Nomenclature for Factors of the HLA System

October 2014

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the September 2014 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.An additional 372 alleles were recently published but have not been included in Table 3 due to space considerations (2).

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (3). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*11:210NCTM8026638KM657949Antonio Balas, Madrid, Spain
A*26:10623462, RMC26119LN614521Maria Loginova, Kirov, Russia
A*26:107N9711052KM979288Francisco de Paula Sanchez Gordo, Malaga, Spain
A*29:75FRFGR33525LN558515Dominique Masson, La Tronche, France
A*31:01:02:02CTM 1026127KM879189Antonio Balas, Madrid, Spain
B*07:235BY01145KF649107Carolyn K Hurley, Washington DC, USA
B*07:236UKT NGS 002LC004128Alexandr Kuranov, Tübingen, Germany
B*08:13881126682KM875664Daniel Fuerst, Ulm, Germany
B*49:3414001440KJ941004Antonio Balas, Madrid, Spain
B*51:18581127544KM875663Daniel Fuerst, Ulm, Germany
B*54:34P08700KM658169Faming Zhu, Hangzhou, China
B*55:02:01:02TU01AB679915Takashi Shiina, Isehara, Japan
B*56:01:01:02TU02AB679916Takashi Shiina, Isehara, Japan
B*58:677711106200KM609464Yan Liao, Nanning, China
C*05:10849381KM657022Runying Tian, Durham, USA
C*16:77N93095106KM875665Daniel Fuerst, Ulm, Germany
DRB1*04:05:17D10075231HE654732Jinghui Qu, Shenzhen, China
DRB1*04:05:18DK1561LN609297Xiang Liu, Beijing, China
DRB1*08:03:05BE7610LN609290Xiang Liu, Beijing, China
DRB1*08:61DA8331LN609296Xiang Liu, Beijing, China
DRB1*08:62DV2595LN609298Xiang Liu, Beijing, China
DRB1*08:63CTJ-20255EU545182Lina Yan, Tianjin, China
DRB1*08:63D11050140KF270568Jinghui Qu, Shenzhen, China
DRB1*12:52BE7520LN609289Xiang Liu, Beijing, China
DRB1*13:194LIG 90004KM591601Maria Elisa Moraes, Rio de Janeiro, Brazil
DRB1*14:04:02D10049542HE654759Jinghui Qu, Shenzhen, China
DQB1*03:03:02:04MAT-92KM519596Jorge Martinez-Laso, Madrid, Spain
DQB1*05:87QB00910KC970437Keming Du, Shanghai, China
E*01:03:01:034395LM654512Marcel GJ Tilanus, Maastricht, The Netherlands
E*01:08N4395LM654513Marcel GJ Tilanus, Maastricht, The Netherlands

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:01:74BY00906JQ040000Carolyn K Hurley, Washington DC, USA
A*02:486HG00009201KM198115Histogenetics, Ossining, USA
A*23:65HG00009200KM198204Histogenetics, Ossining, USA
A*24:248Beijing22607KC473543Xiaoyan Shan, Beijing, China
B*15:268HG00009208KF790850Histogenetics, Ossining, USA
B*15:332HG00009207KM051859Histogenetics, Ossining, USA
B*18:45HG00009204KF790851Histogenetics, Ossining, USA
B*35:144HG00009206KF790855Histogenetics, Ossining, USA
B*35:158HG00009205KF790852Histogenetics, Ossining, USA
B*40:130:02HG00009202KM198209Histogenetics, Ossining, USA
B*41:294307681HG934987Paul Dunn, Auckland, New Zealand
B*51:160BY01204KJ418364Carolyn K Hurley, Washington DC, USA
B*51:168HG00009209KM248726Histogenetics, Ossining, USA
B*57:73HG00009203KM216193Histogenetics, Ossining, USA
C*05:01:29HG00009215KJ749782Histogenetics, Ossining, USA
C*06:127:01HG00009210KM216197Histogenetics, Ossining, USA
C*06:133HG00009211KM198222Histogenetics, Ossining, USA
C*07:02:52HG00009213KM198146Histogenetics, Ossining, USA
C*07:02:63120821109HG934781Dominique Masson, La Tronche, France
C*07:381HG00009214KM365111Histogenetics, Ossining, USA
C*07:397HG00009212KM216196Histogenetics, Ossining, USA
DRB1*03:01:20HG00009242KJ619556Histogenetics, Ossining, USA
DRB1*03:04:0127895LM611904Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*04:1438210HG974603Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*04:100D10002408HE654736Jinghui Qu, Shenzhen, China
DRB1*04:182HG00009241KM198167Histogenetics, Ossining, USA
DRB1*07:26NDKMS-LSL-DRB1-41HF937425DKMS Life Sciences Lab, Dresden, Germany
DRB1*08:30:03D10071082HE654739Jinghui Qu, Shenzhen, China
DRB1*11:13:0229585LM611905Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*12:488811000959KM382430Huafang Gao, Beijing, China
DRB1*14:17#15310-LNHG974602Marcel GJ Tilanus, Maastricht, The Netherlands
DQB1*02:41HG00009218,
HG00009219
KM198234,
KM198151
Histogenetics, Ossining, USA
DQB1*03:02:06HG00009224KM198157Histogenetics, Ossining, USA
DQB1*03:02:13HG00009222,
HG00009223
KM198228,
KM454994
Histogenetics, Ossining, USA
DQB1*03:139HG00009217KM198165Histogenetics, Ossining, USA
DQB1*05:03:14HG00009232KM454992Histogenetics, Ossining, USA
DQB1*05:11:02HG00009230,
HG00009231
KM248735,
KM248734
Histogenetics, Ossining, USA
DQB1*05:20HG00009228KJ190374Histogenetics, Ossining, USA
DQB1*05:49HG00009235KM365116Histogenetics, Ossining, USA
DQB1*05:52HG00009225,
HG00009226,
HG00009227
KM248738,
KM198154,
KM248731
Histogenetics, Ossining, USA
DQB1*05:69HG00009233,
HG00009234
KM454993,
KM198155
Histogenetics, Ossining, USA
DQB1*05:75HG00009229KM198161Histogenetics, Ossining, USA
DQB1*06:02:20HG00009239KM248732Histogenetics, Ossining, USA
DQB1*06:22:03HG00009238KM248739Histogenetics, Ossining, USA
DQB1*06:125HG00009237KM198150Histogenetics, Ossining, USA
DQB1*06:126HG00009240KM198163Histogenetics, Ossining, USA
DQB1*06:153HG00009216KM198164Histogenetics, Ossining, USA
DQB1*06:155HG00009220,
HG00009221
KM454995,
KM198231
Histogenetics, Ossining, USA
DPB1*04:01:14HG00009256,
HG00009257
KM198191,
KM198182
Histogenetics, Ossining, USA
DPB1*11:01:03HG00009259KM365122Histogenetics, Ossining, USA
DPB1*177:01HG00009247KM216213Histogenetics, Ossining, USA
DPB1*182:01HG00009249KM198192Histogenetics, Ossining, USA
DPB1*184:01HG00009251,
HG00009252
KM198186,
KM198244
Histogenetics, Ossining, USA
DPB1*210:01HG00009243KM198178Histogenetics, Ossining, USA
DPB1*218:01NHG00009255KM198170Histogenetics, Ossining, USA
DPB1*301:01HG00009244KM198184Histogenetics, Ossining, USA
DPB1*309:01HG00009253KM198174Histogenetics, Ossining, USA
DPB1*329:01HG00009260KM365124Histogenetics, Ossining, USA
DPB1*357:01NHG00009248KM248742Histogenetics, Ossining, USA
DPB1*365:01HG00009250KM198243Histogenetics, Ossining, USA
DPB1*369:01HG00009258KJ956777Histogenetics, Ossining, USA
DPB1*382:01NHG00009254KM198168Histogenetics, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
A*02:05:01(4)
A*02:06:01(4)
A*11:101(5)
A*11:188(6)
A*11:192(7)
B*08:132(8)
B*15:325(9)
B*37:06:02(10)
B*55:50(11)
DRB1*15:02:11(12)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010; 75:291-455.
  2. Hernandez-Frederick CJ, Cereb N, Giani AS, et al. Three hundred and seventy-two novel HLA class II alleles identified in potential hematopoietic stem cell donors from Germany, the United States, and Poland. Tissue Antigens. 2014; 84:497-502.
  3. Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic Acids Res. 2013; 41:D1222-7.
  4. Zhang H, Xu YP. Genomic full-length sequence of two HLA-A alleles, A*02:05:01 and A*02:06:01 identified by cloning and sequencing. Tissue Antigens. 2014; 84:505-7.
  5. Zhang X, Li XF, Lin FQ, Zhang KL, Li JP. Identification of a novel HLA allele, HLA-A*11:101, in a platelet donor from China. Tissue Antigens. 2014; 84:508-9.
  6. Li Z, Lu L, Nie D, et al. HLA-A*11:188: a new allele identified by sequence-based typing in a Chinese blood donor. Tissue Antigens. 2014; 84:512-3.
  7. Todorova K, Zuber K, Neuwirt P, Arnold R, Schonemann C, Schulze H. Identification of the novel HLA-A*11:192 allele by HLA typing of a Caucasian individual. Tissue Antigens. 2014; 84:509-10.
  8. Papazoglou A, Gasiewski A, Huynh A, et al. Identification and characterization of a novel HLA-B hybrid allele, B*08:132 with Next Generation Sequencing. Tissue Antigens. 2014; 84:513-4.
  9. Ou G, Wang J, Wang C, Ji X, Chen Q. A novel HLA-B allele, HLA-B*15:325, is identified by sequence-based typing in a HIV infected individual. Tissue Antigens. 2014; 84:514-5.
  10. Li X, Zou H, Gu B, Zhu Y, Chen Q. A novel HLA allele, HLA-B*37:06:02, identified in a Chinese family. Tissue Antigens. 2014; 84:516-7.
  11. Zhang KL, Li XF, Zhang X, Lin FQ, Li JP. A novel HLA allele, HLA-B*55:50, was identified by sequence-based typing. Tissue Antigens. 2014; 84:517-8.
  12. Yang KL, Lee SK, Hung JH, Lin PY. HLA-DRB1*15:02:11, a variant of HLA-DRB1*15:02:01, revealed in a Taiwanese patient awaiting hematopoietic stem cell transplantation. Tissue Antigens. 2014; 84:519-20.