Nomenclature for Factors of the HLA System

August 2013

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the July 2013 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:13963700HG004399Jane Rowlands, Pontyclun, United Kingdom
A*01:140BY01122KF482390Carolyn K Hurley, Washington DC, USA
A*01:141D11037624KF418558Jinghui Qu, Shenzhen, China
A*01:142D11022135KF418559Jinghui Qu, Shenzhen, China
A*02:01:97D11048675KF418564Jinghui Qu, Shenzhen, China
A*02:03:05D11043271KF418566Jinghui Qu, Shenzhen, China
A*02:03:06D11023212KF418568Jinghui Qu, Shenzhen, China
A*02:439NBY01093KF318741Carolyn K Hurley, Washington DC, USA
A*02:440QBY01097KF318737Carolyn K Hurley, Washington DC, USA
A*02:441271111662KF501489Wangxia Li, Wuhan, China
A*02:442D11022869KF418560Jinghui Qu, Shenzhen, China
A*02:443D11013527KF418561Jinghui Qu, Shenzhen, China
A*02:444D11049071KF418562Jinghui Qu, Shenzhen, China
A*02:445D11016259KF418563Jinghui Qu, Shenzhen, China
A*02:446D11019201KF418565Jinghui Qu, Shenzhen, China
A*02:447D11006287KF418567Jinghui Qu, Shenzhen, China
A*11:01:51BY01094KF318740Carolyn K Hurley, Washington DC, USA
A*11:15190172837KC577585Daniel Fuerst, Ulm, Germany
A*11:1520271211454AKF515273Wen Qiang, Wuhan, China
A*31:78BY01123KF482388Carolyn K Hurley, Washington DC, USA
A*31:79BY01119KF482387Carolyn K Hurley, Washington DC, USA
A*32:59BY01124KF482389Carolyn K Hurley, Washington DC, USA
A*33:73NMDA0000156, MDA0000157KF442969,
KF442970
Kai Cao, Houston, USA
A*33:74N101961KF515524Chun-Ying Lin, Taipei, Taiwan
A*68:105PI12-3632KF460577Michele Curcio, Pisa, Italy
A*68:106BY01120KF482392Carolyn K Hurley, Washington DC, USA
A*74:18BY01096KF318738Carolyn K Hurley, Washington DC, USA
A*74:19BY01116KF482384Carolyn K Hurley, Washington DC, USA
B*07:200HG00006018KC875893Histogenetics, Ossining, USA
B*07:201NHG00006019KC959260Histogenetics, Ossining, USA
B*07:202HG00006022KC991060Histogenetics, Ossining, USA
B*07:203HG00006023KF015529Histogenetics, Ossining, USA
B*07:204BY01113KF482402Carolyn K Hurley, Washington DC, USA
B*08:113ERL_20095HG421893Juergen Zingsem, Erlangen, Germany
B*14:01:04HG00006017KC959274Histogenetics, Ossining, USA
B*15:2844521100952KC701036Xin Li, Harbin, China
B*15:285HG00006001KC904412Histogenetics, Ossining, USA
B*15:286HG00006003KC875905Histogenetics, Ossining, USA
B*15:287HG00006004KC904400Histogenetics, Ossining, USA
B*15:288HG00006005KC632165Histogenetics, Ossining, USA
B*15:289HG00006006KC959287Histogenetics, Ossining, USA
B*15:290HG00006012KF015528Histogenetics, Ossining, USA
B*15:291HG00006026KF015530Histogenetics, Ossining, USA
B*27:107BY01125KF498960Carolyn K Hurley, Washington DC, USA
B*37:42NBY01104KF482393Carolyn K Hurley, Washington DC, USA
B*38:44HG00006024KC875894Histogenetics, Ossining, USA
B*38:45HG00006025KC904402Histogenetics, Ossining, USA
B*40:249Xi`an 57428KF437296XiaoFang Wang, Xian, China
B*44:182BY01112KF482401Carolyn K Hurley, Washington DC, USA
B*44:183BY01106KF482395Carolyn K Hurley, Washington DC, USA
B*44:84:02BY01109KF482397Carolyn K Hurley, Washington DC, USA
B*46:43HG00006002KC875899Histogenetics, Ossining, USA
B*51:01:43JMDP36K0203AB836681Kenji Tadokoro, Tokyo, Japan
B*51:24:05HG00006014KC904404Histogenetics, Ossining, USA
B*52:01:19HG00006000KC959272Histogenetics, Ossining, USA
B*52:10:03HG00006016KC904420Histogenetics, Ossining, USA
B*55:60HG00006011KC959286Histogenetics, Ossining, USA
B*57:01:16HG00006008KC748293Histogenetics, Ossining, USA
B*57:67HG00006007KC875915Histogenetics, Ossining, USA
B*57:68HG00006009KC991061Histogenetics, Ossining, USA
B*58:48BY01110KF482399Carolyn K Hurley, Washington DC, USA
C*03:02:11HG00006086KC503875Histogenetics, Ossining, USA
C*03:04:42HG00006076KC875935Histogenetics, Ossining, USA
C*03:214HG00006083KF015538Histogenetics, Ossining, USA
C*03:215HG00006084KC959295Histogenetics, Ossining, USA
C*03:216HG00006087KC904431Histogenetics, Ossining, USA
C*03:217HG00006089KC991068Histogenetics, Ossining, USA
C*03:218MDA0000158KF498958Kai Cao, Houston, USA
C*04:155HG00006092KC904442Histogenetics, Ossining, USA
C*04:156HG00006093KC904443Histogenetics, Ossining, USA
C*04:157HG00006094KC875928Histogenetics, Ossining, USA
C*04:158142149KF500544Elaine Hodges, Durham, USA
C*05:97HG00006057KC875929Histogenetics, Ossining, USA
C*06:02:01:032454JX512226Zahra Mehdizadeh Kashi, Beaverton, USA
C*06:02:31HG00006031KC875918Histogenetics, Ossining, USA
C*06:02:32HG00006033,
HG00006034
KC904421,
KF015542
Histogenetics, Ossining, USA
C*06:02:33HG00006037KF015532Histogenetics, Ossining, USA
C*06:02:34HG00006051,
HG00006052,
HG00006053,
HG00006054
KC875924,
KC875925,
KC875926,
KC875927
Histogenetics, Ossining, USA
C*06:112HG00006035KF015546Histogenetics, Ossining, USA
C*06:113HG00006036KC904433Histogenetics, Ossining, USA
C*06:114HG00006038KF015543Histogenetics, Ossining, USA
C*06:115HG00006050KC875916Histogenetics, Ossining, USA
C*07:01:35HG00006040KC875939Histogenetics, Ossining, USA
C*07:01:36HG00006041KC904430Histogenetics, Ossining, USA
C*07:01:37HG00006044KC904422Histogenetics, Ossining, USA
C*07:325HG00006027KC904438Histogenetics, Ossining, USA
C*07:326HG00006028KC875923Histogenetics, Ossining, USA
C*07:327HG00006029KC875937Histogenetics, Ossining, USA
C*07:328HG00006032KC959296Histogenetics, Ossining, USA
C*07:329NHG00006039KC959292Histogenetics, Ossining, USA
C*07:330HG00006042KC904432Histogenetics, Ossining, USA
C*07:331HG00006043KC959299Histogenetics, Ossining, USA
C*07:332HG00006045KF015537Histogenetics, Ossining, USA
C*07:333HG00006046KC904428Histogenetics, Ossining, USA
C*07:334HG00006047KC875919Histogenetics, Ossining, USA
C*07:335HG00006048KC959293Histogenetics, Ossining, USA
C*07:336HG00006049KC959303Histogenetics, Ossining, USA
C*07:337D10111441KF175453Jinghui Qu, Shenzhen, China
C*08:90HG00006055KC959307Histogenetics, Ossining, USA
C*08:91HG00006056KC959304Histogenetics, Ossining, USA
C*08:92HG00006058KC904434Histogenetics, Ossining, USA
C*08:93HG00006059KC959309Histogenetics, Ossining, USA
C*12:02:10D10057658KF175486Jinghui Qu, Shenzhen, China
C*12:03:26HG00006060KF015539Histogenetics, Ossining, USA
C*12:03:27HG00006067KC904425Histogenetics, Ossining, USA
C*12:03:28D10065867KF175489Jinghui Qu, Shenzhen, China
C*12:100HG00006068KF015534Histogenetics, Ossining, USA
C*12:101HG00006069,
HG00006070
KC904440,
KC959324
Histogenetics, Ossining, USA
C*12:102HG00006071,
HG00006072
KC959315,
KC959313
Histogenetics, Ossining, USA
C*12:103HG00006073KC959300Histogenetics, Ossining, USA
C*12:104ND10093103KF175483Jinghui Qu, Shenzhen, China
C*12:105ND10092617KF175484Jinghui Qu, Shenzhen, China
C*12:106D10097830KF175485Jinghui Qu, Shenzhen, China
C*12:107D10068520KF175487Jinghui Qu, Shenzhen, China
C*12:108D10106688KF175488Jinghui Qu, Shenzhen, China
C*12:109D10025823KF175490Jinghui Qu, Shenzhen, China
C*12:110D10128214KF175491Jinghui Qu, Shenzhen, China
C*12:111D10103042KF175492Jinghui Qu, Shenzhen, China
C*14:02:13HG00006090KC959318Histogenetics, Ossining, USA
C*14:02:14D10115904KF175494Jinghui Qu, Shenzhen, China
C*14:02:15D10111022KF175496Jinghui Qu, Shenzhen, China
C*14:55HG00006091KC904423Histogenetics, Ossining, USA
C*14:56D10088662KF175493Jinghui Qu, Shenzhen, China
C*14:57D10097204KF175495Jinghui Qu, Shenzhen, China
C*14:58D10081884KF175497Jinghui Qu, Shenzhen, China
C*15:02:17D10077717KF175498Jinghui Qu, Shenzhen, China
C*15:02:18D10110834KF175500Jinghui Qu, Shenzhen, China
C*15:02:19D10064532KF175504Jinghui Qu, Shenzhen, China
C*15:10:03HG00006088KF015545Histogenetics, Ossining, USA
C*15:72HG00006077KC959320Histogenetics, Ossining, USA
C*15:73HG00006078KC959316Histogenetics, Ossining, USA
C*15:74HG00006079KC959319Histogenetics, Ossining, USA
C*15:75HG00006080KC959308Histogenetics, Ossining, USA
C*15:76HG00006081KC875932Histogenetics, Ossining, USA
C*15:77HG00006082KF015544Histogenetics, Ossining, USA
C*15:78D10093291KF175499Jinghui Qu, Shenzhen, China
C*15:79D10124011KF175501Jinghui Qu, Shenzhen, China
C*15:80D10122209KF175502Jinghui Qu, Shenzhen, China
C*15:81D10029837KF175503Jinghui Qu, Shenzhen, China
C*15:82D10105562KF175505Jinghui Qu, Shenzhen, China
C*16:01:14HG00006064KC592339Histogenetics, Ossining, USA
C*16:01:15HG00006065KC904429Histogenetics, Ossining, USA
C*16:02:10HG00006062KC904426Histogenetics, Ossining, USA
C*16:02:11HG00006063KC875930Histogenetics, Ossining, USA
C*16:60HG00006061KC904439Histogenetics, Ossining, USA
C*17:01:01:032454JX512225Zahra Mehdizadeh Kashi, Beaverton, USA
C*17:20HG00006030KC959323Histogenetics, Ossining, USA
C*17:21HG00006074KC959314Histogenetics, Ossining, USA
DRB1*01:60BY01098KF482403Carolyn K Hurley, Washington DC, USA
DRB1*04:95:02BY01103KF482408Carolyn K Hurley, Washington DC, USA
DRB1*07:27D11024371KF270566Jinghui Qu, Shenzhen, China
DRB1*07:28D11032796KF270567Jinghui Qu, Shenzhen, China
DRB1*09:01:10D11026285KF270569Jinghui Qu, Shenzhen, China
DRB1*09:22D11017395KF270570Jinghui Qu, Shenzhen, China
DRB1*12:16:03D11048765KF270576Jinghui Qu, Shenzhen, China
DRB1*12:41D11026433KF270572Jinghui Qu, Shenzhen, China
DRB1*12:42D11010719KF270573Jinghui Qu, Shenzhen, China
DRB1*12:43D11014850KF270575Jinghui Qu, Shenzhen, China
DRB1*14:14313061928KF413408Mingrui Huo, Beijing, China
DRB1*14:144D11035687KF270577Jinghui Qu, Shenzhen, China
DRB1*15:100BY01099KF482404Carolyn K Hurley, Washington DC, USA
DRB1*15:99BY01100KF482405Carolyn K Hurley, Washington DC, USA
DQB1*03:02:1013202937KC788284Daniel Fuerst, Ulm, Germany
DQB1*05:44D10075685HE804226Jinghui Qu, Shenzhen, China
DQB1*06:110BBMR donorKF280209Zareen Goburdhun, London, United Kingdom
DQB1*06:111101888KF515523Chun-Ying Lin, Taipei, Taiwan
DPB1*166:01T1D9JX524133Yann-Jinn Lee, Taipei County, Taiwan

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:377BY01095KF318739Carolyn K Hurley, Washington DC, USA
A*02:419D11021516KF418569Jinghui Qu, Shenzhen, China
A*02:437Xi`an 57500KF413873Tianju Wang, Xi`an, China
A*03:162N64362HG417079Jane Rowlands, Pontyclun, United Kingdom
A*24:46BY01121KF482391Carolyn K Hurley, Washington DC, USA
A*30:02:06BY01117KF482385Carolyn K Hurley, Washington DC, USA
A*68:86BY01118KF482386Carolyn K Hurley, Washington DC, USA
B*15:03:04HG00006013KC959268Histogenetics, Ossining, USA
B*15:141JMDP01K0166AB836683Kenji Tadokoro, Tokyo, Japan
B*38:01:06BY01105KF482394Carolyn K Hurley, Washington DC, USA
B*40:81102073KF515525Chun-Ying Lin, Taipei, Taiwan
B*46:40271211808KF515274Yuanyan Zhu, Wuhan, China
B*50:17BY01111KF482400Carolyn K Hurley, Washington DC, USA
B*51:126BY01108KF482398Carolyn K Hurley, Washington DC, USA
B*57:61HG00006010KC875897Histogenetics, Ossining, USA
C*02:02:13HG00006827JQ824461Histogenetics, Ossining, USA
C*02:49HG00006826KC748285Histogenetics, Ossining, USA
C*03:139HG00006085KC875936Histogenetics, Ossining, USA
C*07:314HG00006075KC904435Histogenetics, Ossining, USA
C*12:41BY01092KF318743Carolyn K Hurley, Washington DC, USA
C*12:60HG00006066KF015540Histogenetics, Ossining, USA
C*16:45BY01091KF318742Carolyn K Hurley, Washington DC, USA
DRB1*03:88BY01102KF482407Carolyn K Hurley, Washington DC, USA
DRB1*08:30:03BY01101KF482406Carolyn K Hurley, Washington DC, USA
DRB1*11:23:02Xi`an 57977KF412898Mengli Liu, Xi’an, China
DRB1*14:13613-77KF432139,
KF432140
A-Hyun Lim, Seoul, South Korea
DQB1*02:01:08D11013102KF270524Jinghui Qu, Shenzhen, China
DQB1*02:12D11045606KF270525Jinghui Qu, Shenzhen, China

Table 3: Recently Published Sequences


Sequence References
A*02:393 (3)
B*13:68 (4)
B*39:01:16 (5)
B*40:211 (6)
B*40:227 (7)
B*48:19 (8)
E*01:06 (9)
DRB1*13:154 (10)
DRB1*14:05:04 (11)
DRB1*14:130 (11)
DRB1*14:131 (11)
DRB1*14:137N (11)
DRB1*15:01:21 (11)
DRB1*15:37:02 (11)
DRB1*15:81 (11)
DRB1*15:87 (11)
DRB1*15:88(11)
DRB1*16:20(11)
DQB1*02:01:07(11)
DQB1*02:01:08(11)
DQB1*02:02:02(11)
DQB1*02:08(11)
DQB1*02:09(11)
DQB1*02:11(11)
DQB1*02:12(11)
DQB1*03:01:07(11)
DQB1*03:01:08(11)
DQB1*03:01:09(11)
DQB1*03:01:10(11)
DQB1*03:01:11(11)
DQB1*03:39(12
DQB1*03:46(11)
DQB1*03:47(11)
DQB1*03:49(11)
DQB1*03:50(11)
DQB1*03:51(11)
DQB1*04:09 (13)
DPB1*142:01 (14)
MICA*008:05 (15)

References:

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  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55:280-7.
  3. Longa LA, Perotti L, Piovano F, Prucca M, Menardi G, Peano G. A novel HLA allele, HLA-A*02:393, identified in a two generation Italian family. Tissue Antigens. 2013: 82: 203-4.
  4. Chi XY, Feng ZH, Hu B, Zhao L, Jiao SX. A novel HLA-B*13 allele, B*13:68, was identified by sequencing-based typing. Tissue Antigens. 2013: 82: 204-5.
  5. Miyazono T, Shiina T, Michino J, Yasumura S, Sugiyama T. A novel HLA-B allele, HLA-B*39:01:16, identified by super high-resolution single-molecule sequence-based typing in a Japanese individual. Tissue Antigens. 2013: 82: 205-6.
  6. Sun Y, Xie JH, Yang JH, et al. Identification of a novel HLA-B*40 allele, HLA-B*40:211, in a Chinese individual. Tissue Antigens. 2013: 82: 207.
  7. Wang W, He J, Zhang W, Zhu FM, Lv HJ. A novel HLA allele, HLA-B*40:227, was identified by polymerase chain reaction sequence-based typing in a Chinese individual. Tissue Antigens. 2013: 82: 208-9.
  8. Zhang WD, Li W, Zhang KY, Shan XY, Jia YJ. The novel HLA-B*48:19 allele, identified by sequence-based typing in a Chinese individual. Tissue Antigens. 2013: 82: 209-10.
  9. Veiga-Castelli LC, Felicio LP, Georg RC, Castelli EC, Donadi EA. A nonsynonymous mutation at HLA-E defines the new E*01:06 allele in Brazilian individuals. Tissue Antigens. 2013: 82: 216-7.
  10. Barbuti S, Putignano AL, Rombola G, Marchetti L, Curcio M, Scatena F. Identification of a novel HLA-DRB1*13 variant allele: DRB1*13:154. Tissue Antigens. 2013: 82: 210-1.
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  12. Jin SZ, Zou HY. Identification of a new HLA-DQB1*03 variant, DQB1*03:39, by sequence-based typing in a Chinese Han individual. Tissue Antigens. 2013: 82: 213-4.
  13. Testi M, Troiano M, Guagnano A, Testa G, Andreani M. A new allele, HLA-DQB1*04:09. Tissue Antigens. 2013: 82: 215-6.
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  15. Du ZH, Jiao SX, Du B, Liu XH, Wu ZJ. Identification of a novel allele MICA*008:05 by sequence-based typing. Tissue Antigens. 2013: 82: 217-8.