Nomenclature for Factors of the HLA System
December 2005
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2006 67:262-4
- Human Immunology. 2005 66:1268-70
- International Journal of Immunogenetics. 2006 33:147-9
The following sequences have been submitted to the Nomenclature Committee since the November 2005 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
In February 2005 the allele A*3014L was named (1). The allele has a mutation in codon 164 encoding a cysteine residue contributing to a structurally critical disulphide bond in the α2 domain of the HLA molecule. Expression studies performed on cells with this allele showed its protein to have a much reduced expression compared to normal, and the allele name was thus given the suffix 'L' to indicate this low expression. Since then several other alleles have been reported that have also lost one of the two cysteine residues (position 101 and 164) which form the α2 domain disulphide bond. It has not, however, been possible to ascertain the expression status of these alleles, due to a lack of viable material. The naming of these alleles was considered by the Nomenclature Committee at their meeting in Melbourne, Australia, during the 14th HLA and Immunogenetics Workshop. As a result of these discussions, it was decided to introduce an additional suffix, Q, to indicate a 'Questionable' expression level. The first four alleles to receive this suffix have been named and are included in this report, A*3211Q, B*3565Q, B*3938Q and Cw*0322Q. It is anticipated that when further examples of these alleles are described, their expression status will be determined and the suffix changed accordingly.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author | References |
|---|---|---|---|---|
| A*0322 | I-126320 | AM161452 | Rainer Blasczyk, Hannover, Germany | |
| A*2458 | 0301009 | AM157679 | Martin Danzer, Linz, Austria | |
| A*3211Q | BY00069 | DQ123858, DQ123859 |
Carolyn K. Hurley, Washington, U.S.A. | |
| B*080103 | CambsB8 | AM158301 | Reyna Goodman, Cambridge, U.K. | |
| B*0827 | N2917 | DQ320644, DQ320645 |
Lee Ann Baxter-Lowe, San Francisco, U.S.A. | |
| B*3563 | B05-2224 | DQ321673 | Kyung Wha Lee, Anyang City, South Korea | |
| B*3564 | 2005101152 | DQ301507, DQ301508 |
Oh-Joong Kwon, Sungdong-gu, Seoul, South Korea | |
| B*3565Q | MHH999711, MHHZ-00012113 |
AJ278746, AJ278747, AJ879892 |
Rainer Blasczyk, Hannover, Germany | |
| B*3938Q | BY00061 | DQ105566, DQ105567, DQ105568 |
Carolyn K. Hurley, Washington, U.S.A. | |
| B*550202 | N2915 | DQ320646, DQ320647 |
Lee Ann Baxter-Lowe, San Francisco, U.S.A. | |
| Cw*0322Q | C3Var | AM157129 | Derek Middleton, Belfast, U.K. | |
| Cw*0513 | 255461 | DQ327710 | Kaimo Hirv, Ulm, Germany | |
| Cw*1516 | SHWA39771AN | AM158319 | Ann-Margaret Little, London, U.K. | |
| DPB1*1502 | DACO41672AN | AM158320 | Ann-Margaret Little, London, U.K. | |
| DRB1*1455 | 259316 | DQ327711 | Kaimo Hirv, Ulm, Germany | |
| DRB3*0221 | 120720 | DQ311653 | Antonio Amoroso, Torino, Italy |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author | References |
|---|---|---|---|---|
| A*03010101 | PGF | AL671277 | Stephan Beck, Cambridge, U.K. | (2) |
| B*070201 | PGF | AL671277 | Stephan Beck, Cambridge, U.K. | (2) |
| Cw*070101 | CGM1 | D84394 | Hidetoshi Inoko, Kanagawa, Japan | |
| Cw*070101 | COX | AL662833 | Stephan Beck, Cambridge, U.K. | (2) |
| Cw*07020103 | PGF | AL671883 | Stephan Beck, Cambridge, U.K. | (2) |
| E*01010101 | COX | AL662822 | Stephan Beck, Cambridge, U.K. | (2) |
| E*010302 | PGF | AL662873 | Stephan Beck, Cambridge, U.K. | (2) |
| F*01010301 | COX | AL669813 | Stephan Beck, Cambridge, U.K. | (2) |
| F*01030101 | PGF | AL645939 | Stephan Beck, Cambridge, U.K. | (2) |
| G*01010105 | PGF | AL645929 | Stephan Beck, Cambridge, U.K. | (2) |
| G*01010201 | COX | AL671561 | Stephan Beck, Cambridge, U.K. | (2) |
| DRB1*0704 | 12827878 | AM109974 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*080401 | TER322 | AM109975 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*0807 | TER323 | AM109976 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*0811 | ARA016 | AM109977 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*0814 | KE | AM109978 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1105 | DBUG | AM109979 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*110801 | JL | AM109980 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*110802 | HW | AM109981 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1109 | BEL7MON | AM109982 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1113 | TER327 | AM109983 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*111401 | 12762 | AM109984 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*111901 | TER278 | AM109985 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1121 | MUL | AM109986 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1129 | 21690 | AM109987 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*130301 | TER275 | AM109988 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1306 | TER331 | AM109989 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1308 | THA | AM109990 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1310 | TER343 | AM109991 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1311 | 1083933x | AM109992 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*131402 | 31854 | AM109993 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1317 | TER351 | AM109994 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1320 | 10843566 | AM109995 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1329 | TER320 | AM109996 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1336 | 30638, IND-1 | AM109997 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1406 | TER313 | AM109998 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*140701 | HAY, BD | AM109999 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1410 | TER283 | AM110000 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1413 | GRC-138 | AM110001 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1414 | TER279 | AM110002 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1421 | TGI | AM110003 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*150202 | THA | AM110004 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1507 | UBM12218693 | AM110005 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1604 | FORE | AM110006 | Rainer Blasczyk, Hannover, Germany |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*0111N | (3) |
| A*0315 | (4) |
| A*260102 | (5) |
| B*270509 | (6) |
| B*4061 | (7) |
| B*4443 | (8) |
| B*4811 | (9) |
| Cw*0111 | (10) |
| DRB1*110403 | (11) |
| DRB1*1516 | (12) |
References
- Marsh SGE: Nomenclature for factors of the HLA system, update February 2005. Tissue Antigens 2005 65:586-7.
- Stewart CA, Horton R, Allcock RJ, et al.: Complete MHC haplotype sequencing for common disease gene mapping. Genome Res 2004: 14:1176-87.
- Reinders J, Rozemuller EH, Otten HG, et al.: Identification of HLA-A*0111N: a synonymous substitution, introducing an alternative splice site in exon 3, silenced the expression of an HLA-A allele. Hum Immunol 2005 66:912-20.
- Horn PA, DeLuca DS, Blasczyk R: An amino acid contributing to pockets A, B, and D of the peptide-binding groove is altered in A*0315. Tissue Antigens 2005 66:703-4.
- Kwon OJ, Hwang SH, Lee MN, Oh HB: A novel HLA-A*2601 variant, A*260102, identified by sequence-based typing. Tissue Antigens 2005 66:704-5.
- Heymann GA, Hoppe B, Schonemann C, Lassahn A, Salama A: A novel HLA-B*270509 variant escaping detection by PCR-SSO-based histotyping. Tissue Antigens 2005 66:702-3.
- Yan LX, Zhu FM, Lv QF, Zhang W: Identification of a novel HLA-B*4061 allele in the Chinese population. Tissue Antigens 2005 66:705-6.
- Thude H, Hardt C, Schorner U, Ferencik S, Helfricht C, Barz D: Identification of a new HLA-B allele, HLA-B*4443, in a German family. Tissue Antigens 2005 66:696-9.
- Kwon OJ, Hwang SH, Heo YS, Hur SS, Oh HB: Structural aspect of B*4811 molecule, a novel HLA-B*48 allele identified by sequence-based typing. Tissue Antigens 2005 66:707-9.
- Kwon OJ, Hwang SH, Hur SS, Oh HB: Novel HLA-Cw*01 allele, Cw*0111, identified by sequence-based typing. Tissue Antigens 2005 66:706-7.
- Longhi E, Frison S, Andreini E, Favoino B, Poli F, Scalamogna M: Description of a new HLA-DRB1*1104, DRB1*110403. Tissue Antigens 2005 66:700-1.
- Hu ZH, Liu ZH, Xiong YJ, et al.: A novel HLA-DRB1*15 allelic sequence isolated from the Han population of Guangdong, China. Int J Immunogenet 2005 32:221-2.
