 | Anne Dormoy, Strasbourg, France |
| Cw*1517 | NT00638 | DQ354442, DQ354443 |
Carolyn K. Hurley, Washington, USA |
| DRB1*0329 | NT00626 | DQ334726 | Carolyn K. Hurley, Washington, USA |
| DRB1*1456 | 2005111516 | DQ333353 | Oh-Joong Kwon, Seoul, South Korea |
| DRB1*1519 | 29477 | AM040719 | Ella M. Van den Berg-Loonen, Maastricht, The Netherlands |
| DQA1*010204 | 24368 | AM042559 | Ella M. Van den Berg-Loonen, Maastricht, The Netherlands |
| DQA1*0509 | 20700, 218, 28137 |
AM042560 | Ella M. Van den Berg-Loonen, Maastricht, The Netherlands |
| DPB1*1602 | TBCS197 | AB247517 | Masahiro Satake, Tokyo, Japan |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author | References |
|---|---|---|---|---|
| A*01010101 | COX | AL645935 | Stephan Beck, Cambridge, United Kingdom | (1) |
| A*0117 | NT00645 | DQ354430, DQ354431 |
Carolyn K. Hurley, Washington, USA | |
| A*2457 | NT00642 | DQ354434, DQ354435 |
Carolyn K. Hurley, Washington, USA | |
| B*080101 | COX | AL669854 | Stephan Beck, Cambridge, United Kingdom | (1) |
| B*130202 | NT00629 | DQ334731, DQ334732 |
Carolyn K. Hurley, Washington, USA | |
| B*350402 | NT00637 | DQ334741, DQ334742 |
Carolyn K. Hurley, Washington, USA | |
| B*3559 | NT00627 | DQ334727, DQ334728 |
Carolyn K. Hurley, Washington, USA | |
| Cw*0728 | NT00634 | DQ334739, DQ334740 |
Carolyn K. Hurley, Washington, USA | |
| Cw*0732N | NT00597 | DQ372911, DQ372912, DQ372913 |
Carolyn K. Hurley, Washington, USA | |
| E*01010101 | RPCI5 | AB014080 | Hidetoshi Inoko, Isehara, Japan | (2) |
| F*01010301 | RPCI5 | AB023058 | Hidetoshi Inoko, Isehara, Japan | (2) |
| G*01010201 | RPCI5 | AB023057 | Hidetoshi Inoko, Isehara, Japan | (2) |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*0286 | (3) |
| A*0115N | (4) |
| A*2910 | (5) |
References
- Stewart CA, Horton R, Allcock RJ, et al.: Complete MHC haplotype sequencing for common disease gene mapping. Genome Res 2004 14:1176-87.
- Shiina T, Tamiya G, Oka A, et al.: Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region. Proc Natl Acad Sci U S A 1999 96:13282-7.
- Heo YS, Hwang SH, Kwon OJ, Hur SS, Oh HB: Structural aspect of novel HLA-A*02 allele, A*0286, identified by sequence-based typing. Tissue Antigens 2006 67:84-5.
- Bera O, Dubois V, Assaqa A, Belon P, Favre-Victoire I, Gebuhrer L: A deletion in exon 3 results in a new HLA-A*01 null allele (A*0115N) in a Martinican woman. Tissue Antigens 2006 67:61-3.
- Mosebach M, Brixner V, Bader P, Klingebiel TH, Seifried E, Seidl C: Intergenic recombination with HLA-C leads to a novel HLA-A*19 allele, HLA-A*2910, that is characterized by a functionally inactive amino acid exchange in the loop connecting the alpha and alpha domains. Tissue Antigens 2006 67:75-8.
