Nomenclature for Factors of the HLA System

August 2012

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the July 2012 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:48HG00004115JQ713633Histopgenetics, Ossining, USA
A*01:01:49HG00004134JQ713617Histopgenetics, Ossining, USA
A*01:115HG00004116JQ436609Histopgenetics, Ossining, USA
A*01:116HG00004117JQ668171Histopgenetics, Ossining, USA
A*01:117HG00004118JQ359473Histopgenetics, Ossining, USA
A*01:118HG00004133JQ622154Histopgenetics, Ossining, USA
A*01:119HG00004279JX110624Histopgenetics, Ossining, USA
A*02:01:83HG00004138JQ687297Histopgenetics, Ossining, USA
A*02:01:84HG00004238JQ997117Histopgenetics, Ossining, USA
A*02:377HG00004135JQ359474Histopgenetics, Ossining, USA
A*02:378HG00004136JQ739494Histopgenetics, Ossining, USA
A*02:379HG00004137JQ622194Histopgenetics, Ossining, USA
A*02:380HG00004139JQ739465Histopgenetics, Ossining, USA
A*02:381HG00004140JQ359475Histopgenetics, Ossining, USA
A*02:382HG00004236JX027033Histopgenetics, Ossining, USA
A*02:383HG00004237JX027026Histopgenetics, Ossining, USA
A*02:384HG00004285JX089353Histopgenetics, Ossining, USA
A*02:385HG00004286JX089357Histopgenetics, Ossining, USA
A*02:386HG00004239JX027027Histopgenetics, Ossining, USA
A*03:01:35HG00004281JX110623Histopgenetics, Ossining, USA
A*03:01:36HG00004282JX089354Histopgenetics, Ossining, USA
A*03:01:37HG00004235JX027034Histopgenetics, Ossining, USA
A*03:04:03HG00004121JQ436591Histopgenetics, Ossining, USA
A*03:153HG00004120JQ581001Histopgenetics, Ossining, USA
A*03:154HG00004122JQ359453Histopgenetics, Ossining, USA
A*03:155HG00004123JQ388226Histopgenetics, Ossining, USA
A*03:156HG00004132JQ668174Histopgenetics, Ossining, USA
A*03:157HG00004280JX134264Histopgenetics, Ossining, USA
A*03:158HG00004283JX134262Histopgenetics, Ossining, USA
A*03:159BX1655HE978330Xiang Liu, Beijing, China
A*11:130HG00004274JX089351Histopgenetics, Ossining, USA
A*24:214HG00004277JX089352Histopgenetics, Ossining, USA
A*25:21HG00004275JX174599Histopgenetics, Ossining, USA
A*31:67HG00004272JX089356Histopgenetics, Ossining, USA
A*32:01:14HG00004127,
HG00004128
JQ359469,
JQ359470
Histopgenetics, Ossining, USA
A*32:47HG00004125JQ668152Histopgenetics, Ossining, USA
A*32:48NHG00004126JQ687278Histopgenetics, Ossining, USA
A*32:49HG00004130JQ436605Histopgenetics, Ossining, USA
A*32:50HG00004131JQ687279Histopgenetics, Ossining, USA
A*32:51HG00004278JX134263Histopgenetics, Ossining, USA
A*32:52HG00004284JX089355Histopgenetics, Ossining, USA
A*32:530201102501HE971711Silvia Ulrich, Graz, Austria
A*32:54BR9053HE978329Xiang Liu, Beijing, China
A*33:01:07HG00004273JX089349Histopgenetics, Ossining, USA
A*33:18:02BR8853HE978328Xiang Liu, Beijing, China
A*66:18HG00004276JX089360Histopgenetics, Ossining, USA
A*74:17HG00004129JQ768423Histopgenetics, Ossining, USA
B*07:170HG00004224JQ622163Histopgenetics, Ossining, USA
B*07:171HG00004297JX134265Histopgenetics, Ossining, USA
B*07:172HG00004298JX174605Histopgenetics, Ossining, USA
B*07:173HG00004299JX188029Histopgenetics, Ossining, USA
B*07:174HG00004300JX110625Histopgenetics, Ossining, USA
B*07:17596011819JX485639Daniel Fuerst, Ulm, Germany
B*08:98HG00004292JX134268Histopgenetics, Ossining, USA
B*08:99HG00004245JX027037Histopgenetics, Ossining, USA
B*08:100HG00004293,
HG00004246
JX089363,
JX049552
Histopgenetics, Ossining, USA
B*08:101FRCBPO0000000196HE974906Dominique Masson, La Tronche, France
B*13:60BR9570HE978332Xiang Liu, Beijing, China
B*13:61BR9717HE978333Xiang Liu, Beijing, China
B*15:260HG00004250JQ997126Histopgenetics, Ossining, USA
B*15:261HG00004294JX174602Histopgenetics, Ossining, USA
B*15:262NBX1971HE978337Xiang Liu, Beijing, China
B*18:82HG00004291JX134266Histopgenetics, Ossining, USA
B*27:90:02HG00004290JX089362Histopgenetics, Ossining, USA
B*27:97HG00004226,
HG00004227
JQ622171,
JQ436636
Histopgenetics, Ossining, USA
B*27:98HG00004289JX089368Histopgenetics, Ossining, USA
B*35:01:35HG00004249JQ997123Histopgenetics, Ossining, USA
B*35:02:05MUDKPJX459793Grace Hommel-Berrey, Indianapolis, USA
B*35:08:06HG00004248JQ997130Histopgenetics, Ossining, USA
B*35:217HG00004240JX049551Histopgenetics, Ossining, USA
B*35:218HG00004244JQ964645Histopgenetics, Ossining, USA
B*38:02:04BR9375HE978331Xiang Liu, Beijing, China
B*39:78HG00004223JQ359493Histopgenetics, Ossining, USA
B*39:79HG00004301JX110627Histopgenetics, Ossining, USA
B*40:01:28HG00004287JX188028Histopgenetics, Ossining, USA
B*40:01:29HG00004241JX049548Histopgenetics, Ossining, USA
B*40:02:17HG00004243JQ997128Histopgenetics, Ossining, USA
B*40:222BX1802HE978336Xiang Liu, Beijing, China
B*40:223BX1999HE978338Xiang Liu, Beijing, China
B*41:22HG00004288,
HG00004242
JX089366,
JX027050
Histopgenetics, Ossining, USA
B*44:02:26HG00004254JX049549Histopgenetics, Ossining, USA
B*44:03:19HG00004225JQ713642Histopgenetics, Ossining, USA
B*44:34:02HG00004295JX188031Histopgenetics, Ossining, USA
B*44:161HG00004247JQ997124Histopgenetics, Ossining, USA
B*46:36HG00004296JX174604Histopgenetics, Ossining, USA
B*46:3732HE974343Xiao Yang Zhou, Beijing, China
B*49:01:04DESSylvHE970436Sylvie Tourne, Strasbourg, France
B*50:1812000216JQ952567Raffaella Azzarone, L’Aquila, Italy
B*51:01:36HG00004255JX027047Histopgenetics, Ossining, USA
B*51:01:37BX1112HE978334Xiang Liu, Beijing, China
B*51:144SZ-48JX493013Hong-Yan Zou, Shenzhen, China
B*54:28BX1341HE978335Xiang Liu, Beijing, China
B*56:37HG00004252JX027049Histopgenetics, Ossining, USA
B*56:38NHG00004253JX027035Histopgenetics, Ossining, USA
C*02:64HG00004307JX089373Histopgenetics, Ossining, USA
C*03:04:31HG00004262JX049547Histopgenetics, Ossining, USA
C*03:37:02HG00004309,
HG00004310
JX134272,
JX134273
Histopgenetics, Ossining, USA
C*03:165HG00004231JQ277301Histopgenetics, Ossining, USA
C*03:166HG00004305JX174632Histopgenetics, Ossining, USA
C*03:167HG00004260,
HG00004261
JQ997136,
JQ997137
Histopgenetics, Ossining, USA
C*03:168HG00004311JX089372Histopgenetics, Ossining, USA
C*03:169HG00004312JX174628Histopgenetics, Ossining, USA
C*03:170HG00004266JQ824682Histopgenetics, Ossining, USA
C*03:171CBRA59126011634HE974908Dominique Masson, La Tronche, France
C*04:130HG00004263JX049544Histopgenetics, Ossining, USA
C*04:131HG00004264JQ997144Histopgenetics, Ossining, USA
C*04:132HG00004265JQ824654Histopgenetics, Ossining, USA
C*05:01:22HG00002264JN124390Histopgenetics, Ossining, USA
C*05:01:23HG00004306JX134270Histopgenetics, Ossining, USA
C*06:53:02HG00004228JQ277300Histopgenetics, Ossining, USA
C*07:31:02HG00004257JQ997139Histopgenetics, Ossining, USA
C*07:266HG00004229JQ277297Histopgenetics, Ossining, USA
C*07:267HG00004232JQ277304Histopgenetics, Ossining, USA
C*07:268HG00004302JX089375Histopgenetics, Ossining, USA
C*07:269HG00004303JX174629Histopgenetics, Ossining, USA
C*07:270HG00004304JX134271Histopgenetics, Ossining, USA
C*12:03:23HG00004259JQ997156Histopgenetics, Ossining, USA
C*14:46HG00004313JX174612Histopgenetics, Ossining, USA
C*15:05:07HG00004230JQ277302Histopgenetics, Ossining, USA
C*15:62HG00004308JX174610Histopgenetics, Ossining, USA
C*17:14HG00004258JQ997138Histopgenetics, Ossining, USA
DRB1*03:85TTIL0001JX403563Valentina Cappuzzo, Palermo, Italy
DRB1*04:127HG00004316JX089380Histopgenetics, Ossining, USA
DRB1*11:01:17HG00004317JX089377Histopgenetics, Ossining, USA
DRB1*11:132HG00004319JX110629Histopgenetics, Ossining, USA
DRB1*11:133HG00004271JX049541Histopgenetics, Ossining, USA
DRB1*12:37BX1867HE978484Xiang Liu, Beijing, China
DRB1*13:12:03HG00004318JX174636Histopgenetics, Ossining, USA
DRB1*14:128HG00004320JX089376Histopgenetics, Ossining, USA
DRB1*14:129IME 1304-12TJX467694Manuela Testi, Rome, Italy
DRB1*15:78HG00004314JX174633Histopgenetics, Ossining, USA
DRB1*15:79HG00004315JX174634Histopgenetics, Ossining, USA
DRB1*15:80N014591600HE974905Dominique Masson, La Tronche, France

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:64SBT-010AY297166Luke Foster, Manchester, United Kingdom
A*02:344BR8112HE978327Xiang Liu, Beijing, China
A*24:02:05HG00004234,
HG00004233
JX049553,
JQ997107
Histopgenetics, Ossining, USA
B*44:117FRFGR30596HE974907Dominique Masson, La Tronche, France
B*57:57HG00004251JX027040Histopgenetics, Ossining, USA
DQB1*03:02:01SMSBC001JX287366Kai Cao, Houston, USA

Table 3: Recently Published Sequences


Sequence References
A*02:336(3)
A*11:97(4)
B*07:06(5)
B*08:79(5)
B*35:05:03(6)
B*35:188(7)
B*46:01:07(8)
B*52:29(6)
B*54:25(9)
B*57:01:13(6)
C*01:61(10)
C*07:208(11)
E*01:03:05(12)
DRB1*12:16:02(13)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Alaez C, Munguia A, Flores HA, Hilario PA, Gorodezky C. Identification of A*02:336 in a Mexican Mestizo acute lymphoblastic leukemia patient from the state of Veracruz. Tissue Antigens. 2012;80:265-6.
  4. Feng ZH, Hu B, Chi XY, Zhao L, Jiao SX. A novel HLA-A*11 allele, A*11:97, was identified by sequencing-based typing. Tissue Antigens. 2012;80:267-8
  5. Balas A, Planelles D, Solves P, Roig R, Vicario JL. Genomic full-length analysis of the B*08:79 allele suggests exon shuffling involving the B*08:01:01 and B*07:06 alleles. Tissue Antigens. 2012;80:268-70.
  6. Swelsen WT, Hartog KS, Poell B, Varlack SV, Lardy NM. Characterization of three new HLA-B alleles: B*35:05:03, B*52:29 and B*57:01:13. Tissue Antigens. 2012;80:270-1.
  7. Lim AH, Song SN, Shin HH, Kim TE, Kim MH. A novel HLA-B*35 allele, B*35:188, identified by sequence-based typing. Tissue Antigens. 2012;80:271-2.
  8. Jiao SX, Liu XH, Chi XY, Zhao L, Feng ZH. Identification of a novel HLA-B*46 allele, B*46:01:07, in a Chinese individual. Tissue Antigens. 2012;80:272-3.
  9. Lim AH, Song SN, Lee JY, Lee SA, Kim MH. A novel HLA-B*54 allele, B*54:25, identified by sequence-based typing. Tissue Antigens. 2012;80:274-5.
  10. Tao SD, Zhang W, He J, Zhu FM, Lv HJ. Identification of a novel HLA-C*01:61 allele by polymerase chain reaction sequence-based typing in a Chinese leukemia patient. Tissue Antigens. 2012;80:275-6
  11. Zhang W, Wang W, He J, Zhu FM, Lv HJ. Sequence-based HLA high-resolution typing of a bone marrow donor/recipient pair reveals the novel HLA allele HLA-C*07:208. Tissue Antigens. 2012;80:276-8.
  12. Veiga-Castelli LC, Castelli EC, Beauchemin K, Donadi EA, Roger M. A novel HLA-E allele, E*01:03:05, identified in two Brazilian individuals. Tissue Antigens. 2012;80:200-1.
  13. Lim AH, Song SN, Shin GS, Lee SA, Kim MH. A novel HLA-DRB1*12 allele, DRB1*12:16:02, identified by sequence-based typing. Tissue Antigens. 2012;80:278-9.