Nomenclature for Factors of the HLA System

January 2013

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the December 2012 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence known as C*03:12 has been shown to be identical to the C*03:19 allele, consequently the designation C*03:12 has been abandoned.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:12738071KC462570Jianping Li, Shenyang, Liaoning, China
A*02:404 20091KC405612Jianping Li, Shenyang, Liaoning, China
A*02:40558063KC405614Jianping Li, Shenyang, Liaoning, China
A*02:40658993KC405616Jianping Li, Shenyang, Liaoning, China
A*02:40759859KC405617Jianping Li, Shenyang, Liaoning, China
A*02:408Chan001KC414222Niu Yang, Changsha, China
A*02:409BY00994KC488161Carolyn K Hurley, Washington DC, USA
A*02:410BY00995KC488162Carolyn K Hurley, Washington DC, USA
A*03:01:3993085887KC213979Daniel Fuerst, Ulm, Germany
A*11:01:4655492KC473555Jianping Li, Shenyang, Liaoning, China
A*11:140XianHaYa4807KC454399Jun Qi, Xian, China
A*23:57BY00973KC296447Carolyn K Hurley, Washington DC, USA
A*29:511219215HE819237John Crowley, Dublin, Eire
A*29:52BY00993KC488160Carolyn K Hurley, Washington DC, USA
A*30:7258557KC473558Jianping Li, Shenyang, Liaoning, China
A*31:7254111KC473552Jianping Li, Shenyang, Liaoning, China
A*31:7359039KC473559Jianping Li, Shenyang, Liaoning, China
A*80:0393334KC433572Raquel Fabreti, Belo Horizonte, Brazil
B*07:182NBY00954JX844226Carolyn K Hurley, Washington DC, USA
B*13:6452975KC473550Jianping Li, Shenyang, Liaoning, China
B*15:26916797KC405611Jianping Li, Shenyang, Liaoning, China
B*15:27055647KC473556Jianping Li, Shenyang, Liaoning, China
B*35:227H12607KC429788Faming Zhu, Hangzhou, China
B*38:437311211100KC414223Niu Yang, Changsha, China
B*40:06:0743503-DKC462572Jianping Li, Shenyang, Liaoning, China
B*46:01:0855427KC473554Jianping Li, Shenyang, Liaoning, China
B*51:01:4151718KC473549Jianping Li, Shenyang, Liaoning, China
B*54:01:04CB201200511KC414858Faming Zhu, Hangzhou, China
B*67:01:0314669KC462567Jianping Li, Shenyang, Liaoning, China
C*05:880004079KC470079Francisco de Paula Sanchez Gordo, Malaga, Spain
C*07:30038122HF549024Katia Gagne, Nantes, France
C*08:7530433HF568778Carles Serra-Pages, Barcelona, Spain
C*08:7631076HF568779Carles Serra-Pages, Barcelona, Spain
C*16:56014639441HF545601Dominique Masson, La Tronche, France
DRB1*04:15338737-DKC462571Jianping Li, Shenyang, Liaoning, China
DRB1*07:23218178HF568780Klaus Witter, München, Germany
DRB1*11:14343005KC405613Jianping Li, Shenyang, Liaoning, China
DRB1*12:39BY00987KC296448Carolyn K Hurley, Washington DC, USA
DRB1*14:32:0358761KC405615Jianping Li, Shenyang, Liaoning, China
DRB1*14:127:0226309KC462568Jianping Li, Shenyang, Liaoning, China
DQB1*02:12D10018201HE804190Jinghui Qu, Shenzhen, China
DQB1*03:01:09D10023673HE804203Jinghui Qu, Shenzhen, China
DQB1*03:01:10D10022592HE804204Jinghui Qu, Shenzhen, China
DQB1*03:01:11D10052228HE804205Jinghui Qu, Shenzhen, China
DQB1*03:4843567KC427090Runying Tian, Durham, USA
DQB1*03:49D10118557HE804199Jinghui Qu, Shenzhen, China
DQB1*03:50D10016942HE804200Jinghui Qu, Shenzhen, China
DQB1*03:51D10117434HE804202Jinghui Qu, Shenzhen, China
DQB1*04:10SH004AB773253Hiroshi Furukawa, Sagamihara, Japan
DQB1*06:04:0410062712KC461183Manuela Testi, Rome, Italy
DPB1*142:01EDBKC342219Antonio Balas, Madrid, Spain
MICA*0762335PWKC213978Daniel Fuerst, Ulm, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:06:01MDA0000050KC465060Kai Cao, Houston, USA
A*24:03:02 MDA0000053,
MDA0000054
KC477655Kai Cao, Houston, USA
A*24:25MDA0000051KC465061Kai Cao, Houston, USA
A*24:81MDA0000052KC465062Kai Cao, Houston, USA
A*30:07MDA0000056KC477658Kai Cao, Houston, USA
A*30:10MDA0000058,
MDA0000059
KC495076Kai Cao, Houston, USA
A*34:05MDA0000055KC477657Kai Cao, Houston, USA
A*68:31MDA0000057KC477659Kai Cao, Houston, USA
B*13:47BY00997KC488163Carolyn K Hurley, Washington DC, USA
B*40:1827311113807KC414224Niu Yang, Changsha, China
B*40:229Xian-4807KC454400Jun Qi, Xian, China
B*50:3135871KC462569Jianping Li, Shenyang, Liaoning, China
C*03:19R428619HF547300Tatiana Lebedeva, Dedham, USA
DRB1*07:20BY00982KC296450Carolyn K Hurley, Washington DC, USA
DQB1*06:4934921,
124219,
124435,
125231
KC427091Runying Tian, Durham, USA

Table 3: Recently Published Sequences


Sequence References
A*24:02:17 3
A*24:128 4
B*07:55 5
B*13:18 6
C*04:112 7
DRB1*09:20 8

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Liu N, Zhang Z, Shan X, Ni L, Wang L. A novel HLA-A allele, A*24:02:17, identified by sequence-based typing. Tissue Antigens. 2013. 81:119-20.
  4. Wang L, Zhang Z, Cui S, Shan X. Identification of a novel HLA-A allele, A*24:128 in a Chinese individual. Tissue Antigens. 2013: 81:120-1.
  5. Liu N, Zhang Z, Shan X, Wang L, Cui S. A novel HLA-B allele, B*07:55, identified by sequence-based typing. Tissue Antigens. 2013: 81:121-3.
  6. Liu N, Zhang Z, Shan X, Cui S, Zhao B. A novel HLA-B allele, B*13:18, identified by sequence-based typing. Tissue Antigens. 2013: 81:123-4.
  7. Ferriola D, Heron S, Lind C, Monos DS. Characterization of a new HLA-C*04 allele, C*04:112. Tissue Antigens. 2013: 81:124-5.
  8. Hommel-Berrey GA, House KD, Backfish KA, Arnoff TS, Lobashevsky AL. Identification of a novel HLA-DRB1 allele, DRB1*09:20, by sequence-based typing in an unrelated bone marrow donor. Tissue Antigens. 2013. 81:125-6.