Nomenclature for Factors of the HLA System

February 2014

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the January 2014 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:148HG00007174KF501497Histogenetics, Ossining, USA
A*01:149HG00007175KF501494Histogenetics, Ossining, USA
A*01:150HG00007176,
HG00007177
KF291263,
KF291261
Histogenetics, Ossining, USA
A*02:11:06HG00007187KF438195Histogenetics, Ossining, USA
A*02:484HG00007184KF535955Histogenetics, Ossining, USA
A*02:485HG00007185KF263492Histogenetics, Ossining, USA
A*02:486HG00007186KF291262Histogenetics, Ossining, USA
A*02:487HG00007188KF291260Histogenetics, Ossining, USA
A*02:488I031KJ205532Wangxia Li, Wuhan, China
A*03:01:45HG00007180KF415250Histogenetics, Ossining, USA
A*03:184HG00007178KF415249Histogenetics, Ossining, USA
A*03:185HG00007179KF312402Histogenetics, Ossining, USA
A*11:01:60HG00007154KF471684Histogenetics, Ossining, USA
A*11:01:61HG00007155KF535960Histogenetics, Ossining, USA
A*11:01:62HG00007162KF312406Histogenetics, Ossining, USA
A*11:183HG00006371KF036233Histogenetics, Ossining, USA
A*11:184HG00007159KF535957Histogenetics, Ossining, USA
A*11:185HG00007160KF381221Histogenetics, Ossining, USA
A*11:186HG00007161KF381218Histogenetics, Ossining, USA
A*11:187HG00007163KF263491Histogenetics, Ossining, USA
A*11:188sz13010552AKJ185393Daming Wang, Shenzhen, China
A*24:275HG00007170KF381222Histogenetics, Ossining, USA
A*24:276HG00007172KF471695Histogenetics, Ossining, USA
A*24:277HG00007173KF381224Histogenetics, Ossining, USA
A*25:25HG00007166KF438193Histogenetics, Ossining, USA
A*29:01:06HG00007146KF535951Histogenetics, Ossining, USA
A*29:60D51775HG931084Odile Avinens, Montpellier, Cedex 5, France
A*30:82HG00007169KF312401Histogenetics, Ossining, USA
A*31:01:21HG00007149KF263494Histogenetics, Ossining, USA
A*31:01:22HG00007150KF415246Histogenetics, Ossining, USA
A*31:85HG00007147KF501496Histogenetics, Ossining, USA
A*31:86HG00007148KF312405Histogenetics, Ossining, USA
A*32:01:16HG00007183KF501493Histogenetics, Ossining, USA
A*32:62HG00007181KF381223Histogenetics, Ossining, USA
A*33:03:25HG00007151KF535952Histogenetics, Ossining, USA
A*33:86HG00007145KF535953Histogenetics, Ossining, USA
A*68:110HG00007153KF381220Histogenetics, Ossining, USA
A*68:111HG00007167KF438192Histogenetics, Ossining, USA
A*69:03HG00007165KF438194Histogenetics, Ossining, USA
B*07:151:02HG00007237KF381233Histogenetics, Ossining, USA
B*07:211HG00007239KF291264Histogenetics, Ossining, USA
B*07:212Xian63062KF961695Jun Qi, Xian, China
B*07:33:03HG00007238KF291269Histogenetics, Ossining, USA
B*08:01:24HG00007210KF263501Histogenetics, Ossining, USA
B*08:117HG00007211KF415251Histogenetics, Ossining, USA
B*08:118HG00007212KF291265Histogenetics, Ossining, USA
B*08:119HG00007213KF535965Histogenetics, Ossining, USA
B*13:74HG00007214KF312408Histogenetics, Ossining, USA
B*13:75HG00007215KF438186Histogenetics, Ossining, USA
B*13:76N8811300178KJ137675Xiangming Zhu, Kunming, China
B*15:01:35HG00007228KF501499Histogenetics, Ossining, USA
B*15:308HG00007220KF381238Histogenetics, Ossining, USA
B*15:309HG00007227KF381228Histogenetics, Ossining, USA
B*15:310HG00007229KF471722Histogenetics, Ossining, USA
B*15:311HG00007231KF291266Histogenetics, Ossining, USA
B*15:312HG00007232KF381226Histogenetics, Ossining, USA
B*18:98HG00007208KF263496Histogenetics, Ossining, USA
B*18:99HG00007209KF471723Histogenetics, Ossining, USA
B*27:05:27HG00007206KF438187Histogenetics, Ossining, USA
B*27:119HG00007203KF471724Histogenetics, Ossining, USA
B*27:120HG00007204KF381237Histogenetics, Ossining, USA
B*27:121HG00007205KF381236Histogenetics, Ossining, USA
B*27:122HG00007207KF501505Histogenetics, Ossining, USA
B*35:08:07HG00007236KF263498Histogenetics, Ossining, USA
B*35:251HG00007222KF535967Histogenetics, Ossining, USA
B*35:252HG00007230KF438189Histogenetics, Ossining, USA
B*39:01:18HG00007240KF471719Histogenetics, Ossining, USA
B*39:89HG00007242KF471721Histogenetics, Ossining, USA
B*40:01:38HG00007193KF471720Histogenetics, Ossining, USA
B*40:01:39Xian57248KF955602Mengli Liu, Xié─˘an, China
B*40:273HG00007196KF501507Histogenetics, Ossining, USA
B*40:274HG00007198KF501504Histogenetics, Ossining, USA
B*40:275HG00007201KF501509Histogenetics, Ossining, USA
B*40:276HG00007202KF263502Histogenetics, Ossining, USA
B*40:35:02HG00007200KF381230Histogenetics, Ossining, USA
B*41:32HG00007194KF415252Histogenetics, Ossining, USA
B*44:188HG00007190,
HG00007191
KF312407,
KF501502
Histogenetics, Ossining, USA
B*44:189HG00007216KF501500Histogenetics, Ossining, USA
B*44:190HG00007217KF312413Histogenetics, Ossining, USA
B*44:191HG00007218KF381234Histogenetics, Ossining, USA
B*49:01:05HG00007192KF501508Histogenetics, Ossining, USA
B*49:01:06HG00007195KF312410Histogenetics, Ossining, USA
B*51:01:46HG00007233KF312412Histogenetics, Ossining, USA
B*51:08:02HG00007235KF381231Histogenetics, Ossining, USA
B*51:167HG00007189KF535962Histogenetics, Ossining, USA
B*51:168HG00007234KF438188Histogenetics, Ossining, USA
B*51:169DAGFHG530131Valerie Dubois, Lyon, France
B*52:37HG00007225KF535966Histogenetics, Ossining, USA
B*53:01:10HG00007243KF381232Histogenetics, Ossining, USA
B*53:32HG00007221KF312409Histogenetics, Ossining, USA
B*53:33HG00007223,
HG00007224
KF291267,
KF291268
Histogenetics, Ossining, USA
B*58:59HG00007226KF535963Histogenetics, Ossining, USA
C*01:92HG00007244KF291280Histogenetics, Ossining, USA
C*03:240sz4176CKJ185392Daming Wang, Shenzhen, China
C*06:125HG00007245KF471730Histogenetics, Ossining, USA
C*06:126HG00007249KF263507Histogenetics, Ossining, USA
C*06:127HG00007250KF535968Histogenetics, Ossining, USA
C*06:128NHG00007256KF381239Histogenetics, Ossining, USA
C*07:01:40HG00007257KF438198Histogenetics, Ossining, USA
C*07:02:54HG00007247KF501517Histogenetics, Ossining, USA
C*07:355HG00007246KF263503Histogenetics, Ossining, USA
C*07:356HG00007248KF501520Histogenetics, Ossining, USA
C*07:357HG00007254KF291273Histogenetics, Ossining, USA
C*07:358HG00007255KF291275Histogenetics, Ossining, USA
C*07:359ABAL772993HG796222Steven GE Marsh, London, United Kingdom
C*07:76:02HG00007251KF501515Histogenetics, Ossining, USA
DRB1*03:96CG6408 HG797651Xiang Liu, Beijing, China
DRB1*03:97D53384HG931083Odile Avinens, Montpellier, Cedex 5, France
DRB1*04:56:0293087236KJ407396Daniel Fuerst, Ulm, Germany
DRB1*11:08:03ASUS286789HG796223Steven GE Marsh, London, United Kingdom
DRB1*11:154CH4408 HG797655Xiang Liu, Beijing, China
DRB1*12:45CW5931 HG797653Xiang Liu, Beijing, China
DRB1*12:46RUCH133143HG796224Steven GE Marsh, London, United Kingdom
DRB1*14:147AV8315 HG797654Xiang Liu, Beijing, China
DRB1*15:01:23CV2407 HG797652Xiang Liu, Beijing, China
DQA1*01:05:02224036HG803546Klaus Witter, M?║nchen, Germany
DQB1*03:115CB7886HG797650Xiang Liu, Beijing, China
DPA1*02:02:06G993041KF555375Chen-Chung Chu, New Taipei City, Taiwan
DPB1*02:01:12HG00006346KF152908Histogenetics, Ossining, USA
DPB1*04:01:16HG00006343KF184352Histogenetics, Ossining, USA
DPB1*11:01:03HG00006350KF220355Histogenetics, Ossining, USA
DPB1*214:01HG00006340KF220354Histogenetics, Ossining, USA
DPB1*215:01HG00006341,
HG00006342
KF036208,
KF128979
Histogenetics, Ossining, USA
DPB1*216:01NHG00006344KF220350Histogenetics, Ossining, USA
DPB1*217:01HG00006345KF128976Histogenetics, Ossining, USA
DPB1*218:01NHG00006347KF220351Histogenetics, Ossining, USA
DPB1*219:01HG00006348KF220358Histogenetics, Ossining, USA
DPB1*220:01HG00006349KF152909Histogenetics, Ossining, USA
DPB1*221:01HG00006351KF152906Histogenetics, Ossining, USA
DPB1*222:01HG00006352KF128972Histogenetics, Ossining, USA
MICA*0801189P249987KJ413140Daniel Fuerst, Ulm, Germany
MICA*0811198P09205115KJ413141Daniel Fuerst, Ulm, Germany
MICA*082G20111107003HG931177Dabin Tang, Chengdu, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:407HG00007709KF749232Histogenetics, Ossining, USA
A*11:52Q120823772HG792591Dominique Masson, La Tronche, France
A*24:213HG00007953KF976733Histogenetics, Ossining, USA
A*24:248BJ1025KC473543Xiaoyan Shan, Beijing, China
A*68:99HG00007948,
HG00007949
KJ017980,
KF951104
Histogenetics, Ossining, USA
A*68:104HG00007693KF790833Histogenetics, Ossining, USA
B*15:01:31HG00007579,
HG00007580
KF381225,
KF438185
Histogenetics, Ossining, USA
B*15:07:03HG00007722KF804112Histogenetics, Ossining, USA
B*15:282HG00007725KF749238Histogenetics, Ossining, USA
B*35:01:35HG00007578KF577614Histogenetics, Ossining, USA
B*37:01:09HG00007577KF501506Histogenetics, Ossining, USA
B*40:130:02HG00007846KF882434Histogenetics, Ossining, USA
B*40:268HG00007715KF737192Histogenetics, Ossining, USA
B*46:01:18TMOI2014KJ011856Pei Yongfeng, Nanning, China
B*57:63HG00007975KF976737Histogenetics, Ossining, USA
C*12:94HG00007879KF840755Histogenetics, Ossining, USA
DRB1*04:01:12HG00007664KF501540Histogenetics, Ossining, USA
DRB1*12:02:01HG00007914KF925417Histogenetics, Ossining, USA
DRB1*13:158HG00007665KF263514Histogenetics, Ossining, USA
DQB1*02:27HG00007749KF737221Histogenetics, Ossining, USA
DQB1*02:29HG00007645,
HG00007646
KF501532,
KF673225
Histogenetics, Ossining, USA
DQB1*03:02:06HG00007634KF647800Histogenetics, Ossining, USA
DQB1*03:45HG00007635KF647802Histogenetics, Ossining, USA
DQB1*03:72HG00007648KF415268Histogenetics, Ossining, USA
DQB1*04:02:03HG00007649KF535977Histogenetics, Ossining, USA
DQB1*04:02:04HG00007650,
HG00007651
KF673220,
KF471735
Histogenetics, Ossining, USA
DQB1*04:11HG00007647KF647809Histogenetics, Ossining, USA
DQB1*05:01:04HG00007636KF535973Histogenetics, Ossining, USA
DQB1*05:01:05HG00007637,
HG00007638
KF577632,
KF501527
Histogenetics, Ossining, USA
DQB1*05:01:08HG00007639,
HG00007640,
HG00007641
KF415260,
KF501530,
KF471742
Histogenetics, Ossining, USA
DQB1*05:03:08HG00007644KF673217Histogenetics, Ossining, USA
DQB1*05:19HG00007758KF804122Histogenetics, Ossining, USA
DQB1*05:23HG00007642,
HG00007643
KF501524,
KF263511
Histogenetics, Ossining, USA
DQB1*05:43HG00007905KF882449Histogenetics, Ossining, USA
DQB1*06:02:07HG00007652KF673227Histogenetics, Ossining, USA
DQB1*06:03:07HG00007633KF415263Histogenetics, Ossining, USA
DQB1*06:03:09HG00007630KF602018Histogenetics, Ossining, USA
DQB1*06:09:02HG00007631,
HG00007632
KF602021,
KF602023
Histogenetics, Ossining, USA
DQB1*06:11:0124019938HG915713Thibaut Gervais, Brussels, Belgium
DQB1*06:15:02HG00007655,
HG00007656
KF673224,
KF602016
Histogenetics, Ossining, USA
DQB1*06:22:02HG00007653KF673222Histogenetics, Ossining, USA
DQB1*06:71HG00007654KF602026Histogenetics, Ossining, USA
DQB1*06:74HG00007657KF501533Histogenetics, Ossining, USA
DQB1*06:78HG00007658KF312422Histogenetics, Ossining, USA
DQB1*06:81HG00007659,
HG00007660,
HG00007661,
HG00007662,
HG00007663
KF501523,
KF535982,
KF602019,
KF381256,
KF471737
Histogenetics, Ossining, USA
DQB1*06:93HG00007629KF291285Histogenetics, Ossining, USA
DPB1*02:01:09HG00007673KF673246Histogenetics, Ossining, USA
DPB1*04:01:06HG00007666,
HG00007667,
HG00007668,
HG00007669,
HG00007670
KF263522,
KF415276,
KF471759,
KF501542,
KF501558
Histogenetics, Ossining, USA
DPB1*04:01:07HG00007671KF560463Histogenetics, Ossining, USA
DPB1*04:01:15HG00007927KF882487Histogenetics, Ossining, USA
DPB1*09:01:02HG00007677,
HG00007678,
HG00007679,
HG00007680
KF535996,
KF647813,
KF471747,
KF415275
Histogenetics, Ossining, USA
DPB1*13:01:02HG00007682,
HG00007683,
HG00007684
KF577637,
KF560452,
KF560455
Histogenetics, Ossining, USA
DPB1*150:01HG00007672KF438219Histogenetics, Ossining, USA
DPB1*155:01HG00007674,
HG00007675,
HG00007676
KF673232,
KF647812,
KF577646
Histogenetics, Ossining, USA
DPB1*158:01HG00007681KF535991Histogenetics, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
A*03:168N(3)
B*08:113(4)
B*44:184(5)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55:280-7.
  3. Abad ML, Balas A, Andersen I, Rodriguez-Calvo MI, Eiras A, Vicario JL. A new non-expressed allele HLA-A*03:168N, identified by serological and sequence-based typing in a voluntary Norwegian hematopoietic stem cell donor. Tissue Antigens. 2014; 83:195-6.
  4. Strobel J, Ringwald J, Hauck-Dlimi B, Eckstein R, Zingsem J. The novel allele, HLA-B*08:113, identified in a German cord blood donor and his mother. Tissue Antigens. 2014; 83:197-8.
  5. Wada A, Shiina T, Michino J, Yasumura S, Sugiyama T. A novel HLA-B allele, HLA-B*44:184, identified by super high-resolution single-molecule sequence-based typing in a Japanese individual. Tissue Antigens. 2014; 83:198-9.