Nomenclature for Factors of the HLA System
August 2009
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2009 75:98-101
- Human Immunology. 2010 71:112-5
- International Journal of Immunogenetics. 2010 37:55-8
The following sequences have been submitted to the Nomenclature Committee since the July 2009 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*0143 | BY00515 | GQ426484 | Carolyn K Hurley, Washington DC, USA |
| A*0360 | LUMC-A60 | FN544086 | Jacqy DH Anholts, Leiden, The Netherlands |
| A*1148 | RAVE676425AN | FN433878 | Steven GE Marsh, London, United Kingdom |
| A*1149 | P4081 | GQ478195 | Lixing Yan, Hangzhou, China |
| A*1150 | LIWE52997AN | FN435324 | Steven GE Marsh, London, United Kingdom |
| A*3328 | BY00513 | GQ426486 | Carolyn K Hurley, Washington DC, USA |
| A*9292 | 09213041 | GQ422609 | Daniel Fuerst, Ulm, Germany |
| A*9293 | BY00514 | GQ426485 | Carolyn K Hurley, Washington DC, USA |
| B*070214 | 91550018 | GQ375767 | Daniel Fuerst, Ulm, Germany |
| B*150111 | NT01069 | GQ251347 | Carolyn K Hurley, Washington DC, USA |
| B*350110 | BY00486 | GQ410105 | Carolyn K Hurley, Washington DC, USA |
| B*440209 | 09210739 | GQ375769 | Daniel Fuerst, Ulm, Germany |
| B*4483 | 192434 | FM886991 | Klaus Witter, M�nchen, Germany |
| B*4907 | CTM-8004574 | GQ454860 | Antonio Balas, Madrid, Spain |
| B*520105 | BY00488 | GQ410107 | Carolyn K Hurley, Washington DC, USA |
| Cw*0362 | LUMC-C62, 09d02439 | FN544087 | Jacqy DH Anholts, Leiden, The Netherlands |
| Cw*050106 | VIBU601426AN | FN432836 | Steven GE Marsh, London, United Kingdom |
| Cw*0776 | LISU617232AN | FN433487 | Steven GE Marsh, London, United Kingdom |
| Cw*1224 | JATH473491AN | FN538998 | Steven GE Marsh, London, United Kingdom |
| DRB1*0839 | 42595 | FN433880 | Thibaut Gervais, Brussels, Belgium |
| DRB1*130303 | BY00512 | GQ426487 | Carolyn K Hurley, Washington DC, USA |
| DRB1*1491 | 073069 | GQ202277 | Botao Zhao, Beijing, China |
| DRB5*0114 | LUMC-DRB5n61 | FN430425 | Jacqy DH Anholts, Leiden, The Netherlands |
| DQB1*040302 | AN181945 | FN433879 | Francesca Poli, Milano, Italy |
| DQB1*0637 | 09212635 | GQ422610 | Daniel Fuerst, Ulm, Germany |
| DPB1*350102 | 193318 | FN256252 | Klaus Witter, M�nchen, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*0133 | HN-3282501 | FJ392140 | Histogenetics, Ossining, USA |
| A*0135 | HN-756979, HN-36829-1 | FJ619457, FJ976746 | Histogenetics, Ossining, USA |
| A*020122 | HN-54826-1 | FJ619455 | Histogenetics, Ossining, USA |
| A*020126 | HN-61784-1, HN-52186-0 | FJ785201, FJ875538 | Histogenetics, Ossining, USA |
| A*0285 | HN-3232099 | FJ792530 | Histogenetics, Ossining, USA |
| A*0347 | HN-709721 | FJ489878 | Histogenetics, Ossining, USA |
| A*0348 | HN-43969-2, HN-40494-9 | FJ875685, FJ976753 | Histogenetics, Ossining, USA |
| A*0350 | HN-703138 | FJ792520 | Histogenetics, Ossining, USA |
| A*0351 | HN-763009, HN-4096256 | FJ619459, FJ976747 | Histogenetics, Ossining, USA |
| A*1130 | HN-75401-4 | FJ765881 | Histogenetics, Ossining, USA |
| A*1144 | HN-0852668 | FJ765937 | Histogenetics, Ossining, USA |
| A*2319Q | HN-7579920 | FJ875682 | Histogenetics, Ossining, USA |
| A*2321 | HN-756995 | FJ619458 | Histogenetics, Ossining, USA |
| A*240216 | HN-4337452 | FJ976745 | Histogenetics, Ossining, USA |
| A*241302 | HN-73720-6 | FJ976749 | Histogenetics, Ossining, USA |
| A*2485 | HN-3493876 | FJ875681 | Histogenetics, Ossining, USA |
| A*2487 | HN-80015-1 | FJ875536 | Histogenetics, Ossining, USA |
| A*2490N | HN-1869218 | FJ887803 | Histogenetics, Ossining, USA |
| A*2493 | HN-684098 | FJ600636 | Histogenetics, Ossining, USA |
| A*2508 | HN-51803-6 | FJ358628 | Histogenetics, Ossining, USA |
| A*2638 | HN-718979 | FJ792522 | Histogenetics, Ossining, USA |
| A*9246 | HN-7435974 | FJ765884 | Histogenetics, Ossining, USA |
| A*9249 | HN-53007-3 | FJ976758 | Histogenetics, Ossining, USA |
| A*9253 | HN-0168836 | FJ765885 | Histogenetics, Ossining, USA |
| A*9254 | HN-47750-2, HN-50748-0 | FJ765939, FJ785210 | Histogenetics, Ossining, USA |
| A*9261 | HN-40502-3 | FJ875546 | Histogenetics, Ossining, USA |
| A*9264 | HN-18979-6, HN-28220-2, HN-90276-3 | FJ765906, FJ765910, FJ875533 | Histogenetics, Ossining, USA |
| A*9277 | HN-9035051, HN-674214 | FJ489876, FJ594707 | Histogenetics, Ossining, USA |
| B*070207 | HN-48912-4 | FJ868485 | Histogenetics, Ossining, USA |
| B*070208 | HN-3999114 | FJ392162 | Histogenetics, Ossining, USA |
| B*071802 | HN-3157224 | FJ594549 | Histogenetics, Ossining, USA |
| B*072202 | HN-6966060 | FJ600623 | Histogenetics, Ossining, USA |
| B*0763 | HN-6008615 | FJ594617 | Histogenetics, Ossining, USA |
| B*0768 | HN-00794-6, HN-61579-6 | FJ594697, FJ765970 | Histogenetics, Ossining, USA |
| B*0771 | HN-7668309 | FJ765770 | Histogenetics, Ossining, USA |
| B*0772 | HN-7715052 | FJ765552 | Histogenetics, Ossining, USA |
| B*0776 | HN-692448 | FJ468325 | Histogenetics, Ossining, USA |
| B*0839 | HN-4582414, HN-93071-6 | FJ765570, FJ952586 | Histogenetics, Ossining, USA |
| B*132201 | HN-s5746869 | FJ765805 | Histogenetics, Ossining, USA |
| B*140202 | HN-2931859 | FJ594622 | Histogenetics, Ossining, USA |
| B*1409 | HN-6998912 | FJ765779 | Histogenetics, Ossining, USA |
| B*1412 | HN-57692-5 | FJ976863 | Histogenetics, Ossining, USA |
| B*1825 | HN-6764895 | FJ875654 | Histogenetics, Ossining, USA |
| B*270509 | HN-11822-8 | FJ976781 | Histogenetics, Ossining, USA |
| B*270510 | HN-2922057 | FJ600616 | Histogenetics, Ossining, USA |
| B*2742 | HN-4123369 | FJ976780 | Histogenetics, Ossining, USA |
| B*2749 | HN-09752-5 | FJ640577 | Histogenetics, Ossining, USA |
| B*2750 | HN-779823 | FJ489871 | Histogenetics, Ossining, USA |
| B*350107 | HN-5812299 | FJ594590 | Histogenetics, Ossining, USA |
| B*350402 | HN-6211559, HN-9792975 | FJ594620, FJ792534 | Histogenetics, Ossining, USA |
| B*3555 | HN-03375-3 | FJ875661 | Histogenetics, Ossining, USA |
| B*390105 | HN-6381722 | FJ765837 | Histogenetics, Ossining, USA |
| B*391902 | HN-1241139 | FJ875657 | Histogenetics, Ossining, USA |
| B*4054 | HN-0888695 | FJ594623 | Histogenetics, Ossining, USA |
| B*4078 | HN-33851-9, HN-34166-1 | FJ600621, FJ600622 | Histogenetics, Ossining, USA |
| B*4087 | HN-3043303 | FJ875658 | Histogenetics, Ossining, USA |
| B*4209 | HN-5428807 | FJ594721 | Histogenetics, Ossining, USA |
| B*4453 | HN-1660955 | FJ594555 | Histogenetics, Ossining, USA |
| B*480302 | HN-1833602 | FJ594559 | Histogenetics, Ossining, USA |
| B*5156 | HN-61747-2 | FJ765948 | Histogenetics, Ossining, USA |
| B*5165 | HN-7648279, HN-16760-2, HN-40799-5 | FJ765929, FJ765852, FJ765952 | Histogenetics, Ossining, USA |
| B*5167 | HN-90439-1 | FJ858890 | Histogenetics, Ossining, USA |
| B*550203 | HN-0381249 | FJ765802 | Histogenetics, Ossining, USA |
| B*5533 | HN-62070-0 | FJ969945 | Histogenetics, Ossining, USA |
| B*5717 | HN-6965989 | FJ502333 | Histogenetics, Ossining, USA |
| B*5818 | HN-6543265 | FJ765806 | Histogenetics, Ossining, USA |
| B*5824 | HN-0954615 | FJ765824 | Histogenetics, Ossining, USA |
| B*9550 | HN-9419667 | FJ765556 | Histogenetics, Ossining, USA |
| B*9555 | HN-7712737 | FJ765551 | Histogenetics, Ossining, USA |
| B*9558 | HN-697595 | FJ468326 | Histogenetics, Ossining, USA |
| B*9559 | HN-749933, HN-2141102 | FJ489872, FJ976855 | Histogenetics, Ossining, USA |
| B*9570 | HN-6944719 | FJ765789 | Histogenetics, Ossining, USA |
| Cw*0103 | 7550800434 | GQ472834 | Yunping Xu, Shenzhen, China |
| Cw*0108 | 7550800556 | GQ472835 | Yunping Xu, Shenzhen, China |
| Cw*0126 | HN-726956 | FJ792496 | Histogenetics, Ossining, USA |
| Cw*020202 | 7550800714 | GQ472836 | Yunping Xu, Shenzhen, China |
| Cw*020207 | HN-709325, HN-55574-4, HN-46896-4, HN41928-9, HN-34692-0, HN-99447-2, HN-13976-5, HN-58481-2 | FJ792502, FJ858900, FJ858905, FJ875586, FJ875618, FJ917725, FJ976785, FJ976827 | Histogenetics, Ossining, USA |
| Cw*021602 | HN-79217-5, HN-96848-6 | FJ976790, FJ976838 | Histogenetics, Ossining, USA |
| Cw*0226 | HN-749974 | FJ792494 | Histogenetics, Ossining, USA |
| Cw*0319 | HN-3182240 | FJ875638 | Histogenetics, Ossining, USA |
| Cw*0403 | 75505703 | GQ472837 | Yunping Xu, Shenzhen, China |
| Cw*0440 | HN-742987 | FJ792499 | Histogenetics, Ossining, USA |
| Cw*0524 | HN-37600-3 | FJ969924 | Histogenetics, Ossining, USA |
| Cw*070101 | 7550800619 | GQ472838 | Yunping Xu, Shenzhen, China |
| Cw*070102 | 7550800303 | GQ472839 | Yunping Xu, Shenzhen, China |
| Cw*0760 | HN-23230-7, HN-83996-1, HN-33890-7, HN-35587-7, HN-77749-0 | FJ976806, FJ976810, FJ976820, FJ976821, FJ976880 | Histogenetics, Ossining, USA |
| Cw*0768 | HN-727525, HN-58409-4, HN-16429-0, HN-58361-9 | FJ792498, FJ858901, FJ858902, FJ976822 | Histogenetics, Ossining, USA |
| Cw*0769 | HN-694436 | FJ792500 | Histogenetics, Ossining, USA |
| Cw*0770 | HN-690939 | FJ792509 | Histogenetics, Ossining, USA |
| Cw*0772 | HN-764015 | FJ792495 | Histogenetics, Ossining, USA |
| Cw*0775 | HN-69363-9, HN-42676-6 | FJ619424, FJ976846 | Histogenetics, Ossining, USA |
| Cw*080301 | 7550800777 | GQ472840 | Yunping Xu, Shenzhen, China |
| Cw*0823 | HN-680161 | FJ792506 | Histogenetics, Ossining, USA |
| Cw*120202 | 7550800375 | GQ472841 | Yunping Xu, Shenzhen, China |
| Cw*12030101 | 7550800556 | GQ472842 | Yunping Xu, Shenzhen, China |
| Cw*1411 | HN-35285-5 | FJ976841 | Histogenetics, Ossining, USA |
| Cw*160401 | 7550800701 | GQ472843 | Yunping Xu, Shenzhen, China |
| DRB1*010110 | HN-55044-1 | FJ392236 | Histogenetics, Ossining, USA |
| DRB1*0120 | HN-81195-8 | FJ766010 | Histogenetics, Ossining, USA |
| DRB1*110111 | HN-3808, HN-0258 | FJ766006, FJ875602 | Histogenetics, Ossining, USA |
| DRB1*111302 | 185405 | FN295562 | Klaus Witter, M�nchen, Germany |
| DRB1*1211 | CS00023 | GQ845416 | Kai Cao, Los Angeles, USA |
| DRB1*131102 | HN-98756-7 | FJ907390 | Histogenetics, Ossining, USA |
| DRB1*1338 | HN-32101-5, HN-61399-0, HN-8904109, HN-74601-2, HN-11283-8 | FJ594734, FJ766009, FJ875597, FJ875608, FJ952588 | Histogenetics, Ossining, USA |
| DRB1*15010101 | 192762 | FM955270 | Klaus Witter, M�nchen, Germany |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*0342 | (1) |
| A*230302 | (2) |
| A*2489 | (3) |
| A*2493 | (1) |
| A*2918 | (1) |
| A*3310 | (2) |
| A*6842 | (2) |
| A*9251 | (4) |
| B*0752 | (2) |
| B*0753 | (2) |
| B*0754 | (2) |
| B*0769 | (5) |
| B*0835 | (2) |
| B*130204 | (2) |
| B*2737 | (2) |
| B*2739 | (2) |
| B*350803 | (2) |
| B*3574 | (2) |
| B*3816 | (2) |
| B*4080 | (2) |
| B*4458N | (2) |
| B*4610 | (2) |
| B*510902 | (2) |
| B*512402 | (6) |
| B*5148 | (2) |
| B*5313 | (2) |
| B*550203 | (7) |
| B*5526 | (2) |
| B*5712 | (2) |
| B*5715 | (2) |
| Cw*0347 | (2) |
| Cw*040106 | (8) |
| Cw*041502 | (2) |
| Cw*0516 | (2) |
| Cw*0524 | (9) |
| Cw*0820 | (10) |
| Cw*0821 | (11) |
| Cw*1221 | (2) |
| G*01010106 | (12) |
| DRB1*090202 | (13) |
| DRB1*0908 | (14) |
| DRB1*1218 | (15) |
| DRB1*1532 | (16) |
| DPB1*1302 | (17) |
References
- Dubois V, Giannoli C, Favre-Victoire I. Three new HLA-A alleles determined by sequence-based typing: A*2493, A*2918 and A*0342. Tissue Antigens. 2009 74:250-1.
- Lazaro AM, Xiao Y, Masaberg C, et al. Description of novel class I alleles encountered during routine registry typing in 2007. Tissue Antigens. 2009 74:238-40.
- Xiao Y, Zhou XY, Liu N, Zhang ZX, Cai JP. Identification of a novel allele HLA-A*2489 by sequence-based typing in a Chinese individual. Tissue Antigens. 2009 74:249-50.
- Kervaire B, Schmidt AH, Villard J, Tiercy JM. Sequence of a novel HLA-A2 allele in a haematopoietic stem cell donor of the international registry. Tissue Antigens. 2009 74:248-9.
- Testi M, Battarra M, Troiano M, Testa G, Andreani M. Identification of a novel HLA-B*07 allele in an Iranian family: B*0769. Tissue Antigens. 2009 74:252-3.
- Kim KW, Kwon OJ, Kwon SY, Cho NS, Oh DJ. A new HLA-B*5124 variant, B*512402 allele, identified by sequence-based typing. Tissue Antigens. 2009 74:253-4.
- Yan LX, Zhu FM, Zhang W, He J. A novel allele HLA-B*550203 was identified by polymerase chain reaction-sequence-based typing. Tissue Antigens. 2009 74:254-5.
- Han SH, Heo YA, Kwon OJ, Yoon HR, Lee KR. Identification of a novel HLA-Cw*04 allele, HLA-Cw*040106, by sequence-based typing in the Korean population. Tissue Antigens. 2009 74:256-7.
- Figueiredo C, Jaimes Y, Horn PA, Blasczyk R, Eiz-Vesper B. The new HLA-Cw*0524 allele increase the variability of position 49 in HLA-C. Tissue Antigens. 2009 74:258-9.
- Deng ZH, Xu YP, Wang DM. Sequence analysis of the novel HLA-Cw*08 variant allele, Cw*0820, in a Chinese Han individual. Tissue Antigens. 2009 74:260-1.
- Wang DM, Deng ZH. Identification of a novel HLA-Cw*08 variant allele, Cw*0821. Tissue Antigens. 2009 74:261-2.
- Roman A, Cervera I, Herraiz MA, Vidart J, Martinez-Laso J. A new allele, HLA-G*01010106, with changes in intron 2. Tissue Antigens. 2009 74:270-1.
- Chu CC, Lee HL, Lin M. A novel HLA-DRB1 allele, DRB*090202, is identified in a Taiwanese family. Tissue Antigens. 2009 74:262-3.
- Kim YH, Kang YM, Lee GE, Cho YS. HLA-DRB1*0908, a new allele was identified by sequence-based typing in a Korean individual. Tissue Antigens. 2009 74:264-5.
- Gao SQ, Deng ZH, Xu YP. Identification of a novel HLA-DRB1*12 allele, DRB1*1218, in Chinese population. Tissue Antigens. 2009 74:265-7.
- Alaez C, Munguia A, Garcia D, Gomez K, Gorodezky C. DRB1*1532, a new DR15 allele, identified in a Mexican unrelated donor from Veracruz, Mexico. Tissue Antigens. 2009 74:267-8.
- Moonsamy P, Bonella P, Goodwin G, Dolan L, Erlich HA. The identification of a new HLA-DPB1 allele (*1302) in one family and the detection of a recombination event between the DR and the DQ regions in another Caucasian T1DGC family. Tissue Antigens. 2009 74:268-70.
