Nomenclature for Factors of the HLA System

May 2006

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the April 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://www.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting Author References
A*030105 Z-00023171 AM261460 Rainer Blasczyk, Hannover, Germany  
A*0324 T05-915 DQ403156,
DQ403157
Rajeshree Patel, London, UK  
A*2464 BM05-322,
BM05-316
DQ523225 Ee-Chee Ren, Singapore, Singapore  
A*2631 4497370 DQ530236 Antonio Balas, Madrid, Spain  
A*9203 K9503143 DQ485737 Marie Lin, Taipei, Taiwan  
B*0750 FFM1840AN AM236590 Ann-Margaret Little, London, UK  
B*350106 BY00106 DQ514598 Carolyn K. Hurley, Washington, USA  
B*3814 UA-2005-TP-3911 AM261745 Mats Bengtsson, Uppsala, Sweden  
B*4067 TBC35457 AB257503 Masahiro Satake, Tokyo, Japan  
B*5142 604706 AM260212 Mats Bengtsson, Uppsala, Sweden  
B*5210 0601407 DQ537945 Cynthia Moehlenkamp, Albuquerque, USA  
B*5617 BY00105 DQ514600 Carolyn K. Hurley, Washington, USA  
B*5902 TBC60261 AB257504 Masahiro Satake, Tokyo, Japan  
Cw*0215 US-1-0446-2875-8 AM260635 Alois Wlpl, Martinsried, Germany  
Cw*030305 BY00111 DQ514597 Carolyn K. Hurley, Washington, USA  
Cw*0421 NT00664 DQ525630 Carolyn K. Hurley, Washington, USA  
Cw*0514 NT00667 DQ535033,
DQ535035
Carolyn K. Hurley, Washington, USA  
Cw*06020102 PAT541 DQ249182 Philip Stuart, Ann Arbor, USA (1)
Cw*0739 BY00112 DQ514599 Carolyn K. Hurley, Washington, USA  
DPB1*1902 BS169 DQ485789 Dimitri Monos, Philadelphia, USA  
DRB1*0459 NT00660 DQ525631 Carolyn K. Hurley, Washington, USA  
DRB1*115402 BY00110 DQ514604 Carolyn K. Hurley, Washington, USA  
DRB1*1156 NT00666 DQ525634 Carolyn K. Hurley, Washington, USA  
DRB1*1157 NT00668 DQ535034 Carolyn K. Hurley, Washington, USA  
DRB1*1215 KS9504263 DQ533486 Marie Lin, Taipei, Taiwan  
DRB1*1373 BY00108 DQ514602 Carolyn K. Hurley, Washington, USA  
DRB1*1460 DR14VEDA AM259285 Irma Joosten, Nijmegen, The Netherlands  
DRB1*1461 BJ003 DQ494324 Zhixin Zhang, Beijing, China  
DRB1*150106 BY00109, BY00107 DQ514603,
DQ514601
Carolyn K. Hurley, Washington, USA  
DRB1*1520 DR15donnew AM258966 Irma Joosten, Nijmegen, The Netherlands  
DRB1*1521 BY00113 DQ525633 Carolyn K. Hurley, Washington, USA  
DRB1*1522 NT00665 DQ525632 Carolyn K. Hurley, Washington, USA  

Table 2: Confirmatory Sequences


Sequence Cell Identification Accession Number Submitting Author References
A*2452 BY00115 DQ535036 Carolyn K. Hurley, Washington, USA  
A*260101 QBL AL845454 Stephan Beck, Cambridge, UK (2)
B*070201 PAT541 DQ249181 Philip Stuart, Ann Arbor, USA (1)
B*080101 PAT135 PAT144 DQ249172,
DQ249174
Philip Stuart, Ann Arbor, USA (1)
B*140201 PAT135 PAT218 DQ249173,
DQ249176
Philip Stuart, Ann Arbor, USA (1)
B*15010101 PAT218 DQ249177 Philip Stuart, Ann Arbor, USA (1)
B*380101 PAT144 PAT495 DQ249175,
DQ249179
Philip Stuart, Ann Arbor, USA (1)
B*4446 JUCH70904AN AM236591 Ann-Margaret Little, London, UK  
B*5001 PAT541 DQ249182 Philip Stuart, Ann Arbor, USA (1)
B*570101 PAT495 DQ249180 Philip Stuart, Ann Arbor, USA (1)
Cw*0210 MAN527 Z96924 Steven G.E. Marsh, London, UK  
Cw*030401 PAT218 DQ249177 Philip Stuart, Ann Arbor, USA (1)
Cw*06020101 PAT495 DQ249180 Philip Stuart, Ann Arbor, USA (1)
Cw*070101 PAT135 PAT144 DQ249172,
DQ249174
Philip Stuart, Ann Arbor, USA (1)
Cw*07020103 PAT541 DQ249181 Philip Stuart, Ann Arbor, USA (1)
Cw*0802 PAT135 PAT218 DQ249173,
DQ249176
Philip Stuart, Ann Arbor, USA (1)
Cw*120301 PAT144, PAT495 DQ249175,
DQ249179
Philip Stuart, Ann Arbor, USA (1)
DQA1*050101 QBL AL935026 Stephan Beck, Cambridge, UK (2)
DRA*0101 QBL AL935032 Stephan Beck, Cambridge, UK (2)
DRB1*030101 QBL AL929581 Stephan Beck, Cambridge, UK (2)
DRB1*1331 NT00661 DQ525629 Carolyn K. Hurley, Washington, USA  
E*01010101 QBL AL844213 Stephan Beck, Cambridge, UK (2)
G*01010201 QBL BX001005 Stephan Beck, Cambridge, UK (2)

Table 3: Recently Published Sequences


Sequence References
A*0290 (3)
B*270402 (4)
B*3936 (5)
B*4059 (6)
B*4814 (7)
Cw*0322Q (8)
DRB1*1370 (9)
MICA*00703 (10)
MICA*01802 (10)
MICA*053 (10)

References

  1. Nair RP, Stuart PE, Nistor I, et al.: Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet 2006 78:827-51.
  2. Traherne JA, Horton R, Roberts AN, et al.: Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History. PLoS Genet 2006 2:e9.
  3. Liu ML, Ye SH, Qi J, Liu S, Zhang Y: Identification of an HLA-A*02 allele variant (A*0290) in a Chinese donor. Tissue Antigens 2006 67:338-9.
  4. Jeong SM, Hur SS, Kwon OJ, Nah SY: A new HLA-B*27 allele, HLA-B*270402, identified by sequence-based typing. Tissue Antigens 2006 67:340-1.
  5. Yan LX, Zhu FM, Lv QF, Zhang W, He J: Identification of a novel HLA-B*39 allele, B*3936, by sequencing-based typing. Tissue Antigens 2006 67:341-2.
  6. Shan X, Gao G, He X, Wu G, Zhang Z: Identification of a novel HLA-B allele HLA-B*4059 in Chinese bone marrow donors. Tissue Antigens 2006 67:339-40.
  7. Liu ML, Qi J, Liu S, Zhang Y, Wei XQ: Identification of a novel HLA-B*48 allele, B*4814, in a Chinese marrow donor of Han descent. Tissue Antigens 2006 67:342-3.
  8. Middleton D, Meenagh A, Marsh SG, Martin J: A HLA-Cw*03 allele, Cw*0322Q with limited or no expression. Tissue Antigens 2006 67:343-5.
  9. Horn PA, Zingsem J, Eckstein R, Blasczyk R: Novel HLA-DRB1*1370 allele identified in a cord blood donor and her mother. Tissue Antigens 2006 67:345-7.
  10. Quiroga I, Sweeney D, Sutton PM, et al.: The identification of three novel MICA alleles by sequence-based typing. Tissue Antigens 2006 67:321-5.