Nomenclature for Factors of the HLA System

September 2006

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the August 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

The sequence B*150105 was recently shown to be in error and has now been renamed B*9520, the name B*150105 has now been abandoned.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author References
A*0325 NT00682 DQ987874 Carolyn Hurley, Washington, USA  
A*2506 92313 DQ902552 Mary Sue Leffell, Baltimore, USA  
A*9204 90340 DQ902554 Mary Sue Leffell, Baltimore, USA  
B*151103 BY00132 DQ924379 Carolyn Hurley, Washington, USA  
B*370104 TBC60885 AB261695 Masahiro Satake, Tokyo, Japan  
B*4069 BY00135 DQ984197 Carolyn Hurley, Washington, USA  
B*440204 NT00681 DQ987875 Carolyn Hurley, Washington, USA  
B*4449 K101008 AM396519 Ciaran Dunne, Dublin, Eire  
B*460102 K9505035 DQ985229 Marie Lin, Taipei, Taiwan  
B*5144N 92426 DQ902553 Mary Sue Leffell, Baltimore, USA  
B*5145 BY00130 DQ924380 Carolyn Hurley, Washington, USA  
B*5409 BY00134 DQ984200 Carolyn Hurley, Washington, USA  
B*5523 BY00129 DQ924383 Carolyn Hurley, Washington, USA  
B*5524 K102665 AM396518 Ciaran Dunne, Dublin, Eire  
B*5618 SZ-5 EF016753 Zhen Li, Shenzhen, China  
B*5711 K104827 AM295982 Ciaran Dunne, Dublin, Eire  
B*9520 TBC183836 AB183461 Masahiro Satake, Tokyo, Japan  
B*9521 K33818 DQ912834 Marie Lin, Taipei, Taiwan  
Cw*010204 37109 AM397243 Thibaut Gervais, Brussels, Belgium  
Cw*0332 NT00678 DQ984199 Carolyn Hurley, Washington, USA  
Cw*0742 CTM-0694504 DQ983641 Antonio Balas, Madrid, Spain  
Cw*1609 E355 DQ916147 Angelica Canossi, L'Aquila, Italy  
K*01010101 RPCI5 AB023056 Hidetoshi Inoko, Isehara, Japan (1)
K*01010101 PGF AL671277 Stephan Beck, Cambridge, UK (2)
K*01010102 COX AL645935 Stephan Beck, Cambridge, UK (2)
K*01010102 APD CR759913 Stephan Beck, Cambridge, UK  
K*01010103 QBL AL845454 Stephan Beck, Cambridge, UK (3)
K*01010104 SSTO BX005091 Stephan Beck, Cambridge, UK  
K*0102 BOLETH AF055066 Annie Hampe, Rennes, France (4)
K*0102 DBB CR388220 Stephan Beck, Cambridge, UK  
K*0103 CGM1 AC004203 Daniel E Geraghty, Seattle, USA  
K*0103 MOU CR392333 Stephan Beck, Cambridge, UK  
K*0103 SPLEN2 AK092921 Henrik Yudate, Chiba, Japan (5)
L*01010101 DBB CR388382 Stephan Beck, Cambridge, UK  
L*01010101 SSTO BX248419 Stephan Beck, Cambridge, UK  
L*01010102 RPCI5 AB014088 Hidetoshi Inoko, Isehara, Kanagawa, Japan (1)
L*01010102 QBL AL844220 Stephan Beck, Cambridge, UK (3)
L*01010103 PGF AL662782 Stephan Beck, Cambridge, UK (2)
L*010102 COX AL662832 Stephan Beck, Cambridge, UK (2)
L*0102 CGM1 AC004191 Daniel E Geraghty, Seattle, USA  
L*0102 MOU BX927189 Stephan Beck, Cambridge, UK  
DQB1*030103 CHAST03 AM259941 Valerie Dubois, Lyon, France  
DQB1*0319 143576 AM400970 Klaus Witter, München, Germany  
DQB1*0505 HONO-05 AM259942 Valerie Dubois, Lyon, France  
DRB1*0116 2006-038-07126 AM286281 Brian Norwell, Burlington, USA  
DRB1*0906 NT00680 DQ987876 Carolyn Hurley, Washington, USA  

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author References
A*02010101 BOLETH AF055066 Annie Hampe, Rennes, France (4)
A*2428 TBC60703 AB261694 Masahiro Satake, Tokyo, Japan  
B*0748 BY00131 DQ924381 Carolyn Hurley, Washington, USA  
B*350402 NT00679 DQ984201 Carolyn Hurley, Washington, USA  
B*4042 NT00677 DQ984198 Carolyn Hurley, Washington, USA  
B*5136 BY00133 DQ924382 Carolyn Hurley, Washington, USA  
F*01010108 BOLETH AF055066 Annie Hampe, Rennes, France (4)
G*01010201 BOLETH AF055066 Annie Hampe, Rennes, France (4)
DQB1*060302 KN166757 AM400237 Klaus Witter, München, Germany  

Table 3: Recently Published Sequences


Sequence References
A*010104 (6)
A*0279 (7)
A*1126 (8)
A*2464 (9)
B*070204 (15)
B*0738 (15)
B*0742 (15)
B*0821 (15)
B*0829 (10)
B*2730 (11)
B*130202 (15)
B*1312 (15)
B*1575 (15)
B*1598 (15)
B*1599 (15)
B*270507 (15)
B*2728 (15)
B*350104 (15)
B*3556 (12)
B*3558 (15)
B*3811 (15)
B*3931 (15)
B*3932 (15)
B*4045 (15)
B*4107 (15)
B*420501 (15)
B*4420 (12)
B*4427 (12)
B*4812 (15)
B*510106 (15)
B*5520 (15)
B*5612 (13)
B*5616 (15)
Cw*0730 (14)
Cw*0736 (10)

References

  1. Shiina T, Tamiya G, Oka A, et al.: Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region. Proc Natl Acad Sci U S A 1999 96:13282-7.
  2. Stewart CA, Horton R, Allcock RJ, et al.: Complete MHC haplotype sequencing for common disease gene mapping. Genome Res 2004 14:1176-87.
  3. Traherne JA, Horton R, Roberts AN, et al.: Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History. PLoS Genet 2006 2:e9.
  4. Hampe A, Coriton O, Andrieux N, et al.: A 356-Kb sequence of the subtelomeric part of the MHC Class I region. DNA Seq 1999 10:263-99.
  5. Yudate HT, Suwa M, Irie R, et al.: HUNT: launch of a full-length cDNA database from the Helix Research Institute. Nucleic Acids Res 2001 29:185-8.
  6. Yu M, Hall JE, 3rd, Hartman K, et al.: A novel human leukocyte antigen-A*01 allele, A*010104, identified by polymerase chain reaction-sequence-based typing in a Caucasian hematopoietic stem cell donor. Tissue Antigens 2006 68:263.
  7. Liu F, Wang S, Ye Y, Zhang H, Zhang Y, Chen W: Identification and functional perspective of a novel HLA-A allele: A*0279. Immunogenetics 2006 58:339-46.
  8. Chu CC, Lee HL, Lin M: A*1126: a novel HLA-A11 variant identified by sequence-based typing method. Tissue Antigens 2006 68:263-5.
  9. Lim S, Chen SH, Ren EC: Identification of a new HLA-A*2464 variant in the Singapore Chinese population. Tissue Antigens 2006 68:265-7.
  10. Balas A, Alonso-Nieto M, Garcia-Sanchez F, Vicario JL: Characterization of two new human leukocyte antigen class I alleles B*0829 and Cw*0736. Tissue Antigens 2006 68:267-8.
  11. Vidan-Jeras B, Kunilo S, Fae I, Kandus A, Fischer GF: A novel HLA-B*2730 allele found in a Slovene patient affected with IgA nephropathy. Int J Immunogenet 2006 33:371-3.
  12. Voorter CE, Gervais T, Mulkers EM, Latinne D, van den Berg-Loonen EM: Identification of the new allele B*3556 and extension of the sequences of B*4420 and B*4427. Tissue Antigens 2006 68:253-6.
  13. Chu CC, Chang HL, Chen ZS, Lee HL, Lin M: A novel HLA-B allele, B*5612, identified by sequence-based typing method. Int J Immunogenet 2006 33:343-5.
  14. Bontadini A, Delfino L, Manfroi S, et al.: Characterization of a new HLA-C allele in a Caucasian Italian family by sequence-based typing: HLA-Cw*0730. Tissue Antigens 2006 68:268-9.
  15. Lazaro AM, Cao K, Masaberg C, et al.: Twenty-three novel HLA-B alleles identified during intermediate-resolution testing. Tissue Antigens 2006 68:245-8.