Nomenclature for Factors of the HLA System

January 2016

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the December 2016 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


SequenceCell identificationAccession numberSubmitting author
A*01:01:01:08282004KY419425Vera Balz, Dsseldorf, Germany
A*01:01:01:09281454KY419426Vera Balz, Dsseldorf, Germany
A*01:01:01:10293849KY419427Vera Balz, Dsseldorf, Germany
A*02:01:01:19130087KY419428Vera Balz, Dsseldorf, Germany
A*02:01:01:20279696KY419429Vera Balz, Dsseldorf, Germany
A*02:01:01:21295673KY419430Vera Balz, Dsseldorf, Germany
A*02:01:01:22295044,120259,286954KY419431Vera Balz, Dsseldorf, Germany
A*02:01:01:2395035KY419432Vera Balz, Dsseldorf, Germany
A*02:01:01:24289180KY419433Vera Balz, Dsseldorf, Germany
A*02:01:01:25281241KY419434Vera Balz, Dsseldorf, Germany
A*02:01:130416121,301601KY391795Talitha de Hoop, Utrecht, The Netherlands
A*02:05:01:02107110KY419435Vera Balz, Dsseldorf, Germany
A*02:670HG00012761KY345172Histogenetics, Ossining, USA
A*02:671HG00012762KY296551Histogenetics, Ossining, USA
A*03:01:01:11286116,277074KY419437Vera Balz, Dsseldorf, Germany
A*03:01:01:12284643KY419438Vera Balz, Dsseldorf, Germany
A*03:276HG00012758KY364235Histogenetics, Ossining, USA
A*11:01:01:05295837KY419440Vera Balz, Dsseldorf, Germany
A*11:261289263KY419441Vera Balz, Dsseldorf, Germany
A*24:02:01:11125291,125292KY419444Vera Balz, Dsseldorf, Germany
A*24:02:101274362KY419445Vera Balz, Dsseldorf, Germany
A*24:347:02HG00012757KY345171Histogenetics, Ossining, USA
A*25:01:01:02100379KY419447Vera Balz, Dsseldorf, Germany
A*26:01:01:06276835KY419448Vera Balz, Dsseldorf, Germany
A*26:01:01:07286377KY419449Vera Balz, Dsseldorf, Germany
A*26:01:01:0873345KY419450Vera Balz, Dsseldorf, Germany
A*26:01:01:09256977KY419451Vera Balz, Dsseldorf, Germany
A*29:02:01:0429556, 27958, 52583KY419453Vera Balz, Dsseldorf, Germany
A*30:11475643KY419454Vera Balz, Dsseldorf, Germany
A*32:01:01:04112111KY419455Vera Balz, Dsseldorf, Germany
A*32:100HG00012759, HG00012760KY263961KY296550Histogenetics, Ossining, USA
A*32:101QDKMS-LSL-A-845LN994746DKMS Life Sciences Lab, Dresden, Germany
A*68:164scu22150KY368174Francisco de Paula Sanchez Gordo, Malaga, Spain
B*07:02:52253049KY419460Vera Balz, Dsseldorf, Germany
B*07:291259017KY419461Vera Balz, Dsseldorf, Germany
B*08:01:01:04266660KY419462Vera Balz, Dsseldorf, Germany
B*13:02:01:0228209, 71441KY419463Vera Balz, Dsseldorf, Germany
B*13:100277219KY419464Vera Balz, Dsseldorf, Germany
B*15:01:01:10240389KY419465Vera Balz, Dsseldorf, Germany
B*15:01:01:11295746KY419466Vera Balz, Dsseldorf, Germany
B*15:07:01:0298963,94204,76970,28453KY419467Vera Balz, Dsseldorf, Germany
B*15:09:02278303KY419468Vera Balz, Dsseldorf, Germany
B*15:17:06HG00012796KY345181Histogenetics, Ossining, USA
B*15:18:01:03BY01431KY464940Carolyn K Hurley, Washington DC, USA
B*15:425HG00012804KY345183Histogenetics, Ossining, USA
B*18:01:01:07273722KY419470Vera Balz, Dsseldorf, Germany
B*18:04:02HG00012795KY263979Histogenetics, Ossining, USA
B*27:02:01:03260850, 219700KY419472Vera Balz, Dsseldorf, Germany
B*27:05:02:0254200KY419474Vera Balz, Dsseldorf, Germany
B*27:05:02:03121742,125278KY419475Vera Balz, Dsseldorf, Germany
B*27:05:02:04Q237050KY419367Vera Balz, Dsseldorf, Germany
B*35:03:01:04281414,283710KY419479Vera Balz, Dsseldorf, Germany
B*35:03:01:05125015,267108,289232KY419480Vera Balz, Dsseldorf, Germany
B*35:05:01:03265817KY419478Vera Balz, Dsseldorf, Germany
B*35:08:01:02284438KY419481Vera Balz, Dsseldorf, Germany
B*35:336276623KY419476Vera Balz, Dsseldorf, Germany
B*39:06:02:04268511KY419484Vera Balz, Dsseldorf, Germany
B*39:09:01:02BY01434KY464938Carolyn K Hurley, Washington DC, USA
B*39:127HG00012802KX711909Histogenetics, Ossining, USA
B*40:01:02:05274658KY419485Vera Balz, Dsseldorf, Germany
B*44:02:01:06287730KY419488Vera Balz, Dsseldorf, Germany
B*44:03:01:05181561KY419489Vera Balz, Dsseldorf, Germany
B*44:03:01:0692349KY419490Vera Balz, Dsseldorf, Germany
B*44:03:01:07121747KY419491Vera Balz, Dsseldorf, Germany
B*44:03:01:08297416KY419492Vera Balz, Dsseldorf, Germany
B*44:267N274382KY419368Vera Balz, Dsseldorf, Germany
B*51:01:01:1427631, 27612, 6928, 28669, 44151KY419494Vera Balz, Dsseldorf, Germany
B*51:01:01:15276952KY419495Vera Balz, Dsseldorf, Germany
B*51:01:01:1676926KY419496Vera Balz, Dsseldorf, Germany
B*51:01:01:17109994KY419497Vera Balz, Dsseldorf, Germany
B*51:01:01:18290751KY419498Vera Balz, Dsseldorf, Germany
B*51:01:01:19293176KY419499Vera Balz, Dsseldorf, Germany
B*51:01:01:20268734KY419500Vera Balz, Dsseldorf, Germany
B*51:01:01:2121329, 67685KY419501Vera Balz, Dsseldorf, Germany
B*51:01:56285340, 281763, 115272, 101132KY419502Vera Balz, Dsseldorf, Germany
B*51:218HG00012801KY345179Histogenetics, Ossining, USA
B*51:219284169KY419503Vera Balz, Dsseldorf, Germany
B*52:01:01:04282115KY419504Vera Balz, Dsseldorf, Germany
B*55:85BY01428KY464944Carolyn K Hurley, Washington DC, USA
B*58:01:01:04BY01435,BY01433KY464937Carolyn K Hurley, Washington DC, USA
C*01:02:01:02103629KY419372Vera Balz, Dsseldorf, Germany
C*01:137N280659KY419369Vera Balz, Dsseldorf, Germany
C*02:02:02:06100506, 286375, 300230, 100366KY419373Vera Balz, Dsseldorf, Germany
C*02:02:02:07217925KY419374Vera Balz, Dsseldorf, Germany
C*02:02:02:08126452KY419375Vera Balz, Dsseldorf, Germany
C*02:02:02:09120258KY419376Vera Balz, Dsseldorf, Germany
C*02:02:02:10245650KY419377Vera Balz, Dsseldorf, Germany
C*02:02:02:11296224KY419378Vera Balz, Dsseldorf, Germany
C*02:02:33SEV161205_8349791KY399965Oh-Joong Kwon, Seoul, South Korea
C*03:03:01:03282863KY419380Vera Balz, Dsseldorf, Germany
C*03:03:01:04285186KY419381Vera Balz, Dsseldorf, Germany
C*03:03:01:0528105KY419382Vera Balz, Dsseldorf, Germany
C*03:03:01:06283896KY419383Vera Balz, Dsseldorf, Germany
C*03:04:01:05137452KY419384Vera Balz, Dsseldorf, Germany
C*03:04:01:06275957KY419385Vera Balz, Dsseldorf, Germany
C*03:04:01:07281355KY419386Vera Balz, Dsseldorf, Germany
C*03:352HG00012818KY345185Histogenetics, Ossining, USA
C*03:353HG00012819KY263989Histogenetics, Ossining, USA
C*04:01:01:08292102KY419389Vera Balz, Dsseldorf, Germany
C*04:01:01:09223299KY419390Vera Balz, Dsseldorf, Germany
C*04:01:01:1025410KY419391Vera Balz, Dsseldorf, Germany
C*04:01:82211404KY419392Vera Balz, Dsseldorf, Germany
C*04:04:01:02BY01420 KY379092Carolyn K Hurley, Washington DC, USA
C*04:264HG00012820KY263988Histogenetics, Ossining, USA
C*04:265HG00012821KY263981Histogenetics, Ossining, USA
C*04:266HG00012822KY263986Histogenetics, Ossining, USA
C*04:267197270257294KY419393Vera Balz, Dsseldorf, Germany
C*04:268295237KY419394Vera Balz, Dsseldorf, Germany
C*05:01:01:06273536KY419395Vera Balz, Dsseldorf, Germany
C*05:01:01:07281153KY419396Vera Balz, Dsseldorf, Germany
C*05:149HG00012811KY263990Histogenetics, Ossining, USA
C*06:02:01:04296419KY419398Vera Balz, Dsseldorf, Germany
C*06:02:01:05209008KY419399Vera Balz, Dsseldorf, Germany
C*06:02:01:06281355KY419401Vera Balz, Dsseldorf, Germany
C*07:01:01:09MUMC1968LT618799Marcel GJ Tilanus, Maastricht, The Netherlands
C*07:01:01:10266453KY419402Vera Balz, Dsseldorf, Germany
C*07:01:01:11298341KY419403Vera Balz, Dsseldorf, Germany
C*07:01:01:12298270298310KY419404Vera Balz, Dsseldorf, Germany
C*07:01:01:13258284KY419405Vera Balz, Dsseldorf, Germany
C*07:01:01:14Q241952KY419370Vera Balz, Dsseldorf, Germany
C*07:02:01:14271147KY419406Vera Balz, Dsseldorf, Germany
C*07:02:79256986KY419407Vera Balz, Dsseldorf, Germany
C*07:581HG00012807KY399929Histogenetics, Ossining, USA
C*07:582QHG00012808KX711933Histogenetics, Ossining, USA
C*07:583HG00012812KY263982Histogenetics, Ossining, USA
C*07:584192768KY419409Vera Balz, Dsseldorf, Germany
C*07:585109461KY419410Vera Balz, Dsseldorf, Germany
C*07:586295502KY419411Vera Balz, Dsseldorf, Germany
C*08:147187212KY419412Vera Balz, Dsseldorf, Germany
C*12:207HG00012813KY263983Histogenetics, Ossining, USA
C*12:208HG00012814KY263984Histogenetics, Ossining, USA
C*12:209218857KY419414Vera Balz, Dsseldorf, Germany
C*12:210289263KY419415Vera Balz, Dsseldorf, Germany
C*12:211282557KY419416Vera Balz, Dsseldorf, Germany
C*15:02:01:05279650, 278877, 278607, 277867KY419417Vera Balz, Dsseldorf, Germany
C*15:02:01:06289528, 287457, 286577, 282160, 204757, 202483KY419418Vera Balz, Dsseldorf, Germany
C*15:02:01:0763374KY419419Vera Balz, Dsseldorf, Germany
C*15:138HG00012805KY399925Histogenetics, Ossining, USA
C*16:01:01:03257545KY419422Vera Balz, Dsseldorf, Germany
C*16:106275320KY419424Vera Balz, Dsseldorf, Germany
DPA1*01:1494-16KY244023Reem Ameen, Jabriya, Kuwait
DPB1*637:01HG00012864KY345204Histogenetics, Ossining, USA
DPB1*638:01HG00012865KY345201Histogenetics, Ossining, USA
DPB1*639:01HG00012867KY399944Histogenetics, Ossining, USA
DQB1*02:8988-15KY230421Reem Ameen, Jabriya, Kuwait
DQB1*02:90HG00012828KY263998Histogenetics, Ossining, USA
DQB1*03:257HG00012825KY263996Histogenetics, Ossining, USA
DQB1*03:258HG00012833KY296577Histogenetics, Ossining, USA
DQB1*03:259HG00012832KY345188Histogenetics, Ossining, USA
DQB1*05:14401-16-278-0007X KY379031Ahmed Mostafa, Calgary, Canada
DQB1*05:145HG00012835KY263992Histogenetics, Ossining, USA
DQB1*05:146HG00012836KY263994Histogenetics, Ossining, USA
DQB1*06:231HG00012831KY345186Histogenetics, Ossining, USA
DQB1*06:232HG00012838KY399933Histogenetics, Ossining, USA
DRB1*01:03:02HG00012854KY399937Histogenetics, Ossining, USA
DRB1*03:138HG00012851KY296582Histogenetics, Ossining, USA
DRB1*04:222HG00012846KY264004Histogenetics, Ossining, USA
DRB1*04:223HG00012847KY264005Histogenetics, Ossining, USA
DRB1*07:77HG00012845KY345191Histogenetics, Ossining, USA
DRB1*11:209HG00012850KY264003Histogenetics, Ossining, USA
DRB1*11:210HG00012855KY296580Histogenetics, Ossining, USA
DRB1*11:42:02HG00012853KY296583Histogenetics, Ossining, USA
DRB1*12:65HG00012849KY364243Histogenetics, Ossining, USA
DRB1*13:232P489EF541487Yan Li, Guangzhou, China
DRB1*13:233296123EPLKY171939Maria Elisa Moraes, Rio de Janeiro, Brazil
DRB1*15:143HG00012842KY345189Histogenetics, Ossining, USA
DRB1*15:144HG00012844KY264006Histogenetics, Ossining, USA
DRB1*15:145UA2016tp2754LT707066Mats Bengtsson, Uppsala, Sweden
DRB1*15:15:03HG00012840, HG00012841KY345192KY296585Histogenetics, Ossining, USA
DRB1*16:02:07HG00012843KY296584Histogenetics, Ossining, USA
DRB3*02:62HG00012857KY345197Histogenetics, Ossining, USA
DRB3*02:63HG00012858KY345193Histogenetics, Ossining, USA
DRB3*02:64HG00012859KY296588Histogenetics, Ossining, USA
DRB3*02:65HG00012860KY345196Histogenetics, Ossining, USA
DRB3*03:12HG00012861KY345195Histogenetics, Ossining, USA
DRB3*03:13UA2016TP2987LT707072Mats Bengtsson, Uppsala, Sweden
DRB4*01:49HG00012862KY399939Histogenetics, Ossining, USA

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:01:120AL00000007KY129729Histogenetics, Ossining, USA
A*02:528:0212455KY419436Vera Balz, Dsseldorf, Germany
B*07:252AL00000025KY129739Histogenetics, Ossining, USA
B*07:287HG00012800KY263976Histogenetics, Ossining, USA
B*35:04:01BY01429KY464943Carolyn K Hurley, Washington DC, USA
B*35:19BY01430KY464942Carolyn K Hurley, Washington DC, USA
B*35:279121300834LT627192Frank Gruenebach, Tbingen, Germany
B*37:58AL00000012KY078224Histogenetics, Ossining, USA
B*39:06:02:039694, 6359, 5667, 5980KY419483Vera Balz, Dsseldorf, Germany
B*41:49AL00000009KY129734Histogenetics, Ossining, USA
B*44:250AL00000013KY129744Histogenetics, Ossining, USA
B*49:38AL00000024KY129738Histogenetics, Ossining, USA
B*55:74AL00000016KY078226Histogenetics, Ossining, USA
C*01:02:30BY01413KY379096Carolyn K Hurley, Washington DC, USA
C*02:02:02:02BY01410, BY01411KY379095Carolyn K Hurley, Washington DC, USA
C*02:08BY01415KY379097Carolyn K Hurley, Washington DC, USA
C*02:12852244KY419379Vera Balz, Dsseldorf, Germany
C*03:38:01BY01412KY379093Carolyn K Hurley, Washington DC, USA
C*04:04:01:01BY01416KY379089Carolyn K Hurley, Washington DC, USA
C*04:184AL00000031KY129748Histogenetics, Ossining, USA
C*04:65BY01418KY379091Carolyn K Hurley, Washington DC, USA
C*07:441:02253585KY419408Vera Balz, Dsseldorf, Germany
C*08:08:01BY01408KY379088Carolyn K Hurley, Washington DC, USA
C*15:10:02BY01417KY379090Carolyn K Hurley, Washington DC, USA
C*15:88BY01409KY379094Carolyn K Hurley, Washington DC, USA
C*16:01:04BY01414KY379098Carolyn K Hurley, Washington DC, USA
DPA1*02:07:01:01UA2016tp2805LT707074Mats Bengtsson, Uppsala, Sweden
DQB1*03:255HG00012826KY264001Histogenetics, Ossining, USA
DQB1*05:66:02AL00000035, AL00000036, AL00000037, HG00012834KY129757KY129756KY129755KY263993.Histogenetics, Ossining, USA
DRB1*03:132UA16tp850LT707071Mats Bengtsson, Uppsala, Sweden
DRB1*11:147:02AL00000045KY078229Histogenetics, Ossining, USA
DRB1*13:230HG00012852KY296581Histogenetics, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
B*52:01:01:01(3)
B*52:01:02:01(3)
C*16:97(4)
E*01:01:01:06(5)
G*01:08:02(6)
G*01:20(6)

References:

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  2. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: 423-31.
  3. Li Z, Zou HY.Full-length sequence of 2 HLA-B alleles, B*52:01:01:01 and B*52:01:02:01, identified by cloning and sequencing. HLA 2016 89: 163-165.
  4. Vecchiato C, Lochmann E, Gentilini I.Confirmation of the HLA-C*16:97 allele in multiple individuals, a new common and well defined allele? HLA 2016 89: 170-171.
  5. Xu YP, Wang SX, Hing WZ.A novel HLA-E allele, HLA-E*01:01:01:06, identified in a Chinese Leukemia patient. HLA 2016 89: 260-262.
  6. Arnaiz-Villena A, Enriquez-de-Salamanca M, Palaco-Grber, et al.Characterisation and functional implications of the two new HLA-G alleles found in Amerindian and Caribbean populations. Human Immunology 2016 77: 812-816.