Nomenclature for Factors of the HLA System
December 2012
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2013 81:253-7
- Human Immunology. 2013 74:689-92
- International Journal of Immunogenetics. 2013 40:256-9
The following sequences have been submitted to the Nomenclature Committee since the November 2012 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:52 | HG00005207 | JX573343 | Histogenetics, Ossining, USA |
| A*01:01:53 | HG00005209 | JX970489 | Histogenetics, Ossining, USA |
| A*01:125 | HG00005206 | JX842750 | Histogenetics, Ossining, USA |
| A*01:126 | HG00005208 | JX481999 | Histogenetics, Ossining, USA |
| A*02:398 | HG00005213 | JX842751 | Histogenetics, Ossining, USA |
| A*02:399 | HG00005214 | JX976733 | Histogenetics, Ossining, USA |
| A*02:400 | HG00005215 | JX970491 | Histogenetics, Ossining, USA |
| A*02:401 | BY00989 | KC206054 | Carolyn K Hurley, Washington DC, USA |
| A*02:402 | BY00990 | KC242460 | Carolyn K Hurley, Washington DC, USA |
| A*02:403 | 7311114343 | KC331040 | Jia Luo, Changsha, China |
| A*11:139 | BY00969 | KC172394 | Carolyn K Hurley, Washington DC, USA |
| A*24:228 | HG00005201, HG00005202 | JX970494, JX508847 | Histogenetics, Ossining, USA |
| A*24:229 | BY00972 | KC172391 | Carolyn K Hurley, Washington DC, USA |
| A*24:230 | BY00976 | KC296457 | Carolyn K Hurley, Washington DC, USA |
| A*29:50 | 57863, 57126 | HF549027 | Katia Gagne, Nantes, France |
| A*32:55:02 | HG00005210 | JX524833 | Histogenetics, Ossining, USA |
| A*32:57 | HG00005211 | JQ964635 | Histogenetics, Ossining, USA |
| A*33:65 | HG00005212 | KC019941 | Histogenetics, Ossining, USA |
| A*33:66 | BY00966 | KC172385 | Carolyn K Hurley, Washington DC, USA |
| A*33:67 | D48384 | HF562463 | Odile Avinens, Montpellier, Cedex 5, France |
| A*68:99 | BY00977 | KC296458 | Carolyn K Hurley, Washington DC, USA |
| B*07:02:38 | HG00005252 | JX976744 | Histogenetics, Ossining, USA |
| B*07:178 | HG00005251 | JX667725 | Histogenetics, Ossining, USA |
| B*07:179 | HG00005253 | JX573352 | Histogenetics, Ossining, USA |
| B*07:180 | HG00005255 | JX992557 | Histogenetics, Ossining, USA |
| B*07:181N | HG00005256 | JX290324 | Histogenetics, Ossining, USA |
| B*08:59:02 | HG00005228 | JX992559 | Histogenetics, Ossining, USA |
| B*08:106 | 47583 | HF549026 | Katia Gagne, Nantes, France |
| B*14:02:08 | HG00005250 | JX508843 | Histogenetics, Ossining, USA |
| B*15:266 | HG00005246 | JX573345 | Histogenetics, Ossining, USA |
| B*15:267 | JABR079173AN | HF549286 | Steven GE Marsh, London, United Kingdom |
| B*15:268 | HG00005242 | JQ237629 | Histogenetics, Ossining, USA |
| B*18:85 | HG00005227 | JX842741 | Histogenetics, Ossining, USA |
| B*18:86 | BY00992 | KC256922 | Carolyn K Hurley, Washington DC, USA |
| B*27:05:21 | HG00005222 | JX885892 | Histogenetics, Ossining, USA |
| B*27:05:22 | HG00005223 | JX842745 | Histogenetics, Ossining, USA |
| B*35:01:37 | HG00005237 | JX885886 | Histogenetics, Ossining, USA |
| B*35:221 | HG00005235 | JX970480 | Histogenetics, Ossining, USA |
| B*35:222 | HG00005236 | JX482001 | Histogenetics, Ossining, USA |
| B*35:223 | HG00005239 | JX976740 | Histogenetics, Ossining, USA |
| B*35:224 | HG00005240 | KC019943 | Histogenetics, Ossining, USA |
| B*35:225 | HG00005249 | JX667722 | Histogenetics, Ossining, USA |
| B*35:226 | 7311113942 | KC331039 | Jia Luo, Changsha, China |
| B*39:01:16 | T1 | AB746911 | Takayoshi Miyazono, Toyama City, Japan |
| B*39:80 | HG00005257 | JX524830 | Histogenetics, Ossining, USA |
| B*39:81 | HG00005258 | JX842742 | Histogenetics, Ossining, USA |
| B*40:231 | HG00005217 | JX441347 | Histogenetics, Ossining, USA |
| B*40:232 | HG00005221 | JX508842 | Histogenetics, Ossining, USA |
| B*40:233 | 7311212497 | KC331042 | Jia Luo, Changsha, China |
| B*41:26 | HG00005216 | JX667720 | Histogenetics, Ossining, USA |
| B*42:18 | HG00005225 | JX970468 | Histogenetics, Ossining, USA |
| B*44:168 | HG00005229 | HM467519 | Histogenetics, Ossining, USA |
| B*44:169 | HG00005230 | JN242436 | Histogenetics, Ossining, USA |
| B*44:170 | HG00005231 | JX228010 | Histogenetics, Ossining, USA |
| B*44:171N | HG00005232 | JX976737 | Histogenetics, Ossining, USA |
| B*44:172 | HG00005233 | JX992558 | Histogenetics, Ossining, USA |
| B*48:30 | BY00962 | KC172389 | Carolyn K Hurley, Washington DC, USA |
| B*50:31 | HG00005218 | JX885888 | Histogenetics, Ossining, USA |
| B*51:01:40 | HG00005248 | JX524827 | Histogenetics, Ossining, USA |
| B*51:150 | HG00005247 | JX174606 | Histogenetics, Ossining, USA |
| B*52:01:17 | HG00005234 | JX508844 | Histogenetics, Ossining, USA |
| B*53:01:08 | BY00964 | KC172387 | Carolyn K Hurley, Washington DC, USA |
| B*55:58 | D40300 | HE962575 | Odile Avinens, Montpellier, Cedex 5, France |
| B*56:01:05 | HG00005244 | JX976742 | Histogenetics, Ossining, USA |
| B*56:39 | HG00005245 | JX228016 | Histogenetics, Ossining, USA |
| B*57:62 | HG00005243 | JX992560 | Histogenetics, Ossining, USA |
| B*58:40 | HG00005241 | JX573348 | Histogenetics, Ossining, USA |
| C*01:74 | HG00005259 | JX667731 | Histogenetics, Ossining, USA |
| C*01:75 | 39742 | HF549025 | Katia Gagne, Nantes, France |
| C*02:67 | HG00004495 | JQ911895 | Histogenetics, Ossining, USA |
| C*03:04:33 | HG00005285 | JX573354 | Histogenetics, Ossining, USA |
| C*03:04:34 | HG00005286 | JX188034 | Histogenetics, Ossining, USA |
| C*03:04:35 | HG00005289 | JX667729 | Histogenetics, Ossining, USA |
| C*03:184 | HG00005284 | JX976751 | Histogenetics, Ossining, USA |
| C*03:185 | HG00005288 | JX842739 | Histogenetics, Ossining, USA |
| C*04:01:46 | HG00005292 | JX842737 | Histogenetics, Ossining, USA |
| C*04:01:47 | HG00005296 | JX573355 | Histogenetics, Ossining, USA |
| C*04:01:48 | HG00005298 | JX667728 | Histogenetics, Ossining, USA |
| C*04:140 | HG00005290, HG00005291 | JX976752, JX976748 | Histogenetics, Ossining, USA |
| C*04:141 | HG00005294 | JX842738 | Histogenetics, Ossining, USA |
| C*04:142 | HG00005295 | JX970482 | Histogenetics, Ossining, USA |
| C*04:143 | HG00005297 | JX228048 | Histogenetics, Ossining, USA |
| C*04:144 | H12554 | KC242613 | Faming Zhu, Hangzhou, China |
| C*04:98:02 | HG00005293 | JX992562 | Histogenetics, Ossining, USA |
| C*05:01:26 | HG00004492 | JQ824585 | Histogenetics, Ossining, USA |
| C*05:86 | HG00005273 | JX228039 | Histogenetics, Ossining, USA |
| C*05:87 | HG00005274 | JX842740 | Histogenetics, Ossining, USA |
| C*06:02:25 | HG00005264 | JX228044 | Histogenetics, Ossining, USA |
| C*06:94 | HG00005261 | KC019947 | Histogenetics, Ossining, USA |
| C*06:95 | HG00005262 | JX976746 | Histogenetics, Ossining, USA |
| C*06:96 | HG00005265, HG00005266 | JX524826, JX970483 | Histogenetics, Ossining, USA |
| C*07:01:32 | HG00005269 | JX174620 | Histogenetics, Ossining, USA |
| C*07:01:33 | HG00005271 | JX992563 | Histogenetics, Ossining, USA |
| C*07:296 | HG00005260 | JX027053 | Histogenetics, Ossining, USA |
| C*07:297 | HG00005267 | JX667734 | Histogenetics, Ossining, USA |
| C*07:298 | HG00005268 | JQ824480 | Histogenetics, Ossining, USA |
| C*07:299 | HG00005270 | JN123944 | Histogenetics, Ossining, USA |
| C*08:01:09 | SZ-152 | JX982104 | Hong-Yan Zou, Shenzhen, China |
| C*08:02:09 | HG00005276 | JX508840 | Histogenetics, Ossining, USA |
| C*08:73 | HG00005272 | KC019949 | Histogenetics, Ossining, USA |
| C*08:74 | HG00005299 | JX573356 | Histogenetics, Ossining, USA |
| C*12:93 | HG00005279 | JX842736 | Histogenetics, Ossining, USA |
| C*12:94 | 30298 | HF549023 | Katia Gagne, Nantes, France |
| C*15:05:08 | HG00005282 | JX508841 | Histogenetics, Ossining, USA |
| C*15:66 | HG00005283 | JX524824 | Histogenetics, Ossining, USA |
| C*16:01:12 | HG00005277 | JX524825 | Histogenetics, Ossining, USA |
| C*16:01:13 | HG00004480 | JQ824490 | Histogenetics, Ossining, USA |
| C*17:16 | HG00005280 | JX976750 | Histogenetics, Ossining, USA |
| C*17:17 | HG00005281 | JX174626 | Histogenetics, Ossining, USA |
| C*17:18 | HG00004487 | JQ824675 | Histogenetics, Ossining, USA |
| C*17:19 | HG00004488 | JQ997152 | Histogenetics, Ossining, USA |
| DRB1*01:55 | HG00005324 | JX508845 | Histogenetics, Ossining, USA |
| DRB1*01:56 | 37622 | HF549029 | Katia Gagne, Nantes, France |
| DRB1*03:01:21 | HG00005310 | KC019952 | Histogenetics, Ossining, USA |
| DRB1*03:89 | HG00005311 | JX458909 | Histogenetics, Ossining, USA |
| DRB1*04:01:12 | HG00005305 | JX458928 | Histogenetics, Ossining, USA |
| DRB1*04:148 | HG00005303 | JX524823 | Histogenetics, Ossining, USA |
| DRB1*04:149 | HG00005304 | JX481995 | Histogenetics, Ossining, USA |
| DRB1*04:150 | HG00005306 | JX667744 | Histogenetics, Ossining, USA |
| DRB1*04:151 | HG00005307 | JX458929 | Histogenetics, Ossining, USA |
| DRB1*04:152 | BY00984 | KC296449 | Carolyn K Hurley, Washington DC, USA |
| DRB1*08:51 | HG00005308 | JX458897 | Histogenetics, Ossining, USA |
| DRB1*08:52 | HG00005309 | JX970510 | Histogenetics, Ossining, USA |
| DRB1*08:53 | L343755089 | HF564898 | Steven GE Marsh, London, United Kingdom |
| DRB1*11:01:18 | HG00005317 | JX842733 | Histogenetics, Ossining, USA |
| DRB1*11:140 | HG00005318 | JQ824756 | Histogenetics, Ossining, USA |
| DRB1*11:141 | HG00005319 | JX976768 | Histogenetics, Ossining, USA |
| DRB1*11:142 | BY00968, BY00983 | KC172383 | Carolyn K Hurley, Washington DC, USA |
| DRB1*13:02:08 | HG00005315 | JX842735 | Histogenetics, Ossining, USA |
| DRB1*13:155 | HG00005312 | JX976765 | Histogenetics, Ossining, USA |
| DRB1*13:156 | HG00005313 | JX976767 | Histogenetics, Ossining, USA |
| DRB1*13:157 | HG00005314 | JX976764 | Histogenetics, Ossining, USA |
| DRB1*13:158 | HG00005316 | JX970521 | Histogenetics, Ossining, USA |
| DRB1*14:138 | BY00988 | KC296461 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:139 | BY00986 | KC296452 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:140 | HG00005321 | JX970516 | Histogenetics, Ossining, USA |
| DRB1*15:02:10 | BY00979 | KC296455 | Carolyn K Hurley, Washington DC, USA |
| DRB1*15:90 | HG00005300 | JX508846 | Histogenetics, Ossining, USA |
| DRB1*15:91 | HG00005301 | JX842732 | Histogenetics, Ossining, USA |
| DRB1*15:92 | HG00005302 | JX976763 | Histogenetics, Ossining, USA |
| DRB1*16:02:03 | 7311211917 | KC331041 | Jia Luo, Changsha, China |
| DRB1*16:21N | BY00980 | KC296454 | Carolyn K Hurley, Washington DC, USA |
| DQB1*02:02:02 | D10018380 | HE804191 | Jinghui Qu, Shenzhen, China |
| DQB1*02:11 | D10110551 | HE804189 | Jinghui Qu, Shenzhen, China |
| DQB1*03:01:07 | D10101571 | HE804194 | Jinghui Qu, Shenzhen, China |
| DQB1*03:01:08 | D10077192 | HE804196 | Jinghui Qu, Shenzhen, China |
| DQB1*03:46 | D10086597 | HE804192 | Jinghui Qu, Shenzhen, China |
| DQB1*03:47 | D10118836 | HE804195 | Jinghui Qu, Shenzhen, China |
| DQB1*04:09 | IME 649-12T | KC238309 | Manuela Testi, Rome, Italy |
| DQB1*05:19 | KLSIS | KC285590 | Grace Hommel-Berrey, Indianapolis, USA |
| DPB1*09:01:02 | UA2012tp4239 | HF562215 | Mats Bengtsson, Uppsala, Sweden |
| MICA*075 | 2014S231529 | KC213977 | Daniel Fuerst, Ulm, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:384 | BY00978 | KC296456 | Carolyn K Hurley, Washington DC, USA |
| A*26:73 | BY00970 | KC172393 | Carolyn K Hurley, Washington DC, USA |
| A*29:44 | BY00961 | KC172388 | Carolyn K Hurley, Washington DC, USA |
| A*34:02:01 | CTM-4687797 | KC196274 | Antonio Balas, Madrid, Spain |
| B*07:91 | HG00005254 | JX228011 | Histogenetics, Ossining, USA |
| B*07:143 | HG00005224 | JN123826 | Histogenetics, Ossining, USA |
| B*35:167 | HG00005238 | JX885889 | Histogenetics, Ossining, USA |
| B*39:62 | BY00951 | JX844223 | Carolyn K Hurley, Washington DC, USA |
| B*40:22N | HG00005219 | JX441342 | Histogenetics, Ossining, USA |
| B*53:26 | BY00963 | KC172390 | Carolyn K Hurley, Washington DC, USA |
| C*03:145 | HG00005287 | JX482016 | Histogenetics, Ossining, USA |
| C*05:22:01 | HG00005275 | JX228028 | Histogenetics, Ossining, USA |
| C*12:58 | HG00005278 | JX228027 | Histogenetics, Ossining, USA |
| DRB1*11:28:02 | BY00981 | KC296451 | Carolyn K Hurley, Washington DC, USA |
| DRB1*13:101 | HG00005320 | JN604881 | Histogenetics, Ossining, USA |
| DRB1*15:57 | BY00991 | KC256921 | Carolyn K Hurley, Washington DC, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:227N | 3 |
| A*02:374 | 4 |
| A*33:61 | 5 |
| B*07:156 | 6 |
| B*13:20 | 7 |
| B*13:23 | 8 |
| B*18:79 | 9 |
| B*51:141 | 10 |
| B*54:16 | 11 |
| DRB1*12:03:03 | 12 |
| DRB1*13:143 | 12 |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
- Wang L, Zhang ZX, Shan XY, Liu N, Ni L. Identification of a novel HLA-A allele HLA-A*02:227N. Tissue Antigens. 2013: 81: 46-7.
- De Zorzi M, Caggiari L, Crovatto M, Talamini R, Garziera M, De Re V. A new human leukocyte antigen class I allele: HLA-A*02:374. Tissue Antigens. 2013: 81: 48-9.
- Su YP, Dai M, Sun A, Su XH, Liu F, Chen M. Identification of a novel HLA-A allele A*33:61 in a Chinese individual. Tissue Antigens. 2013: 81: 49-50.
- Witter K, Albert T, Spannagl M, Dick A. B*07:156, revealed by sequence-based typing of a leukemia patient and confirmed by allele-specific amplification. Tissue Antigens. 2013: 81: 50-1.
- Wang L, Zhang ZX, Shan XY, Wei L, Wang LJ. Identification of a novel HLA-B allele HLA-B*13:20 in a Chinese individual. Tissue Antigens. 2013: 81: 51-3.
- Gong Z, Zhang ZX, Shan X, Wang L, Liu N. Identification of a new HLA-B*13 allele, HLA-B*13:23. Tissue Antigens. 2013: 81: 53-4.
- Endres RO, Hoffman AD, Palmer P, Scott I, Souza S. Characterization of the novel HLA-B*18:79 allele. Tissue Antigens. 2013: 81: 57-8.
- Caggiari L, De Zorzi M, Izzo F, Tornesello ML, Buonaguro FM, De Re V. Identification and sequence analysis of a novel human leukocyte antigen allele B*51:141. Tissue Antigens. 2013: 81: 58-9.
- Gong Z, Zhang ZX, Shan X, Li D, Li W. A novel HLA-B*54 allele, B*54:16. Tissue Antigens. 2013: 81: 54-5.
- Kim KM, Sung HY, Kang MS, Huh JY. Identification of two novel HLA alleles: HLA-DRB1*12:03:03 and HLA-DRB1*13:143. Tissue Antigens. 2013: 81: 55-6.
