Nomenclature for Factors of the HLA System

December 2008

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the November 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

The sequence previously named as DRB1*1171 has now been shown to be a correction of the DRB1*110201 allele sequence, as such the name DRB1*1171 has now been abandoned.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*0133 BY00386 FJ517146 Carolyn K Hurley, Washington DC, USA
A*030110 BY00387 FJ517145 Carolyn K Hurley, Washington DC, USA
A*0346 BY00374 FJ464348 Carolyn K Hurley, Washington DC, USA
A*1140 BY00385 FJ517147 Carolyn K Hurley, Washington DC, USA
A*2497 BY00373 FJ464349 Carolyn K Hurley, Washington DC, USA
A*2508 By00377 FJ464345 Carolyn K Hurley, Washington DC, USA
A*260107 LUMC-A56 FM945329 Jacqy DH Anholts, Leiden, The Netherlands
A*2919 BY00367 FJ464355 Carolyn K Hurley, Washington DC, USA
A*3028 BY00378 FJ464344 Carolyn K Hurley, Washington DC, USA
A*3124 BY00372 FJ464350 Carolyn K Hurley, Washington DC, USA
A*3218 BY00370 FJ464352 Carolyn K Hurley, Washington DC, USA
A*3218 BY00371 FJ464351 Carolyn K Hurley, Washington DC, USA
A*3323 BY00376 FJ464346 Carolyn K Hurley, Washington DC, USA
A*6845 BY00368 FJ464354 Carolyn K Hurley, Washington DC, USA
A*6846 BY00390 FJ517142 Carolyn K Hurley, Washington DC, USA
A*9253 BY00375 FJ464347 Carolyn K Hurley, Washington DC, USA
A*9254 BY00388 FJ517144 Carolyn K Hurley, Washington DC, USA
A*9255 BY00389 FJ517143 Carolyn K Hurley, Washington DC, USA
A*9256 BY00391 FJ517141 Carolyn K Hurley, Washington DC, USA
B*2745 Henan-13 FJ411059 Bowei Zhang, Zhengzhou, China
B*4094 LUMC-B40 FM945330 Jacqy DH Anholts, Leiden, The Netherlands
Cw*04010103 08009370 FJ515899 Yunping Xu, Shenzhen, China
Cw*05010102 SSTO BX243810 Stephan Beck, London, United Kingdom
Cw*0523 FRFLY15266 FM865852 Anne Dormoy, Strasbourg, France
G*010117 BCCR-773,
BCCR-1502
FJ460464 Michel Roger, Montreal, Canada
G*010118 BCCR-991 FJ469162 Michel Roger, Montreal, Canada
G*010119 Rog338,
Rog342,
Rog366,
Rog425
FJ464336 Michel Roger, Montreal, Canada
G*010405 Rog482,
Rog500,
Rog504
FJ464335 Michel Roger, Montreal, Canada
DRB1*0478 SZGSQ2 FJ547092 Su-Qing Gao, Shenzhen, China
DRB1*111302 97708 FM878944 Juergen Enczmann, Duesseldorf, Germany
DRB1*1218 SZK1 FJ481086 Su-Qing Gao, Shenzhen, China
DRB3*0224 W153 FJ515276 Erik Rozemuller, Utrecht, The Netherlands
DRB3*030103 THAI742 FJ515277 Erik Rozemuller, Utrecht, The Netherlands
DPB1*2402 191849 FM883600 Klaus Witter, München, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*0287 BY00382 FJ464340 Carolyn K Hurley, Washington DC, USA
A*1117 BY00379 FJ464343 Carolyn K Hurley, Washington DC, USA
A*2495 BY00363 FJ358709 Carolyn K Hurley, Washington DC, USA
A*3118 BY00381 FJ464341 Carolyn K Hurley, Washington DC, USA
A*3217 BY00369 FJ464353 Carolyn K Hurley, Washington DC, USA
A*7408 BY00383 FJ464339 Carolyn K Hurley, Washington DC, USA
A*9246 BY00384 FJ464338 Carolyn K Hurley, Washington DC, USA
B*4442 BT00380 FJ464342 Carolyn K Hurley, Washington DC, USA
G*010112 SSTO BX247949 Stephan Beck, London, United Kingdom
DRB1*0474 FFM5175 FM886832 Veronika Brixner, Frankfurt/Main, Germany
DRB1*110201 72393 FM209426 Juergen Enczmann, Duesseldorf, Germany
DPB1*1701 UCLA0584 FM882212 Klaus Witter, München, Germany

Table 3: Recently Published Sequences


Sequence References
A*1135 (1)
A*2486N (2)
A*9250 (3)
B*3572 (4)
B*370103 (4)
B*3714 (5)
B*4076 (6)
B*4081 (7)
B*4617 (8)
B*580102 (9)
B*9509 (4)
Cw*0222 (10)
Cw*0434 (10)
Cw*0436 (11)
DRB1*0462 (4)
DRB1*1157 (4)
DRB1*1167 (12)
DRB1*1478 (13)
DRB1*150204 (4)
DRB3*010105 (14)
DRB3*0112 (14)
DRB3*0113 (14)
DPA1*010602 (15)
MICA*054 (16)
MICA*056 (16)

References

  1. Han SH, Jung SM, Park SR, Chung SY, Han H. Identification of a new HLA-A*11 allele, HLA-A*1135, by sequence-based typing in Korean individual. Tissue Antigens. 2009 73:62-3.
  2. Yan LX, Zhu FM, Zhang W, He YM, He JJ. Full-length sequence of a novel null allele, HLA-A*2486N. Tissue Antigens. 2009 73:63-5.
  3. Canossi A, Del Beato T, Liberatore G, Papola F, Adorno D. Identification of the novel HLA-A*9250 allele by sequence-based typing in a Caucasian bone marrow donor from Italy. Tissue Antigens. 2009 73:65-7.
  4. Lazaro AM, Hwang WY, Yeoh AE, Ng J, Posch PE. Characterization of new HLA-B and -DRB1 alleles from Singapore. Tissue Antigens. 2009 73:75-6.
  5. Emmerich F, Schonemann C, Diederich G, Salama A. Haplotype-specific sequencing reveals a novel HLA-B*37 allele, B*3714. Tissue Antigens. 2009 73:67.
  6. Li SY, Xie JH, Dong L, Yan LN, Yuan YH. Identification of the novel allele HLA-B*4076 by sequence-based typing in a Chinese individual. Tissue Antigens. 2009 73:68-9.
  7. Zou HY, Li Z, Cheng LH, Wang DM, Deng ZH. Identification of a new HLA-B*40 allele, HLA-B*4081, in a Chinese individual. Tissue Antigens. 2009 73:70-2.
  8. Sohn YH, Oh HB, Heo YS, Kwon OJ. Structural aspects of B*4617 molecule, a novel HLA-B*46 allele identified by sequence-based typing. Tissue Antigens. 2009 73:72-4.
  9. Zhu FM, Zhang W, He J, Yan LX. Identification of the novel allele HLA-B*580102 by sequence-based typing in a Chinese individual. Tissue Antigens. 2009 73:74-5.
  10. Johnson J, Street J, Hammond L, Iley C, Darke C. Two new HLA-C alleles: Cw*0222 and Cw*0434. Tissue Antigens. 2009 73:76-8.
  11. Lim J, Kim Y, Cho B, Chung NG, Bok JN. A novel HLA-Cw*0436 allele identified by haplotype-specific extraction and sequence-based typing. Tissue Antigens. 2009 73:78-9.
  12. Testi M, Lai S, Alba F, Andreani M, Carcassi C. Identification of a new HLA DRB1 allele (HLA-DRB1*1167) in a potential hematopoietic stem cell donor from Iraqi Kurdistan. Tissue Antigens. 2009 73:80-1.
  13. Han SH, Jung SM, Park SR, Chung SY, Han H. Identification of a new HLA-DRB1*14 variant, HLA-DRB1*1478, in a Korean individual. Tissue Antigens. 2009 73:81-3.
  14. Lee KW, Jung YA. Description of three novel HLA-DRB3 alleles: DRB3*010105, DRB3*0112 and DRB3*0113. Tissue Antigens. 2009 73:83-4.
  15. Peterson TA, Luo M, Mao X, Brunham RC, Plummer FA. Identification of a novel DPA1 allele, DPA1*010602, in an East African population. Hum Immunol. 2008 69:885-6.
  16. Cox ST, Stephens HA, Fernando R, Grant J, Madrigal JA, Little AM. Two novel MICA alleles, MICA*054 and MICA*056. Tissue Antigens. 2009 73:85-7.