Nomenclature for Factors of the HLA System
June 2013
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2013 82:229-33
- Human Immunology. 2013 74:1417-20
- International Journal of Immunogenetics. 2013 40:434-7
The following sequences have been submitted to the Nomenclature Committee since the May 2013 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. Following information made available on the cell surface expression of a number of alleles, the Q suffix has now been removed from the B*44:142Q allele, and it will now be listed as B*44:142. In addition the Q suffix has been added to the following alleles B*44:160Q, C*02:67Q, C*03:169Q, C*06:74Q, C*07:235Q and C*08:70Q.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:134 | HG00005951 | KC875881 | Histogenetics, Ossining, USA |
| A*01:135 | HG00005952 | KC904389 | Histogenetics, Ossining, USA |
| A*01:136 | HG00005953 | KC904384 | Histogenetics, Ossining, USA |
| A*01:137 | HG00005954, HG00005955 | KF015519, KC632156 | Histogenetics, Ossining, USA |
| A*01:138 | HG00005956 | KC904394 | Histogenetics, Ossining, USA |
| A*02:01:90 | HG00005965 | KC904385 | Histogenetics, Ossining, USA |
| A*02:01:91 | HG00005966 | KC959247 | Histogenetics, Ossining, USA |
| A*02:01:92 | HG00005968 | KC875884 | Histogenetics, Ossining, USA |
| A*02:01:93 | HG00005969 | KC991052 | Histogenetics, Ossining, USA |
| A*02:01:94 | HG00005971 | KC875879 | Histogenetics, Ossining, USA |
| A*02:01:95 | HG00005972 | KC875888 | Histogenetics, Ossining, USA |
| A*02:433 | HG00005963 | KC959250 | Histogenetics, Ossining, USA |
| A*02:434 | HG00005964 | KC959251 | Histogenetics, Ossining, USA |
| A*02:435 | HG00005967 | KC537763 | Histogenetics, Ossining, USA |
| A*02:436 | HG00005970 | KC904388 | Histogenetics, Ossining, USA |
| A*02:437 | F03899 | KF113857 | Keming Du, Shanghai, China |
| A*02:438 | JMDP01K0143 | AB771579 | Kenji Tadokoro, Tokyo, Japan |
| A*03:172 | HG00005957 | KF015524 | Histogenetics, Ossining, USA |
| A*03:173 | HG00005958 | KC875890 | Histogenetics, Ossining, USA |
| A*03:174 | HG00005960 | KC959237 | Histogenetics, Ossining, USA |
| A*11:01:50 | HG00005924 | KC959259 | Histogenetics, Ossining, USA |
| A*11:147 | HG00005931 | KC875878 | Histogenetics, Ossining, USA |
| A*11:148 | HG00005932 | KC959244 | Histogenetics, Ossining, USA |
| A*11:149 | HG00005933 | KC959234 | Histogenetics, Ossining, USA |
| A*11:150 | HG00005939 | KC875875 | Histogenetics, Ossining, USA |
| A*23:60 | HG00005946 | KC904381 | Histogenetics, Ossining, USA |
| A*24:02:66 | HG00005947 | KC959246 | Histogenetics, Ossining, USA |
| A*24:02:67 | HG00005948 | KC959232 | Histogenetics, Ossining, USA |
| A*24:02:68 | HG00005950 | KC904383 | Histogenetics, Ossining, USA |
| A*24:02:69 | SZGSQ-20 | KF134169 | Su-Qing Gao, Shenzhen, China |
| A*24:02:70 | JMDP01K0144 | AB826449 | Kenji Tadokoro, Tokyo, Japan |
| A*24:242 | HG00005942 | KC959245 | Histogenetics, Ossining, USA |
| A*24:243 | HG00005943 | KC875877 | Histogenetics, Ossining, USA |
| A*24:244 | HG00005944 | KC904393 | Histogenetics, Ossining, USA |
| A*24:245 | HG00005945 | KC875874 | Histogenetics, Ossining, USA |
| A*24:246 | HG00005949 | KC959230 | Histogenetics, Ossining, USA |
| A*25:23 | HG00005934 | KC904391 | Histogenetics, Ossining, USA |
| A*26:93 | HG00005935 | KC959257 | Histogenetics, Ossining, USA |
| A*26:94 | HG00005961 | KC991050 | Histogenetics, Ossining, USA |
| A*29:55 | 13210187 | KF152915 | Daniel Fuerst, Ulm, Germany |
| A*31:75 | HG00005926 | KC875883 | Histogenetics, Ossining, USA |
| A*31:76 | HG00005927 | KF015522 | Histogenetics, Ossining, USA |
| A*31:77 | HG00005928 | KC904386 | Histogenetics, Ossining, USA |
| A*33:03:15 | HG00005929 | KC959229 | Histogenetics, Ossining, USA |
| A*33:71 | HG00005925 | KC904387 | Histogenetics, Ossining, USA |
| A*68:27:02 | HG00005937 | KC959258 | Histogenetics, Ossining, USA |
| A*68:75:02 | HG00005938 | KC904395 | Histogenetics, Ossining, USA |
| A*68:102 | HG00005940 | KC875885 | Histogenetics, Ossining, USA |
| A*69:02 | HG00005936 | KC875887 | Histogenetics, Ossining, USA |
| B*07:02:39 | HG00005807 | KC748247 | Histogenetics, Ossining, USA |
| B*08:111 | ID 20289 | KF229774 | Alessandra Moscetti, Rome, Italy |
| B*46:42 | 5761200253 | KF142386 | Faming Zhu, Hangzhou, China |
| B*50:33 | HG00005975 | KF015526 | Histogenetics, Ossining, USA |
| B*54:30 | JMDP01K0156 | AB826451 | Kenji Tadokoro, Tokyo, Japan |
| B*56:01:06 | HG00005795 | KC592313 | Histogenetics, Ossining, USA |
| B*57:01:15 | HG00005801 | KC592316 | Histogenetics, Ossining, USA |
| C*01:79 | P11892 | KC970438 | Keming Du, Shanghai, China |
| C*03:03:21 | HG00005835 | KC592326 | Histogenetics, Ossining, USA |
| C*04:152 | HG00005852 | KC603579 | Histogenetics, Ossining, USA |
| C*06:02:27 | HG00005819 | KC473876 | Histogenetics, Ossining, USA |
| C*07:315 | UEN9477 | HG000018 | Katja Goldmann, Erlangen, Germany |
| C*08:01:10 | P07172 | KF160920 | Faming Zhu, Hangzhou, China |
| C*14:02:12 | HG00005850 | KC424460 | Histogenetics, Ossining, USA |
| C*14:52 | H130190 | KF142385 | Faming Zhu, Hangzhou, China |
| C*16:39:02 | 140182 | KF114897 | Elaine Hodges, Durham, USA |
| DRB1*01:59 | HG00005918 | KC859256 | Histogenetics, Ossining, USA |
| DRB1*03:92 | HG00005905 | KC748264 | Histogenetics, Ossining, USA |
| DRB1*03:93 | HG00005910, HG00005911, HG00005912 | KC748268, KC859259, KC859260 | Histogenetics, Ossining, USA |
| DRB1*04:01:13 | HG00005903 | KC537774 | Histogenetics, Ossining, USA |
| DRB1*04:161 | HG00005901 | KC473889 | Histogenetics, Ossining, USA |
| DRB1*04:162 | HG00005902 | KC748279 | Histogenetics, Ossining, USA |
| DRB1*04:163 | HG00005904 | KC441512 | Histogenetics, Ossining, USA |
| DRB1*11:01:19 | HG00005915 | KC592359 | Histogenetics, Ossining, USA |
| DRB1*11:01:20 | E09496 | KC970427 | Keming Du, Shanghai, China |
| DRB1*11:29 | MDA0000155 | KF055223 | Kai Cao, Houston, USA |
| DRB1*11:84:03 | HG00005914 | KC503881 | Histogenetics, Ossining, USA |
| DRB1*11:146 | HG00005909 | KC441510 | Histogenetics, Ossining, USA |
| DRB1*11:147 | HG00005916 | KC592360 | Histogenetics, Ossining, USA |
| DRB1*12:40 | 13210010 | KF152914 | Daniel Fuerst, Ulm, Germany |
| DRB1*14:141 | 54005 | JF827308 | Jianping Li, Shenyang, Liaoning, China |
| DRB1*14:141 | HN04 | HE820983 | Wei Jin Huang, Beijing, China |
| DRB1*14:142 | HG00005913 | KC592358 | Histogenetics, Ossining, USA |
| DRB1*15:97 | HG00005899 | KC473891 | Histogenetics, Ossining, USA |
| DRB1*15:98 | HG00005900 | KC592357 | Histogenetics, Ossining, USA |
| DQA1*01:12 | R44096 | HG315526 | Hien Tran, Heidelberg, Germany |
| DQB1*02:01:12 | HG00005869 | KC473882 | Histogenetics, Ossining, USA |
| DQB1*02:01:13 | HG00005871 | KC537779 | Histogenetics, Ossining, USA |
| DQB1*02:32 | HG00005870 | KC424474 | Histogenetics, Ossining, USA |
| DQB1*02:33 | HG00005884, HG00005885 | KC592345, KC441502 | Histogenetics, Ossining, USA |
| DQB1*03:01:19 | 13207892 | KC992725 | Daniel Fuerst, Ulm, Germany |
| DQB1*03:01:20 | D10055733 | HE804201 | Jinghui Qu, Shenzhen, China |
| DQB1*03:02:08 | HG00005883 | KC537775 | Histogenetics, Ossining, USA |
| DQB1*03:02:09 | D10110606 | HE804207 | Jinghui Qu, Shenzhen, China |
| DQB1*03:81 | HG00005872 | KC603585 | Histogenetics, Ossining, USA |
| DQB1*03:82 | 6591 | HF937259 | Aida Turganbekova, Astana, Kazakhstan |
| DQB1*03:83 | D10054279 | HE804197 | Jinghui Qu, Shenzhen, China |
| DQB1*03:84N | D10108912 | JX402004 | Jinghui Qu, Shenzhen, China |
| DQB1*03:85 | D10066278 | JX402005 | Jinghui Qu, Shenzhen, China |
| DQB1*03:86 | D10050752 | HE804209 | Jinghui Qu, Shenzhen, China |
| DQB1*03:87 | D10117496 | HE804210 | Jinghui Qu, Shenzhen, China |
| DQB1*03:88 | D10053275 | HE804211 | Jinghui Qu, Shenzhen, China |
| DQB1*03:89 | D10029625 | HE804212 | Jinghui Qu, Shenzhen, China |
| DQB1*04:01:03 | D10059008 | HE804215 | Jinghui Qu, Shenzhen, China |
| DQB1*04:01:04 | D10099711 | HE804220 | Jinghui Qu, Shenzhen, China |
| DQB1*04:02:04 | HG00005888 | KC859263 | Histogenetics, Ossining, USA |
| DQB1*04:14 | D10090062 | HE804216 | Jinghui Qu, Shenzhen, China |
| DQB1*04:15 | D10109375 | HE804217 | Jinghui Qu, Shenzhen, China |
| DQB1*04:16 | D10017857 | HE804218 | Jinghui Qu, Shenzhen, China |
| DQB1*04:17 | D10065768 | HE804219 | Jinghui Qu, Shenzhen, China |
| DQB1*05:01:09 | D10102511 | HE804224 | Jinghui Qu, Shenzhen, China |
| DQB1*05:02:05 | D10100521 | HE804230 | Jinghui Qu, Shenzhen, China |
| DQB1*05:02:06 | D10047357 | HE804231 | Jinghui Qu, Shenzhen, China |
| DQB1*05:02:07 | D10088072 | HE804238 | Jinghui Qu, Shenzhen, China |
| DQB1*05:03:08 | HG00005887 | KC859264 | Histogenetics, Ossining, USA |
| DQB1*05:03:09 | 1017 | HG008038 | Xingjie Li, Chengdu, China |
| DQB1*05:03:10 | D10016417 | HE804242 | Jinghui Qu, Shenzhen, China |
| DQB1*05:05:02 | D10055861 | HE804244 | Jinghui Qu, Shenzhen, China |
| DQB1*05:28 | HG00005886 | KC632191 | Histogenetics, Ossining, USA |
| DQB1*05:29 | D10053058 | HE804223 | Jinghui Qu, Shenzhen, China |
| DQB1*05:30 | D10095218 | HE804222 | Jinghui Qu, Shenzhen, China |
| DQB1*05:31 | D10096119 | HE804227 | Jinghui Qu, Shenzhen, China |
| DQB1*05:32 | D10121515 | HE804228 | Jinghui Qu, Shenzhen, China |
| DQB1*05:33 | D10054129 | HE804233 | Jinghui Qu, Shenzhen, China |
| DQB1*05:34 | D10112545 | HE804234 | Jinghui Qu, Shenzhen, China |
| DQB1*05:35 | D10052296 | HE804235 | Jinghui Qu, Shenzhen, China |
| DQB1*05:36 | D10086208 | HE804236 | Jinghui Qu, Shenzhen, China |
| DQB1*05:37 | D10124774 | HE804237 | Jinghui Qu, Shenzhen, China |
| DQB1*05:38 | D10108025 | HE804239 | Jinghui Qu, Shenzhen, China |
| DQB1*05:39 | D10107984 | HE804240 | Jinghui Qu, Shenzhen, China |
| DQB1*05:40 | D10087597 | HE804241 | Jinghui Qu, Shenzhen, China |
| DQB1*05:41N | D10020378 | JX402008 | Jinghui Qu, Shenzhen, China |
| DQB1*05:42 | D10054690 | HE804243 | Jinghui Qu, Shenzhen, China |
| DQB1*05:43 | D10107493 | HE804232 | Jinghui Qu, Shenzhen, China |
| DQB1*06:01:09 | D10025539 | HE804249 | Jinghui Qu, Shenzhen, China |
| DQB1*06:01:10 | D10026100 | HE804251 | Jinghui Qu, Shenzhen, China |
| DQB1*06:02:07 | HG00005889 | KC748262 | Histogenetics, Ossining, USA |
| DQB1*06:02:08 | HG00005892 | KC632184 | Histogenetics, Ossining, USA |
| DQB1*06:02:09 | HG00005893 | KC592346 | Histogenetics, Ossining, USA |
| DQB1*06:02:10 | HG00005897 | KC748259 | Histogenetics, Ossining, USA |
| DQB1*06:03:08 | HG00005878 | KC592350 | Histogenetics, Ossining, USA |
| DQB1*06:03:09 | HG00005880 | KC537778 | Histogenetics, Ossining, USA |
| DQB1*06:04:07 | HG00005881 | KC441505 | Histogenetics, Ossining, USA |
| DQB1*06:90 | HG00005873, HG00005874, HG00005875 | KC859261, KC592353, KC632183 | Histogenetics, Ossining, USA |
| DQB1*06:91 | HG00005876 | KC632180 | Histogenetics, Ossining, USA |
| DQB1*06:92 | HG00005877 | KC632186 | Histogenetics, Ossining, USA |
| DQB1*06:93 | HG00005879 | KC592347 | Histogenetics, Ossining, USA |
| DQB1*06:94 | HG00005882 | KC603587 | Histogenetics, Ossining, USA |
| DQB1*06:95 | HG00005890 | KC748260 | Histogenetics, Ossining, USA |
| DQB1*06:96 | HG00005891 | KC424475 | Histogenetics, Ossining, USA |
| DQB1*06:97 | HG00005896 | KC592343 | Histogenetics, Ossining, USA |
| DQB1*06:98 | D10060739 | HE804245 | Jinghui Qu, Shenzhen, China |
| DQB1*06:99 | D10110477 | HE804246 | Jinghui Qu, Shenzhen, China |
| DQB1*06:100 | D10016352 | HE804247 | Jinghui Qu, Shenzhen, China |
| DQB1*06:101 | D10060083 | HE804248 | Jinghui Qu, Shenzhen, China |
| DQB1*06:102N | D10046766 | JX402009 | Jinghui Qu, Shenzhen, China |
| DQB1*06:103 | D10030032 | HE804250 | Jinghui Qu, Shenzhen, China |
| DQB1*06:104 | D10103528 | HE804252 | Jinghui Qu, Shenzhen, China |
| DQB1*06:105 | D10050078 | HE804253 | Jinghui Qu, Shenzhen, China |
| DPB1*13:01:02 | HG00005652 | JX842728 | Histogenetics, Ossining, USA |
| DPB1*163:01 | HG00005921 | KC859266 | Histogenetics, Ossining, USA |
| DPB1*164:01 | HG00005922 | KC592363 | Histogenetics, Ossining, USA |
| DPB1*165:01 | HG00005923 | KC592362 | Histogenetics, Ossining, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author | A*01:25 | 10839496 | HG004398 | Jane Rowlands, Pontyclun, United Kingdom |
|---|---|---|---|
| A*03:167 | HG00005959 | KC537765 | Histogenetics, Ossining, USA |
| A*29:40 | HG00005930 | KC875886 | Histogenetics, Ossining, USA |
| A*30:59N | HG00005941 | KC959226 | Histogenetics, Ossining, USA |
| A*32:45N | 53460 | HG004403 | Jane Rowlands, Pontyclun, United Kingdom |
| A*32:54 | P07127 | KF160919 | Faming Zhu, Hangzhou, China |
| B*07:56:02 | JMDP36K0175 | AB826450 | Kenji Tadokoro, Tokyo, Japan |
| B*41:27 | HG00005974 | KC904410 | Histogenetics, Ossining, USA |
| B*57:11 | 63534 | HG004401 | Jane Rowlands, Pontyclun, United Kingdom |
| DRB1*04:05:01 | MDA0000141 | KF055209 | Kai Cao, Houston, USA |
| DRB1*04:06:01 | MDA0000142 | KF055210 | Kai Cao, Houston, USA |
| DRB1*04:09 | MDA0000143, MDA0000144, MDA0000145 |
KF055211, KF055212, KF055213 | Kai Cao, Houston, USA |
| DRB1*04:17:02 | MDA0000146, MDA0000147, MDA0000148 |
KF055214, KF055215, KF055216 | Kai Cao, Houston, USA |
| DRB1*07:05 | MDA0000149 | KF055217 | Kai Cao, Houston, USA |
| DRB1*08:10 | MDA0000150 | KF055218 | Kai Cao, Houston, USA |
| DRB1*09:06 | MDA0000151 | KF055219 | Kai Cao, Houston, USA |
| DRB1*11:01:02 | MDA0000152, MDA0000153, MDA0000154 |
KF055220, KF055221, KF055222 | Kai Cao, Houston, USA |
| DQB1*03:44 | D10059477 | HE804193 | Jinghui Qu, Shenzhen, China |
| DQB1*05:01:08 | D10083697 | HE804225 | Jinghui Qu, Shenzhen, China |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| B*13:02:13 | 3 |
| MICA*070 | 4 |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55:280-7.
- Yang KL, Lee SK, Lin PY. Identification of the novel HLA-B*13:02:13 allele in a Taiwanese haematopoietic stem cell donor and the probable HLA haplotype in association with B*13:02:13. Int J Immunogenet. 2013 40:241-2.
- Moran D, Morishima S, Malkki M, Petersdorf EW. Identification of the MICA*070 allele by sequencing and phasing. Hum Immunol. 2013 74:557-61.
