Nomenclature for Factors of the HLA System
August 2012
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2012 80:560-3
- Human Immunology. 2012 74:135-7
- International Journal of Immunogenetics. 2013 40:161-4
The following sequences have been submitted to the Nomenclature Committee since the July 2012 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:48 | HG00004115 | JQ713633 | Histopgenetics, Ossining, USA |
| A*01:01:49 | HG00004134 | JQ713617 | Histopgenetics, Ossining, USA |
| A*01:115 | HG00004116 | JQ436609 | Histopgenetics, Ossining, USA |
| A*01:116 | HG00004117 | JQ668171 | Histopgenetics, Ossining, USA |
| A*01:117 | HG00004118 | JQ359473 | Histopgenetics, Ossining, USA |
| A*01:118 | HG00004133 | JQ622154 | Histopgenetics, Ossining, USA |
| A*01:119 | HG00004279 | JX110624 | Histopgenetics, Ossining, USA |
| A*02:01:83 | HG00004138 | JQ687297 | Histopgenetics, Ossining, USA |
| A*02:01:84 | HG00004238 | JQ997117 | Histopgenetics, Ossining, USA |
| A*02:377 | HG00004135 | JQ359474 | Histopgenetics, Ossining, USA |
| A*02:378 | HG00004136 | JQ739494 | Histopgenetics, Ossining, USA |
| A*02:379 | HG00004137 | JQ622194 | Histopgenetics, Ossining, USA |
| A*02:380 | HG00004139 | JQ739465 | Histopgenetics, Ossining, USA |
| A*02:381 | HG00004140 | JQ359475 | Histopgenetics, Ossining, USA |
| A*02:382 | HG00004236 | JX027033 | Histopgenetics, Ossining, USA |
| A*02:383 | HG00004237 | JX027026 | Histopgenetics, Ossining, USA |
| A*02:384 | HG00004285 | JX089353 | Histopgenetics, Ossining, USA |
| A*02:385 | HG00004286 | JX089357 | Histopgenetics, Ossining, USA |
| A*02:386 | HG00004239 | JX027027 | Histopgenetics, Ossining, USA |
| A*03:01:35 | HG00004281 | JX110623 | Histopgenetics, Ossining, USA |
| A*03:01:36 | HG00004282 | JX089354 | Histopgenetics, Ossining, USA |
| A*03:01:37 | HG00004235 | JX027034 | Histopgenetics, Ossining, USA |
| A*03:04:03 | HG00004121 | JQ436591 | Histopgenetics, Ossining, USA |
| A*03:153 | HG00004120 | JQ581001 | Histopgenetics, Ossining, USA |
| A*03:154 | HG00004122 | JQ359453 | Histopgenetics, Ossining, USA |
| A*03:155 | HG00004123 | JQ388226 | Histopgenetics, Ossining, USA |
| A*03:156 | HG00004132 | JQ668174 | Histopgenetics, Ossining, USA |
| A*03:157 | HG00004280 | JX134264 | Histopgenetics, Ossining, USA |
| A*03:158 | HG00004283 | JX134262 | Histopgenetics, Ossining, USA |
| A*03:159 | BX1655 | HE978330 | Xiang Liu, Beijing, China |
| A*11:130 | HG00004274 | JX089351 | Histopgenetics, Ossining, USA |
| A*24:214 | HG00004277 | JX089352 | Histopgenetics, Ossining, USA |
| A*25:21 | HG00004275 | JX174599 | Histopgenetics, Ossining, USA |
| A*31:67 | HG00004272 | JX089356 | Histopgenetics, Ossining, USA |
| A*32:01:14 | HG00004127, HG00004128 | JQ359469, JQ359470 | Histopgenetics, Ossining, USA |
| A*32:47 | HG00004125 | JQ668152 | Histopgenetics, Ossining, USA |
| A*32:48N | HG00004126 | JQ687278 | Histopgenetics, Ossining, USA |
| A*32:49 | HG00004130 | JQ436605 | Histopgenetics, Ossining, USA |
| A*32:50 | HG00004131 | JQ687279 | Histopgenetics, Ossining, USA |
| A*32:51 | HG00004278 | JX134263 | Histopgenetics, Ossining, USA |
| A*32:52 | HG00004284 | JX089355 | Histopgenetics, Ossining, USA |
| A*32:53 | 0201102501 | HE971711 | Silvia Ulrich, Graz, Austria |
| A*32:54 | BR9053 | HE978329 | Xiang Liu, Beijing, China |
| A*33:01:07 | HG00004273 | JX089349 | Histopgenetics, Ossining, USA |
| A*33:18:02 | BR8853 | HE978328 | Xiang Liu, Beijing, China |
| A*66:18 | HG00004276 | JX089360 | Histopgenetics, Ossining, USA |
| A*74:17 | HG00004129 | JQ768423 | Histopgenetics, Ossining, USA |
| B*07:170 | HG00004224 | JQ622163 | Histopgenetics, Ossining, USA |
| B*07:171 | HG00004297 | JX134265 | Histopgenetics, Ossining, USA |
| B*07:172 | HG00004298 | JX174605 | Histopgenetics, Ossining, USA |
| B*07:173 | HG00004299 | JX188029 | Histopgenetics, Ossining, USA |
| B*07:174 | HG00004300 | JX110625 | Histopgenetics, Ossining, USA |
| B*07:175 | 96011819 | JX485639 | Daniel Fuerst, Ulm, Germany |
| B*08:98 | HG00004292 | JX134268 | Histopgenetics, Ossining, USA |
| B*08:99 | HG00004245 | JX027037 | Histopgenetics, Ossining, USA |
| B*08:100 | HG00004293, HG00004246 | JX089363, JX049552 | Histopgenetics, Ossining, USA |
| B*08:101 | FRCBPO0000000196 | HE974906 | Dominique Masson, La Tronche, France |
| B*13:60 | BR9570 | HE978332 | Xiang Liu, Beijing, China |
| B*13:61 | BR9717 | HE978333 | Xiang Liu, Beijing, China |
| B*15:260 | HG00004250 | JQ997126 | Histopgenetics, Ossining, USA |
| B*15:261 | HG00004294 | JX174602 | Histopgenetics, Ossining, USA |
| B*15:262N | BX1971 | HE978337 | Xiang Liu, Beijing, China |
| B*18:82 | HG00004291 | JX134266 | Histopgenetics, Ossining, USA |
| B*27:90:02 | HG00004290 | JX089362 | Histopgenetics, Ossining, USA |
| B*27:97 | HG00004226, HG00004227 | JQ622171, JQ436636 | Histopgenetics, Ossining, USA |
| B*27:98 | HG00004289 | JX089368 | Histopgenetics, Ossining, USA |
| B*35:01:35 | HG00004249 | JQ997123 | Histopgenetics, Ossining, USA |
| B*35:02:05 | MUDKP | JX459793 | Grace Hommel-Berrey, Indianapolis, USA |
| B*35:08:06 | HG00004248 | JQ997130 | Histopgenetics, Ossining, USA |
| B*35:217 | HG00004240 | JX049551 | Histopgenetics, Ossining, USA |
| B*35:218 | HG00004244 | JQ964645 | Histopgenetics, Ossining, USA |
| B*38:02:04 | BR9375 | HE978331 | Xiang Liu, Beijing, China |
| B*39:78 | HG00004223 | JQ359493 | Histopgenetics, Ossining, USA |
| B*39:79 | HG00004301 | JX110627 | Histopgenetics, Ossining, USA |
| B*40:01:28 | HG00004287 | JX188028 | Histopgenetics, Ossining, USA |
| B*40:01:29 | HG00004241 | JX049548 | Histopgenetics, Ossining, USA |
| B*40:02:17 | HG00004243 | JQ997128 | Histopgenetics, Ossining, USA |
| B*40:222 | BX1802 | HE978336 | Xiang Liu, Beijing, China |
| B*40:223 | BX1999 | HE978338 | Xiang Liu, Beijing, China |
| B*41:22 | HG00004288, HG00004242 | JX089366, JX027050 | Histopgenetics, Ossining, USA |
| B*44:02:26 | HG00004254 | JX049549 | Histopgenetics, Ossining, USA |
| B*44:03:19 | HG00004225 | JQ713642 | Histopgenetics, Ossining, USA |
| B*44:34:02 | HG00004295 | JX188031 | Histopgenetics, Ossining, USA |
| B*44:161 | HG00004247 | JQ997124 | Histopgenetics, Ossining, USA |
| B*46:36 | HG00004296 | JX174604 | Histopgenetics, Ossining, USA |
| B*46:37 | 32 | HE974343 | Xiao Yang Zhou, Beijing, China |
| B*49:01:04 | DESSylv | HE970436 | Sylvie Tourne, Strasbourg, France |
| B*50:18 | 12000216 | JQ952567 | Raffaella Azzarone, L�Aquila, Italy |
| B*51:01:36 | HG00004255 | JX027047 | Histopgenetics, Ossining, USA |
| B*51:01:37 | BX1112 | HE978334 | Xiang Liu, Beijing, China |
| B*51:144 | SZ-48 | JX493013 | Hong-Yan Zou, Shenzhen, China |
| B*54:28 | BX1341 | HE978335 | Xiang Liu, Beijing, China |
| B*56:37 | HG00004252 | JX027049 | Histopgenetics, Ossining, USA |
| B*56:38N | HG00004253 | JX027035 | Histopgenetics, Ossining, USA |
| C*02:64 | HG00004307 | JX089373 | Histopgenetics, Ossining, USA |
| C*03:04:31 | HG00004262 | JX049547 | Histopgenetics, Ossining, USA |
| C*03:37:02 | HG00004309, HG00004310 | JX134272, JX134273 | Histopgenetics, Ossining, USA |
| C*03:165 | HG00004231 | JQ277301 | Histopgenetics, Ossining, USA |
| C*03:166 | HG00004305 | JX174632 | Histopgenetics, Ossining, USA |
| C*03:167 | HG00004260, HG00004261 | JQ997136, JQ997137 | Histopgenetics, Ossining, USA |
| C*03:168 | HG00004311 | JX089372 | Histopgenetics, Ossining, USA |
| C*03:169 | HG00004312 | JX174628 | Histopgenetics, Ossining, USA |
| C*03:170 | HG00004266 | JQ824682 | Histopgenetics, Ossining, USA |
| C*03:171 | CBRA59126011634 | HE974908 | Dominique Masson, La Tronche, France |
| C*04:130 | HG00004263 | JX049544 | Histopgenetics, Ossining, USA |
| C*04:131 | HG00004264 | JQ997144 | Histopgenetics, Ossining, USA |
| C*04:132 | HG00004265 | JQ824654 | Histopgenetics, Ossining, USA |
| C*05:01:22 | HG00002264 | JN124390 | Histopgenetics, Ossining, USA |
| C*05:01:23 | HG00004306 | JX134270 | Histopgenetics, Ossining, USA |
| C*06:53:02 | HG00004228 | JQ277300 | Histopgenetics, Ossining, USA |
| C*07:31:02 | HG00004257 | JQ997139 | Histopgenetics, Ossining, USA |
| C*07:266 | HG00004229 | JQ277297 | Histopgenetics, Ossining, USA |
| C*07:267 | HG00004232 | JQ277304 | Histopgenetics, Ossining, USA |
| C*07:268 | HG00004302 | JX089375 | Histopgenetics, Ossining, USA |
| C*07:269 | HG00004303 | JX174629 | Histopgenetics, Ossining, USA |
| C*07:270 | HG00004304 | JX134271 | Histopgenetics, Ossining, USA |
| C*12:03:23 | HG00004259 | JQ997156 | Histopgenetics, Ossining, USA |
| C*14:46 | HG00004313 | JX174612 | Histopgenetics, Ossining, USA |
| C*15:05:07 | HG00004230 | JQ277302 | Histopgenetics, Ossining, USA |
| C*15:62 | HG00004308 | JX174610 | Histopgenetics, Ossining, USA |
| C*17:14 | HG00004258 | JQ997138 | Histopgenetics, Ossining, USA |
| DRB1*03:85 | TTIL0001 | JX403563 | Valentina Cappuzzo, Palermo, Italy |
| DRB1*04:127 | HG00004316 | JX089380 | Histopgenetics, Ossining, USA |
| DRB1*11:01:17 | HG00004317 | JX089377 | Histopgenetics, Ossining, USA |
| DRB1*11:132 | HG00004319 | JX110629 | Histopgenetics, Ossining, USA |
| DRB1*11:133 | HG00004271 | JX049541 | Histopgenetics, Ossining, USA |
| DRB1*12:37 | BX1867 | HE978484 | Xiang Liu, Beijing, China |
| DRB1*13:12:03 | HG00004318 | JX174636 | Histopgenetics, Ossining, USA |
| DRB1*14:128 | HG00004320 | JX089376 | Histopgenetics, Ossining, USA |
| DRB1*14:129 | IME 1304-12T | JX467694 | Manuela Testi, Rome, Italy |
| DRB1*15:78 | HG00004314 | JX174633 | Histopgenetics, Ossining, USA |
| DRB1*15:79 | HG00004315 | JX174634 | Histopgenetics, Ossining, USA |
| DRB1*15:80N | 014591600 | HE974905 | Dominique Masson, La Tronche, France |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:64 | SBT-010 | AY297166 | Luke Foster, Manchester, United Kingdom |
| A*02:344 | BR8112 | HE978327 | Xiang Liu, Beijing, China |
| A*24:02:05 | HG00004234, HG00004233 | JX049553, JQ997107 | Histopgenetics, Ossining, USA |
| B*44:117 | FRFGR30596 | HE974907 | Dominique Masson, La Tronche, France |
| B*57:57 | HG00004251 | JX027040 | Histopgenetics, Ossining, USA |
| DQB1*03:02:01 | SMSBC001 | JX287366 | Kai Cao, Houston, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:336 | (3) |
| A*11:97 | (4) |
| B*07:06 | (5) |
| B*08:79 | (5) |
| B*35:05:03 | (6) |
| B*35:188 | (7) |
| B*46:01:07 | (8) |
| B*52:29 | (6) |
| B*54:25 | (9) |
| B*57:01:13 | (6) |
| C*01:61 | (10) |
| C*07:208 | (11) |
| E*01:03:05 | (12) |
| DRB1*12:16:02 | (13) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
- Alaez C, Munguia A, Flores HA, Hilario PA, Gorodezky C. Identification of A*02:336 in a Mexican Mestizo acute lymphoblastic leukemia patient from the state of Veracruz. Tissue Antigens. 2012;80:265-6.
- Feng ZH, Hu B, Chi XY, Zhao L, Jiao SX. A novel HLA-A*11 allele, A*11:97, was identified by sequencing-based typing. Tissue Antigens. 2012;80:267-8
- Balas A, Planelles D, Solves P, Roig R, Vicario JL. Genomic full-length analysis of the B*08:79 allele suggests exon shuffling involving the B*08:01:01 and B*07:06 alleles. Tissue Antigens. 2012;80:268-70.
- Swelsen WT, Hartog KS, Poell B, Varlack SV, Lardy NM. Characterization of three new HLA-B alleles: B*35:05:03, B*52:29 and B*57:01:13. Tissue Antigens. 2012;80:270-1.
- Lim AH, Song SN, Shin HH, Kim TE, Kim MH. A novel HLA-B*35 allele, B*35:188, identified by sequence-based typing. Tissue Antigens. 2012;80:271-2.
- Jiao SX, Liu XH, Chi XY, Zhao L, Feng ZH. Identification of a novel HLA-B*46 allele, B*46:01:07, in a Chinese individual. Tissue Antigens. 2012;80:272-3.
- Lim AH, Song SN, Lee JY, Lee SA, Kim MH. A novel HLA-B*54 allele, B*54:25, identified by sequence-based typing. Tissue Antigens. 2012;80:274-5.
- Tao SD, Zhang W, He J, Zhu FM, Lv HJ. Identification of a novel HLA-C*01:61 allele by polymerase chain reaction sequence-based typing in a Chinese leukemia patient. Tissue Antigens. 2012;80:275-6
- Zhang W, Wang W, He J, Zhu FM, Lv HJ. Sequence-based HLA high-resolution typing of a bone marrow donor/recipient pair reveals the novel HLA allele HLA-C*07:208. Tissue Antigens. 2012;80:276-8.
- Veiga-Castelli LC, Castelli EC, Beauchemin K, Donadi EA, Roger M. A novel HLA-E allele, E*01:03:05, identified in two Brazilian individuals. Tissue Antigens. 2012;80:200-1.
- Lim AH, Song SN, Shin GS, Lee SA, Kim MH. A novel HLA-DRB1*12 allele, DRB1*12:16:02, identified by sequence-based typing. Tissue Antigens. 2012;80:278-9.
