Nomenclature for Factors of the HLA System

December 2017

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the November 2017 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


SequenceCell identificationAccession numberSubmitting author
A*02:01:01:28SYSU002MG571441,Riga Wu, Guangzhou, China
A*02:705HG00013510,HG00013511MG450946,MG450947,Histogenetics, Ossining, USA
A*02:70637864MG603049,Maria Loginova, Kirov, Russia
A*03:01:64HG00013505MG450938,Histogenetics, Ossining, USA
A*24:392RB001MG463105,Mary Krueger, Indianapolis, USA
A*24:393dentTMG571526,Chun-Ying Lin, Taipei, Taiwan
A*24:39441308MG652492,Maria Loginova, Kirov, Russia
A*25:46HG00013504MG450937,Histogenetics, Ossining, USA
A*29:02:22HG00013509MG450945,Histogenetics, Ossining, USA
A*29:110HG00013508MG450943,Histogenetics, Ossining, USA
A*29:11181177284 MG655229,Daniel Fuerst, Ulm, Germany
A*30:02:20HG00013507MG450940,Histogenetics, Ossining, USA
A*30:12793107603MG592697,Daniel Fuerst, Ulm, Germany
A*31:01:02:08AN00598LT906363,Steven GE Marsh, London, United Kingdom
A*31:133HG00013562MG450944,Histogenetics, Ossining, USA
A*32:107HG00013561MG450942,Histogenetics, Ossining, USA
A*33:137HG00013560MG450941,Histogenetics, Ossining, USA
A*66:29HG00013506MG450939,Histogenetics, Ossining, USA
A*68:17481175766MG592696,Daniel Fuerst, Ulm, Germany
B*13:108HG00013512MG450948,Histogenetics, Ossining, USA
B*14:5937351MG637404,Carles Serra-Pages, Barcelona, Spain
B*15:435SZ-174MG595995,Hong-Yan Zou, Shenzhen, China
B*18:05:01:02NT01659MG397153,Carolyn K Hurley, Washington DC, USA
B*18:18:01:02NT01704MG525288,Carolyn K Hurley, Washington DC, USA
B*18:37:02HR-3449251MG674187,Renata Zunec, Zagreb, Croatia
B*27:165HG00013516MG450955,Histogenetics, Ossining, USA
B*27:16684025397MG586092,Daniel Fuerst, Ulm, Germany
B*27:16796092886MG603739,Daniel Fuerst, Ulm, Germany
B*35:359Ca922MG571527,Chun-Ying Lin, Taipei, Taiwan
B*35:360HG00013567MG450957,Histogenetics, Ossining, USA
B*37:69HG00013515MG450954,Histogenetics, Ossining, USA
B*37:70HG00013564MG450952,Histogenetics, Ossining, USA
B*39:05:01:02NT01768bMG553951,Carolyn K Hurley, Washington DC, USA
B*39:14:01:02NT01754MG553992,Carolyn K Hurley, Washington DC, USA
B*40:20:01:02NT01767MG553949,Carolyn K Hurley, Washington DC, USA
B*41:54HG00013514MG450951,Histogenetics, Ossining, USA
B*44:02:48HG00013566MG450956,Histogenetics, Ossining, USA
B*44:03:41Cal27MG602224,Chun-Ying Lin, Taipei, Taiwan
B*44:15:01:02NT01771MG553953,Carolyn K Hurley, Washington DC, USA
B*44:210:02HG00013563MG450949,Histogenetics, Ossining, USA
B*51:2292730MG603050,Maria Loginova, Kirov, Russia
B*56:5560799393MG585356,Antonio Balas, Madrid, Spain
C*01:148HG00013521MG450965,Histogenetics, Ossining, USA
C*02:133HG00013522MG450966,Histogenetics, Ossining, USA
C*02:134HG00013571MG450967,Histogenetics, Ossining, USA
C*03:370HG00013519MG450963,Histogenetics, Ossining, USA
C*03:371HG00013572MG450969,Histogenetics, Ossining, USA
C*04:285HG00013527MG450973,Histogenetics, Ossining, USA
C*04:286JXZJ20170408005MG595744,Faming Zhu, Hangzhou, China
C*05:15717226573MG600409,Daniel Fuerst, Ulm, Germany
C*06:212HG00013524MG450970,Histogenetics, Ossining, USA
C*07:608HG00013517MG450960,Histogenetics, Ossining, USA
C*07:609HG00013520MG450964,Histogenetics, Ossining, USA
C*07:610HG00013570MG450961,Histogenetics, Ossining, USA
C*08:19:0239086MG603047,Maria Loginova, Kirov, Russia
C*08:158HG00013526MG450972,Histogenetics, Ossining, USA
C*08:159JXZJ20170323005MG595743,Faming Zhu, Hangzhou, China
C*12:03:43HG00013569MG450959,Histogenetics, Ossining, USA
C*12:195:0386023526MG586093,Daniel Fuerst, Ulm, Germany
C*12:220JXZJ20170315001MG595742,Faming Zhu, Hangzhou, China
C*12:22117091301MG601741,Mingrui Huo, Beijing, China
C*14:9081171261MG586094,Daniel Fuerst, Ulm, Germany
C*15:151R47723LT966067,Edward KL Yang, Hualien, Taiwan
C*16:02:14HG00013525MG450971,Histogenetics, Ossining, USA
DPB1*691:01N86023552MG586096,Daniel Fuerst, Ulm, Germany
DPB1*692:0190252258MG586097,Daniel Fuerst, Ulm, Germany
DPB1*693:01N17222009MG603736,Daniel Fuerst, Ulm, Germany
DQB1*02:10484026539MG603738,Daniel Fuerst, Ulm, Germany
DQB1*03:01:01:20HB11MG571443,Riga Wu, Guangzhou, China
DQB1*03:23:03YFJY-DQ-1208-1MG557647,Qian Zhang, Jinan, China
DRB1*07:8481166781MG586100,Daniel Fuerst, Ulm, Germany
DRB3*03:1586016295MG603735,Daniel Fuerst, Ulm, Germany
DRB4*01:03:0681172337MG586102,Daniel Fuerst, Ulm, Germany
DRB4*01:6281163755MG586101,Daniel Fuerst, Ulm, Germany
DRB4*01:6381153001KY307855,Daniel Fuerst, Ulm, Germany
DRB5*02:1886023558MG586105,Daniel Fuerst, Ulm, Germany
E*01:01:01:10R23MG193558,Mehdi Alizadeh, Rennes, Frances
F*01:01:01:15R17MG193556,Mehdi Alizadeh, Rennes, Frances
F*01:01:01:16R40MG193563,Mehdi Alizadeh, Rennes, Frances
F*01:01:02:08R43MG193567,Mehdi Alizadeh, Rennes, Frances
G*01:04:01:02R40MG193564,Mehdi Alizadeh, Rennes, Frances

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*11:21N60798308,MG572797,Antonio Balas, Madrid, Spain
A*24:02:01:06AN00987,LT962584,Steven GE Marsh, London, United Kingdom
A*24:234NT01597,MG199208,Carolyn K Hurley, Washington DC, USA
A*24:314TMO34358,MG585355,Antonio Balas, Madrid, Spain
A*26:1260797855,MG572796,Antonio Balas, Madrid, Spain
A*29:11EGAN00001256168,LT963457,Martin Pollard, Hinxton, United Kingdom
A*31:01:02:02AN01015,LT962612,Steven GE Marsh, London, United Kingdom
A*32:02NT01621,MG372825,Carolyn K Hurley, Washington DC, USA
B*27:05:07NT01789,MG553969,Carolyn K Hurley, Washington DC, USA
B*27:14NT01748,MG553933,Carolyn K Hurley, Washington DC, USA
B*27:20NT01749,MG553934,Carolyn K Hurley, Washington DC, USA
B*27:91NT01818,MG680101,Carolyn K Hurley, Washington DC, USA
B*35:01:02NT01790,MG553970,Carolyn K Hurley, Washington DC, USA
B*35:01:04NT01791,MG553971,Carolyn K Hurley, Washington DC, USA
B*35:02:02NT01792,MG553972,Carolyn K Hurley, Washington DC, USA
B*35:08:01:01NT01795,NT01796,MG553973,Carolyn K Hurley, Washington DC, USA
B*35:08:02NT01797,MG553974,Carolyn K Hurley, Washington DC, USA
B*35:10NT01750,NT01751a,MG553935,Carolyn K Hurley, Washington DC, USA
B*35:16NT01752,NT01753,MG553937,Carolyn K Hurley, Washington DC, USA
B*35:20:02NT01798,MG553975,Carolyn K Hurley, Washington DC, USA
B*35:21NT01755,NT01756,MG553938,Carolyn K Hurley, Washington DC, USA
B*35:22NT01819,MG680102,Carolyn K Hurley, Washington DC, USA
B*35:23NT01820,MG680103,Carolyn K Hurley, Washington DC, USA
B*35:26NT01757,MG553939,Carolyn K Hurley, Washington DC, USA
B*35:27NT01821,NT01822,MG680104,Carolyn K Hurley, Washington DC, USA
B*35:28NT01823,MG680105,Carolyn K Hurley, Washington DC, USA
B*35:30NT01824,NT01825,NT01700B,MG680106,MG525284,Carolyn K Hurley, Washington DC, USA
B*35:33NT01758 ,MG553940,Carolyn K Hurley, Washington DC, USA
B*35:36NT01759,MG553941,Carolyn K Hurley, Washington DC, USA
B*35:44NT01826,NT01827,MG680107,Carolyn K Hurley, Washington DC, USA
B*35:47NT01760,MG553942,Carolyn K Hurley, Washington DC, USA
B*35:77NT01761,MG553943,Carolyn K Hurley, Washington DC, USA
B*35:108:01NT01817,MG553991,Carolyn K Hurley, Washington DC, USA
B*38:06NT01828,MG680108,Carolyn K Hurley, Washington DC, USA
B*38:35NT01762,MG553944,Carolyn K Hurley, Washington DC, USA
B*39:01:04NT01799,MG553976,Carolyn K Hurley, Washington DC, USA
B*39:02:01NT01800,MG553977,Carolyn K Hurley, Washington DC, USA
B*39:03:01:01NT01751b,MG553936,Carolyn K Hurley, Washington DC, USA
B*39:12NT01763,MG553945,Carolyn K Hurley, Washington DC, USA
B*39:15NT01829,MG680109,Carolyn K Hurley, Washington DC, USA
B*39:19:01NT01801 ,MG553978,Carolyn K Hurley, Washington DC, USA
B*39:20NT01830,MG680110,Carolyn K Hurley, Washington DC, USA
B*39:37NT01764,MG553946,Carolyn K Hurley, Washington DC, USA
B*40:01:03NT01802 ,MG553979,Carolyn K Hurley, Washington DC, USA
B*40:11:02NT01803,NT01804,MG553980,Carolyn K Hurley, Washington DC, USA
B*40:12NT01765,MG553947,Carolyn K Hurley, Washington DC, USA
B*40:16NT01766,MG553948,Carolyn K Hurley, Washington DC, USA
B*40:27:01NT01805,NT01806,MG553981,Carolyn K Hurley, Washington DC, USA
B*40:170NT01786,MG553966,Carolyn K Hurley, Washington DC, USA
B*41:02:01NT01807,MG553982,Carolyn K Hurley, Washington DC, USA
B*41:07NT01768,NT01769,MG553950,Carolyn K Hurley, Washington DC, USA
B*41:16NT01770,MG553952,Carolyn K Hurley, Washington DC, USA
B*44:03:08NT01810,MG553984,Carolyn K Hurley, Washington DC, USA
B*44:20NT01772,MG553954,Carolyn K Hurley, Washington DC, USA
B*44:24NT01773,MG553955,Carolyn K Hurley, Washington DC, USA
B*44:37:0148013_P17-7990234G,LT965073,Marcel GJ Tilanus, Maastricht, The Netherlands
B*44:146NT01787,MG553967,Carolyn K Hurley, Washington DC, USA
B*47:03NT01774,MG553956,Carolyn K Hurley, Washington DC, USA
B*51:01:09NT01811,MG553985,Carolyn K Hurley, Washington DC, USA
B*51:04NT01775,MG553957,Carolyn K Hurley, Washington DC, USA
B*51:22NT01776,MG553958,Carolyn K Hurley, Washington DC, USA
B*51:40NT01777,MG553959,Carolyn K Hurley, Washington DC, USA
B*51:43NT01778,MG553960,Carolyn K Hurley, Washington DC, USA
B*51:64NT01779,MG553961,Carolyn K Hurley, Washington DC, USA
B*51:65NT01780,MG553962,Carolyn K Hurley, Washington DC, USA
B*51:152NT01788,MG553968,Carolyn K Hurley, Washington DC, USA
B*53:01:03NT01812 ,MG553986,Carolyn K Hurley, Washington DC, USA
B*55:26NT01781,MG553963,Carolyn K Hurley, Washington DC, USA
B*56:01:04NT01813,MG553987,Carolyn K Hurley, Washington DC, USA
B*56:05:01NT01814,MG553988,Carolyn K Hurley, Washington DC, USA
B*56:06NT01782,MG553964,Carolyn K Hurley, Washington DC, USA
B*56:27NT01783,MG553965,Carolyn K Hurley, Washington DC, USA
B*57:01:10NT01815,MG553989,Carolyn K Hurley, Washington DC, USA
B*57:93HG00013565,MG450953,Histogenetics, Ossining, USA
B*78:02:02NT01816,MG553990,Carolyn K Hurley, Washington DC, USA
C*04:4148012_P17-7990053J,LT965072,Marcel GJ Tilanus, Maastricht, The Netherlands
C*07:01:01:02AN01010,LT962607,Steven GE Marsh, London, United Kingdom
C*07:02:1648014_P17-7990666Z,LT965075,Marcel GJ Tilanus, Maastricht, The Netherlands
DQB1*03:01:01:12SYSU001,MG571442,Riga Wu, Guangzhou, China
DRB1*03:01:01:02EC,LT963666,Steven GE Marsh, London, United Kingdom
DRB1*03:02:01RSH,LT963704,Steven GE Marsh, London, United Kingdom
DRB1*04:10:01CB,LT963648,Steven GE Marsh, London, United Kingdom
F*01:03:01:03R29,MG193559,Mehdi Alizadeh, Rennes, Frances
G*01:01:01:0114d02728,MF538780,Jos Drabbels, Leiden, The Netherlands
G*01:01:02:0114d02725,MF538779,Jos Drabbels, Leiden, The Netherlands

Table 3: Recently Published Sequences


Sequence References
A*02:01:72(3)
A*02:189(4)
A*02:692(5)
A*03:01:62(6)
A*03:283N(7)
A*24:02:56(8)
A*24:383(9)
A*31:108(10)
A*68:167(7)
B*35:348(11)
B*57:91(12)
C*03:327(7)
C*03:361(7)
C*07:02:82(6)
C*07:565(13)
C*12:03:42(6)
C*14:87(14)
DRB1*04:01:17(15)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010 75: 291-455.
  2. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: 423-31.
  3. Zhang X, Lin FQ, Wu C, et al.Sequencing of the novel HLA-A*02:01:72 allele in a Chinese hematopoietic stem cell donor. HLA 2018 91: 56-57.
  4. Zhong YP, Quan ZR, Gao SQ.Identification of a novel allele, HLA-A*02:189, in a Chinese Han individual. HLA 2018 91: 58-59.
  5. Zhu Y, Han B, Chi X, et al.A novel HLA-A*02 allele, A*02:692, was identified by sequencing-based typing. HLA 2018 91: 59-60.
  6. Moya-Quiles MR, Balas A, Muro M, et al.Three new HLA class I alleles with synonymous mutations: HLA-A*03:01:62, -C*07:02:82 and -C*12:03:42. HLA 2018 91: 60-61.
  7. Polvi A, Peräsaari J, Linjama T, et al.Description of four new HLA alleles in the Finnish population: A*03:283N, A*68:167, C*03:327, C*03:361 HLA 2018 91: 61-62.
  8. Lin FQ, Zhang X, Zhang B, et al.The novel HLA-A*24:02 variant, HLA-A*24:02:56, identified by sequencing in a Chinese individual. HLA 2018 91: 63-65.
  9. Hu B, Yang Z, Pan H, et al.The novel allele, HLA-A*24:383, was identified in a Chinese individual by sequence-based typing. HLA 2018 91: 65-66.
  10. Ding H, Huang Y, Chen Y, et al.The novel allele, HLA-A*31:108, identified by sequence-based typing in a Chinese individual. HLA 2018 91: 66-68.
  11. Ma WH, Wu YQ, Feng ZH, et al.A novel HLA-B allele, HLA-B*35:348, was identified by sequencing-based typing. HLA 2018 91: 68-69.
  12. Enrich E, Campos E, Caro-Oleas JL, et al.Identification of the novel HLA-B*57:91 allele, by Next Generation Sequencing in a Spanish individual. HLA 2018 91: 69-70.
  13. Wang J, Zhang Y, Li Q, et al.Sequence-based typing identification of the novel HLA-C*07:565 variant in a Chinese family. HLA 2018 91: 71-72.
  14. Yang KL, Lin PY.Discovery of HLA-C*14:87, a novel HLA-C*14 variant, in a Taiwanese individual. HLA 2018 91: 72-73.
  15. Feng ZH, Yang ZX, Ma WH, et al.A novel HLA class II allele, HLA-DRB1*04:01:17, identified in a Chinese volunteer donor for CMDP. HLA 2018 91: 74-75.