Nomenclature for Factors of the HLA System
April 2005
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2005 66:251-3
- Human Immunology. 2005 66:1019-21
- International Journal of Immunogenetics. 2005 32:325-6
The following sequences have been submitted to the Nomenclature Committee since the March 2005 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author | References |
|---|---|---|---|---|
| A*01010102N | CTM7681276 | AY973959 | Jose L. Vicario, Madrid, Spain | |
| A*0114 | K95443 | AJ829713 | Ann-Margaret Little, London, United Kingdom | |
| A*0280 | NT00529 | AY956754, AY956755 |
Carolyn K. Hurley, Washington, U.S.A. | |
| A*0281 | DKM326178 | AY973958 | Jose L. Vicario, Madrid, Spain | |
| A*2452 | TBC53522 | AB211247 | Masahiro Satake, Tokyo, Japan | |
| A*260102 | 2005031636 | DQ003050, DQ003051 |
Oh-Joong Kwon, Seoul, Republic of Korea | |
| A*260103 | TBC53385 | AB211246 | Masahiro Satake, Tokyo, Japan | |
| A*2625N | 40261 | AY963804, AY963805, AY963806 |
Debra Hiraki, Palo Alto, U.S.A. | |
| A*2626 | Cr01-4298 | AJ890835 | Francesca Poli, Milano, Italy | |
| B*0741 | CTM8683455 | AY971144 | Jose L. Vicario, Madrid, Spain | |
| B*0742 | NT00571 | DQ007037, DQ007038 |
Carolyn K. Hurley, Washington, U.S.A. | |
| B*130202 | NT00574 | DQ007041, DQ007042 |
Carolyn K. Hurley, Washington, U.S.A. | |
| B*1407N | CTM5683370 | AY973957 | Jose L. Vicario, Madrid, Spain | |
| B*2729 | UA-2004-TP-3826 | AJ937708 | Mats Bengtsson, Uppsala, Sweden | |
| B*350104 | NT00573 | DQ007039, DQ007040 |
Carolyn K. Hurley, Washington, U.S.A. | |
| B*3811 | NT00566 | AY956752, AY956753 |
Carolyn K. Hurley, Washington, U.S.A. | |
| B*391302 | CTM2097181 | AY973956 | Jose L. Vicario, Madrid, Spain | |
| B*3934 | CTM6681254 | AY973955 | Jose L. Vicario, Madrid, Spain | |
| B*5138 | CB12239 | AY957951, AY957952 |
Sue Davey, London, United Kingdom | |
| B*5407 | TBC53384 | AB211245 | Masahiro Satake, Tokyo, Japan | |
| Cw*0211 | CTM4900800 | AY973961 | Jose L. Vicario, Madrid, Spain | |
| Cw*0612 | 2005031636, 2005040419 | DQ003052, DQ003053 |
Oh-Joong Kwon, Seoul, Republic of Korea | |
| DOA*0102 | GRB2024703 | AY947480 | Jong-Keuk Lee, Seoul, Republic of Korea | |
| DOA*0103 | GRB2022544 | AY947481 | Jong-Keuk Lee, Seoul, Republic of Korea | |
| DOA*0104N | GRB2010154 | AY947482 | Jong-Keuk Lee, Seoul, Republic of Korea | |
| DQB1*0624 | S.C. | AJ964903 | Peter Schranz, Karlsruhe, Germany | |
| DRB1*0113 | CTM-1096976 | DQ002917 | Antonio Balas, Madrid, Spain | |
| DRB1*040602 | CTM-9096471 | AY961074 | Antonio Balas, Madrid, Spain | |
| DRB1*0905 | OPH11907 | AB207269 | Yoshifumi Hisayama, Osaka, Japan | |
| DRB1*111102 | CTM-3095924 | AY961065 | Antonio Balas, Madrid, Spain | |
| DRB1*1368 | 952An | AY963587 | Valli De Re, Aviano, Italy |
Table 2: Confirmatory Sequences
| Sequence | Cell Identification | Accession Number | Submitting Author | References |
|---|---|---|---|---|
| B*0733 | 34303 | AJ937776 | Thibaut Gervais, Brussels, Belgium | |
| B*180101 | BY00058 | DQ007938 | Carolyn K. Hurley, Washington, U.S.A. | |
| B*1802 | BY000569 | DQ007939 | Carolyn K. Hurley, Washington, U.S.A. | |
| B*4812 | NT00569 | AY956750, AY956751 |
Carolyn K. Hurley, Washington, U.S.A. | |
| Cw*04010101 | MHHZ-00013039 | AJ879943 | Rainer Blasczyk, Hannover, Germany | |
| Cw*0509 | CTM2682049 | AY973960 | Jose L. Vicario, Madrid, Spain | |
| DRB1*040701 | CTM-0096476 | AY961075 | Antonio Balas, Madrid, Spain | |
| DRB1*0408 | CTM-1096458 | AY961068 | Antonio Balas, Madrid, Spain | |
| DRB1*0806 | CTM-3096152 | AY961076 | Antonio Balas, Madrid, Spain | |
| DRB1*0813 | CTM-2096080 | AY961077 | Antonio Balas, Madrid, Spain | |
| DRB1*0818 | CTM-1097277 | AY961078 | Antonio Balas, Madrid, Spain | |
| DRB1*1115 | CTM-1096184 | AY961066 | Antonio Balas, Madrid, Spain | |
| DRB1*1327 | CTM-6095542 | AY961070 | Antonio Balas, Madrid, Spain | |
| DRB1*1411 | CTM-7095922 | AY961071 | Antonio Balas, Madrid, Spain |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*03010103 | (2) |
| B*1531 | (3) |
| B*1590 | (3) |
| B*1591 | (3) |
| B*2726 | (3) |
| B*3549 | (4) |
| B*4440 | (5) |
| B*4705 | (3) |
| B*5136 | (6) |
| B*5614 | (7) |
| Cw*0110 | (8) |
| Cw*0209 | (8) |
| Cw*030304 | (8) |
| Cw*0317 | (8) |
| Cw*0413 | (8) |
| Cw*0414 | (8) |
| Cw*0415 | (8) |
| Cw*0509 | (8) |
| Cw*0510 | (8) |
| Cw*0611 | (8) |
| Cw*070103 | (8) |
| Cw*0724 | (8) |
| Cw*0725 | (8) |
| Cw*0811 | (8) |
| Cw*0812 | (8) |
| Cw*120303 | (8) |
| Cw*1212 | (8) |
| Cw*150504 | (8) |
| Cw*1512 | (8) |
| DRB1*090103 | (9) |
| DPA1*010303 | (10) |
| DPA1*0303 | (10) |
| DOB*010103 | (11) |
References
- Vilches C, Sepulveda S, Balas A, et al.: Complete coding sequences and haplotypic associations of HLA-B*0707, -B*1524, -B*4405, -B*4802, -DRB1*0409, -DRB1*0411, -DRB1*1115, -DRB1*1305, and the novel allele -DRB1*0709. Group-specific amplification of cDNA from DRB1 alleles associated to DRB3 and DRB4. Tissue Antigens 2005 65:529-38.
- Mayor NP, Cox ST, McWhinnie AJ, et al.: Sequence of a novel HLA-A*0301 intronic variant (A*03010103). Tissue Antigens 2005 65:107-9.
- Luo M, Mao X, Plummer FA: Identification of four novel HLA-B alleles, B*1590, B*1591, B*2726, and B*4705, from an East African population by high-resolution sequence-based typing. Tissue Antigens 2005 65:187-91.
- Chang Y, Desai L, Fan TX, Santana Z, Day NK: Characterization of a novel allele HLA-B*3549. Tissue Antigens 2005 65:192-4.
- Heymann GA, Hoppe B, Nagy M, Schoenemann C, Kiesewetter H, Salama A: B*4440: a novel HLA-B allele identified by sequence-specific oligonucleotide hybridization and sequence-specific amplification. Tissue Antigens 2005 65:195-8.
- Yan LX, Zhu FM, Lv QF, Zhang W, Zhang HQ, He J: Identification of HLA-B*5136 in the Chinese population. Tissue Antigens 2005 65:280-2.
- Yan LX, Zhu FM, Lv QF, Zhang HQ, Zhang W, He J: Identification of a new HLA-B*56 variant, B*5614. Tissue Antigens 2005 65:278-9.
- Lebedeva TV, Ohashi M, Huang A, Vasconcellos S, Flesch S, Yu N: Emerging new alleles suggest high diversity of HLA-C locus. Tissue Antigens 2005 65:101-6.
- Hu Z, Liu Z, Xiong Y, et al.: A novel HLA-DRB1*09 allele, HLA-DRB1*090103*, isolated from the Han population of Guangdong, China. Tissue Antigens 2005 65:293-4.
- Luo M, Bamforth J, Gill K, Cohen C, Brunham RC, Plummer FA: High-resolution sequence-based DPA1 typing identified two novel DPA1 alleles, DPA1*010303 and DPA1*0303, from a Kenyan population. Tissue Antigens 2005 65:120-2.
- Gu H, Lee JK, Oh B: Identification of a novel HLA-DOB-allele, DOB*010103, by sequence-based typing in the Korean population. Tissue Antigens 2005 65:287-8.
