Nomenclature for Factors of the HLA System

July 2008

Compiled by Steven GE Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the May 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author
A*0340 07216728 EU445574 Andrea Vigh, Ulm, Germany
A*0341 NT00997 EU872416 Carolyn K Hurley, Washington DC, USA
A*1137 07219762 EU445573 Andrea Vigh, Ulm, Germany
A*3123 ROOS4408AN FM177143 Ann-Margaret Little, London, United Kingdom
A*6608 HUAF247AN FM177142 Ann-Margaret Little, London, United Kingdom
A*9249 07215356 EU445572 Andrea Vigh, Ulm, Germany
A*9250 G048 EU812119 Angelica Canossi, L’Aquila, Italy
B*0767N MHHI-602067 AM920503 Peter Horn, Hannover, Germany
B*080106 070685 FM179947 Martin Danzer, Linz, Austria
B*0837 070878 FM179948 Martin Danzer, Linz, Austria
B*4617 34151259a EU871946 Oh-Joong Kwon, Seoul, South Korea
B*5533 07218217 EU445575 Andrea Vigh, Ulm, Germany
B*9550 317529-B15new AM980457 Tatiana Lebedeva, Dedham, USA
Cw*010206 080549 FM179946 Martin Danzer, Linz, Austria
Cw*0435 08200445 EU445578 Andrea Vigh, Ulm, Germany
Cw*0436 08041801 EU874896 Jihyang Lim, Seoul, South Korea
Cw*0520 303308-C5new AM980450 Tatiana Lebedeva, Dedham, USA
Cw*0618 07215243 EU445577 Andrea Vigh, Ulm, Germany
Cw*0758 BY00342 EU847250 Carolyn K Hurley, Washington DC, USA
Cw*0759 LUMC-C52 FM178479 Jacqy DH Anholts, Leiden, The Netherlands
Cw*0760 NT01002 EU872421 Carolyn K Hurley, Washington DC, USA
Cw*0761N 249317 AM980449 Tatiana Lebedeva, Dedham, USA
Cw*0762 071572 FM179945 Martin Danzer, Linz, Austria
Cw*0817 C139470 EU850411 Robert Endres, Tempe, USA
Cw*0818 306061-C8new AM980453 Tatiana Lebedeva, Dedham, USA
Cw*1410 NT00989 EU847248 Carolyn K Hurley, Washington DC, USA
Cw*1612 07217636 EU445576 Andrea Vigh, Ulm, Germany
DRB1*010108 51202 FM162178 Juergen Enczmann, Duesseldorf, Germany
DRB1*010109 28249 FM196527 Juergen Enczmann, Duesseldorf, Germany
DRB1*010205 115664 FM162176 Juergen Enczmann, Duesseldorf, Germany
DRB1*070103 CTM0000474 EU835481 Antonio Balas, Madrid, Spain
DRB1*100103 18794 FM162177 Juergen Enczmann, Duesseldorf, Germany
DRB1*111002 LA177441 FM179954 Francesca Poli, Milano, Italy
DRB1*1387 30195 FM196526 Juergen Enczmann, Duesseldorf, Germany
DRB1*1482 45161 FM196525 Juergen Enczmann, Duesseldorf, Germany
DRB3*010105 B07-2819,
B07-1737,
BM-4028, H-05046
EU873151 Kyung Wha Lee, Anyang City, South Korea
DRB3*0112 B07-1953 EU873152 Kyung Wha Lee, Anyang City, South Korea
DRB3*0113 B07-2896 EU873153 Kyung Wha Lee, Anyang City, South Korea
DQB1*0323 MHHI-633843 FM200854 Rainer Blasczyk, Hannover, Germany
DQB1*061402 08201310 EU445579 Andrea Vigh, Ulm, Germany

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*240202 NT00994 EU872413 Carolyn K Hurley, Washington DC, USA
A*2405 NT00995 EU872414 Carolyn K Hurley, Washington DC, USA
A*3204 NT00998 EU872418 Carolyn K Hurley, Washington DC, USA
A*6831 BY00175 EU847252 Carolyn K Hurley, Washington DC, USA
A*7406 NT00996 EU872415 Carolyn K Hurley, Washington DC, USA
B*5414 K19992 AB368299 Etsuko Maruya, Kyoto, Japan
Cw*033801 NT00999 EU872417 Carolyn K Hurley, Washington DC, USA
Cw*0413 NT00993 EU847244 Carolyn K Hurley, Washington DC, USA
Cw*0510 NT01000 EU972419 Carolyn K Hurley, Washington DC, USA
Cw*0604 NT01001 EU872420 Carolyn K Hurley, Washington DC, USA
Cw*0606 NT00988 EU847249 Carolyn K Hurley, Washington DC, USA
Cw*0710 NT00987 EU847251 Carolyn K Hurley, Washington DC, USA
Cw*0719 NT00991 EU847246 Carolyn K Hurley, Washington DC, USA
Cw*0751 NT01004 EU872423 Carolyn K Hurley, Washington DC, USA
Cw*0806 NT00990 EU847247 Carolyn K Hurley, Washington DC, USA
Cw*1219 NT01003 EU872422 Carolyn K Hurley, Washington DC, USA
Cw*1404 NT00992 EU847245 Carolyn K Hurley, Washington DC, USA
DRB1*1424 TER411 FM179681 Anne Dormoy, Strasbourg, France

Table 3: Recently Published Sequences


Sequence References
A*9213N (1)
B*3713 (2)
B*4085 (3)
B*4086 (4)
Cw*040105 (5)
DRB1*1168 (6)
DRB1*131403 (6)

References

  1. Hammond L, Limmer M, Dyer CR, Rantes CH, Dunn PP. A new HLA-A*02 null allele, HLA-A*9213N. Tissue Antigens. 2008 72:176-7.
  2. Lin W, Shan X, Zhang Z. Identification of a novel HLA-B allele, HLA-B*3713, in a Chinese individual. Tissue Antigens. 2008 72:177-9
  3. Han SH, Heo YA, Kwon OJ, Lee A, Lee KR. A new HLA-B*40 allele, HLA-B*4085, identified by sequence-based typing in the Korean population. Tissue Antigens. 2008 72:179-80
  4. Zhu C, Zhang Y, Nie X, He W, Fang Y, Liu Y. A novel HLA-B*40 allele, B*4086, was identified by sequence-based typing in a Chinese donor. Tissue Antigens. 2008 72:181-2
  5. Deng ZH, Yang BC, Zhou HY, Wang DM, Chen SW, Xu AL. Characterization and sequence analysis of the novel HLA-Cw*040105 allele in a Chinese Uygur individual. Tissue Antigens. 2008 72:182-4
  6. Tavoularis S, E. R, Sayer D. identification of two novel DRB1 alleles. Tissue Antigens. 2008 71:359