Nomenclature for Factors of the HLA System

February 2016

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the January 2016 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/ipd/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:201HG00011193KU248908Histogenetics, Ossining, USA
A*02:524:02HG00011200KR868778Histogenetics, Ossining, USA
A*02:611HG00011197KU167554Histogenetics, Ossining, USA
A*02:612HG00011198KU167556Histogenetics, Ossining, USA
A*02:613HG00011201KU302254Histogenetics, Ossining, USA
A*02:614R41246LT158301Edward KL Yang, Hualien, Taiwan
A*03:243HG00011181KT282149Histogenetics, Ossining, USA
A*03:244HG00011195KU167553Histogenetics, Ossining, USA
A*03:245HG00011196KU302261Histogenetics, Ossining, USA
A*03:24617880LT160731Maria Loginova, Kirov, Russia
A*11:01:7114977LT160730Maria Loginova, Kirov, Russia
A*11:236HG00011186KU302257Histogenetics, Ossining, USA
A*11:237HG00011187KU167555Histogenetics, Ossining, USA
A*11:238NHG00011189KU248905Histogenetics, Ossining, USA
A*23:71HG00011192KU302255Histogenetics, Ossining, USA
A*24:02:9720278LT160732Maria Loginova, Kirov, Russia
A*24:335HG00011190KU167558Histogenetics, Ossining, USA
A*24:336HG00011191KU214471Histogenetics, Ossining, USA
A*31:106HG00011182KU248906Histogenetics, Ossining, USA
A*31:107HG00011184KU167557Histogenetics, Ossining, USA
A*33:107HG00011183KU302256Histogenetics, Ossining, USA
A*33:1080270907169KU641691Wen Qiang, Wuhan, China
A*68:143HG00011188KT282150Histogenetics, Ossining, USA
A*68:144216199KU233192Konstantinos Barsakis, Palo Alto, USA
B*07:268HG00011218KU248909Histogenetics, Ossining, USA
B*08:160NT01316KU324540Carolyn K Hurley, Washington DC, USA
B*08:161HG00011207KU302266Histogenetics, Ossining, USA
B*13:01:12D315253LT158304Edward KL Yang, Hualien, Taiwan
B*13:89HG00011209KU214474Histogenetics, Ossining, USA
B*13:900270905529KU641690Wen Qiang, Wuhan, China
B*14:54HG00011217KU302268Histogenetics, Ossining, USA
B*15:381HG00011205KU302262Histogenetics, Ossining, USA
B*15:382HG00011220KU167563Histogenetics, Ossining, USA
B*35:312HG00011212KU302271Histogenetics, Ossining, USA
B*35:313NT01319KU324537Carolyn K Hurley, Washington DC, USA
B*38:61HG00011219KU302269Histogenetics, Ossining, USA
B*39:116N0270907525KU641692Wen Qiang, Wuhan, China
B*40:01:460271110296KU641693Wen Qiang, Wuhan, China
B*40:01:470271210542KU641694Wen Qiang, Wuhan, China
B*40:06:15HG00011202KU167560Histogenetics, Ossining, USA
B*40:186:02SYNPC211KU598668Wei Tian, Changsha, China
B*40:328HG00011206KU167561Histogenetics, Ossining, USA
B*40:329AS3213LT158302Edward KL Yang, Hualien, Taiwan
B*41:46HG00011203KT282158Histogenetics, Ossining, USA
B*44:239HG00011210KU302265Histogenetics, Ossining, USA
B*49:42HG00011204KU167564Histogenetics, Ossining, USA
B*52:60HG00011208KU302264Histogenetics, Ossining, USA
B*52:61HG00011213KU302270Histogenetics, Ossining, USA
B*55:01:16HG00011216KU167562Histogenetics, Ossining, USA
B*57:83NT01312KU324522Carolyn K Hurley, Washington DC, USA
B*67:06JRC-D08-041LC121599Masahiro Satake, Tokyo, Japan
C*02:113HG00011239KU302276Histogenetics, Ossining, USA
C*02:114HG00011240KU167570Histogenetics, Ossining, USA
C*03:03:31NT01307KU324534Carolyn K Hurley, Washington DC, USA
C*03:314HG00011241KU302278Histogenetics, Ossining, USA
C*03:315HG00011242KU302280Histogenetics, Ossining, USA
C*03:316NHG00011243KU302301Histogenetics, Ossining, USA
C*04:231HG00011244KU302272Histogenetics, Ossining, USA
C*04:232HG00011245KU302274Histogenetics, Ossining, USA
C*05:129HG00011234KU214475Histogenetics, Ossining, USA
C*06:174HG00011221KU167573Histogenetics, Ossining, USA
C*06:175NHG00011222KU167568Histogenetics, Ossining, USA
C*07:341:02D228203LT158303Edward KL Yang, Hualien, Taiwan
C*07:490HG00011224KU248913Histogenetics, Ossining, USA
C*07:491NHG00011225KU167569Histogenetics, Ossining, USA
C*07:492HG00011227KU302277Histogenetics, Ossining, USA
C*07:493HG00011228KR047761Histogenetics, Ossining, USA
C*07:494QHG00011229KU167574Histogenetics, Ossining, USA
C*07:495HG00011230KU187267Histogenetics, Ossining, USA
C*07:496HG00011231KU167571Histogenetics, Ossining, USA
C*07:497HG00011232KU248912Histogenetics, Ossining, USA
C*07:498HG00011233KU302273Histogenetics, Ossining, USA
C*08:130NHG00011235KU167567Histogenetics, Ossining, USA
C*12:173HG00011238KU167577Histogenetics, Ossining, USA
DRB1*01:73HG00011267KU248916Histogenetics, Ossining, USA
DRB1*01:74292118KU522303Elena Longhi, Milano, Italy
DRB1*03:128HG00011265KU302288Histogenetics, Ossining, USA
DRB1*03:129HG00011266KU302287Histogenetics, Ossining, USA
DRB1*04:03:12HG00011262KU167582Histogenetics, Ossining, USA
DRB1*08:80HG00011263KU167585Histogenetics, Ossining, USA
DRB1*13:214HG00011264KU187271Histogenetics, Ossining, USA
DRB1*14:173K140401LC109323Yuto Horie, Kyoto, Japan
DRB1*15:01:29HG00011259KU187272Histogenetics, Ossining, USA
DRB1*16:38HG00011258KU167580Histogenetics, Ossining, USA
DQB1*02:66HG00011247KU302284Histogenetics, Ossining, USA
DQB1*02:67NHG00011253KU214477Histogenetics, Ossining, USA
DQB1*03:223HG00011251KU302286Histogenetics, Ossining, USA
DQB1*03:224HG00011252KU187270Histogenetics, Ossining, USA
DQB1*04:34HG00011255KU167579Histogenetics, Ossining, USA
DQB1*06:201HG00011257KU248914Histogenetics, Ossining, USA
DQB1*06:202M-570130LN997812Kristin Kipper, Martinsried, Germany
DPB1*547:01BWU053_AD11859KU055451Oh-Joong Kwon, Seoul, South Korea
G*01:08:02EKU1KP739973Antonio Arnaiz-Villena, Madrid, Spain
G*01:20Dom1KP739974Antonio Arnaiz-Villena, Madrid, Spain

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:71HG00011311KU350642Histogenetics, Ossining, USA
A*01:169HG00011313KT803907Histogenetics, Ossining, USA
A*01:198HG00011312KU167559Histogenetics, Ossining, USA
A*02:08KLOKU233198Konstantinos Barsakis, Palo Alto, USA
A*02:11:01GRC-138KU233200Konstantinos Barsakis, Palo Alto, USA
A*02:11:09HG00011315KU302259Histogenetics, Ossining, USA
A*02:30FH21KU233199Konstantinos Barsakis, Palo Alto, USA
A*24:14LC101KU319386Konstantinos Barsakis, Palo Alto, USA
A*24:322HG00011309KT895306Histogenetics, Ossining, USA
A*24:324HG00011310KT803908Histogenetics, Ossining, USA
A*26:03:01SMKU233195Konstantinos Barsakis, Palo Alto, USA
A*29:40139370KU319388Konstantinos Barsakis, Palo Alto, USA
A*29:81HG00011308KU302260Histogenetics, Ossining, USA
A*30:03JSKU319389Konstantinos Barsakis, Palo Alto, USA
A*30:78NDL61_05C49901_A04KU319382Konstantinos Barsakis, Palo Alto, USA
A*68:05LC83KU233196Konstantinos Barsakis, Palo Alto, USA
A*74:27HG00011314KU350638Steven GE Marsh, London, United Kingdom
B*08:135HG00011319KC424466Histogenetics, Ossining, USA
B*08:137HG00011318JX089367Histogenetics, Ossining, USA
B*15:369HG00011320KU248911Histogenetics, Ossining, USA
B*27:141HG00011317KU360743Histogenetics, Ossining, USA
B*39:108HG00011321KT600087Histogenetics, Ossining, USA
B*40:318HG00011322KT600088Histogenetics, Ossining, USA
B*44:03:32HG00011211KU248910Histogenetics, Ossining, USA
B*49:41HG00011316KU302267Histogenetics, Ossining, USA
C*02:55:02HG00011333KT844485Histogenetics, Ossining, USA
C*06:158HG00011324KT895317Histogenetics, Ossining, USA
C*07:01:51HG00011226KU302279Histogenetics, Ossining, USA
C*07:310HG00011325KC875921Histogenetics, Ossining, USA
C*07:429HG00011326KU095794Histogenetics, Ossining, USA
C*07:450HG00011327KU167572Histogenetics, Ossining, USA
C*08:02:10HG00011329KC441498Histogenetics, Ossining, USA
C*08:103NT01306KU324527Carolyn K Hurley, Washington DC, USA
C*12:153 HG00011236,
HG00011237
KU167576,
KU214476
Histogenetics, Ossining, USA
C*12:162HG00011331KT895311Histogenetics, Ossining, USA
C*12:163HG00011328KT968849Histogenetics, Ossining, USA
C*12:164HG00011330KU187266Histogenetics, Ossining, USA
C*15:118HG00011332KT600100Histogenetics, Ossining, USA
C*18:06HG00011323JX970481Histogenetics, Ossining, USA
DRB5*01:02THAKU593571Konstantinos Barsakis, Palo Alto, USA
DRB5*01:03119990KU593574Konstantinos Barsakis, Palo Alto, USA
DRB5*01:08N164787KU593575Konstantinos Barsakis, Palo Alto, USA
DRB5*02:02DAN723KU593572Konstantinos Barsakis, Palo Alto, USA
DRB5*02:03156478KU593579Konstantinos Barsakis, Palo Alto, USA
DQB1*02:62HG00011248KU214479Histogenetics, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
A*03:181(3)
A*03:229(3)
A*11:01:69(4)
A*11:120(5)
A*11:231(6)
A*24:02:96(7)
A*24:258(8)
A*24:305(8)
B*15:300(9)
B*35:307(10)
B*40:01:44(11)
B*54:34(12)
B*55:02:10(13)
B*55:70(14)
B*55:77(15)
C*03:313(16)
C*04:212(17)
C*16:90(18)
DRB1*12:48(19)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: D423-31.
  3. Tao SD, Chen NY, Dong LN, He J, Zhu FM. Identification of two novel HLA-A alleles, HLA-A*03:181 and HLA-A*03:229 in Chinese individuals. HLA 2016: 87: 165-6.
  4. Yang EK, Hung JH, Lin PY. Discovery of HLA-A*11:01:69, a novel HLA-A*11:01 variant, in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 166-7.
  5. Zhang X, Li GJ, Li XF, Fan H, Li JP. A new HLA-A allele, HLA-A*11:120, sequenced in a Chinese hematopoietic stem cell donor. HLA 2016: 87: 168-70.
  6. Yang KL, Hung JH, Lin PY. HLA-A*11:231, a novel variant of HLA-A*11, found in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 170-1.
  7. Zhu YY, Qiang W, Shen G, Zou J, Liu GJ. HLA-A*24:02:96, a novel variant of HLA-A*24:02:01:01, identified in a Chinese individual by sequence-based typing. HLA 2016: 87: 171-2.
  8. He JJ, Chen NY, Dong LN, He J, Zhu FM. Two novel HLA-A alleles: A*24:258 and A*24:305 were identified in Chinese individuals. HLA 2016: 87: 173-4.
  9. Li WX, Xia JA, Mao Y, Li G, Shen G. Identification of a new HLA-B allele, HLA-B*15:300, in a Chinese individual. HLA 2016: 87: 175-6.
  10. Yang KL, Hung JH, Lin PY. Discovery of HLA-B*35:307, a novel HLA-B*35 variant, in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 178-9.
  11. Yang KL, Hung JH, Lin PY. HLA-B*40:01:44, a novel variant of HLA-B*40:01, discovered in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 179-80.
  12. Han ZD, Dong LN, Wang W, He J, Zhu FM. Identification of a novel HLA-B*54:34 allele by polymerase chain reaction sequence-based typing in a Chinese leukemia patient. HLA 2016: 87: 180-2.
  13. Yang KL, Hung JH, Lin PY. Discovery of HLA-B*55:02:10, a novel HLA-B*55:02 variant, in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 182-3.
  14. Wang W, Chen NY, Dong LN, He J, Zhu FM. A novel allele, HLA-B*55:70 was identified in a Chinese cord blood donor. HLA 2016: 87: 183-5.
  15. Qiang W, Shen G, Zhu YY, Zou J. A novel allele, HLA-B*55:77, identified by sequence-based typing in a Chinese individual. HLA 2016: 87: 185-6.
  16. Suzuki S, Sato T, Akatsuka H, Kimura M, Shiina T. Identification of a novel HLA-C allele, HLA-C*03:313, in a Japanese individual. HLA 2016: 87: 186-7.
  17. Yang EK, Ng J, Lazaro A, Hung JH, Lin PY. Detection of HLA-C*04:212, a novel HLA-C*04 variant, in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 187-9.
  18. Liu B, Yang P, Ma Z, Ma Y, Sheng X. Identification of a novel HLA-C*16 variant, HLA-C*16:90, in a Chinese individual. HLA 2016: 87: 189-90.
  19. Zhu X, Yang T, Tan R, Su P, Gao H. A novel HLA-DRB1 allele, HLA-DRB1*12:48. HLA 2016: 87: 190-1.