Nomenclature for Factors of the HLA System

December 2010

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the November 2010 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*24:17181106411HQ680840Daniel Fuerst, Ulm, Germany
B*27:79CS0915385FR734083Yubin Xie, Changsha, China
B*40:1625351000186HQ699675Zhi-Hui Feng, Qingdao, China
B*44:02:17SRANNHQ693697Youri Serov, Indianapolis, USA
B*44:27:0296059046HQ662947Daniel Fuerst, Ulm, Germany
B*44:1275321000627HQ699674Zhi-Hui Feng, Qingdao, China
B*51:01:2596058186HQ662948Daniel Fuerst, Ulm, Germany
C*01:51BY00755HQ700664Carolyn K Hurley, Washington DC, USA
C*03:108BY00783HQ717417Carolyn K Hurley, Washington DC, USA
C*07:171BY00754HQ700665Carolyn K Hurley, Washington DC, USA
C*16:01:06BY00758HQ700661Carolyn K Hurley, Washington DC, USA
DRB1*03:60BY00772HQ717408Carolyn K Hurley, Washington DC, USA
DRB1*04:95BY00770HQ700650Carolyn K Hurley, Washington DC, USA
DRB1*07:20BY00773HQ700647Carolyn K Hurley, Washington DC, USA
DRB1*07:21BY00766HQ700653Carolyn K Hurley, Washington DC, USA
DRB1*08:04:06BY00782HQ717418Carolyn K Hurley, Washington DC, USA
DRB1*08:42BY00769HQ700651Carolyn K Hurley, Washington DC, USA
DRB1*09:11XIAN47785HQ677626Mengli Liu, Xi’an, China
DRB1*11:102BY00779HQ717421Carolyn K Hurley, Washington DC, USA
DRB1*14:106BY00765HQ700654Carolyn K Hurley, Washington DC, USA
DRB1*14:107BY00763HQ700656Carolyn K Hurley, Washington DC, USA
DRB1*14:108BY00752HQ717409Carolyn K Hurley, Washington DC, USA
DRB1*14:109BY00786HQ717414Carolyn K Hurley, Washington DC, USA
DRB1*15:5281104378HQ696865Daniel Fuerst, Ulm, Germany
DRB1*16:18BY00771HQ700649Carolyn K Hurley, Washington DC, USA
DQB1*05:1110011772HQ662946Daniel Fuerst, Ulm, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
B*15:31CS00060HQ693236Kai Cao, Los Angeles, USA
B*15:34CS00061HQ696952Kai Cao, Los Angeles, USA
C*03:69BY00790HQ717410Carolyn K Hurley, Washington DC, USA
C*04:77BY00756HQ700663Carolyn K Hurley, Washington DC, USA
C*05:27BY00760HQ700659Carolyn K Hurley, Washington DC, USA
C*15:36BY00759HQ700660Carolyn K Hurley, Washington DC, USA
C*16:22 BY00757,
BY00784
HQ700662Carolyn K Hurley, Washington DC, USA
C*16:26BY00787HQ717413Carolyn K Hurley, Washington DC, USA
DRB1*04:42BY00776HQ717424Carolyn K Hurley, Washington DC, USA
DRB1*11:84BY00775HQ717425Carolyn K Hurley, Washington DC, USA
DRB1*12:20BY00764HQ700655Carolyn K Hurley, Washington DC, USA
DRB1*13:48BY00774HQ700648Carolyn K Hurley, Washington DC, USA
DRB1*14:52BY00777HQ717423Carolyn K Hurley, Washington DC, USA
DRB1*14:103JMDP36K086AB602446Kenji Tadokoro, Tokyo, Japan
DRB1*16:14BY00768HQ700652Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences


Sequence References
A*02:182 (3)
A*02:230 (4)
A*24:135 (5)
B*39:60 (6)
B*40:122 (7)
B*40:127 (7)
DRB1*10:01:01 (8)
DRB1*11:95 (9)
DQB1*05:01:03 (10)
G*01:01:01:01 (11)
G*01:01:01:02(11)
G*01:01:01:05(11)
G*01:01:02:01(11)
G*01:01:05(11)
G*01:01:08(11)
G*01:03(11)
G*01:04:01(11)
G*01:04:03(11)
G*01:04:04(11)
G*01:06(11)
G*01:08(11)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Wurm M, Tischer S, Immenschuh S, Bade-Doeding C, Blasczyk R, Eiz-Vesper B. The amino acid variation of HLA-A*02:182 in a highly conserved region is predicted to be functionally similar to HLA-A*02:01:01:01 allele. Tissue Antigens. 2011; 77: 149-50.
  4. Zhu FM, He YM, Lv HJ, Yan LX. Identification of a new HLA-A*02 allele, HLA-A*02:230, using polymerase chain reaction sequence-based typing in a Chinese individual. Tissue Antigens. 2011; 77: 150-1.
  5. Cervelli C, Canossi A, Azzarone R, Scimitarra M, Papola F. Sequence-based typing identification of the novel HLA-A*24:135 variant in a Maldivian family with a bone marrow patient. Tissue Antigens. 2011; 77: 152-3.
  6. Ko SY, Oh HB, Heo YS, Jun JH, Kwon OJ. B*39:60, a novel HLA-B*39 allele identified by sequence-based typing. Tissue Antigens. 2011; 77: 155-6.
  7. Miao F, Sun H, Pan N, Shen Y, Xie W, Zhang J. Two novel HLA class I alleles, HLA-B*40:122 and HLA-B*40:127. Tissue Antigens. 2011; 77: 156-7.
  8. Liu B, Xiong Y, Tian C, Zhong Y, Liu SM. The complete genomic sequence of HLA-DRB1*10:01:01 was identified by sequencing in a Han Chinese individual. Tissue Antigens. 2011; 77: 159-60.
  9. Sohn YH, Oh HB, Heo YS, Park N, Kwon OJ. Identification of a novel HLA-DRB1 allele, DRB1*11:95. Tissue Antigens. 2011; 77: 160-1.
  10. Jakubauskas A, Griskevicius L. Sequence-based typing showed a novel HLA-DQB1*05 allele, DQB1*05:01:03. Tissue Antigens. 2011; 77: 157-8.
  11. Cervera I, Herraiz MA, Penaloza J, et al. Human leukocyte antigen-G allele polymorphisms have evolved following three different evolutionary lineages based on intron sequences. Hum Immunol. 2010; 71: 1109-15.