Nomenclature for Factors of the HLA System

January 2014

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the December 2013 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:147QBY01169KF946539Carolyn K Hurley, Washington DC, USA
A*02:01:104D10019137FR871039Jinghui Qu, Shenzhen, China
A*02:07:065711301816KF926833Faming Zhu, Hangzhou, China
A*02:479D10046104FR871033Jinghui Qu, Shenzhen, China
A*02:480D10119316FR871043Jinghui Qu, Shenzhen, China
A*02:481ID-1646770, ID-1609010KF955287Gisele Rampim, Sao Paulo, Brazil
A*02:4828811300353KJ137678Xiangming Zhu, Kunming, China
A*02:483BY01194KJ155016Carolyn K Hurley, Washington DC, USA
A*03:183BY01189KJ155023Carolyn K Hurley, Washington DC, USA
A*11:01:57D10116293FR871081Jinghui Qu, Shenzhen, China
A*11:01:58D10021448FR871093Jinghui Qu, Shenzhen, China
A*11:01:59D10079623FR871096Jinghui Qu, Shenzhen, China
A*11:177D11015069KF418547Jinghui Qu, Shenzhen, China
A*11:178D11048709KF418587Jinghui Qu, Shenzhen, China
A*11:179D10100109FR871074Jinghui Qu, Shenzhen, China
A*11:180NBY01193KJ155019Carolyn K Hurley, Washington DC, USA
A*11:181BY01190KJ155022Carolyn K Hurley, Washington DC, USA
A*11:182QBY01185KJ155026Carolyn K Hurley, Washington DC, USA
A*24:02:84D11016158KF418597Jinghui Qu, Shenzhen, China
A*24:271D11044208KF418598Jinghui Qu, Shenzhen, China
A*24:272D10022733FR871107Jinghui Qu, Shenzhen, China
A*24:273D10127189FR871109Jinghui Qu, Shenzhen, China
A*24:274BY01192KJ155020Carolyn K Hurley, Washington DC, USA
A*26:99D11016263KF418599Jinghui Qu, Shenzhen, China
A*29:59BY01195KJ155017Carolyn K Hurley, Washington DC, USA
A*30:8130431730KF871429Oh-Joong Kwon, Seoul, South Korea
A*31:83BY01170KF946538Carolyn K Hurley, Washington DC, USA
A*31:84BY01186KJ155018Carolyn K Hurley, Washington DC, USA
A*33:03:24D11012673KF418556Jinghui Qu, Shenzhen, China
A*68:01:21D10077791FR871171Jinghui Qu, Shenzhen, China
A*68:108D10041725FR871169Jinghui Qu, Shenzhen, China
A*68:109ID-1680708KF955288Gisele Rampim, Sao Paulo, Brazil
A*74:21D10020400FR871172Jinghui Qu, Shenzhen, China
B*08:11690184530HG795414Christian Seidl, Frankfurt am Main, Germany
B*15:305D10107009FR849777Jinghui Qu, Shenzhen, China
B*15:306D10087519FR849779Jinghui Qu, Shenzhen, China
B*15:307D10029692FR849780Jinghui Qu, Shenzhen, China
B*18:9781123712KF938894Daniel Fuerst, Ulm, Germany
B*27:11890184039KF938891Daniel Fuerst, Ulm, Germany
B*35:01:40D10106168FR849798Jinghui Qu, Shenzhen, China
B*35:01:41D10059839KF785770Jinghui Qu, Shenzhen, China
B*35:03:13D10050988KF785772Jinghui Qu, Shenzhen, China
B*35:249D10081787FR849797Jinghui Qu, Shenzhen, China
B*35:250D10094286KF785771Jinghui Qu, Shenzhen, China
B*39:88D11052267KF444977Jinghui Qu, Shenzhen, China
B*40:271D11044186KF444985Jinghui Qu, Shenzhen, China
B*40:272D10091180KF785773Jinghui Qu, Shenzhen, China
B*46:01:16D10120883KF785774Jinghui Qu, Shenzhen, China
B*46:01:172012TB2363KF994787Zhongzheng Zheng, Shanghai, China
B*46:01:18IOTM2014KJ011856Pei Yongfeng, Nanning, China
B*46:582012TB1925KF994786Zhongzheng Zheng, Shanghai, China
B*50:38D10093530KF785775Jinghui Qu, Shenzhen, China
B*59:07D10027565KF785776Jinghui Qu, Shenzhen, China
B*67:05D10107578KF785777Jinghui Qu, Shenzhen, China
C*01:02:252013TB003, 2013TB003KF619447Zhongzheng Zheng, Shanghai, China
C*01:912013TB0166KF994788Zhongzheng Zheng, Shanghai, China
C*03:237FRFGR11086HG792590Dominique Masson, La Tronche, France
C*03:238BY01184KF946534Carolyn K Hurley, Washington DC, USA
C*03:239BY01176KF946526Carolyn K Hurley, Washington DC, USA
C*06:124BY01180KF946530Carolyn K Hurley, Washington DC, USA
C*07:108:0262125801156HG792588Dominique Masson, La Tronche, France
C*07:349D11034700KF527780Jinghui Qu, Shenzhen, China
C*07:350ND11045980KF527787Jinghui Qu, Shenzhen, China
C*07:351BY01181KF946531Carolyn K Hurley, Washington DC, USA
C*07:352BY01175KF946525Carolyn K Hurley, Washington DC, USA
C*07:353BY01174KF946524Carolyn K Hurley, Washington DC, USA
C*07:35490186274HG795412Christian Seidl, Frankfurt am Main, Germany
C*08:103BY01172KF946536Carolyn K Hurley, Washington DC, USA
C*08:104BY01183KF946533Carolyn K Hurley, Washington DC, USA
C*12:116FRFGR32238HG792589Dominique Masson, La Tronche, France
C*14:02:167009213208HG792587Dominique Masson, La Tronche, France
C*15:85BY01182KF946532Carolyn K Hurley, Washington DC, USA
C*16:64BY01177KF946527Carolyn K Hurley, Washington DC, USA
DRB1*03:95ID-1683359KF955289Gisele Rampim, Sao Paulo, Brazil
DRB1*04:03:0913224734KF938892Daniel Fuerst, Ulm, Germany
DQB1*03:11413742891HG795413Christian Seidl, Frankfurt am Main, Germany
DQB1*04:19147317 PFMTHG798915Maria Elisa Moraes, Rio de Janeiro, Brazil
DQB1*05:56D11002393KF270547Jinghui Qu, Shenzhen, China
DQB1*06:01:11D11031202KF270550Jinghui Qu, Shenzhen, China
MICA*0791799P08222556KJ143750Daniel Fuerst, Ulm, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:115HG00007556KF312404Histogenetic, Ossining, USA
A*02:01:86HG00007574KF535956Histogenetic, Ossining, USA
A*02:380HG00007573KF673195Histogenetic, Ossining, USA
A*02:406BY01188KJ155024Carolyn K Hurley, Washington DC, USA
A*02:436HG00007572KF601980Histogenetic, Ossining, USA
A*02:95ANRI6016HG798330Steven GE Marsh, London, United Kingdom
A*11:131HG00007536,
HG00007537,
HG00007538,
HG00007539,
HG00007540,
HG00007541,
HG00007542,
HG00007543,
HG00007544,
HG00007545,
HG00007546,
HG00007547,
HG00007548,
HG00007549,
HG00007550,
HG00007551,
HG00007552,
HG00007553,
HG00007554		KF471685,
KF471698,
KF471699,
KF471700,
KF471701,
KF501498,
KF471691,
KF471692,
KF471693,
KF471687,
KF471703,
KF471705,
KF471707,
KF471710,
KF471711,
KF471712,
KF471713,
KF471714,
KF471715		Histogenetic, Ossining, USA
A*11:153:02HG00007405KF673193Histogenetic, Ossining, USA
A*11:166BY01171KF946537Carolyn K Hurley, Washington DC, USA
A*11:8665924HG803173Jane Rowlands, Pontyclun, United Kingdom
A*23:59HG00007555KF535954Histogenetic, Ossining, USA
A*24:225:028811301000KJ137677Xiangming Zhu, Kunming, China
A*24:2482012TB1658 KF994785Zhongzheng Zheng, Shanghai, China
A*32:01:14HG00007557,
HG00007558,
HG00007559,
HG00007560,
HG00007561,
HG00007562,
HG00007563,
HG00007564,
HG00007565,
HG00007566,
HG00007567,
HG00007568,
HG00007569		KF471686,
KF471702,
KF501491,
KF471718,
KF471716,
KF471708,
KF471709,
KF471706,
KF471704,
KF471688,
KF471689,
KF471696,
KF471697		Histogenetic, Ossining, USA
A*33:03:23D11052291KF418557Jinghui Qu, Shenzhen, China
A*33:64HG00007535KF415248Histogenetic, Ossining, USA
A*33:65HG00007570,
HG00007571		KF601982,
KF601983		Histogenetic, Ossining, USA
B*15:03:04HG00007582KF128938Histogenetic, Ossining, USA
B*15:290HG00007581KF128941Histogenetic, Ossining, USA
B*15:301Xian63712KF961697Liping Chen, Xian, China
B*27:05:21HG00007576KF535964Histogenetic, Ossining, USA
B*39:14CTV-60701654KF737182Antonio Balas, Madrid, Spain
B*41:02:05HG00007575KF438190Histogenetic, Ossining, USA
B*51:24:05HG00007583KF263499Histogenetic, Ossining, USA
C*01:02:222012TB01419 KF994784Zhongzheng Zheng, Shanghai, China
C*02:05:02HG00007470KF647796Histogenetic, Ossining, USA
C*02:64HG00007593KF602004Histogenetic, Ossining, USA
C*03:198HG00007475KF560444Histogenetic, Ossining, USA
C*03:209H130543KF953484Faming Zhu, Hangzhou, China
C*03:214HG00007594KF577619Histogenetic, Ossining, USA
C*04:01:46HG00007595KF471726Histogenetic, Ossining, USA
C*07:01:36HG00007584KF415253Histogenetic, Ossining, USA
C*07:288HG00007585KF381245Histogenetic, Ossining, USA
C*07:5148069HG803172Jane Rowlands, Pontyclun, United Kingdom
C*08:02:08HG00007590,
HG00007591,
HG00007592		KF577624,
KF291278,
KF438196		Histogenetic, Ossining, USA
C*08:74HG00007596KF291279Histogenetic, Ossining, USA
C*12:03:27HG00007586KF312416Histogenetic, Ossining, USA
C*12:90HG00007588KF312414Histogenetic, Ossining, USA
C*12:99HG00007587KF291276Histogenetic, Ossining, USA
C*16:40BY01179KF946529Carolyn K Hurley, Washington DC, USA
C*17:15HG00007589KF501510Histogenetic, Ossining, USA
DRB1*08:0949197HG803170Jane Rowlands, Pontyclun, United Kingdom
DQB1*02:01:07HG00007308KF535986Histogenetic, Ossining, USA
DQB1*02:14HG00007619,
HG00007620,
HG00007621,
HG00007622		KF560448,
KF312426,
KF381263,
KF291287		Histogenetic, Ossining, USA
DQB1*02:18NHG00007623KF415258Histogenetic, Ossining, USA
DQB1*02:19HG00007624KF291295Histogenetic, Ossining, USA
DQB1*02:20NHG00007625KF577626Histogenetic, Ossining, USA
DQB1*02:26HG00007626,
HG00007627,
HG00007628		KF535976,
KF535971,
KF291294		Histogenetic, Ossining, USA
DQB1*02:30HG00007618KF647801Histogenetic, Ossining, USA
DQB1*03:01:08HG00007612,
HG00007613		KF501526,
KF381261		Histogenetic, Ossining, USA
DQB1*03:01:14HG00007614KF535985Histogenetic, Ossining, USA
DQB1*03:02:10HG00007321KF471744Histogenetic, Ossining, USA
DQB1*03:113HG00007317KF438208Histogenetic, Ossining, USA
DQB1*03:14:02HG00007615,
HG00007616,
HG00007617		KF560446,
KF560445,
KF291282		Histogenetic, Ossining, USA
DQB1*03:17:0290128 DRAHG475428Margareth Torres, Sao Paulo, Brazil
DQB1*03:47HG00007303KF415261Histogenetic, Ossining, USA
DQB1*03:54HG00007608,
HG00007609		KF647810,
KF673223		Histogenetic, Ossining, USA
DQB1*03:55HG00007610,
HG00007611		KF602025,
KF381257		Histogenetic, Ossining, USA
DQB1*03:70HG00007607KF312423Histogenetic, Ossining, USA
DQB1*05:04R49831HG795013Hien Tran, Heidelberg, Germany
DQB1*06:01:08HG00007598,
HG00007599,
HG00007600,
HG00007601,
HG00007602,
HG00007603		KF291291,
KF471740,
KF501531,
KF647808,
KF291283,
KF535979		Histogenetic, Ossining, USA
DQB1*06:3310329315HG803174Jane Rowlands, Pontyclun, United Kingdom
DQB1*06:53HG00007597KF471741Histogenetic, Ossining, USA
DQB1*06:55HG00007604KF438204Histogenetic, Ossining, USA
DQB1*06:57HG00007605KF438205Histogenetic, Ossining, USA
DQB1*06:58HG00007606KF291290Histogenetic, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
A*01:139(3)
B*08:108(4)
B*27:05:25(5)
B*39:01:01:03(6)
DRB1*04:11:03(7)
DRB1*10:05(7)
DRB1*13:116(8)
DRB1*14:143(9)
DRB1*15:94(7)
DRB1*16:22(7)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55:280-7.
  3. Street J, Johnson J, Pepperall J, Darke C. A new HLA-A*01 allele - A*01:139. Tissue Antigens. 2014; 83:129-30.
  4. Balas A, Sanchez-Gordo F, Gomez-Zumaquero JM, Prat I, Vicario JL. A new HLA allele, HLA-B*08:108, described in two unrelated Spanish individuals. Tissue Antigens. 2014; 83:130-1.
  5. Street J, Bengtsson M, Johnson J, Harvey C, Darke C. HLA-B*27:05:25 - a further HLA-B*27:05 allele with a synonymous nucleotide substitution. Tissue Antigens. 2014; 83:131-2.
  6. Chen NY, Zhang W, He J, Zhu FM, Lv HJ. Genomic full-length sequence of a novel HLA-B*39:01:01:03 allele was identified in a Chinese individual. Tissue Antigens. 2014; 83:132-4.
  7. Fabreti-Oliveira RA, Nascimento E, Oliveira CK, Vale EM, Vilela B, Santos MA. Four novel HLA alleles, DRB1*04:11:03, DRB1*10:05, DRB1*15:94 and DRB1*16:22, identified in Brazilian individuals. International Journal of Immunogenetics. 2014; 41:151-3.
  8. Mrazek F, Onderkova J, Ambruzova Z, Zachova S, Petrek M. A novel HLA-DRB1 allele, HLA-DRB1*13:116, identified by sequencing-based typing in a member of the Czech national marrow donor registry. International Journal of Immunogenetics. 2014; 41:149-50.
  9. Huo MR, Xi B, Yu Y, Li D. Identification of a novel HLA-DRB1*14 allele, HLA-DRB1*14:143, by sequence-based typing. Tissue Antigens. 2014; 83:134-5.