Nomenclature for Factors of the HLA System
October 2005
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2006 67:258-9
- Human Immunology. 2005 66:1264-5
- International Journal of Immunogenetics. 2006 33:63-4
The following sequences have been submitted to the Nomenclature Committee since the September 2005 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author | References |
|---|---|---|---|---|
| A*0117 | NT00621 | DQ227987, DQ227988 |
Carolyn K. Hurley, Washington, U.S.A. | |
| A*0290 | Xian11519 | DQ234081, DQ234082, DQ234083 |
Mengli Liu, Xi’an, China | |
| A*0321N | PHNI332212AN | AM087469 | Ann-Margaret Little, London, U.K. | |
| A*2455 | NT00620 | DQ205711, DQ205712 |
Carolyn K. Hurley, Washington, U.S.A. | |
| A*2456 | NT00613 | DQ205705, DQ205706 |
Carolyn K. Hurley, Washington, U.S.A. | |
| A*2457 | NT00614 | DQ205707, DQ205708 |
Carolyn K. Hurley, Washington, U.S.A. | |
| A*2627 | NT00615 | DQ205703, DQ205704 |
Carolyn K. Hurley, Washington, U.S.A. | |
| A*3407 | NT00617 | DQ205713, DQ205714 |
Carolyn K. Hurley, Washington, U.S.A. | |
| A*6829 | NT00619 | DQ205717, DQ205718 |
Carolyn K. Hurley, Washington, U.S.A. | |
| A*6830 | NT00616 | DQ205709, DQ205710 |
Carolyn K. Hurley, Washington, U.S.A. | |
| B*1314 | 118591 | AM086443 | Klaus Witter, München, Germany | |
| B*2732 | HUCL325070AN | AM087470 | Ann-Margaret Little, London, U.K. | |
| B*3936 | CB9216 | DQ242650, DQ242651, DQ242652 |
Lixing Yan, Hangzhou, China | |
| B*4814 | Xian4807 | DQ238864, DQ238865 |
Mengli Liu, Xi’an, China | |
| B*9507 | 13890190 | AM087018 | Laura Hammond, Pontyclun, U.K. | |
| B*9508 | CTMAL-5469642 | DQ241733 | Jose L. Vicario, Madrid, Spain | |
| Cw*031102 | 11845457, 14695022 |
AM087957 | Laura Hammond, Pontyclun, U.K. | |
| DRB1*0831 | CAPTN | AM000026 | Sarinder Day, Bristol, U.K. | |
| DRB1*1370 | MHHZ-00014883, MHHZ-00014884 |
AM086025 | Rainer Blasczyk, Hannover, Germany | |
| DRB1*1454 | KOSE, EK, TER284, TER293 |
AM087553 | Rainer Blasczyk, Hannover, Germany | |
| DQB1*0318 | CDC092905 | DQ227421 | Suzanne Cordovado, Atlanta, U.S.A. |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author | References |
|---|---|---|---|---|
| A*0286 | NT00618 | DQ205715, DQ205716 |
Carolyn K. Hurley, Washington, U.S.A. | |
| B*151101 | 13703390 | AM085497 | Laura Hammond, Pontyclun, U.K. | |
| B*1578 | 14513382 | AM085498 | Laura Hammond, Pontyclun, U.K. | |
| B*1804 | 11542527 | AM110757 | Laura Hammond, Pontyclun, U.K. | |
| B*3904 | 13703390 | AM085496 | Laura Hammond, Pontyclun, U.K. | |
| Cw*0319 | 14905442 | AM087019 | Laura Hammond, Pontyclun, U.K. |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| B*5615 | (1) |
| Cw*010203 | (2) |
| DRB1*1368 | (3) |
| DRB1*1609 | (4) |
| DOA*010106 | (5) |
| DOA*0102 | (5) |
| DOA*0103 | (5) |
| DOA*0104N | (5) |
References
- Frison S, Longhi E, de Arias AE, Andreini E, Scalamogna M, Poli F: Identification of a new HLA-B variant, HLA-B*5615. Tissue Antigens 2005 66:238-9.
- Kwon OJ, Hwang SH, Hur SS, Lee MN, Oh HB: Novel HLA-Cw*01 allele, Cw*010203, identified by sequence-based typing*. Tissue Antigens 2005 66:240-1.
- Caggiari L, Simula MP, Marzotto A, et al.: Identification of a novel human DRB1*13 allele by sequence-based DRB typing. Tissue Antigens 2005 66:246-7.
- Miao KR, Pan QQ, Xue M, et al.: A novel HLA allele, DRB1*1609, identified in the Chinese Han population*. Tissue Antigens 2005 66:248-50.
- Moon SM, Gu H, Ryu HJ, et al.: Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing*. Tissue Antigens 2005 66:242-5.
