Nomenclature for Factors of the HLA System

November 2005

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the October 2005 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell Identification Accession Number Submitting Author References
A*1124 PSP9113 AM114414 Kathleen Lebeer, Ghent, Belgium  
A*7412N LCLAg876 AJ865349 Klaus Witter, München, Germany  
B*0745 NT00623 DQ270208,
DQ270209		 Carolyn K. Hurley, Washington, U.S.A.  
B*1315 FRBA36844AN AM114035 Ann-Margaret Little, London, U.K.  
B*1822 BY00078 DQ244137,
DQ244138,
DQ244139		 Carolyn K. Hurley, Washington, U.S.A.  
B*3562 WAJ621 AM114412 Kathleen Lebeer, Ghent, Belgium  
B*3812 F409, F410 DQ239490,
DQ239491,
DQ239492		 Domenico Adorno, L'Aquila, Italy  
B*3937 IR2425 AM114413 Kathleen Lebeer, Ghent, Belgium  
B*4062 2005091432,
2005091665		 DQ250652,
DQ250653		 Oh-Joong Kwon, Sungdong-gu, Seoul, South Korea  
B*4208 LOFE36391AN AM114034 Ann-Margaret Little, London, U.K.  
B*5408N HZB8296 DQ295998,
DQ295999,
DQ29600		 Lixing Yan, Hangzhou, China  
B*9509 BY00079 DQ244125,
DQ244126		 Carolyn K. Hurley, Washington, U.S.A.  
Cw*0321 BY00074 DQ244133,
DQ244134		 Carolyn K. Hurley, Washington, U.S.A.  
Cw*0512 NT00625 DQ289051,
DQ289052		 Carolyn K. Hurley, Washington, U.S.A.  
Cw*0733N NT00594,
NT00608		 DQ145936,
DQ145937,
DQ145938,
DQ145939		 Carolyn K. Hurley, Washington, U.S.A.  
Cw*0734 BY00073 DQ270210,
DQ270211		 Carolyn K. Hurley, Washington, U.S.A.  
Cw*1515 NT00598 DQ289053,
DQ289054		 Carolyn K. Hurley, Washington, U.S.A.  
DRB1*0832 EN120 DQ229933 Yann-Jinn Lee, Taipei County, Taiwan  
DRB1*1213 2005081802 DQ250650 Oh-Joong Kwon, Sungdong-gu, Seoul, South Korea  
DRB1*1371 ALSM4092AN AM158254 Ann-Margaret Little, London, U.K.  

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author References
A*020109 0200402901,
0200402597,
0200402708		 AM040715 Silvia Ulrich, Graz, Austria  
A*310102 MHHZ-00006783 AJ889845 Rainer Blasczyk, Hannover, Germany  
B*0703 1156492+ AM117564 Laura Hammond, Pontyclun, U.K.  
B*3707 LFC197 AM114415 Kathleen Lebeer, Ghent, Belgium  
B*401403 11169540 AM114422 Laura Hammond, Pontyclun, U.K.  
B*4048 BY00076 DQ244135,
DQ244136		 Carolyn K. Hurley, Washington, U.S.A.  
Cw*0108 BY00072 DQ244131,
DQ244132		 Carolyn K. Hurley, Washington, U.S.A.  
Cw*0317 BY00070 DQ244127,
DQ244128		 Carolyn K. Hurley, Washington, U.S.A.  
Cw*0726 BY00071 DQ244129,
DQ244130		 Carolyn K. Hurley, Washington, U.S.A.  
DRB1*0304 35919,
TER336		 AM109967 Rainer Blasczyk, Hannover, Germany  
DRB1*0315 TER317 AM109968 Rainer Blasczyk, Hannover, Germany  
DRB1*040302 TER337 AM109969 Rainer Blasczyk, Hannover, Germany  
DRB1*0415 TER308 AM109970 Rainer Blasczyk, Hannover, Germany  
DRB1*0416 BEL5GB AM109971 Rainer Blasczyk, Hannover, Germany  
DRB1*0431 GE47192 AM109972 Rainer Blasczyk, Hannover, Germany  
DRB1*0434 DWEVE488 AM109973 Rainer Blasczyk, Hannover, Germany  

Table 3: Recently Published Sequences


Sequence References
A*0283N (1)
A*2626 (2)
Cw*0612 (3)
DRB1*040504 (4)
DRB1*0453 (5)
DRB1*0828 (4)
DRB1*1145 (4)
DRB1*1148 (4)
DRB1*130103 (4)
DRB1*1361 (4)
DRB1*1447 (4)
DRB1*1448 (4)
DRB1*1450 (6)
DRB1*1514 (4)
DRB1*1517N (7)
DRB1*160502 (4)
DRB3*020204 (4)
DPB1*010101 (8)
DPB1*010102 (8)
DPB1*020102 (8)
DPB1*0202 (8)
DPB1*040101 (8)
DPB1*0402 (8)
DPB1*0501 (8)
DPB1*0502 (8)
DPB1*0602 (8)
DPB1*0802 (8)
DPB1*0901 (8)
DPB1*0902 (8)
DPB1*1301 (8)
DPB1*1401 (8)
DPB1*1501 (8)
DPB1*1901 (8)

References

  1. Horn PA, Mansmann V, Blasczyk R: Non-expression of HLA-A*0283N. Tissue Antigens 2005 66:335-7.
  2. Longhi E, Frison S, Colombini I, Malagoli A, Crespiatico L, Poli F: HLA-A*2626, a new allele identified through external proficiency-testing exercise. Tissue Antigens 2005 66:325-6.
  3. Hwang SH, Cha CH, Kwon OJ, et al.: Novel HLA-Cw*06 allele, Cw*0612, identified by sequence-based typing. Tissue Antigens 2005 66:330-1.
  4. Lazaro AM, Steiner NK, Moraes ME, et al.: Ten novel HLA-DRB1 alleles and one novel DRB3 allele. Tissue Antigens 2005 66:327-9.
  5. Liu XZ, Li JP, Chi LP, Li XF, Zhang X: Identification of a novel HLA-DRB1 allele. Tissue Antigens 2005 66:333-4.
  6. Tijssen HJ, van der Zeeuw-Hingrez SC, Joosten I: Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*1450. Tissue Antigens 2005 66:332-3.
  7. Lebedeva TV, Ohashi M, Huang A, Zannelli G, Yu N: A frame shift due to a two-nucleotide insertion results in an HLA-DRB1 null allele, DRB1*1517N. Tissue Antigens 2005 66:334-5.
  8. Reinders J, Rozemuller EH, van Gent R, Arts-Hilkes YH, van den Tweel JG, Tilanus MG: Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing. Immunogenetics 2005 57:790-4