Nomenclature for Factors of the HLA System

August 2014

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the July 2014 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*02:07:07H140300KM244732Faming Zhu, Hangzhou, China
A*02:541358491LK932026Edward KL Yang, Hualien, Taiwan
A*03:204DKMS-LSL-A-122LK021941DKMS Life Sciences Lab, Dresden, Germany
A*24:02:90SZGSQ-22KM108305Su-Qing Gao, Shenzhen, China
A*24:289281265046LK937702Jue Wang, Chengdu, China
A*74:2314-389LM651040Steven GE Marsh, London, United Kingdom
B*15:01:37346665LM653276Edward KL Yang, Hualien, Taiwan
B*35:264BY01226KJ912625Carolyn K Hurley, Washington DC, USA
B*38:55QFBF8036KJ820672Raffaella Azzarone, L’Aquila, Italy
B*44:211JRC-D24-010AB971356Kenji Tadokoro, Tokyo, Japan
B*58:63281156631LK937701Jue Wang, Chengdu, China
C*02:89LIG_87594KM280645Margareth Torres, Sao Paulo, Brazil
C*05:10514214143KM111554Daniel Fuerst, Ulm, Germany
C*06:02:41CF1KJ807832Eric Weimer, Chapel Hill, USA
DRB1*03:11591670_C54KM265470Maria Elisa Moraes, Rio de Janeiro, Brazil
DRB1*08:59151930JBACKM217410Maria Elisa Moraes, Rio de Janeiro, Brazil
DRB1*12:50ZJ20131031001KM199687Faming Zhu, Hangzhou, China
DRB1*13:190NGR0007HG965218Laura Bungener, Groningen, The Netherlands
DRB1*14:54:05DKMS-LSL-DRB1-62HG008012DKMS Life Sciences Lab, Dresden, Germany
DRB1*16:01:06DKMS-LSL-DRB1-50HF937419DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:84HIP09133KM017970Anajane Smith, Seattle, USA

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:144HG00008881KJ535530Histogenetics, Ossining, USA
A*01:150HG00008882,
HG00008883
KJ819841,
KJ408855
Histogenetics, Ossining, USA
A*02:11:06HG00008888KJ819848Histogenetics, Ossining, USA
A*02:434HG00008887KJ408857Histogenetics, Ossining, USA
A*03:176HG00008884KJ437167Histogenetics, Ossining, USA
A*03:191HG00008885KJ956735Histogenetics, Ossining, USA
A*11:183HG00008869,
HG00008870,
HG00008871
KJ906526,
KJ819842,
KJ819839
Histogenetics, Ossining, USA
A*23:56HG00008880KJ408851Histogenetics, Ossining, USA
A*24:02:72HG00008878KM051850Histogenetics, Ossining, USA
A*24:02:88HG00008876,
HG00008877
KJ535537,
KJ535541
Histogenetics, Ossining, USA
A*24:276HG00008879KF737260Histogenetics, Ossining, USA
A*24:287303875LM653275Edward KL Yang, Hualien, Taiwan
A*25:24HG00008872KJ749711Histogenetics, Ossining, USA
A*29:54HG00008860KJ535515Histogenetics, Ossining, USA
A*32:01:17HG00008886KJ564306Histogenetics, Ossining, USA
A*33:03:16HG00008867KJ819840Histogenetics, Ossining, USA
A*33:03:25HG00008866KJ819838Histogenetics, Ossining, USA
A*33:64HG00008863,
HG00008864
KJ190351,
KJ535532
Histogenetics, Ossining, USA
A*33:86HG00008861,
HG00008862
KF560433,
KF601979
Histogenetics, Ossining, USA
A*33:90HG00008865KJ956732Histogenetics, Ossining, USA
A*68:01:24HG00008875KJ585753Histogenetics, Ossining, USA
A*68:01:25HG00008873KM051854Histogenetics, Ossining, USA
A*68:104:01HG00008874KJ190353Histogenetics, Ossining, USA
A*68:110HG00008868KF749233Histogenetics, Ossining, USA
A*74:0316317246LM654021Jane Rowlands, Pontyclun, United Kingdom
B*07:163HG00008900,
HG00008901,
HG00008902
KJ142162,
KJ190357,
KJ190358
Histogenetics, Ossining, USA
B*18:95HG00008895KM051860Histogenetics, Ossining, USA
B*27:05:21HG00008890KJ535554Histogenetics, Ossining, USA
B*35:08:07HG00008899KF882436Histogenetics, Ossining, USA
B*35:259HG00008896KJ923268Histogenetics, Ossining, USA
B*40:01:35383192LM653277Edward KL Yang, Hualien, Taiwan
B*40:130:02HG00008889KJ535560Histogenetics, Ossining, USA
B*40:295HG00008891,
HG00008892,
HG00008893,
HG00008894
KJ819870,
KM051855,
KJ819852,
KJ819855
Histogenetics, Ossining, USA
B*53:33HG00008897KJ819856Histogenetics, Ossining, USA
B*58:40HG00008898KJ535553Histogenetics, Ossining, USA
B*82:02:0116338715LM654022Jane Rowlands, Pontyclun, United Kingdom
C*01:74HG00008903KJ535575Histogenetics, Ossining, USA
C*03:02:10HG00008914KJ408832Histogenetics, Ossining, USA
C*03:176HG00008918KJ408835Histogenetics, Ossining, USA
C*03:184HG00008917KJ535588Histogenetics, Ossining, USA
C*03:258P08450KM199686Faming Zhu, Hangzhou, China
C*04:150HG00008922KJ535580Histogenetics, Ossining, USA
C*06:126HG00008906KF712298Histogenetics, Ossining, USA
C*06:127:01HG00008907,
HG00008908
KJ956752,
KJ667120
Histogenetics, Ossining, USA
C*06:132:01HG00008915,
HG00008916
KJ437172,
KJ956753
Histogenetics, Ossining, USA
C*07:76:02HG00008909KM051864Histogenetics, Ossining, USA
C*07:301HG00008905KJ408833Histogenetics, Ossining, USA
C*07:339HG00008910KJ819872Histogenetics, Ossining, USA
C*07:355HG00008904KJ535576Histogenetics, Ossining, USA
C*12:03:29HG00008911KJ437171Histogenetics, Ossining, USA
C*12:90HG00008912,
HG00008913
KJ535592,
KJ535585
Histogenetics, Ossining, USA
C*14:02:17HG00008921KM012022Histogenetics, Ossining, USA
C*14:66HG00008919,
HG00008920
KJ190361,
KJ535590
Histogenetics, Ossining, USA
DRB1*04:03:0236886HG974599Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*04:1519671HG974575Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*04:1634300HG974594Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*04:2634299HG974593Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*04:3128888HG974581Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*04:32TER475HG974580Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*08:04:0139183LK391782Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*08:0733544HG974592Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*11:08:0234459HG974597Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*11:0933097HG974590Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*11:14:0129586HG974584Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*11:19:0133098HG974591Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*11:2135392HG974598Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*11:23:02HG00008986KJ535641Histogenetics, Ossining, USA
DRB1*11:2924033HG974578Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*13:03:0114073HG974572Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*13:0834355HG974595Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*13:2029328HG974582Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*13:3629409HG974583Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*13:50:03HG00008987KJ749791Histogenetics, Ossining, USA
DRB1*13:147HG00008982,
HG00008983,
HG00008984
KJ437185,
KJ535642,
KJ619557
Histogenetics, Ossining, USA
DRB1*13:166HG00008985KJ819911Histogenetics, Ossining, USA
DRB1*14:02:0141941LK391784Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*14:1434205LK391778Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*14:2433401LK391777Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*15:02:0234355HG974596Marcel GJ Tilanus, Maastricht, The Netherlands
DQB1*02:17HG00008938KJ535614Histogenetics, Ossining, USA
DQB1*02:20NHG00008939KJ190366Histogenetics, Ossining, USA
DQB1*02:23HG00008940KJ190367Histogenetics, Ossining, USA
DQB1*02:29HG00008970KJ142189Histogenetics, Ossining, USA
DQB1*03:01:22HG00008930,
HG00008931
KJ585765,
KJ535610
Histogenetics, Ossining, USA
DQB1*03:02:06HG00008951KJ535624Histogenetics, Ossining, USA
DQB1*03:02:10HG00008952KF737212Histogenetics, Ossining, USA
DQB1*03:02:15HG00008949KJ585768Histogenetics, Ossining, USA
DQB1*03:03:11HG00008941,
HG00008942,
HG00008943
KM051874,
KJ585769,
KJ923291
Histogenetics, Ossining, USA
DQB1*03:10:02HG00008937KJ749746Histogenetics, Ossining, USA
DQB1*03:55HG00008928,
HG00008929
KJ535618,
KJ535629
Histogenetics, Ossining, USA
DQB1*03:72HG00008972KJ142185Histogenetics, Ossining, USA
DQB1*03:75HG00008927KJ408826Histogenetics, Ossining, USA
DQB1*03:102HG00008936KJ749739Histogenetics, Ossining, USA
DQB1*03:105HG00008950KJ190370Histogenetics, Ossining, USA
DQB1*03:109HG00008932,
HG00008933,
HG00008934,
HG00008935
KJ819903,
KJ142180,
KJ956756,
KJ535622
Histogenetics, Ossining, USA
DQB1*04:02:04HG00008973KJ437180Histogenetics, Ossining, USA
DQB1*04:02:07HG00008971KJ956759Histogenetics, Ossining, USA
DQB1*04:12HG00008974KJ142174Histogenetics, Ossining, USA
DQB1*05:01:05HG00008961,
HG00008962
KJ142183,
KJ408829
Histogenetics, Ossining, USA
DQB1*05:01:08HG00008967KJ408828Histogenetics, Ossining, USA
DQB1*05:03:14HG00008963KJ535626Histogenetics, Ossining, USA
DQB1*05:06:02HG00008960KF951116Histogenetics, Ossining, USA
DQB1*05:11:02HG00008958,
HG00008959
KJ535621,
KJ142179
Histogenetics, Ossining, USA
DQB1*05:20HG00008956KJ142186Histogenetics, Ossining, USA
DQB1*05:28HG00008957KJ142181Histogenetics, Ossining, USA
DQB1*05:43HG00008968,
HG00008969
KF998309,
KJ094076
Histogenetics, Ossining, USA
DQB1*05:49HG00008965KJ535631Histogenetics, Ossining, USA
DQB1*05:52HG00008953,
HG00008954,
HG00008955
KJ535617,
KJ619519,
KJ535611
Histogenetics, Ossining, USA
DQB1*05:69HG00008964KJ408821Histogenetics, Ossining, USA
DQB1*05:73HG00008966KJ535609Histogenetics, Ossining, USA
DQB1*06:01:13HG00008925KJ749740Histogenetics, Ossining, USA
DQB1*06:02:14HG00008981KJ535625Histogenetics, Ossining, USA
DQB1*06:03:07HG00008946,
HG00008947,
HG00008948
KJ190373,
KJ535613,
KJ437175
Histogenetics, Ossining, USA
DQB1*06:09:06HG00008945KJ956760Histogenetics, Ossining, USA
DQB1*06:15:02HG00008976,
HG00008977
KJ535612,
KJ535615
Histogenetics, Ossining, USA
DQB1*06:53HG00008923KJ437176Histogenetics, Ossining, USA
DQB1*06:55HG00008926KJ142187Histogenetics, Ossining, USA
DQB1*06:74HG00008978,
HG00008979
KJ564317,
KJ190371
Histogenetics, Ossining, USA
DQB1*06:123HG00008975KJ437178Histogenetics, Ossining, USA
DQB1*06:125HG00008980KJ408822Histogenetics, Ossining, USA
DQB1*06:149HG00008944KM051877Histogenetics, Ossining, USA
DQB1*06:153HG00008924KM051880Histogenetics, Ossining, USA
DPB1*02:01:09HG00009040KJ535690Histogenetics, Ossining, USA
DPB1*02:01:12HG00009044KF737246Histogenetics, Ossining, USA
DPB1*04:01:06HG00009001KJ535673Histogenetics, Ossining, USA
DPB1*04:01:08HG00008999KJ535679Histogenetics, Ossining, USA
DPB1*04:01:11HG00009026KM012032Histogenetics, Ossining, USA
DPB1*04:01:12HG00009032KM051894Histogenetics, Ossining, USA
DPB1*04:01:13HG00009046,
HG00009047
KJ749761,
KM012030
Histogenetics, Ossining, USA
DPB1*04:01:16HG00009022KF673239Histogenetics, Ossining, USA
DPB1*11:01:03HG00009069,
HG00009070,
HG00009071
KJ564322,
KF882474,
KJ667144
Histogenetics, Ossining, USA
DPB1*13:01:02HG00009072,
HG00009073,
HG00009074,
HG00009075
KJ408807,
KJ535650,
KJ535655,
KJ535653
Histogenetics, Ossining, USA
DPB1*143:01HG00008988KJ190388Histogenetics, Ossining, USA
DPB1*149:01HG00009000KJ142204Histogenetics, Ossining, USA
DPB1*157:01HG00009052KJ190377Histogenetics, Ossining, USA
DPB1*161:01NHG00009078KJ190376Histogenetics, Ossining, USA
DPB1*172:01HG00008996,
HG00008997,
HG00008998
KJ535674,
KJ923301,
KJ956773
Histogenetics, Ossining, USA
DPB1*177:01HG00009023,
HG00009024,
HG00009025
KJ956772,
KJ906540,
KJ906542
Histogenetics, Ossining, USA
DPB1*178:01HG00009027,
HG00009028
KJ667141,
KJ819927
Histogenetics, Ossining, USA
DPB1*180:01HG00009031KJ408811Histogenetics, Ossining, USA
DPB1*182:01HG00009034,
HG00009035
KJ564319,
KJ749754
Histogenetics, Ossining, USA
DPB1*184:01HG00009036,
HG00009037,
HG00009038
KJ535678,
KJ619572,
KM051891
Histogenetics, Ossining, USA
DPB1*185:01HG00009039KJ923314Histogenetics, Ossining, USA
DPB1*189:01HG00009041,
HG00009042,
HG00009043
KJ535662,
KJ142208,
KJ535646
Histogenetics, Ossining, USA
DPB1*193:01HG00009045KJ619570Histogenetics, Ossining, USA
DPB1*195:01HG00009048KM051890Histogenetics, Ossining, USA
DPB1*200:01HG00009064KJ142198Histogenetics, Ossining, USA
DPB1*201:01HG00009065,
HG00009066,
HG00009067,
HG00009068
KJ437189,
KJ535664,
KJ535659,
KJ749755
Histogenetics, Ossining, USA
DPB1*208:01HG00009076KJ923300Histogenetics, Ossining, USA
DPB1*209:01HG00009079,
HG00009080
KJ819919,
KJ535648
Histogenetics, Ossining, USA
DPB1*210:01HG00008989,
HG00008990
KJ906561,
KJ535649
Histogenetics, Ossining, USA
DPB1*214:01HG00009002,
HG00009003,
HG00009004,
HG00009005,
HG00009006,
HG00009007,
HG00009008,
HG00009009,
HG00009010,
HG00009011,
HG00009012,
HG00009013,
HG00009014,
HG00009015
KM012031,
KF712314,
KF673241,
KF577647,
KF905282,
KF535993,
KF737244,
KF882491,
KF695034,
KF560465,
KF882500,
KJ667140,
KF602033,
KF381278
Histogenetics, Ossining, USA
DPB1*215:01HG00009016,
HG00009017,
HG00009018,
HG00009019,
HG00009020,
HG00009021
KJ619571,
KJ956770,
KF647827,
KJ819926,
KF925427,
KF737318
Histogenetics, Ossining, USA
DPB1*218:01NHG00009049KF501541Histogenetics, Ossining, USA
DPB1*220:01HG00009055,
HG00009056,
HG00009057,
HG00009058,
HG00009059,
HG00009060,
HG00009061,
HG00009062
KJ923313,
KF737245,
KF415271,
KJ585784,
KJ923309,
KF998335,
KF925428,
KF925429
Histogenetics, Ossining, USA
DPB1*221:01HG00009077KF976758Histogenetics, Ossining, USA
DPB1*222:01HG00009081,
HG00009082,
HG00009083
KJ018012,
KF976760,
KF976763
Histogenetics, Ossining, USA
DPB1*301:01HG00008991KJ956765Histogenetics, Ossining, USA
DPB1*306:01HG00009030KJ535670Histogenetics, Ossining, USA
DPB1*311:01HG00009050,
HG00009051
KJ956763,
KF976756
Histogenetics, Ossining, USA
DPB1*313:01HG00009053,
HG00009054
KJ408803,
KJ749760
Histogenetics, Ossining, USA
DPB1*315:01HG00009063KJ749762Histogenetics, Ossining, USA
DPB1*321:01HG00009033KJ142203Histogenetics, Ossining, USA
DPB1*333:01HG00008992,
HG00008993,
HG00008994,
HG00008995
KJ749794,
KJ749764,
KM051895,
KM051896
Histogenetics, Ossining, USA
DPB1*357:01NHG00009029KM012028Histogenetics, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
A*02:01:01:01(3)
A*02:01:79(4)
A*02:03:01(3)
A*02:95(5)
A*02:482(6)
B*35:227(7)
B*52:33(8)
B*55:46(9)
C*04:144(10)
DQB1*05:15(11)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic acids research. 2014; 41: D1222-7.
  3. Tao H, Xu YP, Chen LX. Genomic full-length sequence of two HLA-A alleles, A*02:01:01:01 and A*02:03:01, identified by cloning and sequencing. Tissue Antigens. 2014; 84: 321-3.
  4. Zou HY, Jin SZ, Li Z. HLA-A*02:01:79, a novel allele, which has arisen by silent mutation in codon 230. Tissue Antigens. 2014; 84: 323-4.
  5. Bultitude WP, Mayor NP, McWhinnie AJ, Madrigal JA, Marsh SGE. Genomic sequence of the rare HLA-A*02:95 allele identified by sequence-based typing and cloning. Tissue Antigens. 2014; 84: 324-6.
  6. Zhu X, Yang T, Yao F, et al. A new human leukocyte antigen-A allele, HLA-A*02:482. Tissue Antigens. 2014; 84: 238-9.
  7. Chen NY, Zhang W, Wang W, He J, Zhu FM, Lv HJ. Identification of a novel HLA-B*35:227 allele by polymerase chain reaction sequence-based typing in a Chinese bone marrow donor. Tissue Antigens. 2014; 84: 240-2.
  8. Yang KL, Lee SK, Lin PY. HLA-B*52:33, a variant of HLA-B*52, discovered in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens. 2014; 84: 242-3.
  9. Li JP, Li XF, Zhang X, Lin FQ, Zhang KL. HLA-B*55:46, a novel allele, identified in a Chinese platelet donor. Tissue Antigens. 2014; 84: 243-5.
  10. Zhang W, Tao SD, Wang W, He J, Zhu FM, Lv HJ. Identification of a novel HLA-C*04:144 allele by polymerase chain reaction sequence-based typing. Tissue Antigens. 2014; 84: 245-6.
  11. Han ZD, Wang W, He J, Zhu FM, Lv HJ. A novel HLA-DQB1*05:15 allele was identified in a Chinese individual. Tissue Antigens. 2014; 84: 246-8.