Nomenclature for Factors of the HLA System

December 2005

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

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The following sequences have been submitted to the Nomenclature Committee since the November 2005 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

In February 2005 the allele A*3014L was named (1). The allele has a mutation in codon 164 encoding a cysteine residue contributing to a structurally critical disulphide bond in the α2 domain of the HLA molecule. Expression studies performed on cells with this allele showed its protein to have a much reduced expression compared to normal, and the allele name was thus given the suffix 'L' to indicate this low expression. Since then several other alleles have been reported that have also lost one of the two cysteine residues (position 101 and 164) which form the α2 domain disulphide bond. It has not, however, been possible to ascertain the expression status of these alleles, due to a lack of viable material. The naming of these alleles was considered by the Nomenclature Committee at their meeting in Melbourne, Australia, during the 14th HLA and Immunogenetics Workshop. As a result of these discussions, it was decided to introduce an additional suffix, Q, to indicate a 'Questionable' expression level. The first four alleles to receive this suffix have been named and are included in this report, A*3211Q, B*3565Q, B*3938Q and Cw*0322Q. It is anticipated that when further examples of these alleles are described, their expression status will be determined and the suffix changed accordingly.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at :

Table 1: New Sequences

Sequence Cell Identification Accession Number Submitting Author References
A*0322 I-126320 AM161452 Rainer Blasczyk, Hannover, Germany  
A*2458 0301009 AM157679 Martin Danzer, Linz, Austria  
A*3211Q BY00069 DQ123858,
Carolyn K. Hurley, Washington, U.S.A.  
B*080103 CambsB8 AM158301 Reyna Goodman, Cambridge, U.K.  
B*0827 N2917 DQ320644,
Lee Ann Baxter-Lowe, San Francisco, U.S.A.  
B*3563 B05-2224 DQ321673 Kyung Wha Lee, Anyang City, South Korea  
B*3564 2005101152 DQ301507,
Oh-Joong Kwon, Sungdong-gu, Seoul, South Korea  
B*3565Q MHH999711,
Rainer Blasczyk, Hannover, Germany  
B*3938Q BY00061 DQ105566,
Carolyn K. Hurley, Washington, U.S.A.  
B*550202 N2915 DQ320646,
Lee Ann Baxter-Lowe, San Francisco, U.S.A.  
Cw*0322Q C3Var AM157129 Derek Middleton, Belfast, U.K.  
Cw*0513 255461 DQ327710 Kaimo Hirv, Ulm, Germany  
Cw*1516 SHWA39771AN AM158319 Ann-Margaret Little, London, U.K.  
DPB1*1502 DACO41672AN AM158320 Ann-Margaret Little, London, U.K.  
DRB1*1455 259316 DQ327711 Kaimo Hirv, Ulm, Germany  
DRB3*0221 120720 DQ311653 Antonio Amoroso, Torino, Italy  

Table 2: Confirmatory Sequences

Sequence Cell Identification Accession Number Submitting Author References
A*03010101 PGF AL671277 Stephan Beck, Cambridge, U.K. (2)
B*070201 PGF AL671277 Stephan Beck, Cambridge, U.K. (2)
Cw*070101 CGM1 D84394 Hidetoshi Inoko, Kanagawa, Japan  
Cw*070101 COX AL662833 Stephan Beck, Cambridge, U.K. (2)
Cw*07020103 PGF AL671883 Stephan Beck, Cambridge, U.K. (2)
E*01010101 COX AL662822 Stephan Beck, Cambridge, U.K. (2)
E*010302 PGF AL662873 Stephan Beck, Cambridge, U.K. (2)
F*01010301 COX AL669813 Stephan Beck, Cambridge, U.K. (2)
F*01030101 PGF AL645939 Stephan Beck, Cambridge, U.K. (2)
G*01010105 PGF AL645929 Stephan Beck, Cambridge, U.K. (2)
G*01010201 COX AL671561 Stephan Beck, Cambridge, U.K. (2)
DRB1*0704 12827878 AM109974 Rainer Blasczyk, Hannover, Germany  
DRB1*080401 TER322 AM109975 Rainer Blasczyk, Hannover, Germany  
DRB1*0807 TER323 AM109976 Rainer Blasczyk, Hannover, Germany  
DRB1*0811 ARA016 AM109977 Rainer Blasczyk, Hannover, Germany  
DRB1*0814 KE AM109978 Rainer Blasczyk, Hannover, Germany  
DRB1*1105 DBUG AM109979 Rainer Blasczyk, Hannover, Germany  
DRB1*110801 JL AM109980 Rainer Blasczyk, Hannover, Germany  
DRB1*110802 HW AM109981 Rainer Blasczyk, Hannover, Germany  
DRB1*1109 BEL7MON AM109982 Rainer Blasczyk, Hannover, Germany  
DRB1*1113 TER327 AM109983 Rainer Blasczyk, Hannover, Germany  
DRB1*111401 12762 AM109984 Rainer Blasczyk, Hannover, Germany  
DRB1*111901 TER278 AM109985 Rainer Blasczyk, Hannover, Germany  
DRB1*1121 MUL AM109986 Rainer Blasczyk, Hannover, Germany  
DRB1*1129 21690 AM109987 Rainer Blasczyk, Hannover, Germany  
DRB1*130301 TER275 AM109988 Rainer Blasczyk, Hannover, Germany  
DRB1*1306 TER331 AM109989 Rainer Blasczyk, Hannover, Germany  
DRB1*1308 THA AM109990 Rainer Blasczyk, Hannover, Germany  
DRB1*1310 TER343 AM109991 Rainer Blasczyk, Hannover, Germany  
DRB1*1311 1083933x AM109992 Rainer Blasczyk, Hannover, Germany  
DRB1*131402 31854 AM109993 Rainer Blasczyk, Hannover, Germany  
DRB1*1317 TER351 AM109994 Rainer Blasczyk, Hannover, Germany  
DRB1*1320 10843566 AM109995 Rainer Blasczyk, Hannover, Germany  
DRB1*1329 TER320 AM109996 Rainer Blasczyk, Hannover, Germany  
DRB1*1336 30638, IND-1 AM109997 Rainer Blasczyk, Hannover, Germany  
DRB1*1406 TER313 AM109998 Rainer Blasczyk, Hannover, Germany  
DRB1*140701 HAY, BD AM109999 Rainer Blasczyk, Hannover, Germany  
DRB1*1410 TER283 AM110000 Rainer Blasczyk, Hannover, Germany  
DRB1*1413 GRC-138 AM110001 Rainer Blasczyk, Hannover, Germany  
DRB1*1414 TER279 AM110002 Rainer Blasczyk, Hannover, Germany  
DRB1*1421 TGI AM110003 Rainer Blasczyk, Hannover, Germany  
DRB1*150202 THA AM110004 Rainer Blasczyk, Hannover, Germany  
DRB1*1507 UBM12218693 AM110005 Rainer Blasczyk, Hannover, Germany  
DRB1*1604 FORE AM110006 Rainer Blasczyk, Hannover, Germany  

Table 3: Recently Published Sequences

Sequence References
A*0111N (3)
A*0315 (4)
A*260102 (5)
B*270509 (6)
B*4061 (7)
B*4443 (8)
B*4811 (9)
Cw*0111 (10)
DRB1*110403 (11)
DRB1*1516 (12)


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  2. Stewart CA, Horton R, Allcock RJ, et al.: Complete MHC haplotype sequencing for common disease gene mapping. Genome Res 2004: 14:1176-87.
  3. Reinders J, Rozemuller EH, Otten HG, et al.: Identification of HLA-A*0111N: a synonymous substitution, introducing an alternative splice site in exon 3, silenced the expression of an HLA-A allele. Hum Immunol 2005 66:912-20.
  4. Horn PA, DeLuca DS, Blasczyk R: An amino acid contributing to pockets A, B, and D of the peptide-binding groove is altered in A*0315. Tissue Antigens 2005 66:703-4.
  5. Kwon OJ, Hwang SH, Lee MN, Oh HB: A novel HLA-A*2601 variant, A*260102, identified by sequence-based typing. Tissue Antigens 2005 66:704-5.
  6. Heymann GA, Hoppe B, Schonemann C, Lassahn A, Salama A: A novel HLA-B*270509 variant escaping detection by PCR-SSO-based histotyping. Tissue Antigens 2005 66:702-3.
  7. Yan LX, Zhu FM, Lv QF, Zhang W: Identification of a novel HLA-B*4061 allele in the Chinese population. Tissue Antigens 2005 66:705-6.
  8. Thude H, Hardt C, Schorner U, Ferencik S, Helfricht C, Barz D: Identification of a new HLA-B allele, HLA-B*4443, in a German family. Tissue Antigens 2005 66:696-9.
  9. Kwon OJ, Hwang SH, Heo YS, Hur SS, Oh HB: Structural aspect of B*4811 molecule, a novel HLA-B*48 allele identified by sequence-based typing. Tissue Antigens 2005 66:707-9.
  10. Kwon OJ, Hwang SH, Hur SS, Oh HB: Novel HLA-Cw*01 allele, Cw*0111, identified by sequence-based typing. Tissue Antigens 2005 66:706-7.
  11. Longhi E, Frison S, Andreini E, Favoino B, Poli F, Scalamogna M: Description of a new HLA-DRB1*1104, DRB1*110403. Tissue Antigens 2005 66:700-1.
  12. Hu ZH, Liu ZH, Xiong YJ, et al.: A novel HLA-DRB1*15 allelic sequence isolated from the Han population of Guangdong, China. Int J Immunogenet 2005 32:221-2.