Nomenclature for Factors of the HLA System
November 2015
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2016) 87:122-5
- Human Immunology (2016) 77:436-9
- International Journal of Immunogenetics (2016) 43:116-9
The following sequences have been submitted to the Nomenclature Committee since the October 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:06:22 | NT01289 | KT893441 | Carolyn K Hurley, Washington DC, USA |
| A*02:602 | NT01287 | KT893444 | Carolyn K Hurley, Washington DC, USA |
| A*02:603 | BY01277 | KT957433 | Carolyn K Hurley, Washington DC, USA |
| A*11:01:69 | 396421 | LN890470 | Edward KL Yang, Hualien, Taiwan |
| A*11:230 | Xian66903 | KR559235 | Jun Qi, Xian, China |
| A*11:231 | 396516 | LN890471 | Edward KL Yang, Hualien, Taiwan |
| A*11:232 | 271002202 | KU057095 | Wen Qiang, Wuhan, China |
| A*11:233 | HG00011022 | KU095785 | Histogenetics, Ossining, USA |
| A*11:234 | HG00011023 | KU095787 | Histogenetics, Ossining, USA |
| A*24:02:96 | 271502569 | KU057096 | Wen Qiang, Wuhan, China |
| A*26:118 | SNUH150825_DR00265 | KU132396 | Oh-Joong Kwon, Seoul, South Korea |
| A*26:119 | HG00011020 | KT844478 | Histogenetics, Ossining, USA |
| A*26:120 | HG00011021 | KT803909 | Histogenetics, Ossining, USA |
| A*29:83 | HG00011018 | KT844474 | Histogenetics, Ossining, USA |
| A*30:97 | 0271402674 | KU057091 | Wen Qiang, Wuhan, China |
| A*31:105 | HG00011016 | KT984957 | Histogenetics, Ossining, USA |
| A*33:106 | HG00011017 | KT844475 | Histogenetics, Ossining, USA |
| A*68:02:11 | 0201502402 | KU056811 | Silvia Ulrich, Graz, Austria |
| A*68:02:12 | HG00011019 | KT803905 | Histogenetics, Ossining, USA |
| A*68:140 | NT01284 | KT893447 | Carolyn K Hurley, Washington DC, USA |
| A*68:141 | HG00011025 | KT760486 | Histogenetics, Ossining, USA |
| B*07:261 | CGE-1856 | KU048075 | Stephane Buhler, Geneva, Switzerland |
| B*07:262 | HG00011069 | KU095788 | Histogenetics, Ossining, USA |
| B*07:263 | HG00011075 | KT844482 | Histogenetics, Ossining, USA |
| B*08:01:32 | NT01288 | KT893442 | Carolyn K Hurley, Washington DC, USA |
| B*14:52 | HG00011067 | KT984963 | Histogenetics, Ossining, USA |
| B*15:197:02 | JRC-D01-253 | LC097057 | Kenji Tadokoro, Tokyo, Japan |
| B*15:378 | HG00011061 | KT844481 | Histogenetics, Ossining, USA |
| B*15:379 | HG00011066 | KT943425 | Histogenetics, Ossining, USA |
| B*18:117 | HG00011050 | KT895310 | Histogenetics, Ossining, USA |
| B*18:118 | HG00011052 | KT844479 | Histogenetics, Ossining, USA |
| B*18:119 | IPP2529739 | KU179866 | Cyril Andre, Lausanne, Switzerland |
| B*35:307 | 394164 | LN890468 | Edward KL Yang, Hualien, Taiwan |
| B*35:308 | HG00011054 | KT968842 | Histogenetics, Ossining, USA |
| B*35:309 | HG00011055 | KT943430 | Histogenetics, Ossining, USA |
| B*35:310 | HG00011056 | KT968843 | Histogenetics, Ossining, USA |
| B*35:311 | HG00011062 | KT803913 | Histogenetics, Ossining, USA |
| B*37:58 | 02034458 | LN898126 | Ioannis Theodorou, Paris, France |
| B*39:01:23 | 5711400254 | KT934380 | Faming Zhu, Hangzhou, China |
| B*39:111 | HG00011072 | KT943426 | Histogenetics, Ossining, USA |
| B*39:112 | HG00011073, HG00011074 | KT943428, KT844480 | Histogenetics, Ossining, USA |
| B*39:113 | HG00011076 | KT895307 | Histogenetics, Ossining, USA |
| B*40:01:44 | 385759 | LN890474 | Edward KL Yang, Hualien, Taiwan |
| B*40:322 | Xian66962 | KR604699 | Jun Qi, Xian, China |
| B*40:323 | AMC150903_49663747 | KT897468 | Oh-Joong Kwon, Seoul, South Korea |
| B*40:324 | 271507428 | KU057094 | Wen Qiang, Wuhan, China |
| B*40:325 | HG00011065 | KT895308 | Histogenetics, Ossining, USA |
| B*41:45N | 1007477810074779 | LN901452 | Kremena Todorova, Berlin, Germany |
| B*44:03:33 | NT01286 | KT893445 | Carolyn K Hurley, Washington DC, USA |
| B*44:236 | M-326356 | LN894187 | Kristin Kipper, Martinsried, Germany |
| B*49:41 | HG00011049 | KT943431 | Histogenetics, Ossining, USA |
| B*51:199 | Xian61608 | KT285898 | Jun Qi, Xian, China |
| B*51:200 | M-363747 | LN901211 | Kristin Kipper, Martinsried, Germany |
| B*52:57 | Xian65579 | KT285899 | Jun Qi, Xian, China |
| B*52:58 | HG00011057 | KT984961 | Histogenetics, Ossining, USA |
| B*52:59 | HG00011059 | KT803912 | Histogenetics, Ossining, USA |
| B*55:02:10 | 401240 | LN890472 | Edward KL Yang, Hualien, Taiwan |
| B*55:77 | 0271500703 | KU057092 | Wen Qiang, Wuhan, China |
| B*55:78 | HG00011064 | KT984960 | Histogenetics, Ossining, USA |
| B*56:02:02 | NT01285 | KT893446 | Carolyn K Hurley, Washington DC, USA |
| B*58:77 | 396544 | LN890473 | Edward KL Yang, Hualien, Taiwan |
| B*58:78 | HG00011058 | KT943432 | Histogenetics, Ossining, USA |
| C*04:01:70 | 93093915 | KR534594 | Daniel Fuerst, Ulm, Germany |
| C*07:01:52 | 96084447 | KR139982 | Daniel Fuerst, Ulm, Germany |
| C*07:02:70 | 3587 | LN832408, KR046213 | Xiao Yang Zhou, Beijing, China |
| C*07:02:71 | 90200922 | KR139983 | Daniel Fuerst, Ulm, Germany |
| C*07:477 | KM-DL196 | LN864924 | Jue Wang, Chengdu, China |
| C*07:478 | 07-433 | KC292010.1 | Eun-Jeong Choi, Seoul, Korea |
| C*08:128 | H150622 | KU128403 | Faming Zhu, Hangzhou, China |
| DRB1*07:68N | NT01293 | KT957432 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:04:13 | Xian67509 | KR604700 | Jun Qi, Xian, China |
| DRB1*11:195 | BY01281 | KU053501 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:196 | CN_33803CN_35975 | KT895371 | Lucia Assunta Longa, Cuneo, Italy |
| DRB1*14:171 | BY01282 | KU053500 | Carolyn K Hurley, Washington DC, USA |
| DPB1*05:01:07 | BWU035_AD11911 | KU055449 | Oh-Joong Kwon, Seoul, South Korea |
| DPB1*518:01 | BWU056_AD11889 | KU055452 | Oh-Joong Kwon, Seoul, South Korea |
| DPB1*519:01 | BWU039_AD12001 | KU055450 | Oh-Joong Kwon, Seoul, South Korea |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:190 | HG00010947, HG00010948 | KT438904, KT710869 | Histogenetics, Ossining, USA |
| A*02:01:120 | NT01291 | KT957435 | Carolyn K Hurley, Washington DC, USA |
| A*02:06:01:03 | NT01290 | KT957437 | Carolyn K Hurley, Washington DC, USA |
| A*02:407 | HG00010949 | KP131481 | Histogenetics, Ossining, USA |
| A*26:07:02 | NT01290 | KT957436 | Carolyn K Hurley, Washington DC, USA |
| A*26:115 | HG00011024 | KT984959 | Histogenetics, Ossining, USA |
| A*31:01:24 | HG00010943 | KT438905 | Histogenetics, Ossining, USA |
| A*33:68 | HG00010944 | KP131475 | Histogenetics, Ossining, USA |
| A*68:01:31 | HG00010946 | KT760489 | Histogenetics, Ossining, USA |
| A*68:112:02 | HG00010945 | KT355329 | Histogenetics, Ossining, USA |
| B*13:02:15 | HG00010952 | KP131486 | Histogenetics, Ossining, USA |
| B*15:335 | HG00010956 | KT361893 | Histogenetics, Ossining, USA |
| B*15:347 | 0271502550 | KU057093 | Wen Qiang, Wuhan, China |
| B*18:114 | HG00010951 | KR818713 | Histogenetics, Ossining, USA |
| B*27:101 | BY01276 | KT893440 | Carolyn K Hurley, Washington DC, USA |
| B*27:142 | HG00010950 | KT355337 | Histogenetics, Ossining, USA |
| B*44:18 | NT01292 | KT957434 | Carolyn K Hurley, Washington DC, USA |
| B*44:221 | HG00010957 | KT315591 | Histogenetics, Ossining, USA |
| B*47:01:01:03 | NT01288 | KT893443 | Carolyn K Hurley, Washington DC, USA |
| B*53:01:11 | HG00010955 | KT760499 | Histogenetics, Ossining, USA |
| B*57:77 | HG00010954 | KT355339 | Histogenetics, Ossining, USA |
| B*58:28:02 | HG00010953 | KT282154 | Histogenetics, Ossining, USA |
| C*01:07:02 | HG00010958 | KT355372 | Histogenetics, Ossining, USA |
| C*02:93 | HG00010969 | KT235657 | Histogenetics, Ossining, USA |
| C*02:98 | HG00010970 | KT600104 | Histogenetics, Ossining, USA |
| C*03:03:29 | HG00010972 | KT355369 | Histogenetics, Ossining, USA |
| C*04:141 | HG00010973 | KP131493 | Histogenetics, Ossining, USA |
| C*04:180:01 | HG00010974 | KT760513 | Histogenetics, Ossining, USA |
| C*04:180:02 | HG00010975 | KR677059 | Histogenetics, Ossining, USA |
| C*04:209 | HG00010976, HG00010977 | KT600114, KT760515 | Histogenetics, Ossining, USA |
| C*05:01:30 | HG00010966 | KT315603 | Histogenetics, Ossining, USA |
| C*05:104 | HG00010967 | KT235656 | Histogenetics, Ossining, USA |
| C*06:140 | HG00010959, HG00010960 | KT600110, KT355366 | Histogenetics, Ossining, USA |
| C*06:151 | HG00010961 | KT355365 | Histogenetics, Ossining, USA |
| C*07:02:65 | HG00010964 | KT361895 | Histogenetics, Ossining, USA |
| C*07:411 | HG00010963 | KT282171 | Histogenetics, Ossining, USA |
| C*07:429 | HG00010962 | KT355368 | Histogenetics, Ossining, USA |
| C*12:136 | HG00010965 | KT282161 | Histogenetics, Ossining, USA |
| C*12:144 | HG00010968 | KT355364 | Histogenetics, Ossining, USA |
| C*15:102 | HG00010971 | KT600118 | Histogenetics, Ossining, USA |
| DRB1*07:56 | HG00010997 | KT355355 | Histogenetics, Ossining, USA |
| DRB1*07:61 | HG00010996 | KT361910 | Histogenetics, Ossining, USA |
| DRB1*11:187 | HG00010999 | KT355354 | Histogenetics, Ossining, USA |
| DRB1*11:193 | HG00010998 | KT600134 | Histogenetics, Ossining, USA |
| DRB1*15:01:25 | HG00010993, HG00010994 | KT235671, KT355348 | Histogenetics, Ossining, USA |
| DRB1*15:02:15 | HG00010995 | KT710879 | Histogenetics, Ossining, USA |
| DRB1*16:01:05 | BY01286 | KU159282 | Carolyn K Hurley, Washington DC, USA |
| DRB1*16:01:08 | HG00010988, HG00010989, HG00010990 | KT282189, KT600136, KT438917 | Histogenetics, Ossining, USA |
| DRB1*16:30 | HG00010987 | KT282188 | Histogenetics, Ossining, USA |
| DRB1*16:35 | 396304 | LN890469 | Edward KL Yang, Hualien, Taiwan |
| DRB1*16:37 | HG00010991, HG00010992 | KT600132, KT600133 | Histogenetics, Ossining, USA |
| DQB1*02:01:11 | HG00010980 | KP131509 | Histogenetics, Ossining, USA |
| DQB1*02:01:19 | HG00010981 | KT355347 | Histogenetics, Ossining, USA |
| DQB1*02:01:20 | HG00010978, HG00010979 | KT361906, KT315610 | Histogenetics, Ossining, USA |
| DQB1*02:26 | NT01295 | KU053505 | Carolyn K Hurley, Washington DC, USA |
| DQB1*03:16 | NT01294 | KU053506 | Carolyn K Hurley, Washington DC, USA |
| DQB1*04:02:09 | HG00010738 | KT361904 | Histogenetics, Ossining, USA |
| DQB1*04:27 | HG00010986 | KT315609 | Histogenetics, Ossining, USA |
| DQB1*05:101 | HG00010985 | KT361900 | Histogenetics, Ossining, USA |
| DQB1*05:49 | BY01284 | KU159284 | Carolyn K Hurley, Washington DC, USA |
| DQB1*05:80 | HG00010983 | KT235662 | Histogenetics, Ossining, USA |
| DQB1*05:88 | HG00010984 | KT600128 | Histogenetics, Ossining, USA |
| DQB1*06:01:08 | BY01288 | KU165801 | Carolyn K Hurley, Washington DC, USA |
| DQB1*06:14:01 | NT01296 | KU053502 | Carolyn K Hurley, Washington DC, USA |
| DQB1*06:169 | HG00010982 | KT282180 | Histogenetics, Ossining, USA |
| DQB1*06:48 | BY01287 | KU165800 | Carolyn K Hurley, Washington DC, USA |
| DQB1*06:55 | BY01285 | KU159283 | Carolyn K Hurley, Washington DC, USA |
| DPB1*02:01:15 | HG00011005 | KT760550 | Histogenetics, Ossining, USA |
| DPB1*09:01:04 | HG00011010 | KR868805 | Histogenetics, Ossining, USA |
| DPB1*152:01 | BY01280 | KU053503 | Carolyn K Hurley, Washington DC, USA |
| DPB1*155:01:02 | HG00011007 | KT600147 | Histogenetics, Ossining, USA |
| DPB1*370:01 | HG00011013 | KT600141 | Histogenetics, Ossining, USA |
| DPB1*374:01 | HG00011000 | KT355362 | Histogenetics, Ossining, USA |
| DPB1*385:01 | HG00011008 | KT235670 | Histogenetics, Ossining, USA |
| DPB1*398:01 | HG00011001, HG00011002 | KT235667, KT361914 | Histogenetics, Ossining, USA |
| DPB1*404:01 | HG00011011 | KT361913 | Histogenetics, Ossining, USA |
| DPB1*413:01 | HG00011014 | KT282194 | Histogenetics, Ossining, USA |
| DPB1*418:01 | HG00011004 | KT282195 | Histogenetics, Ossining, USA |
| DPB1*437:01 | HG00011012 | KT600144 | Histogenetics, Ossining, USA |
| DPB1*445:01 | HG00011009 | KT760551 | Histogenetics, Ossining, USA |
| DPB1*448:01 | HG00011015 | KT760548 | Histogenetics, Ossining, USA |
| DPB1*476:01 | HG00011003 | KT438919 | Histogenetics, Ossining, USA |
| DPB1*489:01 | HG00011006 | KT361917 | Histogenetics, Ossining, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:06:01:02 | (3) |
| A*02:575 | (4) |
| B*15:367 | (5) |
| B*50:20 | (6) |
| C*03:280 | (7) |
| DQA1*01:07Q | (8) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens. 2010 75 291-455.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res. 2015 43 D423-31.
- Kwok J, Ho JC, Chan YS, Soormally A, Marsh SGE. Identification of a novel HLA-A*02:06:01:02 allele in a Chinese individual by sequence-based typing. Tissue Antigens. 2015 86 448-9.
- Yang KL, Hung JH, Lin PY. A novel HLA-A*02 variant, HLA-A*02:575, detected in a Taiwanese bone marrow hematopoietic stem cell donor. Tissue Antigens. 2015 86 449-51.
- Ham JY, Yoon CE, Moon JH, Won DI, Suh JS. Identification of a novel HLA-B*15 variant, B*15:367, using sequence-based typing in a Korean woman. Tissue Antigens. 2015 86 451-2.
- Becker PS, Seifried E, Seidl C. Four amino acid exchanges located in the alpha-2 domain specify the novel HLA-B*50:20 allele. Tissue Antigens. 2015 86 453-5.
- Chun S, Song JS, Yu S, Kim JS, Kwon OJ, Kang ES. Identification of a novel HLA-C*03 variant allele, C*03:280 by sequence-based typing. Tissue Antigens. 2015 86 455-6.
- Miyadera H, Bungener LB, Kusano S, Yokoyama S, Tokunaga K, Hepkema BG. Questionable expression of unstable DQ heterodimer containing HLA-DQA1*01:07. Tissue Antigens. 2015 86 413-8.
