Nomenclature for Factors of the HLA System

September 2010

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the August 2010 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:26FRFLY16610FR691049Dominique Masson, La Tronche, France
A*01:78D10006910FR690475Jinghui Qu, Shenzhen, China
A*01:79FRFVA38971FR690873Dominique Masson, La Tronche, France
A*01:80FRFLY18286FR691048Dominique Masson, La Tronche, France
A*01:81 CBRA59099746263,
014090619
FR691050Dominique Masson, La Tronche, France
A*02:280D09014985FR690476Jinghui Qu, Shenzhen, China
A*02:281CD10001668FR690477Jinghui Qu, Shenzhen, China
A*02:282D10011091FR690478Jinghui Qu, Shenzhen, China
A*02:79:02D10012888FR690479Jinghui Qu, Shenzhen, China
A*11:78NP4754, P4755HQ214055Lixing Yan, Hangzhou, China
A*11:79D10008666FR690480Jinghui Qu, Shenzhen, China
A*11:80D10012897FR690481Jinghui Qu, Shenzhen, China
A*24:153D10010022FR690482Jinghui Qu, Shenzhen, China
A*24:154D10008340FR690483Jinghui Qu, Shenzhen, China
A*24:155ND10007032FR690484Jinghui Qu, Shenzhen, China
A*26:56D10011797FR690486Jinghui Qu, Shenzhen, China
A*29:02:07FRFGR28281FR690871Dominique Masson, La Tronche, France
A*29:26FRFVA39523FR690872Dominique Masson, La Tronche, France
A*29:27FRFVA39950FR690874Dominique Masson, La Tronche, France
A*68:66A825HQ201391Annelies Muehlbacher, Innsbruck, Austria
B*08:66BY00730HQ127359Carolyn K Hurley, Washington DC, USA
B*14:02:0613200305FR688111Dominique Masson, La Tronche, France
B*15:25:035760900236HQ171091Lixing Yan, Hangzhou, China
B*35:03:07SDBC-07DGU145554Chuanfu Zhu, Jinan, China
B*38:26BJ082378HM347431Yanjun Jia, Beijing, China
B*40:155N RC070832,
RC076867
HM140623Oh-Joong Kwon, Seoul, South Korea
B*40:1561094-10FR682859Florian Emmerich, Freiburg, Germany
B*40:157BY00733HQ127357Carolyn K Hurley, Washington DC, USA
B*40:158M1233197FR667574Edward KL Yang, Hualien, Taiwan
B*44:114BY00734 HQ127356Carolyn K Hurley, Washington DC, USA
B*44:115FRFLY18407FR687370Dominique Masson, La Tronche, France
B*44:43:02BY00732HQ127358Carolyn K Hurley, Washington DC, USA
B*51:106N0005FN687185Mei Luo, Chengdu, China
B*53:24BY00729HQ127360Carolyn K Hurley, Washington DC, USA
B*57:37FRFVA40153FR687369Dominique Masson, La Tronche, France
C*01:02:13D10007074FR690462Jinghui Qu, Shenzhen, China
C*01:45FRFGR25834FR687364Dominique Masson, La Tronche, France
C*03:101FRFDI04440FR686901Dominique Masson, La Tronche, France
C*03:102D10009386FR690463Jinghui Qu, Shenzhen, China
C*04:81D10008515FR690464Jinghui Qu, Shenzhen, China
C*05:01:15FRFLY18331FR689740Dominique Masson, La Tronche, France
C*05:51QANCB693337ANFR671159Steven GE Marsh, London, United Kingdom
C*06:55D10012700FR690465Jinghui Qu, Shenzhen, China
C*07:137:02DED390FR686493Sylvie Tourne, Strasbourg, France
C*07:156D10012007FR690466Jinghui Qu, Shenzhen, China
C*07:157D10010200FR690467Jinghui Qu, Shenzhen, China
C*07:158D10010746FR690468Jinghui Qu, Shenzhen, China
C*07:159D10012306FR690469Jinghui Qu, Shenzhen, China
C*07:160SD430FR690470Jinghui Qu, Shenzhen, China
C*08:42BY00726HQ127363Carolyn K Hurley, Washington DC, USA
C*08:43CS00039HQ215835Kai Cao, Los Angeles, USA
C*08:44D10006515FR690471Jinghui Qu, Shenzhen, China
C*14:24D10008779FR690472Jinghui Qu, Shenzhen, China
C*14:25D10009731FR690473Jinghui Qu, Shenzhen, China
C*15:02:07

D10007839,
D10003737,
D10006156,
D10012122,
D10008865

FR690474Jinghui Qu, Shenzhen, China
C*15:06:0381103132HQ168401Daniel Fuerst, Ulm, Germany
C*15:44DED390FR686470Sylvie Tourne, Strasbourg, France
C*15:45FRFVA39921FR688114Dominique Masson, La Tronche, France
C*16:15:02FRFGR27627FR686902Dominique Masson, La Tronche, France
DRB1*01:33N20834HM590628Susana G Marino, Chicago, USA
DRB1*01:3493071156HQ168402Daniel Fuerst, Ulm, Germany
DRB1*03:56143KZFN908199Kuvat Momynaliev, Astana, Kazakhstan
DRB1*03:5741KZFN908202Kuvat Momynaliev, Astana, Kazakhstan
DRB1*03:58FRFGR25937FR687365Dominique Masson, La Tronche, France
DRB1*04:92CTM-10900005HQ198249Antonio Balas, Madrid, Spain
DRB1*08:4168HM627215Jun Hu, Xian, China
DRB1*11:04:06153KZFN908201Kuvat Momynaliev, Astana, Kazakhstan
DRB1*13:02:04130KZFN908204Kuvat Momynaliev, Astana, Kazakhstan
DRB1*13:102145KZFN908200Kuvat Momynaliev, Astana, Kazakhstan
DRB1*13:10371kzFN908203Kuvat Momynaliev, Astana, Kazakhstan
DRB1*14:12:02140KZFN908205Kuvat Momynaliev, Astana, Kazakhstan
MICA*002:04GZP2213HM856618Xin Ye, Guangzhou, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:161276-10FR682860Florian Emmerich, Freiburg, Germany
A*02:01:50FRFVA39584FR687367Dominique Masson, La Tronche, France
A*02:08HN-47518-7HQ258917Histogenetics, Ossining, USA
A*02:207FRFGR28402FR687362Dominique Masson, La Tronche, France
A*02:36NT01142HMO21759Carolyn K Hurley, Washington DC, USA
A*11:03NT01170HQ189132Carolyn K Hurley, Washington DC, USA
A*11:33:02FRFVA40159FR687368Dominique Masson, La Tronche, France
A*26:49HN-41380-7GQ199691Histogenetics, Ossining, USA
A*32:26FRFVA00987FR687363Dominique Masson, La Tronche, France
B*07:63HN-12411-2FJ588693Histogenetics, Ossining, USA
B*08:01:02HN-45088-0FJ588696Histogenetics, Ossining, USA
B*35:01:05HN-69161-6FJ588698Histogenetics, Ossining, USA
B*39:24CS00037HQ184435Kai Cao, Los Angeles, USA
B*39:31HN-37890-9FJ588697Histogenetics, Ossining, USA
B*40:115HN-006154GQ449629Histogenetics, Ossining, USA
B*40:49HN-17003-2FJ588699Histogenetics, Ossining, USA
B*44:02:12NT001169HMO21734Carolyn K Hurley, Washington DC, USA
B*51:01:01P3666HM543717Lixing Yan, Hangzhou, China
B*51:90BY00740HQ189131Carolyn K Hurley, Washington DC, USA
B*55:23CS00038HQ189746Kai Cao, Los Angeles, USA
B*57:01:07FRFLY14898FR688112Dominique Masson, La Tronche, France
C*03:165984206FR687254Katherine Poole, Leeds, United Kingdom
C*04:61BY00728HQ127361Carolyn K Hurley, Washington DC, USA
C*12:03:05HN-20102-4GQ180384Histogenetics, Ossining, USA
DRB1*12:24NFRFGR27180FR687366Dominique Masson, La Tronche, France
DRB1*13:96HN-22035-9GQ859582Histogenetics, Ossining, USA
DRB1*15:01:11HN-58560-0GQ900585Histogenetics, Ossining, USA
DRB1*15:33HN-97374-3GU128060Histogenetics, Ossining, USA
DRB1*15:37HN-31685-4GQ449663Histogenetics, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
B*15:144 (3)
B*51:94 (4)
C*06:20 (5)
C*1210:02 (6)
DRB1*08:36 (7)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Dong L, Yan LN, Xie JH, An SP, Yuan YH. A new HLA-B*15 variant, B*15:144, identified by sequence-based typing in a Chinese individual. Tissue Antigens. 2010; 76: 421-2.
  4. Daskalakis M, Emmerich F, Niemeyer C. Identification of a novel HLA-B51 allele, HLA-B*51:94. Tissue Antigens. 2010; 76: 423.
  5. Emmerich F, Daskalakis M, Niemeyer CM. A novel HLA-C allele, HLA-Cw*06:20. Tissue Antigens. 2010; 76: 425.
  6. Sun H, Miao F, Pan N, Shen Y, Xie W, Zhang J. Identification of a novel HLA-C allele, C*12:10:02, in a Chinese individual. Tissue Antigens. 2010; 76: 424-5.
  7. Liu J, Liu N, Shan X, Li W, Zhang Z. A novel HLA-DRB1 allele, DRB1*08:36, identified by sequence-based typing. Tissue Antigens. 2010; 76: 426-7.