Nomenclature for Factors of the HLA System

October 2015

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the September 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:197HG00010818KT710866Histogenetics, Ossining, USA
A*01:198HG00010821KT600076Histogenetics, Ossining, USA
A*02:01:121NT01279KT819313Carolyn K Hurley, Washington DC, USA
A*02:599HG00010827KT600073Histogenetics, Ossining, USA
A*02:600HG00010828KT600078Histogenetics, Ossining, USA
A*02:601HG00010829KT710868Histogenetics, Ossining, USA
A*03:01:01:06NT01275KT819308Carolyn K Hurley, Washington DC, USA
A*03:154:0215207482KT803854Daniel Fuerst, Ulm, Germany
A*03:235HG00010822KT760491Histogenetics, Ossining, USA
A*03:236HG00010823KT600070Histogenetics, Ossining, USA
A*24:324HG00010816KT600071Histogenetics, Ossining, USA
A*24:325SZGSQ24KT826594Su-Qing Gao, Shenzhen, China
A*24:326275881KT878496Elena Longhi, Milano, Italy
A*30:01:11NT01272KT819305Carolyn K Hurley, Washington DC, USA
A*31:104HG00010808KT760485Histogenetics, Ossining, USA
A*32:80HG00010824KT760482Histogenetics, Ossining, USA
A*33:105HG00010809KT760493Histogenetics, Ossining, USA
A*68:138HG00010812KT710867Histogenetics, Ossining, USA
A*68:139NT01278KT819312Carolyn K Hurley, Washington DC, USA
A*74:27HG00010825KT760483Histogenetics, Ossining, USA
B*07:257HG00010700KT438907Histogenetics, Ossining, USA
B*07:258HG00010702KT438910Histogenetics, Ossining, USA
B*07:259HG00010857KT760505Histogenetics, Ossining, USA
B*07:260HG00010858KT760506Histogenetics, Ossining, USA
B*08:157HG00010836KT600096Histogenetics, Ossining, USA
B*08:158HG00010838KT710870Histogenetics, Ossining, USA
B*13:86HG00010840KT600089Histogenetics, Ossining, USA
B*13:87BY01270KT764976Carolyn K Hurley, Washington DC, USA
B*14:51HG00010856KT600097Histogenetics, Ossining, USA
B*15:04:03HG00010849KT600091Histogenetics, Ossining, USA
B*15:375N60750978KT768091Antonio Balas, Madrid, Spain
B*15:376HG00010852KT600094Histogenetics, Ossining, USA
B*15:377QNT01277KT819311Carolyn K Hurley, Washington DC, USA
B*18:01:24TMO27647KT807796Antonio Balas, Madrid, Spain
B*27:146HG00010830KT600085Histogenetics, Ossining, USA
B*35:301HG00010839KT600081Histogenetics, Ossining, USA
B*35:302HG00010843KT760498Histogenetics, Ossining, USA
B*35:303HG00010845KT760503Histogenetics, Ossining, USA
B*35:304HG00010846KT760495Histogenetics, Ossining, USA
B*35:30596083726KT803855Daniel Fuerst, Ulm, Germany
B*35:30693103407KT803856Daniel Fuerst, Ulm, Germany
B*38:59HG00010706KT355342Histogenetics, Ossining, USA
B*39:108HG00010704KT438911Histogenetics, Ossining, USA
B*39:109HG00010705KT315593Histogenetics, Ossining, USA
B*39:110HG00010708KT315595Histogenetics, Ossining, USA
B*40:318HG00010709KT438909Histogenetics, Ossining, USA
B*40:319HG00010831KT600082Histogenetics, Ossining, USA
B*40:320HG00010834KT600092Histogenetics, Ossining, USA
B*40:321BY01275KT819316Carolyn K Hurley, Washington DC, USA
B*41:42HG00010833KT760494Histogenetics, Ossining, USA
B*41:4315700134KT852371Antonio Balas, Madrid, Spain
B*41:44NT01281KT819315Carolyn K Hurley, Washington DC, USA
B*42:22HG00010701KT282157Histogenetics, Ossining, USA
B*44:03:31HG00010861KT600093Histogenetics, Ossining, USA
B*44:03:32NT01280KT819314Carolyn K Hurley, Washington DC, USA
B*44:128:02LUMC-B-126LN887899Jacqy DH Anholts, Leiden, The Netherlands
B*44:235HG00010841KT760501Histogenetics, Ossining, USA
B*45:18HG00010832KT760496Histogenetics, Ossining, USA
B*48:38HG00010860KT600090Histogenetics, Ossining, USA
B*51:196HG00010853KT760507Histogenetics, Ossining, USA
B*51:197HG00010854KT710873Histogenetics, Ossining, USA
B*51:198HG00010855KT600084Histogenetics, Ossining, USA
B*56:50282336KT821556Elena Longhi, Milano, Italy
B*57:81HG00010850KT600083Histogenetics, Ossining, USA
B*57:82BY01274KT764975Carolyn K Hurley, Washington DC, USA
B*58:59:02HG00010848KT760500Histogenetics, Ossining, USA
B*58:74HG00010699KT315597Histogenetics, Ossining, USA
B*58:75HG00010847KT710871Histogenetics, Ossining, USA
B*58:76NT01271KT764979Carolyn K Hurley, Washington DC, USA
C*01:115HG00010862KT760521Histogenetics, Ossining, USA
C*01:11681136719KT803858Daniel Fuerst, Ulm, Germany
C*01:117NNT01273KT819306Carolyn K Hurley, Washington DC, USA
C*02:06:02BY01271KT764974Carolyn K Hurley, Washington DC, USA
C*02:10:01:02NT01276KT819309Carolyn K Hurley, Washington DC, USA
C*02:109HG00010889KT600113Histogenetics, Ossining, USA
C*03:04:49LUMC-C-117LN887896Jacqy DH Anholts, Leiden, The Netherlands
C*03:57:02HG00010737KT282169Histogenetics, Ossining, USA
C*03:304HG00010736KT282176Histogenetics, Ossining, USA
C*03:305HG00010738KT361896Histogenetics, Ossining, USA
C*03:306HG00010739KT282168Histogenetics, Ossining, USA
C*03:307HG00010894KT710876Histogenetics, Ossining, USA
C*04:218HG00010741,
HG00010742
KT282167,
KT282174
Histogenetics, Ossining, USA
C*04:219HG00010743KT235658Histogenetics, Ossining, USA
C*04:220HG00010865KT760516Histogenetics, Ossining, USA
C*04:221HG00010898KT760514Histogenetics, Ossining, USA
C*04:222HG00010899KT600112Histogenetics, Ossining, USA
C*04:223HG00010900KT600123Histogenetics, Ossining, USA
C*04:224HG00010901KT600106Histogenetics, Ossining, USA
C*04:225NHG00010902KT760508Histogenetics, Ossining, USA
C*04:226LUMC-C-118LN887897Jacqy DH Anholts, Leiden, The Netherlands
C*05:125HG00010724KT361897Histogenetics, Ossining, USA
C*05:126HG00010886KT600122Histogenetics, Ossining, USA
C*06:167HG00010711KT315601Histogenetics, Ossining, USA
C*06:168HG00010712KT235659Histogenetics, Ossining, USA
C*06:169HG00010864KT600116Histogenetics, Ossining, USA
C*06:170HG00010866KT710874Histogenetics, Ossining, USA
C*07:257:04HG00010870KT600119Histogenetics, Ossining, USA
C*07:460HG00010716KT355373Histogenetics, Ossining, USA
C*07:461HG00010717KT355367Histogenetics, Ossining, USA
C*07:462HG00010718KT315604Histogenetics, Ossining, USA
C*07:463HG00010719KT282172Histogenetics, Ossining, USA
C*07:464HG00010721KT315606Histogenetics, Ossining, USA
C*07:465HG00010723KT282179Histogenetics, Ossining, USA
C*07:466HG00010868KT760522Histogenetics, Ossining, USA
C*07:467HG00010869KT760512Histogenetics, Ossining, USA
C*07:468HG00010871KT600103Histogenetics, Ossining, USA
C*07:469HG00010872KT760510Histogenetics, Ossining, USA
C*07:470HG00010875KT600111Histogenetics, Ossining, USA
C*07:471HG00010876KT760524Histogenetics, Ossining, USA
C*07:472HG00010878KT600120Histogenetics, Ossining, USA
C*07:473HG00010879KT760520Histogenetics, Ossining, USA
C*07:474HG00010880KT760532Histogenetics, Ossining, USA
C*07:475HG00010882KT760528Histogenetics, Ossining, USA
C*07:476NHG00010722KT315600Histogenetics, Ossining, USA
C*08:126HG00010725KT361894Histogenetics, Ossining, USA
C*08:127N13QB5759KP760115Janette Kwok, Pokfulam Road, Hong Kong
C*12:168HG00010728KT282164Histogenetics, Ossining, USA
C*12:169HG00010729KT355374Histogenetics, Ossining, USA
C*12:170HG00010888KT600105Histogenetics, Ossining, USA
C*12:171281512KT878495Elena Longhi, Milano, Italy
C*14:73HG00010897KT760529Histogenetics, Ossining, USA
C*15:118HG00010731,
HG00010732
KT282163,
KT282166
Histogenetics, Ossining, USA
C*15:119HG00010890KT760519Histogenetics, Ossining, USA
C*15:120HG00010892KT760530Histogenetics, Ossining, USA
C*16:88HG00010727KT282178Histogenetics, Ossining, USA
C*16:89NHG00010730KT282159Histogenetics, Ossining, USA
C*18:10NT01274KT819307Carolyn K Hurley, Washington DC, USA
DRB1*01:65:02HG00010916KT600135Histogenetics, Ossining, USA
DRB1*03:126HG00010776KT282190Histogenetics, Ossining, USA
DRB1*03:127HG00010912KT760538Histogenetics, Ossining, USA
DRB1*07:67HG00010915KT600137Histogenetics, Ossining, USA
DRB1*08:78NHG00010917KT600130Histogenetics, Ossining, USA
DRB1*11:02:05HG00010922KT760539Histogenetics, Ossining, USA
DRB1*13:211HG00010919KT760542Histogenetics, Ossining, USA
DRB1*13:212HG00010920KT760540Histogenetics, Ossining, USA
DRB1*14:169HG00010780KT438916Histogenetics, Ossining, USA
DRB1*14:170HG00010923KT760543Histogenetics, Ossining, USA
DRB1*15:01:28HG00010914KT760541Histogenetics, Ossining, USA
DRB1*15:128HG00010913KT600131Histogenetics, Ossining, USA
DRB1*15:129NLUMC-DRB1-124LN887900Jacqy DH Anholts, Leiden, The Netherlands
DRB3*01:18HG00010937KT781582Histogenetics, Ossining, USA
DRB3*01:19HG00010938KT781581Histogenetics, Ossining, USA
DRB3*02:02:06LUMC-DRB3-122LN887898Jacqy DH Anholts, Leiden, The Netherlands
DRB3*02:30HG00010939KT781583Histogenetics, Ossining, USA
DRB3*02:31HG00010940KT781584Histogenetics, Ossining, USA
DRB3*02:32HG00010941KT781585Histogenetics, Ossining, USA
DQA1*01:1360753693KT807797Antonio Balas, Madrid, Spain
DQB1*02:65SNUH150818_27385852KT878020Oh-Joong Kwon, Seoul, South Korea
DQB1*03:216HG00010903KT710877Histogenetics, Ossining, USA
DQB1*03:217HG00010905KT760536Histogenetics, Ossining, USA
DQB1*03:21893023157KT803857Daniel Fuerst, Ulm, Germany
DQB1*04:33HG00010910KT600129Histogenetics, Ossining, USA
DQB1*05:66:02IU060320150001KT728007Jeremy Sherrill, Indianapolis, USA
DQB1*05:89:02HG00010906KT760533Histogenetics, Ossining, USA
DQB1*05:110NHG00010908KT600125Histogenetics, Ossining, USA
DQB1*05:111HG00010909KT760534Histogenetics, Ossining, USA
DQB1*06:198HG00010911KT600126Histogenetics, Ossining, USA
DPA1*02:01:01:02BY01256KT716046Carolyn K Hurley, Washington DC, USA
DPB1*14:01:03HG00010931KT760552Histogenetics, Ossining, USA
DPB1*498:01UNC11KT001470Eric Weimer, Chapel Hill, USA
DPB1*499:01HG00010789KT315617Histogenetics, Ossining, USA
DPB1*500:01HG00010791KT315616Histogenetics, Ossining, USA
DPB1*501:01HG00010793KT355357Histogenetics, Ossining, USA
DPB1*502:01HG00010794KT438920Histogenetics, Ossining, USA
DPB1*503:01HG00010796KT361915Histogenetics, Ossining, USA
DPB1*504:01HG00010797KT361912Histogenetics, Ossining, USA
DPB1*505:01HG00010798KT282196Histogenetics, Ossining, USA
DPB1*506:01HG00010800KT235669Histogenetics, Ossining, USA
DPB1*507:01NHG00010802,
HG00010803
KT438918,
KT361911
Histogenetics, Ossining, USA
DPB1*508:01HG00010804KT235664Histogenetics, Ossining, USA
DPB1*509:01HG00010806KT315618Histogenetics, Ossining, USA
DPB1*510:01HG00010925KT600138Histogenetics, Ossining, USA
DPB1*511:01HG00010926KT600145Histogenetics, Ossining, USA
DPB1*512:01HG00010928KT760547Histogenetics, Ossining, USA
DPB1*513:01HG00010930KT600142Histogenetics, Ossining, USA
DPB1*514:01HG00010932,
HG00010933
KT760546,
KT600143
Histogenetics, Ossining, USA
DPB1*515:01HG00010934KT760544Histogenetics, Ossining, USA
DPB1*516:01HG00010935KT760553Histogenetics, Ossining, USA
DPB1*517:01HG00010936KT760549Histogenetics, Ossining, USA

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:190281368KT878494Elena Longhi, Milano, Italy
A*11:190BY01273KT764980Carolyn K Hurley, Washington DC, USA
B*07:02:48HG00010859KT600086Histogenetics, Ossining, USA
B*18:01:21BY01272KT764977Carolyn K Hurley, Washington DC, USA
B*38:01:08HG00010707KT315592Histogenetics, Ossining, USA
B*40:01:40BY01214KJ623754Carolyn K Hurley, Washington DC, USA
C*02:91HG00010733KT282165Histogenetics, Ossining, USA
C*04:01:01:06BY01272KT764978Carolyn K Hurley, Washington DC, USA
C*05:111HG00010884KT600102Histogenetics, Ossining, USA
C*07:02:49BY00761HQ700658Carolyn K Hurley, Washington DC, USA
C*14:70HG00010896KT760517Histogenetics, Ossining, USA
C*16:01:18NT01276KT819310Carolyn K Hurley, Washington DC, USA
DQB1*02:53Q81135639KT803859Daniel Fuerst, Ulm, Germany
DQB1*03:200HG00010904KT760535Histogenetics, Ossining, USA
DQB1*06:04:01NT01262,
NT01263
KT591471Carolyn K Hurley, Washington DC, USA
DPA1*02:02:02BY01262,
BY01263
KT716050Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences


Sequence References
A*02:07:07(3)
A*02:48(4)
A*02:251(4)
A*24:313(5)
A*29:01:08(6)
A*29:01:09(7)
A*33:95(8)
B*35:270(9)
B*35:273(9)
B*46:01:20(10)
C*08:01:09(11)
DRB1*03:04:01(12)
DRB1*03:07(12)
DRB1*03:15(12)
DRB1*04:03:02(12)
DRB1*04:14(12)
DRB1*04:15(12)
DRB1*04:16(12)
DRB1*04:25(12)
DRB1*04:26(12)
DRB1*04:31(12)
DRB1*04:32(12)
DRB1*07:04(12)
DRB1*08:04:01(12)
DRB1*08:06(12)
DRB1*08:07(12)
DRB1*08:10(12)
DRB1*08:11(12)
DRB1*08:14(12)
DRB1*08:16(12)
DRB1*08:35(12)
DRB1*08:77(12)
DRB1*11:05(12)
DRB1*11:06:01(12)
DRB1*11:08:02(12)
DRB1*11:09(12)
DRB1*11:11:01(12)
DRB1*11:13:02(12)
DRB1*11:14:01(12)
DRB1*11:19:01(12)
DRB1*11:21(12)
DRB1*11:29:01(12)
DRB1*13:03:01(12)
DRB1*13:04(12)
DRB1*13:06(12)
DRB1*13:08(12)
DRB1*13:10(12)
DRB1*13:11:01(12)
DRB1*13:14:02(12)
DRB1*13:17(12)
DRB1*13:20(12)
DRB1*13:26:01(12)
DRB1*13:36(12)
DRB1*14:02:01(12)
DRB1*14:06:01(12)
DRB1*14:08(12)
DRB1*14:10(12)
DRB1*14:14(12)
DRB1*14:17(12)
DRB1*14:21(12)
DRB1*14:24(12)
DRB1*15:02:02(12)
DRB1*15:07:01(12)
DRB1*16:04(12)
DRB1*16:07(12)
DRB1*16:36(13)

References:

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