WMDA Directory

HLA Nomenclature in WMDA file format

At the request of the IT Working Group of the World Marrow Donor Association (WMDA), we are making three computer readable files available. These files will document: the official WHO HLA Nomenclature, the relationships between serologically defined antigens and the relationships between HLA allele sequences and their serologically defined antigens.

Updated versions of these files will be released every three months at the time new versions of the IMGT/HLA Database become available.

All four files have a short header with four lines of information, indicating:

  • File Name
  • Date file produced (YYYY-MM-DD)
  • Origin of file (URL)
  • Author

 

hla_nom.txt

Download the hla_nom.txt file

This file contains details of all current and deleted HLA antigens and alleles, and is sorted by locus and antigen/allele number:

  • HLA Locus
  • HLA Antigen or Allele name (digits only)
  • Date assigned (YYYYMMDD)
  • Date deleted, if the name has now been abandoned (YYYYMMDD)
  • Antigen or Allele that the deleted allele was shown to be identical to
  • Reason for the Antigen or Allele to be deleted

Please note that for HLA Antigen names assigned before November 1987, the dates given are only approximate.

This file includes six fields of information, each separated by a semi-colon (;).

HLA Locus HLA Antigen or Allele name (digits only) Date Assigned (YYYYMMDD) Date Deleted (YYYYMMDD) Deleted Antigen/Allele Identical to Reason for Deletion
A 1 19680101


A* 0105N 19990216 20010717 0104N Sequence Identical

 

rel_ser_ser.txt

Download the rel_ser_ser.txt file

This file lists the relationships between all current serologically defined HLA antigens: broad antigens, split antigens and associated antigens.

  • HLA Locus
  • HLA Antigen name (digits only)
  • Split Antigen
  • Associated Antigen

This file includes four fields of information, each separated by a semi-colon (;). The file lists only those antigens for which split or associated antigens exist. Multiple values are separated by a forward slash (/).

HLA Locus HLA Antigen name (digits only) Split HLA Antigens Associated HLA Antigens
A 2
203/210
A 9 23/24
A 10 25/26/34/66

 

rel_dna_ser.txt

Download the rel_dna_ser.txt file

This file contains details of all current HLA alleles and where known their unambiguous, possible or assumed serologically equivalent antigens.

Details of the unambiguous serology is defined from submissions to the WHO Nomenclature Committee for Factors of the HLA System (1) at the time an allele is submitted for naming, or from the WMDA HLA Dictionary 2004 (2). For Null alleles a value of zero (0) is given and for alleles with no corresponding antigen a question mark (?) is given.

In cases where an allele has been shown to be associated with more than one serologically defined antigen, these are indicated in the 'Possible Serology' field. Multiple values are separated by a forward slash (/). In cases where there is currently no information about the serological equivalent of an allele, the 'Assumed Serology' field contains the antigen equivalent as expected by the first two digits of the allele name.

This file contains details of all current HLA antigens and alleles, and is sorted by locus and allele number:

  • HLA Locus
  • HLA Allele Name (digits only)
  • Unambiguous Serological Antigen associated with allele
  • Possible Serological Antigen associated with allele
  • Assumed Serological Antigen associated with allele
  • Expert assigned exceptions in search determinants of some registries

This file includes five fields of information, each separated by a semi-colon (;).

HLA Locus HLA Antigen/ Allele name (digits only) Unambiguous Serology Possible Serology Assumed Serology Expert Assigned Exceptions
A* 010101 1


A* 0104N 0


A* 0110

1
A* 02010102L
0/2

A* 020301 203


B* 1304
15/21
13
B* 8301 ?


 

abdm.txt

Download the abdm.txt file

This file contains details of all HLA Sequences having the same antigen binding domains. This analysis is performed on the protein sequence, and for HLA Class I alleles, identity in the 'antigen binding domains' is based on identical protein sequences as encoded by exons 2 and 3. For HLA Class II alleles this is based on identical protein sequences as encoded by exon 2.

This files lists all HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, -DQA1, -DQB1, -DPA1 and -DPB1 alleles. Those alleles which have identical 'antigen binding domains', are listed together as strings separated by a forward slash (/).

This file includes two fields of information, each separated by a semi-colon (;).

HLA Locus Alleles
A* 010101/010102/010103
A* 0102
A* 0103
A* 0106
A* 0107
A* 02010101/02010102L/020102/020103/020104/020105/020106/020107/020108/020109/020 110/020111/0209/0266/0275

References:

  1. Marsh SGE, Albert ED, Bodmer WF et al. Nomenclature for Factors of the HLA System, 2004.
    Tissue Antigens. 2005 65:301-68
    International Journal of Immunogenetics. 2005 32:107-60
    Human Immunology. 2005 66:571-636
    Click here to download a copy of this report as published in Tissue Antigens is available courtesy of Wiley Blackwell.
  2. Schreuder GMTh, Hurley CK, Marsh SGE et al. The HLA Dictionary 2004: a summary of HLA-A, -B, -C, -DRB1/3/4/5, -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR and -DQ antigens.
    Tissue Antigens. 2005 65:1-55
    Human Immunology. 2005 66:170-210
    International Journal of Immunogenetics. 2005 32:19-69
    Click here to download a copy of this report as published in Tissue Antigens is available courtesy of Wiley Blackwell.

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