Nomenclature for Factors of the HLA System

April 2015

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the March 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence DRB1*11:11:02 has been shown to contain errors and be identical to DRB1*11:11:01. The name DRB1*11:11:02 has been abandoned.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:180HG00009978KP792225Histogenetics, Ossining, USA
A*01:181HG00009979KP325448Histogenetics, Ossining, USA
A*01:182HG00009980KP325450Histogenetics, Ossining, USA
A*01:183HG00009981KP735526Histogenetics, Ossining, USA
A*01:184HG00009982KP325444Histogenetics, Ossining, USA
A*01:185HG00009983KP342341Histogenetics, Ossining, USA
A*01:186NHG00009988KP342332Histogenetics, Ossining, USA
A*02:01:120HG00009996KP711767Histogenetics, Ossining, USA
A*02:06:20HG00009990KP665940Histogenetics, Ossining, USA
A*02:11:08HG00009993KP325451Histogenetics, Ossining, USA
A*02:11:09HG00009995KP792195Histogenetics, Ossining, USA
A*02:574HG00009992KP342339Histogenetics, Ossining, USA
A*02:575388345LN835248Edward KL Yang, Hualien, Taiwan
A*03:01:55HG00009985,
HG00009986		KP342336,
 KP792196		Histogenetics, Ossining, USA
A*03:222HG00009984KP325445Histogenetics, Ossining, USA
A*11:01:68HG00009969KP711770Histogenetics, Ossining, USA
A*11:199:02HG00009994KP735525Histogenetics, Ossining, USA
A*11:216HG00009968KP665938Histogenetics, Ossining, USA
A*11:217043537KP903397Jianping Li, Shenyang, Liaoning, China
A*24:02:95HG00009973KP792193Histogenetics, Ossining, USA
A*24:03:03HG00009976KP711768Histogenetics, Ossining, USA
A*24:306HG00009975KP792223Histogenetics, Ossining, USA
A*24:307HG00009977KP711773Histogenetics, Ossining, USA
A*24:308HG00009989KP711772Histogenetics, Ossining, USA
A*26:113HG00009970KP342333Histogenetics, Ossining, USA
A*26:114HG00009972KP792192Histogenetics, Ossining, USA
A*29:02:16HG00009963KP342335Histogenetics, Ossining, USA
A*29:79HG00009962KP792194Histogenetics, Ossining, USA
A*29:80HG00009964KP792224Histogenetics, Ossining, USA
A*31:96HG00009960KP711771Histogenetics, Ossining, USA
A*31:97044747KP903398Jianping Li, Shenyang, Liaoning, China
A*32:73HG00009987KP325452Histogenetics, Ossining, USA
A*32:74042521KP903394Jianping Li, Shenyang, Liaoning, China
A*33:98HG00009961KP342337Histogenetics, Ossining, USA
A*33:99HG00009965KP665939Histogenetics, Ossining, USA
A*66:23HG00009967KP711769Histogenetics, Ossining, USA
A*68:01:32HG00009991KP325449Histogenetics, Ossining, USA
A*68:02:10HG00009966KP792191Histogenetics, Ossining, USA
A*68:133HG00009971KP711774Histogenetics, Ossining, USA
B*08:148NDKMS-LSL-B-270LN600101DKMS Life Science Lab, Dresden, Germany
B*08:149HG00010003KP711758Histogenetics, Ossining, USA
B*08:150HG00010004,
HG00010005		KP342343,
 KP342344		Histogenetics, Ossining, USA
B*08:151HG00010006KP711752Histogenetics, Ossining, USA
B*15:356HG00010010KP342350Histogenetics, Ossining, USA
B*15:357HG00010015KP711750Histogenetics, Ossining, USA
B*15:358042899KP903395Jianping Li, Shenyang, Liaoning, China
B*15:359068092KP903406Jianping Li, Shenyang, Liaoning, China
B*18:109HG00010002KP342346Histogenetics, Ossining, USA
B*27:139HG00009999KP711765Histogenetics, Ossining, USA
B*27:140HG00010000KP711753Histogenetics, Ossining, USA
B*35:287HG00010011KP792201Histogenetics, Ossining, USA
B*35:288HG00010012KP342345Histogenetics, Ossining, USA
B*37:01:11HG00010001KP665945Histogenetics, Ossining, USA
B*38:57HG00009997KP792198Histogenetics, Ossining, USA
B*39:104DKMS-LSL-B-344LN810150DKMS Life Science Lab, Dresden, Germany
B*40:01:43DKMS-LSL-B-349LN810154DKMS Life Science Lab, Dresden, Germany
B*40:305DKMS-LSL-B-337LN810143DKMS Life Science Lab, Dresden, Germany
B*40:306354762LN831880Edward KL Yang, Hualien, Taiwan
B*41:37DKMS-LSL-B-342LN810149DKMS Life Science Lab, Dresden, Germany
B*44:02:39HG00010007KP325453Histogenetics, Ossining, USA
B*44:03:28DKMS-LSL-B-343LN810148DKMS Life Science Lab, Dresden, Germany
B*44:219HG00010008KP342342Histogenetics, Ossining, USA
B*44:220DRH001LN835179Steven GE Marsh, London, United Kingdom
B*46:64060999KP903399Jianping Li, Shenyang, Liaoning, China
B*49:38DKMS-LSL-B-348LN810153DKMS Life Science Lab, Dresden, Germany
B*49:3914742044LN833603Christian Seidl, Frankfurt am Main, Germany
B*50:01:07HG00009998KP792200Histogenetics, Ossining, USA
B*52:01:28DKMS-LSL-B-347LN810159DKMS Life Science Lab, Dresden, Germany
B*52:47HG00010009KP665944Histogenetics, Ossining, USA
B*52:48HG00010014KP711757Histogenetics, Ossining, USA
B*52:49N066086KP903403Jianping Li, Shenyang, Liaoning, China
B*55:02:095701400166KR106988Faming Zhu, Hangzhou, China
B*55:74HG00010019KP735529Histogenetics, Ossining, USA
B*57:77HG00010018KP711762Histogenetics, Ossining, USA
B*57:78RMC29252LN830752Maria Loginova, Kirov, Russia
B*58:01:01:02P09086KR184728Faming Zhu, Hangzhou, China
C*01:109NH150147KR106987Faming Zhu, Hangzhou, China
C*02:53:02DKMS-LSL-C-383LN811497DKMS Life Science Lab, Dresden, Germany
C*02:101M-356867KP768451Kristin Kipper, Martinsried, Germany
C*03:285DKMS-LSL-C-362LN811477DKMS Life Science Lab, Dresden, Germany
C*03:286DKMS-LSL-C-377LN811491DKMS Life Science Lab, Dresden, Germany
C*03:287DKMS-LSL-C-386LN811500DKMS Life Science Lab, Dresden, Germany
C*04:198DKMS-LSL-C-378LN811492DKMS Life Science Lab, Dresden, Germany
C*04:199DKMS-LSL-C-379LN811493DKMS Life Science Lab, Dresden, Germany
C*04:200DKMS-LSL-C-385LN811499DKMS Life Science Lab, Dresden, Germany
C*05:117DKMS-LSL-C-375LN811489DKMS Life Science Lab, Dresden, Germany
C*06:02:44DKMS-LSL-C-356LN811472DKMS Life Science Lab, Dresden, Germany
C*06:153DKMS-LSL-C-367LN811482DKMS Life Science Lab, Dresden, Germany
C*06:154DKMS-LSL-C-369LN811484DKMS Life Science Lab, Dresden, Germany
C*06:155DKMS-LSL-C-382LN811496DKMS Life Science Lab, Dresden, Germany
C*07:01:01:03DKMS-LSL-C-354LN811470DKMS Life Science Lab, Dresden, Germany
C*07:420DKMS-LSL-C-353LN811469DKMS Life Science Lab, Dresden, Germany
C*07:421DKMS-LSL-C-360LN811475DKMS Life Science Lab, Dresden, Germany
C*07:422DKMS-LSL-C-381LN811495DKMS Life Science Lab, Dresden, Germany
C*07:42390193970KR139984Daniel Fuerst, Ulm, Germany
C*12:03:34:02DKMS-LSL-C-350LN811466DKMS Life Science Lab, Dresden, Germany
C*12:03:36DKMS-LSL-C-368LN811483DKMS Life Science Lab, Dresden, Germany
C*12:153DKMS-LSL-C-357LN811473DKMS Life Science Lab, Dresden, Germany
C*12:154DKMS-LSL-C-365LN811480DKMS Life Science Lab, Dresden, Germany
C*12:155QDKMS-LSL-C-371LN811486DKMS Life Science Lab, Dresden, Germany
C*12:156DKMS-LSL-C-376LN811490DKMS Life Science Lab, Dresden, Germany
C*16:84DKMS-LSL-C-372LN811487DKMS Life Science Lab, Dresden, Germany
DRB1*04:02:04RMC648LN830750Maria Loginova, Kirov, Russia
DRB1*04:191161825LN832410Hien Tran, Heidelberg, Germany
DRB1*08:76067943KP903404Jianping Li, Shenyang, Liaoning, China
DRB1*09:2693017432KR139979Daniel Fuerst, Ulm, Germany
DRB1*11:182168463LN832411Hien Tran, Heidelberg, Germany
DRB1*12:57G20140830001LN811347Xingjie Li, Chengdu, China
DRB1*13:202RMC29428LN830748Maria Loginova, Kirov, Russia
DRB1*15:122RMC29253LN830749Maria Loginova, Kirov, Russia
DRB1*15:123065185KP903402Jianping Li, Shenyang, Liaoning, China
DQB1*02:5990193394KR139978Daniel Fuerst, Ulm, Germany
DQB1*03:181P09221KR047038Faming Zhu, Hangzhou, China
DQB1*03:182K1578794123LN811349John Crowley, Dublin, Eire
DPB1*03:01:0781134787KR139980Daniel Fuerst, Ulm, Germany
DPB1*440:0181134031KR139981Daniel Fuerst, Ulm, Germany
MICA*019:023380P09222203KP835292Daniel Fuerst, Ulm, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*24:02:90HG00009974KP342338Histogenetics, Ossining, USA
A*31:22SZGSQ 23KR108249Su-Qing Gao, Shenzhen, China
B*07:237DKMS-LSL-B-345LN810151DKMS Life Science Lab, Dresden, Germany
B*07:248043227KP903396Jianping Li, Shenyang, Liaoning, China
B*14:10DKMS-LSL-B-336LN810142DKMS Life Science Lab, Dresden, Germany
B*37:52DKMS-LSL-B-339LN810145DKMS Life Science Lab, Dresden, Germany
B*39:64DKMS-LSL-B-340LN810146DKMS Life Science Lab, Dresden, Germany
B*40:01:40068030KP903405Jianping Li, Shenyang, Liaoning, China
B*41:01:04shanxi070KP972655Demei Zhang, Taiyuan, China
B*41:02:06DKMS-LSL-B-341LN810147DKMS Life Science Lab, Dresden, Germany
B*44:05:01DKMS-LSL-B-336LN810141DKMS Life Science Lab, Dresden, Germany
B*44:27:01DKMS-LSL-B-339LN810144DKMS Life Science Lab, Dresden, Germany
B*52:43HG00010013KP711754Histogenetics, Ossining, USA
C*02:32DKMS-LSL-C-363LN811478DKMS Life Science Lab, Dresden, Germany
C*02:81DKMS-LSL-C-374LN811488DKMS Life Science Lab, Dresden, Germany
C*03:51DKMS-LSL-C-351LN811467DKMS Life Science Lab, Dresden, Germany
C*03:250DKMS-LSL-C-364LN811479DKMS Life Science Lab, Dresden, Germany
C*05:92NDKMS-LSL-C-359LN811534DKMS Life Science Lab, Dresden, Germany
C*06:106:02DKMS-LSL-C-384LN811498DKMS Life Science Lab, Dresden, Germany
C*06:129DKMS-LSL-C-280LN600120DKMS Life Science Lab, Dresden, Germany
C*07:60DKMS-LSL-C-380LN811494DKMS Life Science Lab, Dresden, Germany
C*08:72:02DKMS-LSL-C-370LN811485DKMS Life Science Lab, Dresden, Germany
C*12:02:12DKMS-LSL-C-355LN811471DKMS Life Science Lab, Dresden, Germany
C*15:96Q1500327KR054752Mingrui Huo, Beijing, China
DRB1*01:11:02HG00009888KP256335Histogenetics, Ossining, USA
DRB1*03:55C1074386crKR080367Francisco de Paula Sanchez Gordo, Malaga, Spain
DRB1*10:11HG00009885KM670546Histogenetics, Ossining, USA
DRB1*11:11:01CTM-3095924AY961065Antonio Balas, Madrid, Spain
DRB1*11:11:0114034LN830949Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*13:50:03HG00009887KM497470Histogenetics, Ossining, USA
DRB1*14:84D196403LN831883Edward KL Yang, Hualien, Taiwan
DRB1*14:145HG00009886KM586191Histogenetics, Ossining, USA
DRB1*15:102HG00009884KP227743Histogenetics, Ossining, USA
DQB1*02:01:19HG00009871KP227741Histogenetics, Ossining, USA
DQB1*03:01:22HG00009870KP279727Histogenetics, Ossining, USA
DQB1*03:01:27HG00009869KP163958Histogenetics, Ossining, USA
DQB1*03:106HG00009874KM586181Histogenetics, Ossining, USA
DQB1*05:03:16HG00009883KP256333Histogenetics, Ossining, USA
DQB1*05:11:02HG00009876,
HG00009877		KM497461,
 KP256332		Histogenetics, Ossining, USA
DQB1*05:49HG00009878,
HG00009879		KP310897,
 KP227739		Histogenetics, Ossining, USA
DQB1*05:52HG00009875KM497462Histogenetics, Ossining, USA
DQB1*05:71HG00009880KP192455Histogenetics, Ossining, USA
DQB1*05:72HG00009881KP057117Histogenetics, Ossining, USA
DQB1*05:79HG00009867KP057118Histogenetics, Ossining, USA
DQB1*05:88HG00009882KP310899Histogenetics, Ossining, USA
DQB1*06:01:14HG00009868KM198162Histogenetics, Ossining, USA
DQB1*06:118:02HG00009873KM497469Histogenetics, Ossining, USA
DQB1*06:158NHG00009872KP131454Histogenetics, Ossining, USA
DPB1*02:01:12HG00009931,
HG00009932,
HG00009933		KP310914,
 KM497497,
 KM405420		Histogenetics, Ossining, USA
DPB1*02:01:13HG00009930KP057155Histogenetics, Ossining, USA
DPB1*03:01:04HG00009950,
HG00009951		KM405390,
 KM282273		Histogenetics, Ossining, USA
DPB1*04:01:10HG00009906KM586222Histogenetics, Ossining, USA
DPB1*04:01:11HG00009909,
HG00009910		KP256341,
 KP256342		Histogenetics, Ossining, USA
DPB1*04:01:14HG00009937,
HG00009938		KM405386,
 KM405411		Histogenetics, Ossining, USA
DPB1*04:01:22HG00009908KP057138Histogenetics, Ossining, USA
DPB1*04:02:05HG00009934KM987227Histogenetics, Ossining, USA
DPB1*04:02:07HG00009915,
HG00009916		KM455000,
 KM987172		Histogenetics, Ossining, USA
DPB1*05:01:03HG00009892KM405417Histogenetics, Ossining, USA
DPB1*98:012014010804KJ858684Adolfo Eiras, Santiago de Compostela, Spain
DPB1*170:01HG00009893KP227745Histogenetics, Ossining, USA
DPB1*173:01HG00009895KP256344Histogenetics, Ossining, USA
DPB1*178:01HG00009911KP256339Histogenetics, Ossining, USA
DPB1*182:01HG00009917,
HG00009918,
HG00009919		KM282271,
 KM282260,
 KM282263		Histogenetics, Ossining, USA
DPB1*184:01HG00009922,
HG00009923,
HG00009924		KM282262,
 KM282261,
 KP256338		Histogenetics, Ossining, USA
DPB1*185:01HG00009925,
HG00009926		KM282255,
 KM282256		Histogenetics, Ossining, USA
DPB1*199:01HG00009943KP279733Histogenetics, Ossining, USA
DPB1*201:01HG00009944KM282266Histogenetics, Ossining, USA
DPB1*203:01HG00009947,
HG00009948		KP163969,
 KP192472		Histogenetics, Ossining, USA
DPB1*210:01HG00009889KP256337Histogenetics, Ossining, USA
DPB1*212:01HG00009890KP057149Histogenetics, Ossining, USA
DPB1*214:01HG00009901,
HG00009902		KP279734,
 KP256343		Histogenetics, Ossining, USA
DPB1*215:01HG00009905KP279731Histogenetics, Ossining, USA
DPB1*220:01HG00009940KP279737Histogenetics, Ossining, USA
DPB1*221:01HG00009956,
HG00009957		KM282280,
 KM282251		Histogenetics, Ossining, USA
DPB1*296:01LUMC-DPB-127LN795899Jacqy DH Anholts, Leiden, The Netherlands
DPB1*301:01HG00009894KM282258Histogenetics, Ossining, USA
DPB1*303:01HG00009913KP310917Histogenetics, Ossining, USA
DPB1*304:01HG00009914KM405398Histogenetics, Ossining, USA
DPB1*312:01HG00009939KP163976Histogenetics, Ossining, USA
DPB1*315:01HG00009941KP279730Histogenetics, Ossining, USA
DPB1*318:01HG00009896,
HG00009897,
HG00009898,
HG00009899,
HG00009900		KM405424,
 KM455001,
 KP192470,
 KM405416,
 KP227746		Histogenetics, Ossining, USA
DPB1*319:01HG00009907KP131473Histogenetics, Ossining, USA
DPB1*327:01HG00009942KP163972Histogenetics, Ossining, USA
DPB1*338:01HG00009921KP131471Histogenetics, Ossining, USA
DPB1*340:01HG00009928,
HG00009929		KP256345,
 KP279729		Histogenetics, Ossining, USA
DPB1*349:01HG00009958,
HG00009959		KM405423,
 KM586218		Histogenetics, Ossining, USA
DPB1*354:01:02HG00009891KM405391Histogenetics, Ossining, USA
DPB1*355:01HG00009903,
HG00009904		KM405427,
 KM586225		Histogenetics, Ossining, USA
DPB1*357:01NHG00009912KM454997Histogenetics, Ossining, USA
DPB1*359:01HG00009935KP192477Histogenetics, Ossining, USA
DPB1*360:01HG00009936KP227747Histogenetics, Ossining, USA
DPB1*365:01HG00009920KM497495Histogenetics, Ossining, USA
DPB1*369:0186015665KP027047Daniel Fuerst, Ulm, Germany
DPB1*370:01HG00009949KM405426Histogenetics, Ossining, USA
DPB1*380:01HG00009927KP131472Histogenetics, Ossining, USA
DPB1*391:01HG00009952,
HG00009953,
HG00009954,
HG00009955		KM282253,
 KM282279,
 KP279735,
 KM604699		Histogenetics, Ossining, USA
DPB1*393:01HG00009945,
HG00009946		KF976755,
 KJ619569		Histogenetics, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
A*02:07:06(3)
A*02:426(3)
A*11:210N(4)
A*24:02:60(5)
A*26:103(6)
A*26:107N(4)
A*32:67(7)
B*53:39(8)
C*06:103(9)
C*07:393N(10)
C*12:138(11)
DQB1*06:148(12)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens. 2010; 75:291-455.
  2. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res. 2015; 43:D423-31.
  3. Chen NY, He JJ, He J, Zhu FM, Lv HJ. Two novel alleles, HLA-A*02:07:06 and HLA-A*02:426, were identified in Chinese individuals. Tissue Antigens. 2015; 85:499-501.
  4. Balas A, Sanchez-Gordo F, Garcia-Sanchez F, Gomez-Zumaquero JM, Vicario JL. Characterization of two novel HLA-A null alleles: A*11:210N and A*26:107N. Tissue Antigens. 2015; 85:502-4.
  5. Zheng JW, Xie JH, Sun Y, Jiang YQ, Xiang D. Identification of a novel HLA-A*24 variant allele, A*24:02:60. Tissue Antigens. 2015; 85:504-5.
  6. Street J, Climer T, Johnson J, Pepperall J, Darke C. A new HLA-A*26 family allele--HLA-A*26:103. Tissue Antigens. 2015; 85:506-7.
  7. He YM, Wang W, Han ZD, He J, Zhu FM, Lv HJ. A novel HLA-A*32 allele, A*32:67 was identified by polymerase chain reaction sequence-based typing in a Chinese individual. Tissue Antigens. 2015; 85:507-8.
  8. Proust B, Masson D, Giraud C, et al. Identification of a novel HLA allele, HLA-B*53:39, in a Guadaloupean individual. Tissue Antigens. 2015; 85:509-10.
  9. Han ZD, He J, Wang W, Zhu FM, Lv HJ. HLA-C*06:103, a novel allele was identified in a Chinese patient awaiting hematopoietic stem cell transplantation. Tissue Antigens. 2015; 85:510-1.
  10. Yang KL, Lee SK, Hung JH, Lin PY. A single nucleotide deletion in exon 3 of the HLA-C*07:02:01:01 allele produces a novel HLA-C*07 null allele, HLA-C*07:393N. Tissue Antigens. 2015; 85:511-2.
  11. Biderman BV, Yakutik IA, Khamaganova EG, Kuzmina LA, Savchenko VG. Identification of a novel allele HLA-C*12:138 in Russian patient by haplotype-specific sequence-based typing. Tissue Antigens. 2015; 85:513-4.
  12. Wang XJ, Sun HY, Li QH, Ru K. Identification of a novel HLA-DQB1 allele, HLA-DQB1*06:148, by sequence-based typing in a Chinese individual. Tissue Antigens. 2015; 85:514-5.