Nomenclature for Factors of the HLA System

September 2014

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the August 2014 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:164HG00009097,
HG00009098
KM216189,
KM216190
Histogenetics, Ossining, USA
A*01:165HG00009099KM051848Histogenetics, Ossining, USA
A*02:06:18HG00009105KM198107Histogenetics, Ossining, USA
A*02:113:02NHG00008704KJ956728Histogenetics, Ossining, USA
A*02:468:02NHG00008361KJ535511Histogenetics, Ossining, USA
A*02:542HG00009106,
HG00009107,
HG00009108
KM198116,
KM198108,
KM198109
Histogenetics, Ossining, USA
A*02:543ZJCB20140103004KM453232Faming Zhu, Hangzhou, China
A*02:5448811200510KM288585Xiumei Zhen, Beijing, China
A*03:01:52HG00009101KM198200Histogenetics, Ossining, USA
A*03:157:02HG00009100KM051851Histogenetics, Ossining, USA
A*03:205HG00009084KM198201Histogenetics, Ossining, USA
A*03:206HG00009095KM198114Histogenetics, Ossining, USA
A*03:207HG00009096KM051847Histogenetics, Ossining, USA
A*03:208HG00009102KM051849Histogenetics, Ossining, USA
A*03:209HG00009103KM198117Histogenetics, Ossining, USA
A*11:208NHG00007156KF535950Histogenetics, Ossining, USA
A*11:209P113LM655400Ou Guojin, Cheng Du, China
A*23:01:15HG00009094KM198199Histogenetics, Ossining, USA
A*23:68HG00009093KM198119Histogenetics, Ossining, USA
A*24:290HG00006241KF036229Histogenetics, Ossining, USA
A*24:291HG00009092KM198113Histogenetics, Ossining, USA
A*25:27:0284016664KM401558Daniel Fuerst, Ulm, Germany
A*26:01:37HG00009088KM198118Histogenetics, Ossining, USA
A*30:92HG00009091KM198110Histogenetics, Ossining, USA
A*31:01:24HG00008686KJ923260Histogenetics, Ossining, USA
A*32:01:21HG00009104KM198203Histogenetics, Ossining, USA
A*32:6824176011LN554264Thibaut Gervais, Brussels, Belgium
A*34:12HG00009087KM198202Histogenetics, Ossining, USA
A*68:122HG00009086KM051853Histogenetics, Ossining, USA
A*68:123HG00009089,
HG00009090
KM198111,
KM198112
Histogenetics, Ossining, USA
A*68:124HG00009085KM216188Histogenetics, Ossining, USA
B*07:136:02HG00009131KM198128Histogenetics, Ossining, USA
B*07:233HG00009130KM198130Histogenetics, Ossining, USA
B*07:234HG00009129KM198121Histogenetics, Ossining, USA
B*08:137HG00009115KM216191Histogenetics, Ossining, USA
B*13:82SZ-163KM233712Hong-Yan Zou, Shenzhen, China
B*15:336HG00009117KM198210Histogenetics, Ossining, USA
B*15:337HG00009126KM198216Histogenetics, Ossining, USA
B*15:338HG00009125KM248728Histogenetics, Ossining, USA
B*15:339ID-1691472KM242080Vinicius F Echeverria, São Paulo, Brazil
B*18:105CTM-9026291KM401575Antonio Balas, Madrid, Spain
B*27:50:02HG00009114KM051856Histogenetics, Ossining, USA
B*27:132HG00009113KM198214Histogenetics, Ossining, USA
B*27:13312025LM994824Maria Loginova, Kirov, Russia
B*35:08:08HG00009123,
HG00009124
KM198125,
KM198132
Histogenetics, Ossining, USA
B*35:265HG00008381KJ535563Histogenetics, Ossining, USA
B*35:266HG00009119KM198211Histogenetics, Ossining, USA
B*35:267HG00009132KM198123Histogenetics, Ossining, USA
B*35:268HG00009118KM198207Histogenetics, Ossining, USA
B*35:2698811100543KM382428Xiumei Zhen, Beijing, China
B*38:56HG00009133KM198206Histogenetics, Ossining, USA
B*39:99HG00009134,
HG00009135
KM198133,
KM198135
Histogenetics, Ossining, USA
B*41:01:03HG00009136KM198134Histogenetics, Ossining, USA
B*41:34HG00009112KM051857Histogenetics, Ossining, USA
B*44:02:34HG00009116KM216194Histogenetics, Ossining, USA
B*44:212HG00007197KF381227Histogenetics, Ossining, USA
B*44:213HG00007854KF840744Histogenetics, Ossining, USA
B*50:40HG00009109KM248727Histogenetics, Ossining, USA
B*50:41HG00009110,
HG00009111
KM198131,
KM198126
Histogenetics, Ossining, USA
B*51:01:51HG00009128KM198215Histogenetics, Ossining, USA
B*51:184NHG00006280KF220317Histogenetics, Ossining, USA
B*52:41HG00009120KM198213Histogenetics, Ossining, USA
B*52:425771300426KM362860Faming Zhu, Hangzhou, China
B*53:394140207301LN558516Dominique Masson, La Tronche, France
B*57:01:20HG00009127KM198120Histogenetics, Ossining, USA
B*58:01:16HG00009121KM198124Histogenetics, Ossining, USA
B*58:64HG00008737KJ819869Histogenetics, Ossining, USA
B*58:65HG00009122KM198122Histogenetics, Ossining, USA
B*58:668811200140KM382429Xiumei Zhen, Beijing, China
C*01:02:30SPLKP893072Paul Norman, Stanford, USA
C*01:02:31HG00009137KM198148Histogenetics, Ossining, USA
C*01:02:32HG00009140KM198219Histogenetics, Ossining, USA
C*01:02:33HG00009141KM198142Histogenetics, Ossining, USA
C*01:07:02HG00009138KM051861Histogenetics, Ossining, USA
C*01:101HG00008628KJ749734Histogenetics, Ossining, USA
C*01:102HG00008770KJ819893Histogenetics, Ossining, USA
C*01:103HG00009139KM051868Histogenetics, Ossining, USA
C*01:104HG00009142KM198223Histogenetics, Ossining, USA
C*03:03:27HG00009157KM198136Histogenetics, Ossining, USA
C*03:267HG00008427KJ535594Histogenetics, Ossining, USA
C*03:268HG00009156KM198141Histogenetics, Ossining, USA
C*03:269HG00009158KM198144Histogenetics, Ossining, USA
C*03:270HG00009159KM051869Histogenetics, Ossining, USA
C*04:01:65HG00009164KM198145Histogenetics, Ossining, USA
C*04:182HG00009160KM051867Histogenetics, Ossining, USA
C*04:183HG00009161KM051870Histogenetics, Ossining, USA
C*04:184HG00009162KM198217Histogenetics, Ossining, USA
C*04:185HG00009163KM198220Histogenetics, Ossining, USA
C*05:106HG00009151KM216198Histogenetics, Ossining, USA
C*05:107HG00009152KM198218Histogenetics, Ossining, USA
C*06:142HG00009143KM198140Histogenetics, Ossining, USA
C*06:143HG00009144KM198138Histogenetics, Ossining, USA
C*07:01:46HG00009146KM198139Histogenetics, Ossining, USA
C*07:02:65HG00009148KM051863Histogenetics, Ossining, USA
C*07:02:66HG00009149KM051865Histogenetics, Ossining, USA
C*12:135HG00008421KJ535597Histogenetics, Ossining, USA
C*12:136HG00009150KM051866Histogenetics, Ossining, USA
C*12:137HG00009154KM248729Histogenetics, Ossining, USA
C*12:138Pat141150004KM197168Bella Biderman, Moscow, Russia
C*15:102HG00006305KF184347Histogenetics, Ossining, USA
C*15:10314725750LN554268Christian Seidl, Frankfurt am Main, Germany
C*16:02:13HG00009153KM198225Histogenetics, Ossining, USA
C*17:28HG00009155KM198147Histogenetics, Ossining, USA
DRB1*01:02:106213577696LK391508Dominique Masson, La Tronche, France
DRB1*01:65HG00009185KM198166Histogenetics, Ossining, USA
DRB1*03:01:23D12023025 KM374599Jinghui Qu, Shenzhen, China
DRB1*04:185D12002832KM374595Jinghui Qu, Shenzhen, China
DRB1*04:186ND12034120KM374601Jinghui Qu, Shenzhen, China
DRB1*07:35D12001515KM374594Jinghui Qu, Shenzhen, China
DRB1*08:60ND12045758KM374606Jinghui Qu, Shenzhen, China
DRB1*09:24D12019395KM374597Jinghui Qu, Shenzhen, China
DRB1*10:01:05D12028683KM374600Jinghui Qu, Shenzhen, China
DRB1*11:169ND12035566KM374602Jinghui Qu, Shenzhen, China
DRB1*11:170D12039485KM374605Jinghui Qu, Shenzhen, China
DRB1*11:171IL1010383KM588208Matilde Romero, Rio de Janeiro, Brazil
DRB1*12:51CB4373EF514910Yan Li, Guangzhou, China
DRB1*13:12:04D12021005KM374598Jinghui Qu, Shenzhen, China
DRB1*13:191H3343LM994936Olivier Farchi, Lille, France
DRB1*13:192227977LN558514Klaus Witter, München, Germany
DRB1*13:193DKMS-LSL-DRB1-2AB602352DKMS Life Sciences Lab, Dresden, Germany
DRB1*15:07:03D12036397KM374603Jinghui Qu, Shenzhen, China
DRB1*15:114D12002850KM374596Jinghui Qu, Shenzhen, China
DRB1*15:115N3489-1LN608993Xingjie Li, Chengdu, China
DRB1*16:02:04D12037856KM374604Jinghui Qu, Shenzhen, China
DQB1*02:43HG00009170KM248737Histogenetics, Ossining, USA
DQB1*02:44HG00009171KM198226Histogenetics, Ossining, USA
DQB1*02:45HG00009172KM051876Histogenetics, Ossining, USA
DQB1*02:46HG00009173KM198233Histogenetics, Ossining, USA
DQB1*02:47HG00009174KM051871Histogenetics, Ossining, USA
DQB1*02:4884016772KM401560Daniel Fuerst, Ulm, Germany
DQB1*03:158HG00009165,
HG00009166,
HG00009167
KM198158,
KM198159,
KM198160
Histogenetics, Ossining, USA
DQB1*03:159HG00009168KM198229Histogenetics, Ossining, USA
DQB1*03:160HG00009169KM248741Histogenetics, Ossining, USA
DQB1*03:161HG00009178KM248736Histogenetics, Ossining, USA
DQB1*03:16293095782KM401559Daniel Fuerst, Ulm, Germany
DQB1*03:16314218980KM401561Daniel Fuerst, Ulm, Germany
DQB1*03:164H140591KM527944Faming Zhu, Hangzhou, China
DQB1*03:165P08565KM527945Faming Zhu, Hangzhou, China
DQB1*04:24HG00009181KM051878Histogenetics, Ossining, USA
DQB1*04:25NHG00009182KM198149Histogenetics, Ossining, USA
DQB1*05:85HG00009179KM198152Histogenetics, Ossining, USA
DQB1*05:86HG00009180KM198230Histogenetics, Ossining, USA
DQB1*06:01:14HG00008439KJ142176Histogenetics, Ossining, USA
DQB1*06:02:22HG00009184KM198156Histogenetics, Ossining, USA
DQB1*06:04:10HG00009176KM051875Histogenetics, Ossining, USA
DQB1*06:164HG00009175KM051872Histogenetics, Ossining, USA
DQB1*06:165HG00009177KM248730Histogenetics, Ossining, USA
DQB1*06:166HG00009183KM248740Histogenetics, Ossining, USA
DPB1*393:01HG00007812KF712329Histogenetics, Ossining, USA
DPB1*394:01281157486LK937703Jue Wang, Chengdu, China
DPB1*395:01HG00009187KM216212Histogenetics, Ossining, USA
DPB1*396:01HG00009188,
HG00009189
KM198246,
KM198236
Histogenetics, Ossining, USA
DPB1*397:01HG00009190KM198176Histogenetics, Ossining, USA
DPB1*398:01HG00009191,
HG00009192
KM198173,
KM198245
Histogenetics, Ossining, USA
DPB1*399:01HG00009193KM198195Histogenetics, Ossining, USA
DPB1*400:01HG00009194KM198181Histogenetics, Ossining, USA
DPB1*401:01NHG00009195KM198169Histogenetics, Ossining, USA
DPB1*402:01HG00009196KM198197Histogenetics, Ossining, USA
DPB1*403:01NHG00009197KM198235Histogenetics, Ossining, USA
DPB1*404:01HG00009198KM198179Histogenetics, Ossining, USA
DPB1*405:01HG00009199KM198175Histogenetics, Ossining, USA

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:67DKMS-LSL-A-166LK021985DKMS Life Sciences Lab, Dresden, Germany
A*01:161DKMS-LSL-A-165LK021984DKMS Life Sciences Lab, Dresden, Germany
A*03:2623595957LN554265Thibaut Gervais, Brussels, Belgium
A*11:155SZ-162KM233711Hong-Yan Zou, Shenzhen, China
B*35:81CBRA59136283721LN558517Dominique Masson, La Tronche, France
B*35:1486235703111LK391507Dominique Masson, La Tronche, France
B*39:93M4473LM994935Vincent Elsermans, Lille Cedex, France
C*06:122HG00009145KM198224Histogenetics, Ossining, USA
C*07:01:44HG00009147KM198137Histogenetics, Ossining, USA
C*07:18WT49KP893073Paul Norman, Stanford, USA
DRB1*11:154D12053932KM374607Jinghui Qu, Shenzhen, China
DRB1*11:165HG00009186KM051882Histogenetics, Ossining, USA
DRB1*12:45Xian62968KF961693Tianju Wang, Xi`an, China
DRB1*13:25HG00008464KJ535637Histogenetics, Ossining, USA
DRB1*14:35M5284AF177215Vincent Elsermans, Lille Cedex, France

Table 3: Recently Published Sequences


Sequence References
A*11:01:01(3)
A*11:02:01(3)
A*11:02:05(4)
A*11:125(5)
A*11:133(4)
A*11:166(6)
A*11:167(7)
A*24:02:87(8)
A*33:47(9)
B*51:59(10)
B*51:144(11)
C*05:99N(12)
C*08:01:10(13)
MICA*002:01(14)
MICA*012:01(14)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010; 75:291-455.
  2. Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic Acids Research. 2013; 41: D1222-7.
  3. Xu YP, Gao SQ. Genomic full-length sequence of two HLA-A*11 alleles, identified by cloning and sequencing. Tissue antigens. 2014; 84; 406-8.
  4. He JJ, Chen NY, Zhang W, He J, Zhu FM, Lv HJ. Identification of two novel alleles HLA-A*11:133 and A*11:02:05 by polymerase chain reaction sequence-based typing. Tissue antigens. 2014; 84; 409-12.
  5. Zheng JW, Guo ZH, Jiang YQ, et al. A new human leukocyte antigen class I allele: HLA-A*11:125. Tissue antigens. 2014; 84; 408-9.
  6. Yang KL, Lee SK, Hung JH, Lin PY. An HLA-A*11 variant, A*11:166, revealed in a Taiwanese unrelated bone marrow hematopoietic stem cell donor. Tissue antigens. 2014; 84; 405-6.
  7. Yang KL, Lee SK, Hung JH, Lin PY. Discovery of HLA-A*11:167, a variant of HLA-A*11, in a Taiwanese unrelated hematopoietic stem cell donor. Tissue antigens. 2014; 84; 412-3.
  8. Dai DP, Zhou XY, Cai JP. A new HLA-A*24 allele, HLA-A*24:02:87, identified by sequencing-based typing in a Chinese volunteer bone marrow donor. Tissue antigens. 2014; 84; 413-4.
  9. Stuckler C, Danzer M, Raml E, Steitzer H, Gabriel C. Characterization of a novel HLA-A*33 allele, A*33:47, using next-generation sequencing. Tissue antigens. 2014; 84; 414-5.
  10. Luo M, Xiao X, Xiao L. Identification of a novel HLA-B*51 variant allele, B*51:59, in a Chinese Han individual. Tissue antigens. 2014; 84; 417-9.
  11. Jin SZ, Li Z, Zou HY. Identification of a novel HLA-B*51 allele, HLA-B*51:144, in a Chinese individual. Tissue antigens. 2014; 84; 416-7.
  12. Cauwelier B, Nollet F, Gadisseur A, Schroyens W, Berneman Z. A novel HLA-C null allele, HLA-C*05:99N. Tissue antigens. 2014; 84; 420-1.
  13. Tao SD, Zhang W, Wang W, He J, Zhu FM, Lv HJ. A novel HLA-C allele, C*08:01:10 was identified in a Chinese leukemia patient. Tissue antigens. 2014; 84; 419-20.
  14. Xu YP, Gao SQ. Full-length coding sequences of two MICA alleles, MICA*002:01 and MICA*012:01, identified by sequence-based typing in Chinese individuals. Tissue antigens. 2014; 84; 433-5.