Nomenclature for Factors of the HLA System

August 2009

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the July 2009 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*0143BY00515GQ426484Carolyn K Hurley, Washington DC, USA
A*0360LUMC-A60FN544086Jacqy DH Anholts, Leiden, The Netherlands
A*1148RAVE676425ANFN433878Steven GE Marsh, London, United Kingdom
A*1149P4081GQ478195Lixing Yan, Hangzhou, China
A*1150LIWE52997ANFN435324Steven GE Marsh, London, United Kingdom
A*3328BY00513GQ426486Carolyn K Hurley, Washington DC, USA
A*929209213041GQ422609Daniel Fuerst, Ulm, Germany
A*9293BY00514GQ426485Carolyn K Hurley, Washington DC, USA
B*07021491550018GQ375767Daniel Fuerst, Ulm, Germany
B*150111NT01069GQ251347Carolyn K Hurley, Washington DC, USA
B*350110BY00486GQ410105Carolyn K Hurley, Washington DC, USA
B*44020909210739GQ375769Daniel Fuerst, Ulm, Germany
B*4483192434FM886991Klaus Witter, München, Germany
B*4907CTM-8004574GQ454860Antonio Balas, Madrid, Spain
B*520105BY00488GQ410107Carolyn K Hurley, Washington DC, USA
Cw*0362LUMC-C62,
09d02439
FN544087Jacqy DH Anholts, Leiden, The Netherlands
Cw*050106VIBU601426ANFN432836Steven GE Marsh, London, United Kingdom
Cw*0776LISU617232ANFN433487Steven GE Marsh, London, United Kingdom
Cw*1224JATH473491ANFN538998Steven GE Marsh, London, United Kingdom
DRB1*083942595FN433880Thibaut Gervais, Brussels, Belgium
DRB1*130303BY00512GQ426487Carolyn K Hurley, Washington DC, USA
DRB1*1491073069GQ202277Botao Zhao, Beijing, China
DRB5*0114LUMC-DRB5n61FN430425Jacqy DH Anholts, Leiden, The Netherlands
DQB1*040302AN181945FN433879Francesca Poli, Milano, Italy
DQB1*063709212635GQ422610Daniel Fuerst, Ulm, Germany
DPB1*350102193318FN256252Klaus Witter, München, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*0133HN-3282501FJ392140Histogenetics, Ossining, USA
A*0135HN-756979,
HN-36829-1
FJ619457,
FJ976746
Histogenetics, Ossining, USA
A*020122HN-54826-1FJ619455Histogenetics, Ossining, USA
A*020126HN-61784-1,
HN-52186-0
FJ785201,
FJ875538
Histogenetics, Ossining, USA
A*0285HN-3232099FJ792530Histogenetics, Ossining, USA
A*0347HN-709721FJ489878Histogenetics, Ossining, USA
A*0348HN-43969-2,
HN-40494-9
FJ875685,
FJ976753
Histogenetics, Ossining, USA
A*0350HN-703138FJ792520Histogenetics, Ossining, USA
A*0351HN-763009,
HN-4096256
FJ619459,
FJ976747
Histogenetics, Ossining, USA
A*1130HN-75401-4FJ765881Histogenetics, Ossining, USA
A*1144HN-0852668FJ765937Histogenetics, Ossining, USA
A*2319QHN-7579920FJ875682Histogenetics, Ossining, USA
A*2321HN-756995FJ619458Histogenetics, Ossining, USA
A*240216HN-4337452FJ976745Histogenetics, Ossining, USA
A*241302HN-73720-6FJ976749Histogenetics, Ossining, USA
A*2485HN-3493876FJ875681Histogenetics, Ossining, USA
A*2487HN-80015-1FJ875536Histogenetics, Ossining, USA
A*2490NHN-1869218FJ887803Histogenetics, Ossining, USA
A*2493HN-684098FJ600636Histogenetics, Ossining, USA
A*2508HN-51803-6FJ358628Histogenetics, Ossining, USA
A*2638HN-718979FJ792522Histogenetics, Ossining, USA
A*9246HN-7435974FJ765884Histogenetics, Ossining, USA
A*9249HN-53007-3FJ976758Histogenetics, Ossining, USA
A*9253HN-0168836FJ765885Histogenetics, Ossining, USA
A*9254HN-47750-2,
HN-50748-0
FJ765939,
FJ785210
Histogenetics, Ossining, USA
A*9261HN-40502-3FJ875546Histogenetics, Ossining, USA
A*9264HN-18979-6,
HN-28220-2,
HN-90276-3
FJ765906,
FJ765910,
FJ875533
Histogenetics, Ossining, USA
A*9277HN-9035051,
HN-674214
FJ489876,
FJ594707
Histogenetics, Ossining, USA
B*070207HN-48912-4FJ868485Histogenetics, Ossining, USA
B*070208HN-3999114FJ392162Histogenetics, Ossining, USA
B*071802HN-3157224FJ594549Histogenetics, Ossining, USA
B*072202HN-6966060FJ600623Histogenetics, Ossining, USA
B*0763HN-6008615FJ594617Histogenetics, Ossining, USA
B*0768HN-00794-6,
HN-61579-6
FJ594697,
FJ765970
Histogenetics, Ossining, USA
B*0771HN-7668309FJ765770Histogenetics, Ossining, USA
B*0772HN-7715052FJ765552Histogenetics, Ossining, USA
B*0776HN-692448FJ468325Histogenetics, Ossining, USA
B*0839HN-4582414,
HN-93071-6
FJ765570,
FJ952586
Histogenetics, Ossining, USA
B*132201HN-s5746869FJ765805Histogenetics, Ossining, USA
B*140202HN-2931859FJ594622Histogenetics, Ossining, USA
B*1409HN-6998912FJ765779Histogenetics, Ossining, USA
B*1412HN-57692-5FJ976863Histogenetics, Ossining, USA
B*1825HN-6764895FJ875654Histogenetics, Ossining, USA
B*270509HN-11822-8FJ976781Histogenetics, Ossining, USA
B*270510HN-2922057FJ600616Histogenetics, Ossining, USA
B*2742HN-4123369FJ976780Histogenetics, Ossining, USA
B*2749HN-09752-5FJ640577Histogenetics, Ossining, USA
B*2750HN-779823FJ489871Histogenetics, Ossining, USA
B*350107HN-5812299FJ594590Histogenetics, Ossining, USA
B*350402HN-6211559,
HN-9792975
FJ594620,
FJ792534
Histogenetics, Ossining, USA
B*3555HN-03375-3FJ875661Histogenetics, Ossining, USA
B*390105HN-6381722FJ765837Histogenetics, Ossining, USA
B*391902HN-1241139FJ875657Histogenetics, Ossining, USA
B*4054HN-0888695FJ594623Histogenetics, Ossining, USA
B*4078HN-33851-9,
HN-34166-1
FJ600621,
FJ600622
Histogenetics, Ossining, USA
B*4087HN-3043303FJ875658Histogenetics, Ossining, USA
B*4209HN-5428807FJ594721Histogenetics, Ossining, USA
B*4453HN-1660955FJ594555Histogenetics, Ossining, USA
B*480302HN-1833602FJ594559Histogenetics, Ossining, USA
B*5156HN-61747-2FJ765948Histogenetics, Ossining, USA
B*5165HN-7648279,
HN-16760-2,
HN-40799-5
FJ765929,
FJ765852,
FJ765952
Histogenetics, Ossining, USA
B*5167HN-90439-1FJ858890Histogenetics, Ossining, USA
B*550203HN-0381249FJ765802Histogenetics, Ossining, USA
B*5533HN-62070-0FJ969945Histogenetics, Ossining, USA
B*5717HN-6965989FJ502333Histogenetics, Ossining, USA
B*5818HN-6543265FJ765806Histogenetics, Ossining, USA
B*5824HN-0954615FJ765824Histogenetics, Ossining, USA
B*9550HN-9419667FJ765556Histogenetics, Ossining, USA
B*9555HN-7712737FJ765551Histogenetics, Ossining, USA
B*9558HN-697595FJ468326Histogenetics, Ossining, USA
B*9559HN-749933,
HN-2141102
FJ489872,
FJ976855
Histogenetics, Ossining, USA
B*9570HN-6944719FJ765789Histogenetics, Ossining, USA
Cw*01037550800434GQ472834Yunping Xu, Shenzhen, China
Cw*01087550800556GQ472835Yunping Xu, Shenzhen, China
Cw*0126HN-726956FJ792496Histogenetics, Ossining, USA
Cw*0202027550800714GQ472836Yunping Xu, Shenzhen, China
Cw*020207HN-709325,
HN-55574-4,
HN-46896-4,
HN41928-9,
HN-34692-0,
HN-99447-2,
HN-13976-5,
HN-58481-2
FJ792502,
FJ858900,
FJ858905,
FJ875586,
FJ875618,
FJ917725,
FJ976785,
FJ976827
Histogenetics, Ossining, USA
Cw*021602HN-79217-5,
HN-96848-6
FJ976790,
FJ976838
Histogenetics, Ossining, USA
Cw*0226HN-749974FJ792494Histogenetics, Ossining, USA
Cw*0319HN-3182240FJ875638Histogenetics, Ossining, USA
Cw*040375505703GQ472837Yunping Xu, Shenzhen, China
Cw*0440HN-742987FJ792499Histogenetics, Ossining, USA
Cw*0524HN-37600-3FJ969924Histogenetics, Ossining, USA
Cw*0701017550800619GQ472838Yunping Xu, Shenzhen, China
Cw*0701027550800303GQ472839Yunping Xu, Shenzhen, China
Cw*0760HN-23230-7,
HN-83996-1,
HN-33890-7,
HN-35587-7,
HN-77749-0
FJ976806,
FJ976810,
FJ976820,
FJ976821,
FJ976880
Histogenetics, Ossining, USA
Cw*0768HN-727525,
HN-58409-4,
HN-16429-0,
HN-58361-9
FJ792498,
FJ858901,
FJ858902,
FJ976822
Histogenetics, Ossining, USA
Cw*0769HN-694436FJ792500Histogenetics, Ossining, USA
Cw*0770HN-690939FJ792509Histogenetics, Ossining, USA
Cw*0772HN-764015FJ792495Histogenetics, Ossining, USA
Cw*0775HN-69363-9,
HN-42676-6
FJ619424,
FJ976846
Histogenetics, Ossining, USA
Cw*0803017550800777GQ472840Yunping Xu, Shenzhen, China
Cw*0823HN-680161FJ792506Histogenetics, Ossining, USA
Cw*1202027550800375GQ472841Yunping Xu, Shenzhen, China
Cw*120301017550800556GQ472842Yunping Xu, Shenzhen, China
Cw*1411HN-35285-5FJ976841Histogenetics, Ossining, USA
Cw*1604017550800701GQ472843Yunping Xu, Shenzhen, China
DRB1*010110HN-55044-1FJ392236Histogenetics, Ossining, USA
DRB1*0120HN-81195-8FJ766010Histogenetics, Ossining, USA
DRB1*110111HN-3808,
HN-0258
FJ766006,
FJ875602
Histogenetics, Ossining, USA
DRB1*111302185405FN295562Klaus Witter, München, Germany
DRB1*1211CS00023GQ845416Kai Cao, Los Angeles, USA
DRB1*131102HN-98756-7FJ907390Histogenetics, Ossining, USA
DRB1*1338HN-32101-5,
HN-61399-0,
HN-8904109,
HN-74601-2,
HN-11283-8
FJ594734,
FJ766009,
FJ875597,
FJ875608,
FJ952588
Histogenetics, Ossining, USA
DRB1*15010101192762FM955270Klaus Witter, München, Germany
    

Table 3: Recently Published Sequences


Sequence References
A*0342 (1)
A*230302 (2)
A*2489 (3)
A*2493 (1)
A*2918 (1)
A*3310 (2)
A*6842 (2)
A*9251 (4)
B*0752 (2)
B*0753 (2)
B*0754 (2)
B*0769 (5)
B*0835 (2)
B*130204 (2)
B*2737 (2)
B*2739 (2)
B*350803 (2)
B*3574 (2)
B*3816 (2)
B*4080 (2)
B*4458N (2)
B*4610 (2)
B*510902 (2)
B*512402 (6)
B*5148 (2)
B*5313 (2)
B*550203 (7)
B*5526 (2)
B*5712 (2)
B*5715 (2)
Cw*0347 (2)
Cw*040106 (8)
Cw*041502 (2)
Cw*0516 (2)
Cw*0524 (9)
Cw*0820 (10)
Cw*0821 (11)
Cw*1221 (2)
G*01010106 (12)
DRB1*090202 (13)
DRB1*0908 (14)
DRB1*1218 (15)
DRB1*1532 (16)
DPB1*1302 (17)

References

  1. Dubois V, Giannoli C, Favre-Victoire I. Three new HLA-A alleles determined by sequence-based typing: A*2493, A*2918 and A*0342. Tissue Antigens. 2009 74:250-1.
  2. Lazaro AM, Xiao Y, Masaberg C, et al. Description of novel class I alleles encountered during routine registry typing in 2007. Tissue Antigens. 2009 74:238-40.
  3. Xiao Y, Zhou XY, Liu N, Zhang ZX, Cai JP. Identification of a novel allele HLA-A*2489 by sequence-based typing in a Chinese individual. Tissue Antigens. 2009 74:249-50.
  4. Kervaire B, Schmidt AH, Villard J, Tiercy JM. Sequence of a novel HLA-A2 allele in a haematopoietic stem cell donor of the international registry. Tissue Antigens. 2009 74:248-9.
  5. Testi M, Battarra M, Troiano M, Testa G, Andreani M. Identification of a novel HLA-B*07 allele in an Iranian family: B*0769. Tissue Antigens. 2009 74:252-3.
  6. Kim KW, Kwon OJ, Kwon SY, Cho NS, Oh DJ. A new HLA-B*5124 variant, B*512402 allele, identified by sequence-based typing. Tissue Antigens. 2009 74:253-4.
  7. Yan LX, Zhu FM, Zhang W, He J. A novel allele HLA-B*550203 was identified by polymerase chain reaction-sequence-based typing. Tissue Antigens. 2009 74:254-5.
  8. Han SH, Heo YA, Kwon OJ, Yoon HR, Lee KR. Identification of a novel HLA-Cw*04 allele, HLA-Cw*040106, by sequence-based typing in the Korean population. Tissue Antigens. 2009 74:256-7.
  9. Figueiredo C, Jaimes Y, Horn PA, Blasczyk R, Eiz-Vesper B. The new HLA-Cw*0524 allele increase the variability of position 49 in HLA-C. Tissue Antigens. 2009 74:258-9.
  10. Deng ZH, Xu YP, Wang DM. Sequence analysis of the novel HLA-Cw*08 variant allele, Cw*0820, in a Chinese Han individual. Tissue Antigens. 2009 74:260-1.
  11. Wang DM, Deng ZH. Identification of a novel HLA-Cw*08 variant allele, Cw*0821. Tissue Antigens. 2009 74:261-2.
  12. Roman A, Cervera I, Herraiz MA, Vidart J, Martinez-Laso J. A new allele, HLA-G*01010106, with changes in intron 2. Tissue Antigens. 2009 74:270-1.
  13. Chu CC, Lee HL, Lin M. A novel HLA-DRB1 allele, DRB*090202, is identified in a Taiwanese family. Tissue Antigens. 2009 74:262-3.
  14. Kim YH, Kang YM, Lee GE, Cho YS. HLA-DRB1*0908, a new allele was identified by sequence-based typing in a Korean individual. Tissue Antigens. 2009 74:264-5.
  15. Gao SQ, Deng ZH, Xu YP. Identification of a novel HLA-DRB1*12 allele, DRB1*1218, in Chinese population. Tissue Antigens. 2009 74:265-7.
  16. Alaez C, Munguia A, Garcia D, Gomez K, Gorodezky C. DRB1*1532, a new DR15 allele, identified in a Mexican unrelated donor from Veracruz, Mexico. Tissue Antigens. 2009 74:267-8.
  17. Moonsamy P, Bonella P, Goodwin G, Dolan L, Erlich HA. The identification of a new HLA-DPB1 allele (*1302) in one family and the detection of a recombination event between the DR and the DQ regions in another Caucasian T1DGC family. Tissue Antigens. 2009 74:268-70.