Nomenclature for Factors of the HLA System

November 2014

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the October 2014 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:166M-510668KM594523Kristin Kipper, Martinsried, Germany
A*01:167DKMS-LSL-A-267LN600118DKMS Life Sciences Lab, Dresden, Germany
A*01:168HG00009280KM405355Histogenetics, Ossining, USA
A*01:169HG00009281KM405341Histogenetics, Ossining, USA
A*02:545M-540158KM594524Kristin Kipper, Martinsried, Germany
A*02:546M-506906KM594525Kristin Kipper, Martinsried, Germany
A*02:547DKMS-LSL-A-288LN600129DKMS Life Sciences Lab, Dresden, Germany
A*02:548TTIL0002LN614585Valentina Cappuzzo, Palermo, Italy
A*02:548HG00009288KM081660Histogenetics, Ossining, USA
A*02:549HG00009284KM282207Histogenetics, Ossining, USA
A*02:550HG00009285KM586167Histogenetics, Ossining, USA
A*02:551HG00009286KM282213Histogenetics, Ossining, USA
A*02:552HG00009287KM454984Histogenetics, Ossining, USA
A*02:553HG00009292KM282215Histogenetics, Ossining, USA
A*02:554HG00009289KM454985Histogenetics, Ossining, USA
A*02:555HG00009290KM497455Histogenetics, Ossining, USA
A*03:01:53HG00009283KM282212Histogenetics, Ossining, USA
A*11:01:01:02H140454KM362862Faming Zhu, Hangzhou, China
A*11:01:66HG00009268KM405351Histogenetics, Ossining, USA
A*11:211HG00009269KM282217Histogenetics, Ossining, USA
A*23:01:16HG00009278KM282219Histogenetics, Ossining, USA
A*23:6931667LN624391Maria Peixoto, Porto, Portugal
A*24:02:91DKMS-LSL-A-253LN600111DKMS Life Sciences Lab, Dresden, Germany
A*24:292HG00009276KM405345Histogenetics, Ossining, USA
A*24:293HG00009277KM405349Histogenetics, Ossining, USA
A*25:01:08HG00009267KM282218Histogenetics, Ossining, USA
A*25:30HG00009282KM405343Histogenetics, Ossining, USA
A*26:108HG00009271KM405353Histogenetics, Ossining, USA
A*29:02:15HG00009261KM405352Histogenetics, Ossining, USA
A*29:76HG00009263KM282209Histogenetics, Ossining, USA
A*30:02:01:03ZA3007335DLN624505Ernette Du Toit, Cape Town, South Africa
A*30:02:16HG00009274KM586168Histogenetics, Ossining, USA
A*30:93DKMS-LSL-A-212LN600055DKMS Life Sciences Lab, Dresden, Germany
A*32:69DKMS-LSL-A-214LN600058DKMS Life Sciences Lab, Dresden, Germany
A*32:69HG00009279KM081658Histogenetics, Ossining, USA
A*33:03:28HG00009262KM405347Histogenetics, Ossining, USA
A*33:03:29HG00009264KM405350Histogenetics, Ossining, USA
A*66:20HG00009272KM282211Histogenetics, Ossining, USA
A*66:21HG00009273KM405348Histogenetics, Ossining, USA
A*68:125HG00009265KM282208Histogenetics, Ossining, USA
A*68:126HG00009266KM405342Histogenetics, Ossining, USA
A*68:127HG00009270KM454986Histogenetics, Ossining, USA
B*07:237DKMS-LSL-B-207LN600050DKMS Life Sciences Lab, Dresden, Germany
B*08:01:31HG00009304KM497457Histogenetics, Ossining, USA
B*08:139DKMS-LSL-B-239LN600098DKMS Life Sciences Lab, Dresden, Germany
B*08:140HG00009302,
HG00009303
KM282221,
KM405356
Histogenetics, Ossining, USA
B*13:02:17DKMS-LSL-B-224LN600066DKMS Life Sciences Lab, Dresden, Germany
B*15:01:38DKMS-LSL-B-206LN600049DKMS Life Sciences Lab, Dresden, Germany
B*15:17:03DKMS-LSL-B-205LN600048DKMS Life Sciences Lab, Dresden, Germany
B*15:340DKMS-LSL-B-286LN600130DKMS Life Sciences Lab, Dresden, Germany
B*18:106HG00009301KM282222Histogenetics, Ossining, USA
B*27:134HG00009298KM405359Histogenetics, Ossining, USA
B*27:135HG00009299KM586171Histogenetics, Ossining, USA
B*35:270TMO26177KP089982Antonio Balas, Madrid, Spain
B*35:271DKMS-LSL-B-211LN600054DKMS Life Sciences Lab, Dresden, Germany
B*35:272M-532644KP019716Kristin Kipper, Martinsried, Germany
B*35:2730018700KP099603Francisco de Paula Sanchez Gordo, Malaga, Spain
B*37:54HG00009300KM405368Histogenetics, Ossining, USA
B*40:297M-490619KM610238Kristin Kipper, Martinsried, Germany
B*40:298HG00009296KM282232Histogenetics, Ossining, USA
B*41:02:06HG00009294KM586170Histogenetics, Ossining, USA
B*41:35DKMS-LSL-B-269LN600100DKMS Life Sciences Lab, Dresden, Germany
B*44:02:35HG00009308KM282231Histogenetics, Ossining, USA
B*44:02:36HG00009309KM282220Histogenetics, Ossining, USA
B*44:214HG00009307KM405364Histogenetics, Ossining, USA
B*45:15HG00009297KM365103Histogenetics, Ossining, USA
B*49:04:02HG00009295KM405358Histogenetics, Ossining, USA
B*49:35M-535669KP019717Kristin Kipper, Martinsried, Germany
B*50:01:06UKTNGS001LC004127Alexandr Kuranov, Tübingen, Germany
B*50:42M-488122KP019700Kristin Kipper, Martinsried, Germany
B*51:01:01:02DKMS-LSL-B-218LN600062DKMS Life Sciences Lab, Dresden, Germany
B*52:43DKMS-LSL-B-210LN600053DKMS Life Sciences Lab, Dresden, Germany
B*55:01:14HG00009305KM405367Histogenetics, Ossining, USA
B*58:01:17DKMS-LSL-B-213LN600057DKMS Life Sciences Lab, Dresden, Germany
C*01:02:34D191689LN626693Edward KL Yang, Hualien, Taiwan
C*01:105M-516132KP019718Kristin Kipper, Martinsried, Germany
C*01:106DKMS-LSL-C-225LN600067DKMS Life Sciences Lab, Dresden, Germany
C*01:107BY01229KP116914Carolyn K Hurley, Washington DC, USA
C*02:90M-355587KP019702Kristin Kipper, Martinsried, Germany
C*02:91DKMS-LSL-C-237LN600093DKMS Life Sciences Lab, Dresden, Germany
C*02:92NDKMS-LSL-C-279LN600110DKMS Life Sciences Lab, Dresden, Germany
C*03:03:28DKMS-LSL-C-248LN600094DKMS Life Sciences Lab, Dresden, Germany
C*03:271DKMS-LSL-C-275LN600095DKMS Life Sciences Lab, Dresden, Germany
C*04:01:66DKMS-LSL-C-250LN600083DKMS Life Sciences Lab, Dresden, Germany
C*04:186DKMS-LSL-C-228LN600069DKMS Life Sciences Lab, Dresden, Germany
C*04:187DKMS-LSL-C-232LN600072DKMS Life Sciences Lab, Dresden, Germany
C*04:188DKMS-LSL-C-245LN600080DKMS Life Sciences Lab, Dresden, Germany
C*04:189DKMS-LSL-C-285LN600126DKMS Life Sciences Lab, Dresden, Germany
C*04:190BY01236KP116921Carolyn K Hurley, Washington DC, USA
C*04:191NDKMS-LSL-C-271LN600116DKMS Life Sciences Lab, Dresden, Germany
C*05:01:31BY01234KP116919Carolyn K Hurley, Washington DC, USA
C*05:109DKMS-LSL-C-235LN600073DKMS Life Sciences Lab, Dresden, Germany
C*05:110DKMS-LSL-C-259LN600088DKMS Life Sciences Lab, Dresden, Germany
C*05:111DKMS-LSL-C-268LN600091DKMS Life Sciences Lab, Dresden, Germany
C*05:112BY01233KP116918Carolyn K Hurley, Washington DC, USA
C*05:113NDKMS-LSL-C-209LN600052DKMS Life Sciences Lab, Dresden, Germany
C*06:02:42DKMS-LSL-C-240LN600079DKMS Life Sciences Lab, Dresden, Germany
C*06:144M-465859KP019704Kristin Kipper, Martinsried, Germany
C*06:145M-499480KP019703Kristin Kipper, Martinsried, Germany
C*06:146NGR0012HG965220Laura Bungener, Groningen, The Netherlands
C*06:147DKMS-LSL-C-92LN600056DKMS Life Sciences Lab, Dresden, Germany
C*06:148M-518105KP019719Kristin Kipper, Martinsried, Germany
C*06:148DKMS-LSL-C-274LN600117DKMS Life Sciences Lab, Dresden, Germany
C*06:149DKMS-LSL-C-260LN600089DKMS Life Sciences Lab, Dresden, Germany
C*07:01:47DKMS-LSL-C-233LN600074DKMS Life Sciences Lab, Dresden, Germany
C*07:02:67DKMS-LSL-C-261LN600113DKMS Life Sciences Lab, Dresden, Germany
C*07:04:10DKMS-LSL-C-242LN600103DKMS Life Sciences Lab, Dresden, Germany
C*07:257:02M-433809KP019705Kristin Kipper, Martinsried, Germany
C*07:402DKMS-LSL-C-241LN600077DKMS Life Sciences Lab, Dresden, Germany
C*07:403DKMS-LSL-C-262LN600108DKMS Life Sciences Lab, Dresden, Germany
C*07:404BY01230KP116915Carolyn K Hurley, Washington DC, USA
C*07:405BY01231KP116916Carolyn K Hurley, Washington DC, USA
C*08:02:12DKMS-LSL-C-258LN600107DKMS Life Sciences Lab, Dresden, Germany
C*08:113ZA3007335DLN624509Ernette Du Toit, Cape Town, South Africa
C*12:139DKMS-LSL-C-238LN600078DKMS Life Sciences Lab, Dresden, Germany
C*12:140DKMS-LSL-C-247LN600082DKMS Life Sciences Lab, Dresden, Germany
C*12:141DKMS-LSL-C-289LN614589DKMS Life Sciences Lab, Dresden, Germany
C*12:142BY01232KP116917Carolyn K Hurley, Washington DC, USA
C*14:69DKMS-LSL-C-272LN600092DKMS Life Sciences Lab, Dresden, Germany
C*15:02:01:02DKMS-LSL-C-215LN600059DKMS Life Sciences Lab, Dresden, Germany
C*15:104DKMS-LSL-C-281LN600121DKMS Life Sciences Lab, Dresden, Germany
C*15:105QCNUHH-17981533JN412101Oh-Joong Kwon, Seoul, South Korea
C*16:04:03DKMS-LSL-C-256LN600086DKMS Life Sciences Lab, Dresden, Germany
C*16:78M-499432KP019706Kristin Kipper, Martinsried, Germany
DRB1*01:66P111281KJ001130Hyewon Park, Seoul, South Korea
DRB1*01:67M-499199KP019707Kristin Kipper, Martinsried, Germany
DRB1*03:116M-504783KP019708Kristin Kipper, Martinsried, Germany
DRB1*03:117M-436653KP019709Kristin Kipper, Martinsried, Germany
DRB1*08:64M-474844KP019712Kristin Kipper, Martinsried, Germany
DRB1*08:65M-506876KP019713Kristin Kipper, Martinsried, Germany
DRB1*10:08M-443892KP019710Kristin Kipper, Martinsried, Germany
DRB1*11:172M-444093KP019711Kristin Kipper, Martinsried, Germany
DRB1*12:01:06379766LN626694Edward KL Yang, Hualien, Taiwan
DRB1*15:116379755LN626695Edward KL Yang, Hualien, Taiwan
DQB1*02:49M-358023KP019714Kristin Kipper, Martinsried, Germany
DQB1*03:01:2623264LN651357Maria Loginova, Kirov, Russia
DQB1*05:02:11DKMS-LSL-DQB1-221LN600063DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:02:23DKMS-LSL-DQB1-231LN600075DKMS Life Sciences Lab, Dresden, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
HLA AlleleCell identificationAccession numberSubmitting author
A*02:01:10DKMS-LSL-A-244LN600104DKMS Life Sciences Lab, Dresden, Germany
A*02:541HG00009291KM282214Histogenetics, Ossining, USA
A*23:17ZA3007335DLN624506Ernette Du Toit, Cape Town, South Africa
A*29:03DKMS-LSL-A-222LN600064DKMS Life Sciences Lab, Dresden, Germany
A*30:80HG00009275KM405340Histogenetics, Ossining, USA
A*68:101HG00009293KF263493Histogenetics, Ossining, USA
B*07:208HG00009325,
HG00009326
KM282236,
KM282237
Histogenetics, Ossining, USA
B*08:01:01ZA3007335DLN624507Ernette Du Toit, Cape Town, South Africa
B*08:132DKMS-LSL-B-234LN600124DKMS Life Sciences Lab, Dresden, Germany
B*14:01:01ZA3007335DLN624508Ernette Du Toit, Cape Town, South Africa
B*15:272NDKMS-LSL-B-208LN600051DKMS Life Sciences Lab, Dresden, Germany
B*15:319HG00009306KM405365Histogenetics, Ossining, USA
B*35:228DKMS-LSL-B-273LN600102DKMS Life Sciences Lab, Dresden, Germany
B*51:185M-492418KP019701Kristin Kipper, Martinsried, Germany
C*01:67DKMS-LSL-C-246LN600081DKMS Life Sciences Lab, Dresden, Germany
C*01:99DKMS-LSL-C-226LN600068DKMS Life Sciences Lab, Dresden, Germany
C*02:87DKMS-LSL-C-284LN600125DKMS Life Sciences Lab, Dresden, Germany
C*03:140DKMS-LSL-C-276LN600096DKMS Life Sciences Lab, Dresden, Germany
C*03:243DKMS-LSL-C-278LN600123DKMS Life Sciences Lab, Dresden, Germany
C*06:02:31DKMS-LSL-C-282LN600122DKMS Life Sciences Lab, Dresden, Germany
C*06:103DKMS-LSL-C-252LN600085DKMS Life Sciences Lab, Dresden, Germany
C*06:120DKMS-LSL-C-266LN600115DKMS Life Sciences Lab, Dresden, Germany
C*06:127:01BY01237KP116922Carolyn K Hurley, Washington DC, USA
C*07:01:01:01ZA3007335DLN624510Ernette Du Toit, Cape Town, South Africa
C*07:02:63DKMS-LSL-C-255LN600106DKMS Life Sciences Lab, Dresden, Germany
C*07:89BY01238KP116923Carolyn K Hurley, Washington DC, USA
C*07:205DKMS-LSL-C-264LN600114DKMS Life Sciences Lab, Dresden, Germany
C*07:340DKMS-LSL-C-236LN600076DKMS Life Sciences Lab, Dresden, Germany
C*07:351DKMS-LSL-C-265LN600109DKMS Life Sciences Lab, Dresden, Germany
C*08:02:11DKMS-LSL-C-263LN600090DKMS Life Sciences Lab, Dresden, Germany
C*08:28DKMS-LSL-C-277LN600119DKMS Life Sciences Lab, Dresden, Germany
C*08:73DKMS-LSL-C-223LN600065DKMS Life Sciences Lab, Dresden, Germany
C*08:90DKMS-LSL-C-249LN600105DKMS Life Sciences Lab, Dresden, Germany
C*08:94DKMS-LSL-C-257LN600087DKMS Life Sciences Lab, Dresden, Germany
C*12:73DKMS-LSL-C-283LN600097DKMS Life Sciences Lab, Dresden, Germany
C*14:02:17DKMS-LSL-C-251LN600084DKMS Life Sciences Lab, Dresden, Germany
C*16:02:01DKMS-LSL-C-216LN600060DKMS Life Sciences Lab, Dresden, Germany
C*17:08BY01235KP116920Carolyn K Hurley, Washington DC, USA
C*17:17DKMS-LSL-C-217LN600061DKMS Life Sciences Lab, Dresden, Germany
DRB1*03:110HG00009452KM586204Histogenetics, Ossining, USA
DRB1*04:99D10028956HE654735Jinghui Qu, Shenzhen, China
DRB1*11:160HG00009461KM497476Histogenetics, Ossining, USA
DQB1*03:11966494HG518397Jane Rowlands, Pontyclun, United Kingdom
DQB1*03:162HG00009362KM586177Histogenetics, Ossining, USA
DQB1*04:02:03DKMS-LSL-DQB1-287LN600128DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:57DKMS-LSL-DQB1-229LN600070DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:80HG00009236KJ923286Histogenetics, Ossining, USA
DQB1*06:90DKMS-LSL-DQB1-196LN600127DKMS Life Sciences Lab, Dresden, Germany
DPB1*214:01HG00009245,
HG00009246
KM198196,
KM198180
Histogenetics, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
A*68:105(3)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010; 75:291-455.
  2. Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic Acids Research. 2013; 41:D1222-7.
  3. Curcio M, Presciuttini S, Sciarrino R, Fornaciari S, Mariotti ML, Scatena F. Identification and characterization of a novel HLA-A allele, HLA-A*68:105, by genomic sequencing. Int J Immunogenet. 2014; 41:484-5.