Nomenclature for Factors of the HLA System
December 2014
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens (2015) 85:226-229
- Human Immunology (2015) 76:199-202
- International Journal of Immunogenetics (2015) 42:128-131
The following sequences have been submitted to the Nomenclature Committee since the November 2014 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:170 | 93048488 | KP201574 | Daniel Fuerst, Ulm, Germany |
| A*24:294Q | DKMS-LSL-A-230 | LN600071 | DKMS Life Sciences Lab, Dresden, Germany |
| A*26:109 | DKMS-LSL-A-298 | LN681579 | DKMS Life Sciences Lab, Dresden, Germany |
| A*33:95 | H1486 | KJ606927 | Xiaojing Wang, Tianjin, China |
| B*07:02:45 | BAWALL | LN624226 | Paul Dunn, Auckland, Zealand |
| B*07:238 | HG00009327 | KM282225 | Histogenetics, Ossining, USA |
| B*07:239 | HG00009328 | KM081661 | Histogenetics, Ossining, USA |
| B*07:240 | HG00009329 | KM365105 | Histogenetics, Ossining, USA |
| B*07:241 | 10957 | LN680998 | Maria Loginova, Kirov, Russia |
| B*13:83 | ZJ20140318001 | KP228011 | Faming Zhu, Hangzhou, China |
| B*14:43 | HG00009324 | KM365104 | Histogenetics, Ossining, USA |
| B*15:341 | HG00009318 | KM282235 | Histogenetics, Ossining, USA |
| B*15:342 | HG00009319, HG00009320 | KM405357, KM405369 | Histogenetics, Ossining, USA |
| B*15:343 | HG00009321 | KM405361 | Histogenetics, Ossining, USA |
| B*35:03:19 | DKMS-LSL-B-187 | LK022006 | DKMS Life Sciences Lab, Dresden, Germany |
| B*35:274 | HG00009310, HG00009311 | KM454989, KM497456 | Histogenetics, Ossining, USA |
| B*35:275 | HG00009312 | KM365102 | Histogenetics, Ossining, USA |
| B*35:276 | HG00009314, HG00009315 | KM282226, KM282227 | Histogenetics, Ossining, USA |
| B*35:277 | HG00009316 | KM282234 | Histogenetics, Ossining, USA |
| B*35:278 | HG00009323 | KM282228 | Histogenetics, Ossining, USA |
| B*35:279 | CZ-OL-17283 | LN626612 | Frantisek Mrazek, Olomouc, Czech Republic |
| B*39:06:05 | HG00009331 | KM282223 | Histogenetics, Ossining, USA |
| B*39:09:03 | HG00009330 | KM405366 | Histogenetics, Ossining, USA |
| B*39:100 | HG00009332 | KM081664 | Histogenetics, Ossining, USA |
| B*52:44 | H1869 | KM051507 | Xiaojing Wang, Tianjin, China |
| B*55:70 | ZJ20140220001 | KP228010 | Faming Zhu, Hangzhou, China |
| B*56:45 | HG00009322 | KM282233 | Histogenetics, Ossining, USA |
| B*58:01:18 | DKMS-LSL-B-183 | LK022002 | DKMS Life Sciences Lab, Dresden, Germany |
| B*58:68 | HG00009313 | KM282224 | Histogenetics, Ossining, USA |
| B*58:69 | HG00009317 | KM586172 | Histogenetics, Ossining, USA |
| C*01:02:35 | HG00009333 | KM586175 | Histogenetics, Ossining, USA |
| C*02:02:30 | HG00009357 | KM586174 | Histogenetics, Ossining, USA |
| C*02:93 | HG00009348 | KM365109 | Histogenetics, Ossining, USA |
| C*02:94 | HG00009347 | KM282246 | Histogenetics, Ossining, USA |
| C*02:95 | HG00009349 | KM282241 | Histogenetics, Ossining, USA |
| C*03:06:02 | HG00009354 | KM405375 | Histogenetics, Ossining, USA |
| C*03:40:04 | BY01247 | KP116932 | Carolyn K Hurley, Washington DC, USA |
| C*03:87:02 | HG00009353 | KM454991 | Histogenetics, Ossining, USA |
| C*03:272 | HG00009351 | KM081665 | Histogenetics, Ossining, USA |
| C*03:273 | HG00009352 | KM365107 | Histogenetics, Ossining, USA |
| C*03:274 | HG00009355 | KM081668 | Histogenetics, Ossining, USA |
| C*03:275 | HG00009356 | KM282239 | Histogenetics, Ossining, USA |
| C*03:276 | DKMS-LSL-C-294 | LN681575 | DKMS Life Sciences Lab, Dresden, Germany |
| C*03:277N | BY01245 | KP116930 | Carolyn K Hurley, Washington DC, USA |
| C*04:192 | HG00009358 | KM282242 | Histogenetics, Ossining, USA |
| C*04:193 | HG00009359 | KM282244 | Histogenetics, Ossining, USA |
| C*04:194 | HG00009360 | KM282243 | Histogenetics, Ossining, USA |
| C*05:114 | HG00009340 | KM365108 | Histogenetics, Ossining, USA |
| C*06:02:43 | HG00009334 | KM405374, KM365113 | Histogenetics, Ossining, USA |
| C*07:406 | HG00009335 | KF577623 | Histogenetics, Ossining, USA |
| C*07:407 | HG00009336, HG00009337 | KM282247, KM282248 | Histogenetics, Ossining, USA |
| C*07:408 | HG00009338 | KM282238 | Histogenetics, Ossining, USA |
| C*07:409 | HG00009339 | KM405376 | Histogenetics, Ossining, USA |
| C*08:114 | BY01244 | KP116929 | Carolyn K Hurley, Washington DC, USA |
| C*08:115 | BY01246 | KP116931 | Carolyn K Hurley, Washington DC, USA |
| C*12:03:32 | HG00009342 | KM365110 | Histogenetics, Ossining, USA |
| C*12:03:33 | HG00009344 | KM405379 | Histogenetics, Ossining, USA |
| C*12:03:34 | RMC12480 | LN681349 | Maria Loginova, Kirov, Russia |
| C*12:143 | LUMC-C-99 | LN614586 | Maureen Flink, Leiden, The Netherlands |
| C*12:144 | HG00009343 | KM365112 | Histogenetics, Ossining, USA |
| C*12:145 | HG00009345 | KM405377 | Histogenetics, Ossining, USA |
| C*12:146 | BY01239 | KP116924 | Carolyn K Hurley, Washington DC, USA |
| C*12:147 | DKMS-LSL-C-293 | LN680990 | DKMS Life Sciences Lab, Dresden, Germany |
| C*12:148N | HG00009346 | KM405370 | Histogenetics, Ossining, USA |
| C*15:106 | HG00009350 | KM405372 | Histogenetics, Ossining, USA |
| C*16:79 | HG00009341 | KM405373 | Histogenetics, Ossining, USA |
| DRB1*03:01:24 | HG00009451 | KM497471 | Histogenetics, Ossining, USA |
| DRB1*03:118 | HG00009453 | KM497475 | Histogenetics, Ossining, USA |
| DRB1*08:66 | HG00009448 | KM497489 | Histogenetics, Ossining, USA |
| DRB1*08:67 | HG00009449 | KM081669 | Histogenetics, Ossining, USA |
| DRB1*08:68 | HG00009450 | KM497481 | Histogenetics, Ossining, USA |
| DRB1*10:01:06 | HG00009439 | KM497492 | Histogenetics, Ossining, USA |
| DRB1*10:09 | HG00009435 | KM497483 | Histogenetics, Ossining, USA |
| DRB1*10:10 | HG00009436 | KM497485 | Histogenetics, Ossining, USA |
| DRB1*10:11 | HG00009437 | KM586196 | Histogenetics, Ossining, USA |
| DRB1*10:12 | HG00009438 | KM586192 | Histogenetics, Ossining, USA |
| DRB1*10:13 | HG00009440 | KM497488 | Histogenetics, Ossining, USA |
| DRB1*10:14 | HG00009441 | KM497472 | Histogenetics, Ossining, USA |
| DRB1*11:01:25 | HG00009459 | KM586197 | Histogenetics, Ossining, USA |
| DRB1*11:04:12 | HG00009460 | KM497493 | Histogenetics, Ossining, USA |
| DRB1*11:173 | HG00009462 | KM586189 | Histogenetics, Ossining, USA |
| DRB1*11:174 | HG00009464 | KM497494 | Histogenetics, Ossining, USA |
| DRB1*11:175 | HG00009465 | KM497478 | Histogenetics, Ossining, USA |
| DRB1*11:176 | 93090841 | KM023141 | Daniel Fuerst, Ulm, Germany |
| DRB1*12:01:07 | HG00009442 | KM081670 | Histogenetics, Ossining, USA |
| DRB1*12:01:08 | HG00009446 | KM497480 | Histogenetics, Ossining, USA |
| DRB1*12:53 | HG00009443 | KM497486 | Histogenetics, Ossining, USA |
| DRB1*12:54 | HG00009444 | KM497482 | Histogenetics, Ossining, USA |
| DRB1*12:55 | HG00009445 | KM497473 | Histogenetics, Ossining, USA |
| DRB1*13:01:16 | HG00009457 | KM586193 | Histogenetics, Ossining, USA |
| DRB1*13:02:11 | HG00009454 | KM586190 | Histogenetics, Ossining, USA |
| DRB1*13:171:02 | HG00009456 | KM497477 | Histogenetics, Ossining, USA |
| DRB1*13:195 | HG00009434 | KM497474 | Histogenetics, Ossining, USA |
| DRB1*13:196 | HG00009455 | KM497491 | Histogenetics, Ossining, USA |
| DRB1*14:38:02 | HG00009458 | KM497484 | Histogenetics, Ossining, USA |
| DRB1*14:68:02 | HG00009447 | KM081671 | Histogenetics, Ossining, USA |
| DRB1*14:126:02 | INRA342126 | LN609372 | Steven GE Marsh, London, United Kingdom |
| DRB1*15:117 | HG00009377 | KM586212 | Histogenetics, Ossining, USA |
| DRB1*16:25 | HG00009373 | KM586206 | Histogenetics, Ossining, USA |
| DRB1*16:26 | HG00009375 | KM586213 | Histogenetics, Ossining, USA |
| DRB1*16:27 | HG00009376 | KM586210 | Histogenetics, Ossining, USA |
| DRB1*16:28 | HG00009378 | KM586199 | Histogenetics, Ossining, USA |
| DRB1*16:29 | HG00009374 | KM586200 | Histogenetics, Ossining, USA |
| DQB1*02:50 | HG00009366 | KM586187 | Histogenetics, Ossining, USA |
| DQB1*02:51 | HG00009367 | KM586176 | Histogenetics, Ossining, USA |
| DQB1*02:52 | DKMS-LSL-DQB1-295 | LN681576 | DKMS Life Sciences Lab, Dresden, Germany |
| DQB1*02:53Q | DKMS-LSL-DQB1-296 | LN681577 | DKMS Life Sciences Lab, Dresden, Germany |
| DQB1*03:01:27 | HG00009363 | KM586185 | Histogenetics, Ossining, USA |
| DQB1*03:01:28 | HG00009365 | KM365114 | Histogenetics, Ossining, USA |
| DQB1*03:166 | M-358417 | KP019715 | Kristin Kipper, Martinsried, Germany |
| DQB1*03:167 | HG00009364 | KM365115 | Histogenetics, Ossining, USA |
| DQB1*04:26 | HG00009371 | KM586184 | Histogenetics, Ossining, USA |
| DQB1*04:27 | HG00009372 | KM586179 | Histogenetics, Ossining, USA |
| DQB1*05:01:01:03 | DKMS-LSL-DQB1-296 | LN681578 | DKMS Life Sciences Lab, Dresden, Germany |
| DQB1*05:01:19 | HG00009369 | KM497463 | Histogenetics, Ossining, USA |
| DQB1*05:88 | HG00009370 | KM497465 | Histogenetics, Ossining, USA |
| DQB1*05:89 | 86016123 | KP225162 | Daniel Fuerst, Ulm, Germany |
| DQB1*06:03:18 | HG00009368 | KM586186 | Histogenetics, Ossining, USA |
| DQB1*06:167 | HG00009361 | KM497464 | Histogenetics, Ossining, USA |
| DPB1*02:01:16 | HG00009469 | KM455002 | Histogenetics, Ossining, USA |
| DPB1*04:01:25 | HG00009468 | KM405418 | Histogenetics, Ossining, USA |
| DPB1*04:01:26 | HG00009470 | KM405389 | Histogenetics, Ossining, USA |
| DPB1*04:01:27 | HG00003775 | KM405404 | Histogenetics, Ossining, USA |
| DPB1*14:01:02 | HG00009482 | KM282254 | Histogenetics, Ossining, USA |
| DPB1*406:01 | HG00009471 | KM282276 | Histogenetics, Ossining, USA |
| DPB1*407:01 | HG00009483 | KM405401 | Histogenetics, Ossining, USA |
| DPB1*408:01 | HG00009484 | KM586226 | Histogenetics, Ossining, USA |
| DPB1*409:01 | HG00009485 | KM405422 | Histogenetics, Ossining, USA |
| DPB1*410:01 | HG00009486 | KM405396 | Histogenetics, Ossining, USA |
| DPB1*411:01 | HG00009487 | KM405395 | Histogenetics, Ossining, USA |
| DPB1*412:01 | HG00009488 | KM405402 | Histogenetics, Ossining, USA |
| DPB1*413:01 | HG00009489 | KM405419 | Histogenetics, Ossining, USA |
| DPB1*414:01 | DKMS-LSL-DPB1-290 | LN680985 | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*415:01 | DKMS-LSL-DPB1-291 | LN680986 | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*416:01 | DKMS-LSL-DPB1-292 | LN680987 | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*417:01 | UNC6 | KP273229 | Eric Weimer, Chapel Hill, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:17:02 | 11970 | LN623524 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| A*29:02:03 | 35588 | LN623521 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| B*15:30 | UNC3 | KP236588 | Eric Weimer, Chapel Hill, USA |
| C*03:137 | BY01241 | KP116926 | Carolyn K Hurley, Washington DC, USA |
| C*07:216 | BY01243 | KP116928 | Carolyn K Hurley, Washington DC, USA |
| C*12:03:29 | BY01240 | KP116925 | Carolyn K Hurley, Washington DC, USA |
| C*12:122 | BY01242 | KP116927 | Carolyn K Hurley, Washington DC, USA |
| C*17:09 | BY01248 | KP116933 | Carolyn K Hurley, Washington DC, USA |
| DRB1*03:07 | SCL-116A | LN623522 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*07:04 | 37391 | HG974601 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*08:06 | 35913 | LK391780 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*08:10 | 38658 | HG974605 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*08:11 | FH42 | HG974588 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*08:14 | FH44 | HG974604 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*13:14:02 | 36143 | LK391781 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*13:17 | R.B | HG974589 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*14:10 | 34206 | LK391779 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*16:04 | FORE | HG974585 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DQB1*03:139 | 70775 | LN651272 | Jane Rowlands, Pontyclun, United Kingdom |
| DPB1*296:01 | DKMS-LSL-DPB1-219 | LN680988 | DKMS Life Sciences Lab, Dresden, Germany |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:428 | (3) |
| A*02:481 | (4) |
| A*02:510 | (5) |
| A*03:01:01:01 | (6) |
| A*03:02:01 | (6) |
| A*26:01:36 | (7) |
| A*30:81 | (8) |
| A*74:23 | (9) |
| B*08:122 | (10) |
| B*15:179 | (11) |
| B*57:71 | (12) |
| C*07:375 | (13) |
| DPB1*296:01 | (14) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010; 75:291-455.
- Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic Acids Research. 2013; 41: D1222-7.
- Han SH, Heo YA, Kwon OJ, Kim YJ, Lee KR. Identification of a novel HLA-A*02 allele, A*02:428, by sequence-based typing. Tissue Antigens 2014; 84:574-5.
- Echeverria VF, Rampim GF, Gerbase-DeLima M. The HLA-A*02:481 allele was identified in unrelated Brazilians sharing HLA-B*15:17, C*07:01P, DRB1*13:02 and DQB1*06:04. Tissue Antigens. 2014; 84:577-8.
- Yang KL, Lee SK, Hung JH, Lin PY. HLA-A*02:510, a variant of HLA-A*02, discovered in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens. 2014; 84:576-7.
- Tao H, Xu YP, Chen LX. Genomic full-length sequence of two HLA-A alleles, A*03:01:01:01 and A*03:02:01 identified by cloning and sequencing. Tissue Antigens. 2014; 84:578-80.
- Sari G, Yazar M, Tozkir H, Duymaz J, Gurkan H. Identification of a novel HLA-A*26 allele, HLA-A*26:01:36, in a Turkish family by sequence-based typing. Tissue Antigens. 2014; 84:580-1.
- Yoon YA, Kim JS, Yoon CE, Jang JH, Kang ES. A new HLA-A*30 allele, A*30:81, identified by sequence-based typing. Tissue Antigens. 2014; 84:582-3.
- Arrieta-Bolanos E, McWhinnie AJ, Madrigal-Sanchez JJ, et al. A novel HLA-A allele, A*74:23, identified in an individual from Costa Rica. Tissue Antigens. 2014; 84:583-4.
- Buffi O, Iannelli S, Iliescu A, Bontadini A, Nesci S. A new HLA allele, HLA-B*08:122, described in an unrelated donor of Caucasian origin. Tissue Antigens. 2014; 84:585-6.
- Lv R, Xin X, Yu J, Sheng Q. Characterization of a new HLA-B allele, B*15:179:02. Tissue Antigens. 2014; 84:586-7.
- Kuranov AB, Steiert I, Goodridge D, Muller CA. Identification of a new HLA-B*57 allele, HLA-B*57:71, by next-generation sequencing. Tissue Antigens. 2014; 84:587-8.
- Yang KL, Lee SK, Hung JH, Lin PY. HLA-C*07:375, a variant of HLA-C*07, detected in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens. 2014; 84:588-9.
- Presciuttini S, Sciarrino R, Fornaciari S, Mariotti ML, Scatena F, Curcio M. A novel allele, HLA-DPB1*296:01, identified by sequence-based typing in a Thai bone marrow donor. Tissue Antigens. 2014; 84:589-90.
