Nomenclature for Factors of the HLA System

July 2012

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the June 2012 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequences A*33:38, B*58:30 and DRB1*04:05:12 have been shown to be in error and are identical to A*33:44, B*58:01:01 and DRB1*04:05:14 respectively. The names A*33:38, B*58:30 and DRB1*04:05:12 have been abandoned.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:114MDA0000036JX402909Kai Cao, Houston, USA
A*02:01:81JMDP36K0134AB733012Kenji Tadokoro, Tokyo, Japan
A*02:05:06BY00931JX423802Carolyn K Hurley, Washington DC, USA
A*02:375HG00004141JQ687290Histogenetics, Ossining, USA
A*02:376215470HE966413Klaus Witter, München, Germany
A*03:01:34HG00004119JQ797338Histogenetics, Ossining, USA
A*03:152HG00003553JQ007616Histogenetics, Ossining, USA
A*24:211HG00002960JN124111Histogenetics, Ossining, USA
A*24:212JMDP36K112AB733010Kenji Tadokoro, Tokyo, Japan
A*24:213BY00933JX423804Carolyn K Hurley, Washington DC, USA
A*26:78JMDP01K0130AB733013Kenji Tadokoro, Tokyo, Japan
A*33:62JMDP36K0121AB733011Kenji Tadokoro, Tokyo, Japan
B*07:02:34HG00004210JQ713638Histogenetics, Ossining, USA
B*07:02:35HG00004217JQ622153Histogenetics, Ossining, USA
B*07:163HG00004212JQ436627Histogenetics, Ossining, USA
B*07:164HG00004213JQ739489Histogenetics, Ossining, USA
B*07:165HG00004214JQ622168Histogenetics, Ossining, USA
B*07:166HG00004215JQ797375Histogenetics, Ossining, USA
B*07:167NHG00004216JQ581011Histogenetics, Ossining, USA
B*07:168HG00004218JQ411826Histogenetics, Ossining, USA
B*07:169D11000133FR849754Jinghui Qu, Shenzhen, China
B*08:01:18HG00004163JQ768437Histogenetics, Ossining, USA
B*08:56:02HG00004160JQ277294Histogenetics, Ossining, USA
B*08:95HG00004161JQ388222Histogenetics, Ossining, USA
B*08:96HG00004162JQ581023Histogenetics, Ossining, USA
B*08:97HG00004165JQ359501Histogenetics, Ossining, USA
B*13:02:14HG00004168,
HG00004169
JQ581029,
JQ581030
Histogenetics, Ossining, USA
B*13:02:15HG00004170JQ622167Histogenetics, Ossining, USA
B*13:59HG00004167JQ622151Histogenetics, Ossining, USA
B*14:33HG00004207JQ359478Histogenetics, Ossining, USA
B*15:01:30HG00004199JQ668189Histogenetics, Ossining, USA
B*15:18:05HG00004202JQ687310Histogenetics, Ossining, USA
B*15:64:02HG00004203JQ713643Histogenetics, Ossining, USA
B*15:255HG00003728JN123819Histogenetics, Ossining, USA
B*15:256HG00004198JQ687303Histogenetics, Ossining, USA
B*15:257CB201101884JX256447Faming Zhu, Hangzhou, China
B*15:258N20121193HE856820Harald Schulze, Berlin, Germany
B*15:25912-818BJX215261Chia-Ling Chang, Taipei, Taiwan
B*18:77HG00004157JQ668184Histogenetics, Ossining, USA
B*18:78HG00004158JQ797353Histogenetics, Ossining, USA
B*18:79C149105JX139752Robert Endres, Tempe, USA
B*18:80067691HE860493Cinzia Vecchiato, Bolzano, Italy
B*18:81FRFGR30776HE967304Dominique Masson, La Tronche, France
B*27:07:03HG00004151JQ768444Histogenetics, Ossining, USA
B*27:93HG00004149JQ668200Histogenetics, Ossining, USA
B*27:94NHG00004152JQ622185Histogenetics, Ossining, USA
B*27:95HG00004153JQ713635Histogenetics, Ossining, USA
B*27:96HG00004154JQ797371Histogenetics, Ossining, USA
B*35:01:32HG00004186JQ687315Histogenetics, Ossining, USA
B*35:01:33JMDP01K0147AB738078Kenji Tadokoro, Tokyo, Japan
B*35:01:34HG00004185JQ436635Histogenetics, Ossining, USA
B*35:11:03C146675JX144662Robert Endres, Tempe, USA
B*35:64:02HG00002429JF309404Histogenetics, Ossining, USA
B*35:207HG00002423HQ850035Histogenetics, Ossining, USA
B*35:208HG00003047JN561727Histogenetics, Ossining, USA
B*35:209HG00004166JQ687311Histogenetics, Ossining, USA
B*35:210HG00004182JQ768449Histogenetics, Ossining, USA
B*35:211HG00004184JQ436624Histogenetics, Ossining, USA
B*35:212JRC-D78-008AB731188Kenji Tadokoro, Tokyo, Japan
B*35:213HG00004187JQ359498Histogenetics, Ossining, USA
B*35:214HG00004188JQ797361Histogenetics, Ossining, USA
B*35:215HG00004189JQ797359Histogenetics, Ossining, USA
B*35:216NHG00004190JQ768434Histogenetics, Ossining, USA
B*37:01:09HG00004155JQ388225Histogenetics, Ossining, USA
B*37:35HG00004156JQ411821Histogenetics, Ossining, USA
B*37:36HG00004159JQ668190Histogenetics, Ossining, USA
B*38:41HG00004221JQ687304Histogenetics, Ossining, USA
B*38:42HG00004222JQ687300Histogenetics, Ossining, USA
B*39:40:02NHG00004220JQ581010Histogenetics, Ossining, USA
B*39:76HG00004142JQ668202Histogenetics, Ossining, USA
B*39:77D334189HE956703Edward KL Yang, Hualien, Taiwan
B*40:01:2762110764495HE967305Dominique Masson, La Tronche, France
B*40:02:16HG00004150JQ668180Histogenetics, Ossining, USA
B*40:160:02HG00004145JQ622184Histogenetics, Ossining, USA
B*40:217HG00004143JQ797354Histogenetics, Ossining, USA
B*40:218HG00004146JQ668183Histogenetics, Ossining, USA
B*40:219HG00004181JQ622165Histogenetics, Ossining, USA
B*40:220JRC-D08-003AB731187Kenji Tadokoro, Tokyo, Japan
B*40:221D225887HE858252Edward KL Yang, Hualien, Taiwan
B*42:01:03C148524JX144663Robert Endres, Tempe, USA
B*44:02:01:03CG440201-1592JX196202David Sayer, Perth, Australia
B*44:03:17HG00004177JQ768441Histogenetics, Ossining, USA
B*44:03:18HG00004180JQ581021Histogenetics, Ossining, USA
B*44:156HG00004164JQ739487Histogenetics, Ossining, USA
B*44:157HG00004171JQ581022Histogenetics, Ossining, USA
B*44:158HG00004173JQ687314Histogenetics, Ossining, USA
B*44:159HG00004178,
HG00004179
JQ622155,
JQ622156
Histogenetics, Ossining, USA
B*44:160MDA0000037JX402910Kai Cao, Houston, USA
B*46:35JRC-D79-023AB731189Kenji Tadokoro, Tokyo, Japan
B*48:02:03HG00004209JQ359490Histogenetics, Ossining, USA
B*49:23HG00004144JQ359485Histogenetics, Ossining, USA
B*51:01:35C148871, C148909JX185432Robert Endres, Tempe, USA
B*51:138HG00004205JQ277290Histogenetics, Ossining, USA
B*51:139HG00004206JQ277289Histogenetics, Ossining, USA
B*51:140HG00004208JQ359483Histogenetics, Ossining, USA
B*51:141P150JQ965996Valli De Re, Aviano (Pordenone), Italy
B*51:142CHA12-165JX273775Ji Young Huh, Sungnam-si, South Korea
B*51:143JMDP36K0176AB738079Kenji Tadokoro, Tokyo, Japan
B*52:01:13HG00004193JQ359495Histogenetics, Ossining, USA
B*52:01:14HG00004195JQ739484Histogenetics, Ossining, USA
B*52:01:15JMDP36K0173AB738077Kenji Tadokoro, Tokyo, Japan
B*52:31HG00004192JQ359477Histogenetics, Ossining, USA
B*53:29HG00004183JQ768451Histogenetics, Ossining, USA
B*57:01:14HG00004200JQ359502Histogenetics, Ossining, USA
B*57:60HG00004201JQ622175Histogenetics, Ossining, USA
B*58:01:12336891HE858249Edward KL Yang, Hualien, Taiwan
B*58:38HG00004194JQ797355Histogenetics, Ossining, USA
B*58:39NHG00004196JQ687298Histogenetics, Ossining, USA
B*81:06HG00004219JQ622161Histogenetics, Ossining, USA
C*01:02:17CBRA59126036014HE967306Dominique Masson, La Tronche, France
C*03:164JMDP01K0150AB735461Kenji Tadokoro, Tokyo, Japan
C*04:128PM57HE858528Carlos Vilches, Madrid, Spain
C*04:129CBRA59126033702HE967307Dominique Masson, La Tronche, France
C*07:01:28014616751HE967308Dominique Masson, La Tronche, France
C*07:264NQD000001JX198689Maria Bettinotti, Chantilly, USA
C*07:265JMDP01K0136AB735460Kenji Tadokoro, Tokyo, Japan
C*08:65JRC-D43-004AB731191Kenji Tadokoro, Tokyo, Japan
C*08:66JMDP36K0162AB735464Kenji Tadokoro, Tokyo, Japan
C*12:83JRC-D01-107AB731190Kenji Tadokoro, Tokyo, Japan
C*12:84NJMDP01K0151AB735462Kenji Tadokoro, Tokyo, Japan
C*12:85JMDP36K0160AB735463Kenji Tadokoro, Tokyo, Japan
C*14:45JMDP36K0183AB735465Kenji Tadokoro, Tokyo, Japan
DRB1*01:24:02HG00002655JF292482Histogenetics, Ossining, USA
DRB1*04:05:14D10122981FR849723Jinghui Qu, Shenzhen, China
DRB1*04:05:15d315835HE858250Edward KL Yang, Hualien, Taiwan
DRB1*04:126BY00928JX423799Carolyn K Hurley, Washington DC, USA
DRB1*09:20MUDRJJX310102Grace Hommel-Berrey, Indianapolis, USA
DRB1*11:13112C18JQ898685Arturas Jakubauskas, Vilnius, Lithuania
DRB1*13:143CB12-389JX315459Ji Young Huh, Sungnam-si, South Korea
DQA1*01:10214622HE965627Klaus Witter, München, Germany
DQA1*01:11214965HE966412Klaus Witter, München, Germany
DPA1*02:057551200112JX291162Yunping Xu, Shenzhen, China
DPB1*140:017551101236JX291163Yunping Xu, Shenzhen, China
MICB*005:07M0138JX282181Faming Zhu, Hangzhou, China
MICB*005:08M0273JX282184Faming Zhu, Hangzhou, China
MICB*027M0346JX282183Faming Zhu, Hangzhou, China
MICB*028M0373JX282186Faming Zhu, Hangzhou, China
MICB*029M0383JX282187Faming Zhu, Hangzhou, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:14MDA0000028JX198690Kai Cao, Houston, USA
A*02:338BY00932JX423803yCarolyn K Hurley, Washington DC, USA
A*03:150HG00004124JQ713632Histogenetics, Ossining, USA
A*24:02:13MDA0000033JX242896Kai Cao, Houston, USA
A*24:71JMDP36K0154AB733014Kenji Tadokoro, Tokyo, Japan
A*29:34BY00929JX423800Carolyn K Hurley, Washington DC, USA
A*31:24JMDP36K0172AB733015Kenji Tadokoro, Tokyo, Japan
A*33:44D10011031FR690488Jinghui Qu, Shenzhen, China
A*74:03MDA0000026JX186196Kai Cao, Houston, USA
B*07:119HG00004211JQ436616Histogenetics, Ossining, USA
B*15:18:03HG00004204JQ687309Histogenetics, Ossining, USA
B*15:189HG00004197JQ359488Histogenetics, Ossining, USA
B*18:04JMDP01K0148AB738081Kenji Tadokoro, Tokyo, Japan
B*35:200HG00004191JQ687302Histogenetics, Ossining, USA
B*37:22HG00004147,
HG00004148
JQ277314,
JQ359491
Histogenetics, Ossining, USA
B*39:15JMDP36K0158AB738080Kenji Tadokoro, Tokyo, Japan
B*39:62MDA0000032JX242895Kai Cao, Houston, USA
B*44:06MDA0000029JX198691Kai Cao, Houston, USA
B*44:110HG00004174,
HG00004175,
HG00004176
JQ581013,
JQ668182,
JQ581014
Histogenetics, Ossining, USA
B*58:01:01D09002707HM122220Jinghui Qu, Shenzhen, China
B*78:02:02MDA0000030JX206991Kai Cao, Houston, USA
C*01:02:03MDA0000034JX242897Kai Cao, Houston, USA
C*02:07MDA0000031JX206992Kai Cao, Houston, USA
C*03:29JMDP01K0149AB735466Kenji Tadokoro, Tokyo, Japan
C*07:45JMDP01K0153AB735467Kenji Tadokoro, Tokyo, Japan
C*15:27280716AM422983Tatiana Lebedeva, Dedham, USA
DRB1*03:05:01D186855HE858251Edward KL Yang, Hualien, Taiwan
DQA1*04:01:02214940HE965629Klaus Witter, München, Germany
DQA1*05:05:01:02214940HE966411Klaus Witter, München, Germany
DQA1*06:01:01202439HE965628Klaus Witter, München, Germany
MICA*002:01SZMGSQ-16JX275848Su-Qing Gao, Shenzhen, China
MICA*012:01SZMGSQ-18JX392323Su-Qing Gao, Shenzhen, China
MICA*019SZMGSQ-19JX392324Su-Qing Gao, Shenzhen, China
MICA*027SZGSQ-15JX173492Su-Qing Gao, Shenzhen, China
MICA*045SZMGSQ-17JX275849Su-Qing Gao, Shenzhen, China
MICB*005:06M0298JX282182Faming Zhu, Hangzhou, China
MICB*023M0147JX282180Faming Zhu, Hangzhou, China
MICB*026M0112JX282185Faming Zhu, Hangzhou, China

Table 3: Recently Published Sequences


Sequence References
A*02:07:02(3)
A*02:334(4)
A*11:01:18(5)
A*11:01:18(5)
A*23:50(6)
A*24:02:55(7)
A*31:59(8)
B*40:179(9)
C*01:02:15(10)
C*14:36(10)
DRB1*03:77(11)
DRB1*08:48(12)
DRB1*10:04(13)
DRB1*16:16(14)
DQB1*03:38(15)
DPB1*138:01(16)
DPB1*139:01(17)
MICB*005:06(18)
MICB*026(18)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Cho D, Won EJ, Yoon CE, Kwon OJ, Shin MG. HLA-A*02:07:02, a new allele identified by sequence-based typing in a Korean individual. Tissue Antigens. 2012;79:384-5.
  4. Schulze H, Todorova K, Cirocki J, Uharek L, Schonemann C. Detection of a novel HLA-A allele, designated A*02:334. Tissue Antigens. 2012;80:191.
  5. Wang D, Xu Y, Zou H, Deng Z. A novel HLA-A allele detected by sequence-based typing: A*11:01:18. Tissue Antigens. 2012;80:192-3.
  6. Ferriola D, Heron S, Lind C, Monos DS. Identification of a novel HLA-A*23 variant allele, A*23:50. Tissue Antigens. 2012;79:386.
  7. Guolong Y, Limei D, Xinge Y, Jin Y, Peng L. Identification of a novel HLA-A*24:02:55 allele by sequence-based typing. Tissue Antigens. 2012;80:193-4.
  8. Zhang W, Zhu FM, He J, Lv HJ, Yan LX. HLA-A*31:56 and HLA-A*31:59 were identified by polymerase chain reaction sequence-based typing in Chinese individuals. Tissue Antigens. 2012;79:388-9.
  9. Kim KM, Sung HY, Jung B, Kang MS, Huh JY. HLA-B*40:179, a novel allele identified by sequence-based typing in cord blood from a Korean woman. Tissue Antigens. 2012;80:194-5.
  10. Lee KW. Full-length coding sequences of the two novel HLA-C alleles, C*14:36 and C*01:02:15. Tissue Antigens. 2012;79:389-90.
  11. Yang KL, Lee SK, Kao RH, Lin CL, Lin PY. Discovery of the novel HLA-DRB1*03:77 allele in a Taiwanese unrelated hematopoietic stem cell donor by a sequence-based typing method and identification of the probable HLA haplotype in association with DRB1*03:77. Int J Immunogenet. 2012;39:442-4.
  12. Mattar SB, Wowk PF, da Graca Bicalho M. HLA-DRB1*08:48, a novel allele identified in a Brazilian donor. Tissue Antigens. 2012;79:391-2.
  13. Yang KL, Lee SK, Lin CC, et al. Discovery of the novel HLA-DRB1*10:04 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*10:04. Int J Immunogenet. 2012.
  14. Yang KL, Lee SK, Kao RH, Lin CL, Lin PY. Discovery of the novel HLA-DRB1*16:16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB1*16:16. Int J Immunogenet. 2012;39:445-7.
  15. Tao SD, He YM, He J, Zhu FM, Lv HJ. Identification of a novel HLA-DQB1*03:38 allele by polymerase chain reaction sequence-based typing in a Chinese bone marrow donor. Tissue Antigens. 2012;80:198-9.
  16. Perrone MP, Andreani M, Gesuiti P, Condello R, Testi M. Identification of a novel HLA-DPB1 allele, DPB1*138:01, by sequence-based typing. Tissue Antigens. 2012;80:195-6.
  17. Wang D, Xu Y, He LM, Deng Z. Characterization of the novel HLA-DPB1*139:01 allele identified by sequence-based typing in a Chinese Han individual. Tissue Antigens. 2012;80:197-8.
  18. Liu X, Li L, Pan F, Tian W. MICB polymorphism in a southern Chinese Han population: the identification of two new MICB alleles, MICB*005:06 and MICB*026. Hum Immunol. 2012;73:818-23.