Nomenclature for Factors of the HLA System

April 2004

Compiled by Steven GE Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the March 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell Identification Accession Number Submitting Author
A*112402 JMDP01K007 AB430468 Kenji Tadokoro, Tokyo, Japan
A*240216 JMDP01K008 AB434096 Kenji Tadokoro, Tokyo, Japan
A*2636 CHA06-0792 EU557970 HyeYoung Seong, Seongnam, South Korea
A*2636 016149 EU627183 Jianping Li, Shenyang, Liaoning, China
A*2637 0200800714 AM981205 Silvia Ulrich, Graz, Austria
A*3025 0004123 EU623422 Francisco de Paula Sanchez Gordo, Malaga, Spain
A*9242 JMDP01K002 AB427094 Kenji Tadokoro, Tokyo, Japan
A*9243 JMDP01K003 AB429008 Kenji Tadokoro, Tokyo, Japan
A*9244 JMDP01K004 AB429218 Kenji Tadokoro, Tokyo, Japan
A*9245 BJ54 EU649706 Zhixin Zhang, Beijing, China
B*0765 LUMC-B47 AM946388 Jacqy DH Anholts, Leiden, The Netherlands
B*1322 BY00309 EU643607 Carolyn K Hurley, Washington DC, USA
B*1409 BY00313 EU643603 Carolyn K Hurley, Washington DC, USA
B*152703 SZ-13 EU617016 Hong-Yan Zou, Shenzhen, China
B*2743 BY00318 EU643598 Carolyn K Hurley, Washington DC, USA
B*3589 VTIS163461 EU589203 Maude Phipps, Kuala Lumpur, Malaysia
B*3590 BY00316 EU643600 Carolyn K Hurley, Washington DC, USA
B*3591 BY00319 EU643597 Carolyn K Hurley, Washington DC, USA
B*390105 BY00306 EU643610 Carolyn K Hurley, Washington DC, USA
B*4089 DEDKM740290 AM980943 Anne Dormoy, Strasbourg, France
B*4090 BY00304 EU643612 Carolyn K Hurley, Washington DC, USA
B*4509 MO-19507 EU517717 Gisele Rampim, Sao Paulo, Brazil
B*5156 BY00305 EU643611 Carolyn K Hurley, Washington DC, USA
B*5213 BY00312 EU643604 Carolyn K Hurley, Washington DC, USA
B*5531 BY00317 EU643599 Carolyn K Hurley, Washington DC, USA
B*5717 BY00315 EU643601 Carolyn K Hurley, Washington DC, USA
B*5818 BY00310 EU643605 Carolyn K Hurley, Washington DC, USA
B*9547 BY00314 EU643602 Carolyn K Hurley, Washington DC, USA
Cw*0121 SZ-12 EU617015 Zhen Li, Shenzhen, China
Cw*0755N MHHZ-00020178 AM945965 Rainer Blasczyk, Hannover, Germany
Cw*0756 BJ53 EU594580 Zhixin Zhang, Beijing, China
DRB1*0474 SI772 AM947655 Jean-Marie Tiercy, Geneva, Switzerland
DRB1*0907 AS2054 AM947068 Xiang Liu, Beijing, China
DRB1*1478 HistoCB69685 EU588391 Hoon Han, Seoul, South Korea
DRB1*1479 NT00788 EU643616 Carolyn K Hurley, Washington DC, USA
DQB1*0322 175842 AM944346 Klaus Witter, München, Germany
DQB1*060104 BJ52 EU594579 Zhixin Zhang, Beijing, China

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author
A*0260 BRABRI EU580406 Youri Serov, Indianapolis, USA
A*0276 JMDP01K005 AB429497 Kenji Tadokoro, Tokyo, Japan
A*1113 JMDP01K006 AB430331 Kenji Tadokoro, Tokyo, Japan
B*0742 4229311 AM931289 Laura Hammond, Auckland, New Zealand
B*1825 BY00321 EU643595 Carolyn K Hurley, Washington DC, USA
B*356802 BY00296 EU557367 Carolyn K Hurley, Washington DC, USA
B*4059 BY00307 EU643609 Carolyn K Hurley, Washington DC, USA
B*4064 BY00320 EU643596 Carolyn K Hurley, Washington DC, USA
B*4209 BY00308 EU643608 Carolyn K Hurley, Washington DC, USA
B*5155 BY00290 EU557368 Carolyn K Hurley, Washington DC, USA
B*5315 BY00311 EU643606 Carolyn K Hurley, Washington DC, USA
DRB1*0441 NT00791 EU643613 Carolyn K Hurley, Washington DC, USA
DRB1*1121 NT00790 EU643614 Carolyn K Hurley, Washington DC, USA
DRB1*1304 40267 AM949862 Thibaut Gervais, Brussels, Belgium
DRB1*1474 39756 AM982721 Thibaut Gervais, Brussels, Belgium
DRB1*1524 NT00789 EU643615 Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences


Sequence References
A*0339 (1)
A*240215 (2)
A*310103 (3)
A*9216 (4)
A*9237 (5)
B*0745 (6)
B*0826 (6)
B*0828 (7)
B*0831 (6)
B*2731 (6)
B*350106 (6)
B*350402 (6)
B*3566 (6)
B*356801 (6)
B*370102 (6)
B*3711 (6)
B*380102 (6)
B*3813 (6)
B*3935 (6)
B*3939 (6)
B*4108 (6)
B*4209 (6)
B*4444 (6)
B*4448 (6)
B*480302 (6)
B*4815 (6)
B*5140 (6)
B*5411 (8)
B*5523 (6)
B*5529 (9)
B*5617 (6)
B*570103 (6)
B*5710 (6)
B*9505 (6)
B*9510 (6)
B*9519 (6)
B*9531 (3)
G*010113 (10)
DRB1*116502 (11)
DQB1*0634 (12)

References

  1. Balas A, Garcia-Sanchez F, Bustamante L, Vicario JL. New HLA-A allele, A*0339, identified in a Spanish patient. Tissue Antigens. 2008 71:478.

  2. Emmerich F, Schonemann C, Hartmann S, Salama A. Identification of the novel HLA-A*240215 allele by haplotype-specific sequencing. Tissue Antigens. 2008 71:481-2.
  3. Frison S, Longhi E, Andreini E, Poli F, Scalamogna M. Characterization of two novel HLA class I alleles: HLA-A*310103 and HLA-B*9531. Int J Immunogenet. 2008 35:193-5.
  4. Jiang W, Zhang JQ, Pan N, Xu JH, Xie W. Identification of a novel HLA-A allele, HLA-A*9216. Tissue Antigens. 2008 71:479-80. Kelsch R, Binder TM, Sibrowski W. Identification of the novel allele HLA-A*9237 in peripheral blood of a bone marrow donor. Tissue Antigens. 2008 71:480-1.
  5. Lazaro AM, Xiao Y, Cao K, et al. Expanding diversity at the HLA-B locus: 28 novel HLA-B alleles. Tissue Antigens. 2008 71:471-4.
  6. Brixner V, Richter R, Bader P, Seifried E, Seidl C. A new HLA-B*08 allele, HLA-B*0828, found in two voluntary stem cell donors. Tissue Antigens. 2008 71:482-3.
  7. Yan LN, Li SY, Dong Z, et al. Identification of a novel HLA-B*54 allele, B*5411, by sequence-based typing in a Chinese individual. Tissue Antigens. 2008 71:484-5.
  8. Emmerich F, Schonemann C, Galicki L, Salama A. Identification of a novel HLA-B allele, HLA-B*5529, by haplotype-specific sequencing. Tissue Antigens. 2008 71:486.
  9. 1Kang H, Yun HS, Lee JK, Kwack K. Identification of a novel HLA-G allele, HLA-G*010113, in a Korean individual. Tissue Antigens. 2008 71:492-4.
  10. Serov Y, Hommel-Berrey G, Lobashevsky A. Identification of a novel HLA-DRB1 allele, DRB1*116502, by sequence-based typing in an African-American individual. Tissue Antigens. 2008 71:489-90.
  11. Witter K, Albert T, Zahn R, Kauke T. HLA-DQB1*0634, a novel DQB1 allele found by high-resolution HLA typing of a sibling pair for potential bone marrow transplantation. Tissue Antigens. 2008 71:486-8.